Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December 2013 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2013 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease

  • Authors:
    • Ying Huang
    • Yan Lei
    • Zhihua Zheng
    • Xiaohua Wang
    • Mingliang Hu
    • Rongjun Liu
    • Xueqing Yu
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First Affiliated Hospital, Sun Yat‑Sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong 510080, P.R. China
  • Pages: 1831-1835
    |
    Published online on: October 8, 2013
       https://doi.org/10.3892/mmr.2013.1715
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Rosiglitazone (ROG) has been shown to exert beneficial effects on glycemic control and renal protection. Circulatory fibroblast growth factor‑23 (FGF‑23) is a novel independent risk factor for chronic kidney disease (CKD) progression. The current study focused on how ROG impacts on injury of the kidney, and whether FGF‑23 is involved in the process. A total of 24 male Sprague Dawley rats, weighing 250‑280 g, were divided into four groups (n=6 per group):  i) Normal; ii) ROG controls, treated with ROG (10 mg/kg/day); iii) CKD models, treated with adenine (200 mg/kg/day); and iv) ROG treatment, treated with ROG (10 mg/kg/day) and adenine (200 mg/kg/day). The rats were sacrificed after four weeks, and serum, urine and kidney tissues were collected. The data revealed that the serum levels of inorganic phosphate (Pi), intact parathyroid hormone (iPTH) and FGF‑23 were significantly higher in the CKD models compared with those in the normal group (P<0.01), while ROG significantly reduced the serum levels of Pi, iPTH and FGF‑23 (P<0.01). The ratio of protein/creatine (Cr) in the urine and the serum levels of Cr, blood urea nitrogen and uric acid were significantly increased in the CKD models compared with the normal group (P<0.01), however, ROG significantly reduced these parameters (P<0.05). Furthermore, ROG significantly alleviated the tubule interstitial damage index of the CKD models in comparison with that of the controls. These results indicated that ROG mitigates the lesions of chronic kidney disease induced by adenine, and that the system of Pi‑PTH‑FGF‑23 may contribute to this process. The possible mechanisms underlying this process require confirmation in future studies.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bello AK, Hemmelgarn B, Lloyd A, James MT, Manns BJ, Klarenbach S, et al: Associations among estimated glomerular filtration rate, proteinuria, and adverse cardiovascular outcomes. Clin J Am Soc Nephrol. 6:1418–1426. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Sarnak MJ and Astor BC: Implications of proteinuria: CKD progression and cardiovascular outcomes. Adv Chronic Kidney Dis. 18:258–266. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Faul C: Fibroblast growth factor 23 and the heart. Curr Opin Nephrol Hypertens. 21:369–375. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Nakano C, Hamano T, Fujii N, Obi Y, Matsui I, Tomida K, et al: Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis. Bone. 50:1266–1274. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Razzaque MS and Lanske B: The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis. J Endocrinol. 194:1–10. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, et al: Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 113:561–568. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Seiler S, Heine GH and Fliser D: Clinical relevance of FGF-23 in chronic kidney disease. Kidney Int Suppl. 76:S34–S42. 2009. View Article : Google Scholar : PubMed/NCBI

8 

El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, et al: Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int. 75:1297–1307. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Gutiérrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, et al: Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med. 359:584–592. 2008.PubMed/NCBI

10 

Sharma SK, Zou H, Togtokh A, Ene-Iordache B, Carminati S, Remuzzi A, et al: Burden of CKD, proteinuria, and cardiovascular risk among Chinese, Mongolian, and Nepalese participants in the International Society of Nephrology screening programs. Am J Kidney Dis. 56:915–927. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Reel B, Guzeloglu M, Bagriyanik A, Atmaca S, Aykut K, Albayrak G and Hazan E: The effects of PPAR-γ agonist pioglitazone on renal ischemia/reperfusion injury in rats. J Surg Res. 182:176–184. 2013.

12 

Basturk T, Unsal A, Ulas T, Koc Y, Sakaci T, Ahbap E and Borlu F: Effects of rosiglitazone treatment on insulin resistance and TNF-alpha levels in patients with chronic kidney disease: a prospective study. Eur Rev Med Pharmacol Sci. 16:1519–1524. 2012.PubMed/NCBI

13 

Setti G, Hayward A, Dessapt C, Barone F, Buckingham R, White K, et al: Peroxisome proliferator-activated receptor-γ agonist rosiglitazone prevents albuminuria but not glomerulosclerosis in experimental diabetes. Am J Nephrol. 32:393–402. 2010.

