|
1
|
Kobayashi-Sakamoto M, Isogai E and Holen
I: Osteoprotegerin induces cytoskeletal reorganization and
activates FAK, Src, and ERK signaling in endothelial cells. Eur J
Haematol. 85:26–35. 2010.PubMed/NCBI
|
|
2
|
Kadri A, Ea HK, Bazille C, Hannouche D,
Lioté F and Cohen-Solal ME: Osteoprotegerin inhibits cartilage
degradation through an effect on trabecular bone in murine
experimental osteoarthritis. Arthritis Rheum. 58:2379–2386. 2008.
View Article : Google Scholar
|
|
3
|
Komuro H, Olee T, Kühn K, et al: The
osteoprotegerin/receptor activator of nuclear factor
kappaB/receptor activator of nuclear factor kappaB ligand system in
cartilage. Arthritis Rheum. 44:2768–2776. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Kong YY, Yoshida H, Sarosi I, et al: OPGL
is a key regulator of osteoclastogenesis, lymphocyte development
and lymph-node organogenesis. Nature. 397:315–323. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Shimizu S, Asou Y, Itoh S, et al:
Prevention of cartilage destruction with intraarticular
osteoclastogenesis inhibitory factor/osteoprotegerin in a murine
model of osteoarthritis. Arthritis Rheum. 56:3358–3365. 2007.
View Article : Google Scholar
|
|
6
|
Kong YY, Feige U, Sarosi I, et al:
Activated T cells regulate bone loss and joint destruction in
adjuvant arthritis through osteoprotegerin ligand. Nature.
402:304–309. 1999. View
Article : Google Scholar : PubMed/NCBI
|
|
7
|
Kwan Tat S, Pelletier JP, Lajeunesse D,
Fahmi H, Lavigne M and Martel-Pelletier J: The differential
expression of osteoprotegerin (OPG) and receptor activator of
nuclear factor kappaB ligand (RANKL) in human osteoarthritic
subchondral bone osteoblasts is an indicator of the metabolic state
of these disease cells. Clin Exp Rheumatol. 26:295–304. 2008.
|
|
8
|
Kwan Tat S, Amiable N, Pelletier JP, et
al: Modulation of OPG, RANK and RANKL by human chondrocytes and
their implication during osteoarthritis. Rheumatology (Oxford).
48:1482–1490. 2009.PubMed/NCBI
|
|
9
|
Yongchaitrakul T, Manokawinchoke J and
Pavasant P: Osteoprotegerin induces osteopontin via syndecan-1 and
phosphoinositol 3-kinase/Akt in human periodontal ligament cells. J
Periodontal Res. 44:776–783. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Goldring MB and Marcu KB: Cartilage
homeostasis in health and rheumatic diseases. Arthritis Res Ther.
11:2242009. View
Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lories RJ and Luyten FP: The
bone-cartilage unit in osteoarthritis. Nat Rev Rheumatol. 7:43–49.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Verma P and Dalal K: ADAMTS-4 and
ADAMTS-5: key enzymes in osteoarthritis. J Cell Biochem.
112:3507–3514. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Li X, Peng J, Wu M, et al: BMP2 promotes
chondrocyte proliferation via the Wnt/β-catenin signaling pathway.
Mol Med Rep. 4:621–626. 2011.PubMed/NCBI
|
|
14
|
Kotake S, Udagawa N, Hakoda M, et al:
Activated human T cells directly induce osteoclastogenesis from
human monocytes: possible role of T cells in bone destruction in
rheumatoid arthritis patients. Arthritis Rheum. 44:1003–1012. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Rubinfeld H and Seger R: The ERK cascade:
a prototype of MAPK signaling. Mol Biotechnol. 31:151–174. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Dai Y, Rahmani M, Pei XY, et al:
Farnesyltransferase inhibitors interact synergistically with the
Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells
through interruption of both Akt and MEK/ERK pathways and
activation of SEK1/JNK. Blood. 105:1706–1716. 2005. View Article : Google Scholar
|
|
17
|
Kimata M, Michigami T, Tachikawa K, et al:
Signaling of extracellular inorganic phosphate up-regulates cyclin
D1 expression in proliferating chondrocytes via the
Na+/Pi cotransporter Pit-1 and Raf/MEK/ERK pathway.
