Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December 2013 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2013 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer

  • Authors:
    • Lan‑Lan Yang
    • Chong‑Yang Liang
    • Tian‑Cheng Lu
    • Chen‑Yang Zhi
    • Bin Liu
    • Jian‑Hua Zhou
    • Xu‑Ming Liu
    • Hai‑Cheng Gao
    • Wei Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Clinical Pharmacy and Pharmaceutical Management, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 13002, P.R. China, School of Life Sciences, Jilin Agricultural Univesity, Changchun, Jilin 130118, P.R. China, Changchun University of Traditional Chinese Medicine, Changchun, Jilin 130118, P.R. China, Department of General Surgery, Jilin University Second Hospital, Changchun, Jilin 130041, P.R. China, Department of Radiotherapy, Tumor Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 1812-1816
    |
    Published online on: September 27, 2013
       https://doi.org/10.3892/mmr.2013.1706
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The role of tissue transglutaminase (tTG) in cancer development remains an important field of study. The aim of the current study was to understand the involvement of tTG in cancer and the inhibitory effect of cantharidinate on the expression of tTG in human colorectal cancer (CRC) using immunohistochemical and PCR analysis. The results showed that the expression of tTG increased in human CRC and cantharidinate inhibited the expression of tTG. These results suggested that tTG is significant in human CRC and that tTG may be an important target for tumor chemoprevention and treatment. Cantharidinate may be considered as a novel co‑therapy for controlling tTG expression in human CRC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM Jr, et al: Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer. Mol Carcinog. 52:255–264. 2013.PubMed/NCBI

2 

Potter JD: Colorectal cancer: molecules and populations. J Natl Cancer Inst. 91:916–932. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Deschoolmeester V, Baay M, Specenier P, Lardon F and Vermorken JB: A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy. Oncologist. 15:699–731. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Kotzev I, Mirchev M, Manevska B, Ivanova I and Kaneva M: Risk and protective factors for development of colorectal polyps and cancer (Bulgarian experience). Hepatogastroenterology. 55:381–387. 2008.PubMed/NCBI

5 

Domínguez-Ayala M, Díez-Vallejo J and Comas-Fuentes A: Missed opportunities in early diagnosis of symptomatic colorectal cancer. Rev Esp Enferm Dig. 104:343–349. 2012.PubMed/NCBI

6 

Jass JR: Colorectal cancer: a multipathway disease. Crit Rev Oncog. 12:273–287. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Fearon ER: Molecular genetics of colorectal cancer. Annu Rev Pathol. 6:479–507. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Posner MR: Paradigm shift in the treatment of head and neck cancer: the role of neoadjuvant chemotherapy. Oncologist. 10(Suppl 3): 11–19. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Simoglou C, Gymnopoulou E, Simoglou L, Gymnopoulou M, Nikolaou K and Gymnopoulos D: Surgery for colorectal cancer in the small town of Komotini. J Multidiscip Healthc. 5:273–276. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Hu Y, Zhang H, Xiong X, Cao Y, Han Y and Xi Z: Inhibitory effect of tissue transglutaminase (tTG) antisense oligodeoxynucleotides on tTG expression in cultured bovine trabecular meshwork cells. J Huazhong Univ Sci Technolog Med Sci. 25:729–731. 2005. View Article : Google Scholar

11 

van Hazel GA, Pavlakis N, Goldstein D, Olver IN, Tapner MJ, Price D, Bower GD, Briggs GM, Rossleigh MA, Taylor DJ and George J: Treatment of fluorouracil-refractory patients with liver metastases from colorectal cancer by using yttrium-90 resin microspheres plus concomitant systemic irinotecan chemotherapy. J Clin Oncol. 27:4089–4095. 2009.

12 

Gerber DE: Targeted therapies: a new generation of cancer treatments. Am Fam Physician. 77:311–319. 2008.PubMed/NCBI

13 

Dehmer GJ, Douglas JS Jr, Abizaid A, et al: SCAI/ACCF/HRS/ESC/SOLACI/APSIC statement on the use of live case demonstrations at cardiology meetings: assessments of the past and standards for the future. Heart Rhythm. 7:1522–1535. 2010. View Article : Google Scholar

14 

Liu HG and Huang HX: Overview pharmacokinetic about traditional Chinese medicine in recent 10 years. Zhongguo Zhong Yao Za Zhi. 32:2346–2348. 2007.(In Chinese).

