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Article

Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase

  • Authors:
    • Sanli Xing
    • Dingzhu Shen
    • Chuan Chen
    • Jian Wang
    • Te Liu
    • Zhihua Yu
  • View Affiliations / Copyright

    Affiliations: Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China
  • Pages: 1689-1694
    |
    Published online on: October 11, 2013
       https://doi.org/10.3892/mmr.2013.1722
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Abstract

Alzheimer disease (AD) is characterized by the accumulation of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles. Previous studies have shown that Aβ aggregation is one of the most important initiating factors in the pathogenesis of AD. Oligomers of Aβ cause neurotoxicity, synaptic dysfunction and memory impairments that underlie AD. An increasing number of studies have shown that oligomeric Aβ may bind with a number of surface proteins to mediate its neuronal toxicity. Previously, it was shown that ATP synthase is present on the cell surface and binds with oligomeric Aβ. In the present study, ATP synthase was confirmed to be present on the surface of neurons and oligomeric Aβ was observed to induce neuron damage and expression of amyloid precursor protein (APP) and Fe65 increase. Results showed that inhibition of surface ATP synthase may reduce the neuronal damage by LDH release assay and decrease APP and Fe65 expression by immunofluorescence and western blot analysis. These results confirmed that the cell surface ATP synthase is a binding protein for Aβ on neural cells and suggested that the surface ATP synthase may be involved in the neurotoxic effects of oligomeric Aβ and may be an intervening target of pathogenesis of AD.
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Copy and paste a formatted citation
Spandidos Publications style
Xing S, Shen D, Chen C, Wang J, Liu T and Yu Z: Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase. Mol Med Rep 8: 1689-1694, 2013.
APA
Xing, S., Shen, D., Chen, C., Wang, J., Liu, T., & Yu, Z. (2013). Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase. Molecular Medicine Reports, 8, 1689-1694. https://doi.org/10.3892/mmr.2013.1722
MLA
Xing, S., Shen, D., Chen, C., Wang, J., Liu, T., Yu, Z."Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase". Molecular Medicine Reports 8.6 (2013): 1689-1694.
Chicago
Xing, S., Shen, D., Chen, C., Wang, J., Liu, T., Yu, Z."Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase". Molecular Medicine Reports 8, no. 6 (2013): 1689-1694. https://doi.org/10.3892/mmr.2013.1722
Copy and paste a formatted citation
x
Spandidos Publications style
Xing S, Shen D, Chen C, Wang J, Liu T and Yu Z: Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase. Mol Med Rep 8: 1689-1694, 2013.
APA
Xing, S., Shen, D., Chen, C., Wang, J., Liu, T., & Yu, Z. (2013). Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase. Molecular Medicine Reports, 8, 1689-1694. https://doi.org/10.3892/mmr.2013.1722
MLA
Xing, S., Shen, D., Chen, C., Wang, J., Liu, T., Yu, Z."Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase". Molecular Medicine Reports 8.6 (2013): 1689-1694.
Chicago
Xing, S., Shen, D., Chen, C., Wang, J., Liu, T., Yu, Z."Regulation of neuronal toxicity of β‑amyloid oligomers by surface ATP synthase". Molecular Medicine Reports 8, no. 6 (2013): 1689-1694. https://doi.org/10.3892/mmr.2013.1722
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