Bone. 47:938–947. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Feng JQ, Xing L, Zhang JH, et al:
NF-kappaB specifically activates BMP-2 gene expression in growth
plate chondrocytes in vivo and in a chondrocyte cell line in vitro.
J Biol Chem. 278:29130–29135. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Sun HZ, Yang TW, Zang WJ and Wu SF:
Dehydroepiandrosterone-induced proliferation of prostatic
epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway.
J Endocrinol. 204:311–318. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Liu S, Tan WY, Chen QR, et al:
Daintain/AIF-1 promotes breast cancer proliferation via activation
of the NF-kappaB/cyclin D1 pathway and facilitates tumor growth.
Cancer Sci. 99:952–957. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Massoumi R, Chmielarska K, Hennecke K,
Pfeifer A and Fässler R: Cyld inhibits tumor cell proliferation by
blocking Bcl-3-dependent NF-kappaB signaling. Cell. 125:665–677.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Glasson SS, Askew R, Sheppard B, et al:
Deletion of active ADAMTS5 prevents cartilage degradation in a
murine model of osteoarthritis. Nature. 434:644–648. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Zhou Y, Millward-Sadler SJ, Lin H, et al:
Evidence for JNK-dependent up-regulation of proteoglycan synthesis
and for activation of JNK1 following cyclical mechanical
stimulation in a human chondrocyte culture model. Osteoarthritis
Cartilage. 15:884–893. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kita K, Kimura T, Nakamura N, Yoshikawa H
and Nakano T: PI3K/Akt signaling as a key regulatory pathway for
chondrocyte terminal differentiation. Genes Cells. 13:839–850.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Bursell L, Woods A, James CG, Pala D,
Leask A and Beier F: Src kinase inhibition promotes the chondrocyte
phenotype. Arthritis Res Ther. 9:R1052007. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Dong YF, Soung do Y, Chang Y, et al:
Transforming growth factor-beta and Wnt signals regulate
chondrocyte differentiation through Twist1 in a stage-specific
manner. Mol Endocrinol. 21:2805–2820. 2007. View Article : Google Scholar
|
|
27
|
Ryan JA, Eisner EA, DuRaine G, You Z and
Reddi AH: Mechanical compression of articular cartilage induces
chondrocyte proliferation and inhibits proteoglycan synthesis by
activation of the ERK pathway: implications for tissue engineering
and regenerative medicine. J Tissue Eng Regen Med. 3:107–116. 2009.
View Article : Google Scholar
|
|
28
|
Yonekura A, Osaki M, Hirota Y, et al:
Transforming growth factor-beta stimulates articular chondrocyte
cell growth through p44/42 MAP kinase (ERK) activation. Endocr J.
46:545–553. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Yosimichi G, Nakanishi T, Nishida T,
Hattori T, Takano-Yamamoto T and Takigawa M: CTGF/Hcs24 induces
chondrocyte differentiation through a p38 mitogen-activated protein
kinase (p38MAPK), and proliferation through a p44/42
MAPK/extracellular-signal regulated kinase (ERK). Eur J Biochem.
268:6058–6065. 2001. View Article : Google Scholar
|
|
30
|
Kobayashi-Sakamoto M, Isogai E, Hirose K
and Chiba I: Role of alphav integrin in osteoprotegerin-induced
endothelial cell migration and proliferation. Microvasc Res.
76:139–144. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Toffoli B, Bernardi S, Candido R, et al:
Osteoprotegerin induces morphological and functional alterations in
mouse pancreatic islets. Mol Cell Endocrinol. 331:136–142. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Candido R, Toffoli B, Corallini F, et al:
Human full-length osteoprotegerin induces the proliferation of
rodent vascular smooth muscle cells both in vitro and in vivo. J
Vasc Res. 47:252–261. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Bradley EW and Drissi MH: WNT5A regulates
chondrocyte differentiation through differential use of the
CaN/NFAT and IKK/NF-kappaB pathways. Mol Endocrinol. 24:1581–1593.
2010. View Article : Google Scholar : PubMed/NCBI
|
