Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December 2013 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2013 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy

  • Authors:
    • Jun Wang
    • Ming Ming Yang
    • Shi Song Rong
    • Tsz Kin Ng
    • Yan Bo Li
    • Xiao Min Liu
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, P.R. China, Geriatric Research, Education and Clinical Center, Miami Veterans Affairs Medical Center, Miami, FL 33125, USA
  • Pages: 1845-1851
    |
    Published online on: October 2, 2013
       https://doi.org/10.3892/mmr.2013.1710
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Emerging reports have revealed a potential association of paraoxonase (PON) gene polymorphisms with diabetic nephropathy (DN) and diabetic retinopathy (DR). However, the identification of susceptible genes and the quantification of associated risks are elusive owing to a lack of reproducibility. Therefore, a meta‑analysis was conducted in the present study to improve the understanding of the effect of PON1 and PON2 on DN and DR. A total of 10 articles, involving 2,877 patients and 3,246 controls met the inclusion criteria. Functional variants (n=4) were evaluated, including rs662 (p.Q192R) and rs854560 (p.L55M) in PON1; and rs7493 (p.S311C) and rs12026 (p.A148G) in PON2. Overall, PON1‑L55M was found to be significantly associated with DR in all the genetic models: allele [odds ratio (OR)=2.42; 95% confidence interval (CI), 1.91‑3.07]; dominant (OR=5.76; 95% CI, 3.14‑10.55), homozygote (OR=10.53; 95% CI, 5.59‑19.86), heterozygote (OR=3.62; 95% CI, 1.94‑6.74), and recessive (OR=3.56; 95% CI, 2.61‑4.86), with no evidence of between‑study heterogeneity. However, such associations were not detected in DN and the other three polymorphisms did not show any associations with DN or DR. The current meta‑analysis highlighted results for the risk of association of PON1‑55L with DR. The results also indicated that PON2 gene polymorphisms, as well as PON1‑Q192R, may not confer major genetic risk to DN or DR. Additional studies are required to enrich the understanding of PON genes, particularly for its functional role in DR.
View Figures

Figure 1

Figure 2

View References

1 

Resnikoff S, Pascolini D, Etya'ale D, et al: Global data on visual impairment in the year 2002. Bull World Health Organ. 82:844–851. 2004.PubMed/NCBI

2 

Sheetz MJ and King GL: Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA. 288:2579–2588. 2002. View Article : Google Scholar

3 

Stratton IM, Kohner EM, Aldington SJ, et al: UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis. Diabetologia. 44:156–163. 2001.PubMed/NCBI

4 

Pettitt DJ, Saad MF, Bennett PH, Nelson RG and Knowler WC: Familial predisposition to renal disease in two generations of Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 33:438–443. 1990. View Article : Google Scholar : PubMed/NCBI

5 

The Diabetes Control and Complications Trial Research Group. Clustering of long-term complications in families with diabetes in the diabetes control and complications trial. Diabetes. 46:1829–1839. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Canani LH, Araki S, Warram JH and Krolewski AS: Comment - to: Pinizzotto M, Castillo E, Fiaux M, Temler E, Gaillard RC, Ruiz J (2001) Paraoxonase 2 polymorphisms are associated with diabetic nephropathy in Type II diabetes. Diabetologia 44: 104–107. Diabetologia. 44:1062–1064. 2001.PubMed/NCBI

7 

Kao Y, Donaghue KC, Chan A, Bennetts BH, Knight J and Silink M: Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes. Diabet Med. 19:212–215. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Pinizzotto M, Castillo E, Fiaux M, Temler E, Gaillard RC and Ruiz J: Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes. Diabetologia. 44:104–107. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Lyons TJ, Li W, Wells-Knecht MC and Jokl R: Toxicity of mildly modified low-density lipoproteins to cultured retinal capillary endothelial cells and pericytes. Diabetes. 43:1090–1095. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Morrison AC, Bare LA, Luke MM, et al: Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. Cerebrovasc Dis. 26:420–424. 2008. View Article : Google Scholar