15 

Honkanen RE: Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330:283–286. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Deng LP, Dong J, Cai H and Wang W: Cantharidin as an antitumor agent: a retrospective review. Curr Med Chem. 20:159–166. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Huang YP, Ni CH, Lu CC, et al: Suppressions of migration and invasion by cantharidin in TSGH-8301 human bladder carcinoma cells through the inhibitions of matrix metalloproteinase-2/-9 signaling. Evid Based Complement Alternat Med. 2013:1902812013. View Article : Google Scholar : PubMed/NCBI

18 

Zhan YP, Huang XE, Cao J, et al: Clinical study on safety and efficacy of Qinin® (cantharidin sodium) injection combined with chemotherapy in treating patients with gastric cancer. Asian Pac J Cancer Prev. 13:4773–4776. 2012.PubMed/NCBI

19 

Kim YM, Ku MJ, Son YJ, Yun JM, Kim SH and Lee SY: Anti-metastatic effect of cantharidin in A549 human lung cancer cells. Arch Pharm Res. 36:479–484. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Yeh CH, Yang YY, Huang YF, Chow KC and Chen MF: Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction. Chin J Integr Med. 18:676–682. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Agnihotri N, Kumar S and Mehta K: Tissue transglutaminase as a central mediator in inflammation-induced progression of breast cancer. Breast Cancer Res. 15:2022013. View Article : Google Scholar : PubMed/NCBI

22 

Yakubov B, Chelladurai B, Schmitt J, Emerson R, Turchi JJ and Matei D: Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer. Neoplasia. 15:609–619. 2013.PubMed/NCBI

23 

Caffarel MM, Chattopadhyay A, Araujo AM, Bauer J, Scarpini CG and Coleman N: Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma. J Pathol. 231:168–179. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Wang Z, Perez M, Caja S, Melino G, Johnson TS, Lindfors K and Griffin M: A novel extracellular role for tissue transglutaminase in matrix-bound VEGF-mediated angiogenesis. Cell Death Dis. 4:e8082013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang LL, Liang CY, Lu TC, Zhi CY, Liu B, Zhou JH, Liu XM, Gao HC and Huang W: Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer. Mol Med Rep 8: 1812-1816, 2013.
APA
Yang, L., Liang, C., Lu, T., Zhi, C., Liu, B., Zhou, J. ... Huang, W. (2013). Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer. Molecular Medicine Reports, 8, 1812-1816. https://doi.org/10.3892/mmr.2013.1706
MLA
Yang, L., Liang, C., Lu, T., Zhi, C., Liu, B., Zhou, J., Liu, X., Gao, H., Huang, W."Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer". Molecular Medicine Reports 8.6 (2013): 1812-1816.
Chicago
Yang, L., Liang, C., Lu, T., Zhi, C., Liu, B., Zhou, J., Liu, X., Gao, H., Huang, W."Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer". Molecular Medicine Reports 8, no. 6 (2013): 1812-1816. https://doi.org/10.3892/mmr.2013.1706
Copy and paste a formatted citation
x
Spandidos Publications style
Yang LL, Liang CY, Lu TC, Zhi CY, Liu B, Zhou JH, Liu XM, Gao HC and Huang W: Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer. Mol Med Rep 8: 1812-1816, 2013.
APA
Yang, L., Liang, C., Lu, T., Zhi, C., Liu, B., Zhou, J. ... Huang, W. (2013). Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer. Molecular Medicine Reports, 8, 1812-1816. https://doi.org/10.3892/mmr.2013.1706
MLA
Yang, L., Liang, C., Lu, T., Zhi, C., Liu, B., Zhou, J., Liu, X., Gao, H., Huang, W."Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer". Molecular Medicine Reports 8.6 (2013): 1812-1816.
Chicago
Yang, L., Liang, C., Lu, T., Zhi, C., Liu, B., Zhou, J., Liu, X., Gao, H., Huang, W."Role of tissue transglutaminase and effect of cantharidinate in human colorectal cancer". Molecular Medicine Reports 8, no. 6 (2013): 1812-1816. https://doi.org/10.3892/mmr.2013.1706
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team