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Review

Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)

  • Authors:
    • Eduardo Fuentes
    • Luis Guzmán-Jofre
    • Rodrigo Moore-Carrasco
    • Iván Palomo
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, 3460000 Talca, Chile
  • Pages: 1611-1616
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    Published online on: October 7, 2013
       https://doi.org/10.3892/mmr.2013.1714
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Abstract

Metabolic syndrome (MS) includes the presence of arterial hypertension, insulin resistance, dyslipidemia, cardiovascular disease (CVD) and abdominal obesity, which is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of certain pro-inflammatory signaling pathways. Furthermore, the changes presented by the adipose tissue in MS favors the secretion of several molecular mediators capable of activating or suppressing a number of transcription factors, such as the peroxisome proliferator-activated receptors (PPARs), whose main functions include storage regulation and fatty acid catabolization. When they are activated by their ligands (synthetic or endogenous), they control several genes involved in intermediate metabolism, which make them, together with the PPAR gamma coactivator-1-α (PGC-1) and the silent information regulator T1 (SIRT1), good targets for treating metabolic diseases and their cardiovascular complications.
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Copy and paste a formatted citation
Spandidos Publications style
Fuentes E, Guzmán-Jofre L, Moore-Carrasco R and Palomo I: Role of PPARs in inflammatory processes associated with metabolic syndrome (Review). Mol Med Rep 8: 1611-1616, 2013.
APA
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., & Palomo, I. (2013). Role of PPARs in inflammatory processes associated with metabolic syndrome (Review). Molecular Medicine Reports, 8, 1611-1616. https://doi.org/10.3892/mmr.2013.1714
MLA
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., Palomo, I."Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)". Molecular Medicine Reports 8.6 (2013): 1611-1616.
Chicago
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., Palomo, I."Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)". Molecular Medicine Reports 8, no. 6 (2013): 1611-1616. https://doi.org/10.3892/mmr.2013.1714
Copy and paste a formatted citation
x
Spandidos Publications style
Fuentes E, Guzmán-Jofre L, Moore-Carrasco R and Palomo I: Role of PPARs in inflammatory processes associated with metabolic syndrome (Review). Mol Med Rep 8: 1611-1616, 2013.
APA
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., & Palomo, I. (2013). Role of PPARs in inflammatory processes associated with metabolic syndrome (Review). Molecular Medicine Reports, 8, 1611-1616. https://doi.org/10.3892/mmr.2013.1714
MLA
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., Palomo, I."Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)". Molecular Medicine Reports 8.6 (2013): 1611-1616.
Chicago
Fuentes, E., Guzmán-Jofre, L., Moore-Carrasco, R., Palomo, I."Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)". Molecular Medicine Reports 8, no. 6 (2013): 1611-1616. https://doi.org/10.3892/mmr.2013.1714
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