11 

Luke MM, Lalouschek W, Rowland CM, et al: Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry. Cerebrovasc Dis. 28:499–504. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Durrington PN, Mackness B and Mackness MI: Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol. 21:473–480. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Araki S, Makita Y, Canani L, Ng D, Warram JH and Krolewski AS: Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus. Diabetologia. 43:1540–1543. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Ergun MA, Yurtcu E, Demirci H, et al: PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. Biochem Genet. 49:1–8. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Kao YL, Donaghue K, Chan A, Knight J and Silink M: A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM. J Clin Endocrinol Metab. 83:2589–2592. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Kordonouri O, James RW, Bennetts B, et al: Modulation by blood glucose levels of activity and concentration of paraoxonase in young patients with type 1 diabetes mellitus. Metabolism. 50:657–660. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Mackness B, McElduff P and Mackness MI: The paraoxonase-2–310 polymorphism is associated with the presence of microvascular complications in diabetes mellitus. J Intern Med. 258:363–368. 2005.

18 

Murata M, Maruyama T, Suzuki Y, Saruta T and Ikeda Y: Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus. Diabet Med. 21:837–844. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Tiwari AK, Prasad P, BKT, et al: Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetes. J Diabetes Complications. 23:102–111. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Fleiss JL: The statistical basis of meta-analysis. Stat Methods Med Res. 2:121–145. 1993. View Article : Google Scholar

21 

Nivoit P, Wiernsperger N, Moulin P, Lagarde M and Renaudin C: Effect of glycated LDL on microvascular tone in mice: a comparative study with LDL modified in vitro or isolated from diabetic patients. Diabetologia. 46:1550–1558. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Mackness B, Durrington PN, Boulton AJ, Hine D and Mackness MI: Serum paraoxonase activity in patients with type 1 diabetes compared to healthy controls. Eur J Clin Invest. 32:259–264. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Tsuzura S, Ikeda Y, Suehiro T, et al: Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes. Metabolism. 53:297–302. 2004. View Article : Google Scholar

24 

Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ and Furlong CE: The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet. 3:73–76. 1993. View Article : Google Scholar : PubMed/NCBI

25 

Garin MC, James RW, Dussoix P, et al: Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes. J Clin Invest. 99:62–66. 1997. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yang MM, Rong SS, Ng TK, Li YB and Liu XM: Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy. Mol Med Rep 8: 1845-1851, 2013.
APA
Wang, J., Yang, M.M., Rong, S.S., Ng, T.K., Li, Y.B., & Liu, X.M. (2013). Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy. Molecular Medicine Reports, 8, 1845-1851. https://doi.org/10.3892/mmr.2013.1710
MLA
Wang, J., Yang, M. M., Rong, S. S., Ng, T. K., Li, Y. B., Liu, X. M."Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy". Molecular Medicine Reports 8.6 (2013): 1845-1851.
Chicago
Wang, J., Yang, M. M., Rong, S. S., Ng, T. K., Li, Y. B., Liu, X. M."Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy". Molecular Medicine Reports 8, no. 6 (2013): 1845-1851. https://doi.org/10.3892/mmr.2013.1710
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yang MM, Rong SS, Ng TK, Li YB and Liu XM: Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy. Mol Med Rep 8: 1845-1851, 2013.
APA
Wang, J., Yang, M.M., Rong, S.S., Ng, T.K., Li, Y.B., & Liu, X.M. (2013). Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy. Molecular Medicine Reports, 8, 1845-1851. https://doi.org/10.3892/mmr.2013.1710
MLA
Wang, J., Yang, M. M., Rong, S. S., Ng, T. K., Li, Y. B., Liu, X. M."Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy". Molecular Medicine Reports 8.6 (2013): 1845-1851.
Chicago
Wang, J., Yang, M. M., Rong, S. S., Ng, T. K., Li, Y. B., Liu, X. M."Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy". Molecular Medicine Reports 8, no. 6 (2013): 1845-1851. https://doi.org/10.3892/mmr.2013.1710
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team