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Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system

  • Authors:
    • Won Ho Cho
    • Hyun Joo Lee
    • Yoon Ji Choi
    • Joo Han Oh
    • Han Soo Kim
    • Hwan Seong Cho
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery and Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan 602739, Republic of Korea, Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Gyeonnggido 463707, Republic of Korea, Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul 110744, Republic of Korea
    Copyright: © Cho et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1655-1662
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    Published online on: October 17, 2013
       https://doi.org/10.3892/mmr.2013.1737
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Abstract

Osteosarcoma is the most common malignant bone tumor in children and adolescents. This aggressive cancer mostly occurs in the long bones. Therefore, novel therapeutic approaches, such as biological therapies and gene therapy, are required to efficiently treat osteosarcoma. Capsaicin (trans‑8‑methyl‑N‑vanillyl‑6‑nonenamide) has been demonstrated to inhibit the growth of several types of cancer cells and a number of studies have shown that osteosarcoma may be vulnerable to biological therapies. However, little is known regarding the therapeutic effects of capsaicin on osteosarcoma. This study investigated the effects of capsaicin on MG63 human osteosarcoma cells, in addition to elucidating the regulatory signaling pathways underlying the effects of capsaicin, the caspase cascade and the antioxidant enzyme system. The MG63 cell line was treated with various concentrations of capsaicin. Cells were analyzed using MTT and flow cytometry, and the presence of DNA fragmentation was evaluated using TUNEL assay. Results showed capsaicin induced apoptosis in MG63 cells. Thus, capsaicin exhibited an anticancer effect in osteosarcoma cells.
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Copy and paste a formatted citation
Spandidos Publications style
Cho WH, Lee HJ, Choi YJ, Oh JH, Kim HS and Cho HS: Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system. Mol Med Rep 8: 1655-1662, 2013.
APA
Cho, W.H., Lee, H.J., Choi, Y.J., Oh, J.H., Kim, H.S., & Cho, H.S. (2013). Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system. Molecular Medicine Reports, 8, 1655-1662. https://doi.org/10.3892/mmr.2013.1737
MLA
Cho, W. H., Lee, H. J., Choi, Y. J., Oh, J. H., Kim, H. S., Cho, H. S."Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system". Molecular Medicine Reports 8.6 (2013): 1655-1662.
Chicago
Cho, W. H., Lee, H. J., Choi, Y. J., Oh, J. H., Kim, H. S., Cho, H. S."Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system". Molecular Medicine Reports 8, no. 6 (2013): 1655-1662. https://doi.org/10.3892/mmr.2013.1737
Copy and paste a formatted citation
x
Spandidos Publications style
Cho WH, Lee HJ, Choi YJ, Oh JH, Kim HS and Cho HS: Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system. Mol Med Rep 8: 1655-1662, 2013.
APA
Cho, W.H., Lee, H.J., Choi, Y.J., Oh, J.H., Kim, H.S., & Cho, H.S. (2013). Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system. Molecular Medicine Reports, 8, 1655-1662. https://doi.org/10.3892/mmr.2013.1737
MLA
Cho, W. H., Lee, H. J., Choi, Y. J., Oh, J. H., Kim, H. S., Cho, H. S."Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system". Molecular Medicine Reports 8.6 (2013): 1655-1662.
Chicago
Cho, W. H., Lee, H. J., Choi, Y. J., Oh, J. H., Kim, H. S., Cho, H. S."Capsaicin induces apoptosis in MG63 human osteosarcoma cells via the caspase cascade and the antioxidant enzyme system". Molecular Medicine Reports 8, no. 6 (2013): 1655-1662. https://doi.org/10.3892/mmr.2013.1737
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