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Article

CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma

  • Authors:
    • Lin‑Lin Wang
    • Hua‑Ping Tang
    • Guo‑Chao Shi
    • Huan‑Ying Wan
    • Wei Tang
    • Xiao‑Xia Hou
    • Li‑Na Pan
    • Bao‑Yu Shi
    • Lian‑Qin Tao
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Department of Pulmonary Medicine, Qingdao Municipal Hospital, Qingdao University School of Medicine, Qingdao, Shandong 266011, P.R. China
  • Pages: 1432-1438
    |
    Published online on: September 18, 2013
       https://doi.org/10.3892/mmr.2013.1692
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Abstract

In the immune system, CD4+CD25+Foxp3+ regulatory T cells (Tregs) maintain self‑tolerance and Th17 cells mediate inflammatory responses. CD39 is expressed on the surface of a subset of naturally occurring human Tregs that are important in constraining pathogenic Th17 cells. Additional studies have shown that Tregs differentiate into interleukin‑17 (IL‑17)+Foxp3+ T cells. Our previous study indicated an imbalance of Th17 and Tregs in allergic asthma; however, the underlying mechanisms remain poorly understood. Using quantitative PCR (qPCR), CD39 and CD73 mRNA levels in CD4+ T cells were investigated. Flow cytometry was used to analyze the proportion of IL‑17+Foxp3+ T cells, and CD39 and CD73 expressed by CD4+ T cells and Tregs in the peripheral blood of the subjects. The results of the present study demonstrated an increased frequency of CD4+Foxp3+IL‑17+ T cells in moderate to severe asthma. A deficiency in CD39 expressed on the surface of CD4+ T cells and Tregs was observed in asthma patients. The expression of CD39 and CD73 on the surface of CD4+ T cells and Tregs was negatively correlated with the number of Th17 cells. These results indicated that the plasticity of Tregs transforming to IL‑17+Foxp3+CD4+ T cells, the reduced frequency of CD39+ Tregs and less effective suppression of IL‑17 production by residual CD39+ Tregs leads to an imbalance of Th17 and Tregs in asthma. Therefore, enhanced CD39 activity is hypothesized to prevent the progression of asthma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang LL, Tang HP, Shi GC, Wan HY, Tang W, Hou XX, Pan LN, Shi BY and Tao LQ: CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma. Mol Med Rep 8: 1432-1438, 2013.
APA
Wang, L., Tang, H., Shi, G., Wan, H., Tang, W., Hou, X. ... Tao, L. (2013). CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma. Molecular Medicine Reports, 8, 1432-1438. https://doi.org/10.3892/mmr.2013.1692
MLA
Wang, L., Tang, H., Shi, G., Wan, H., Tang, W., Hou, X., Pan, L., Shi, B., Tao, L."CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma". Molecular Medicine Reports 8.5 (2013): 1432-1438.
Chicago
Wang, L., Tang, H., Shi, G., Wan, H., Tang, W., Hou, X., Pan, L., Shi, B., Tao, L."CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma". Molecular Medicine Reports 8, no. 5 (2013): 1432-1438. https://doi.org/10.3892/mmr.2013.1692
Copy and paste a formatted citation
x
Spandidos Publications style
Wang LL, Tang HP, Shi GC, Wan HY, Tang W, Hou XX, Pan LN, Shi BY and Tao LQ: CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma. Mol Med Rep 8: 1432-1438, 2013.
APA
Wang, L., Tang, H., Shi, G., Wan, H., Tang, W., Hou, X. ... Tao, L. (2013). CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma. Molecular Medicine Reports, 8, 1432-1438. https://doi.org/10.3892/mmr.2013.1692
MLA
Wang, L., Tang, H., Shi, G., Wan, H., Tang, W., Hou, X., Pan, L., Shi, B., Tao, L."CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma". Molecular Medicine Reports 8.5 (2013): 1432-1438.
Chicago
Wang, L., Tang, H., Shi, G., Wan, H., Tang, W., Hou, X., Pan, L., Shi, B., Tao, L."CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma". Molecular Medicine Reports 8, no. 5 (2013): 1432-1438. https://doi.org/10.3892/mmr.2013.1692
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