14 

Ren L, Liu N, Zhi H, Li Y, Li Y, Tang R, et al: Vasculoprotective effects of rosiglitazone through modulating renin-angiotensin system in vivo and vitro. Cardiovasc Diabetol. 10:102011. View Article : Google Scholar : PubMed/NCBI

15 

Alessi A, França Neto OR, Prim C, Silva RF, Noronha Ld, Brofman PR, et al: Rosiglitazone and vascular injury in hypercholesterolemic rabbits: neointimal formation assessment. Arq Bras Cardiol. 95:283–288. 2010.PubMed/NCBI

16 

Nakaya H: Roles of PPARgamma in preventing the development of atherosclerosis in LDL receptor null mice. Nihon Rinsho. 68:229–234. 2010.(In Japanese).

17 

Schiffrin EL: Peroxisome proliferator-activated receptors and cardiovascular remodeling. Am J Physiol Heart Circ Physiol. 288:H1037–H1043. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Hu W, Yu Q, Zhang J and Liu D: Rosiglitazone ameliorates diabetic nephropathy by reducing the expression of Chemerin and ChemR23 in the kidney of streptozotocin-induced diabetic rats. Inflammation. 35:1287–1293. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Bergwitz C and Jüppner H: Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med. 61:91–104. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Pontoriero G, Cozzolino M, Locatelli F and Brancaccio D: CKD patients: the dilemma of serum PTH levels. Nephron Clin Pract. 116:c263–c268. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Levin A, Djurdjev O, Beaulieu M and Er L: Variability and risk factors for kidney disease progression and death following attainment of stage 4 CKD in a referred cohort. Am J Kidney Dis. 52:661–671. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Kincaid-Smith P, Fairley KF, Farish S, Best JD and Proietto J: Reduction of proteinuria by rosiglitazone in non-diabetic renal disease. Nephrology (Carlton). 13:58–62. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Betz B, Schneider R, Kress T, Schick MA, Wanner C and Sauvant C: Rosiglitazone affects nitric oxide synthases and improves renal outcome in a rat model of severe ischemia/reperfusion injury. PPAR Res. 2012:2193192012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Lei Y, Zheng Z, Wang X, Hu M, Liu R and Yu X: Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease. Mol Med Rep 8: 1831-1835, 2013.
APA
Huang, Y., Lei, Y., Zheng, Z., Wang, X., Hu, M., Liu, R., & Yu, X. (2013). Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease. Molecular Medicine Reports, 8, 1831-1835. https://doi.org/10.3892/mmr.2013.1715
MLA
Huang, Y., Lei, Y., Zheng, Z., Wang, X., Hu, M., Liu, R., Yu, X."Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease". Molecular Medicine Reports 8.6 (2013): 1831-1835.
Chicago
Huang, Y., Lei, Y., Zheng, Z., Wang, X., Hu, M., Liu, R., Yu, X."Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease". Molecular Medicine Reports 8, no. 6 (2013): 1831-1835. https://doi.org/10.3892/mmr.2013.1715
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Lei Y, Zheng Z, Wang X, Hu M, Liu R and Yu X: Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease. Mol Med Rep 8: 1831-1835, 2013.
APA
Huang, Y., Lei, Y., Zheng, Z., Wang, X., Hu, M., Liu, R., & Yu, X. (2013). Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease. Molecular Medicine Reports, 8, 1831-1835. https://doi.org/10.3892/mmr.2013.1715
MLA
Huang, Y., Lei, Y., Zheng, Z., Wang, X., Hu, M., Liu, R., Yu, X."Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease". Molecular Medicine Reports 8.6 (2013): 1831-1835.
Chicago
Huang, Y., Lei, Y., Zheng, Z., Wang, X., Hu, M., Liu, R., Yu, X."Rosiglitazone alleviates injury in rats with adenine‑induced chronic kidney disease". Molecular Medicine Reports 8, no. 6 (2013): 1831-1835. https://doi.org/10.3892/mmr.2013.1715
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team