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Article

Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion

  • Authors:
    • In Sik Hwang
    • Ji Eun Kim
    • Young Ju Lee
    • Mun Hwa Kwak
    • Hong Gu Lee
    • Hye Sung Kim
    • Hee Seob Lee
    • Dae Youn Hwang
  • View Affiliations / Copyright

    Affiliations: Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang‑si 627‑706, Republic of Korea, Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 133‑702, Republic of Korea, Department of Nanomaterials Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Miryang-si 627‑706, Republic of Korea, Department of Food Science and Nutrition, College of Human Ecology, Pusan National University, Busan 609-735, Republic of Korea
  • Pages: 166-172
    |
    Published online on: October 24, 2013
       https://doi.org/10.3892/mmr.2013.1757
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Abstract

Cheonggukjang (CKJ), a fermented soybean product, has been reported to have beneficial effects on various chronic diseases, including cardiovascular disease, cancer and immune diseases. To investigate whether CKJ induces growth sensitivity in mammals, alterations of key parameters related to their growth were analyzed. Sprague‑Dawley (SD) rats were treated with a high concentration of CKJ (H‑CKJ) or a low concentration of CKJ (L‑CKJ) for 10 days, and compared with vehicle-treated rats. The CKJ contained a high concentration of total flavonoids, phenolic compounds, daidzein and genistein, compared with the non-fermented soybean product. Body weight was higher in the H‑CKJ‑treated group compared with that in the vehicle‑ and L‑CKJ‑treated groups, whereas the weights of three organs (the brain, liver and kidney) were higher in the L‑CKJ‑treated group compared with the remaining two groups. However, no significant differences in femur length and weight were detected between the CKJ‑ and vehicle‑treated groups. The thickness of the epiphyseal growth plate in proximal femoral epiphysis was broadest in the H‑CKJ‑treated group compared with the vehicle- and L‑CKJ‑treated groups. Furthermore, the level of growth hormone (GH) was highest in the serum of the L‑CKJ‑treated group, although that of the H‑CKJ‑treated group was lower compared with that in the L‑CKJ group. Moreover, the expression levels of the GH receptor increased in the liver tissue, but not in the muscle tissue, of the L‑CKJ‑ and H‑CKJ‑treated groups. In the downstream signaling pathway of the GH receptor, the phosphorylation levels of Akt and Erk were differentially regulated between the liver and muscle. These results suggest that CKJ extract may enhance the sensitivity of the femur, liver and muscle epiphyseal growth plate in SD rats, through the upregulation of GH secretion.
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View References

1 

Lee JJ, Lee DS and Kim HB: Fermentation patterns of chungkookjang and Kanjang by Bacillus licheniformis B1. Kor J Microbiol. 35:296–301. 1999.

2 

Su CL, Wu CJ, Chen FN, Wang BJ, Shen SR and Won SJ: Supernatant of bacterial fermented soybean induces apoptosis of human hepatocellular carcinoma Hep 3B cells via activation of caspase 8 and mitochondria. Food Chem Toxicol. 45:303–314. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Nakajima N, Nozaki N, Ishihara K, Ishikawa A and Tsuji H: Analysis of isoflavone content in tempeh, a fermented soybean, and preparation of a new isoflavone-enriched tempeh. J Biosci Bioeng. 100:685–687. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Kwon DY, Jang JS, Lee JE, Kim YS, Shin DH and Park S: The isoflavonoid aglycone-rich fractions of Chungkukjang, fermented unsalted soybean, enhance insulin signaling and peroxisome proliferation-activated receptor-gamma activity in vitro. Biofactors. 26:245–258. 2006. View Article : Google Scholar

5 

Baek HI, Kim SR, Yang JA, Kim MG, Chae SW and Cha YS: Effect of chungkookjang supplementation on obesity and atherosclerotic indices in overweight/obese subjects: a 12-week, randomized, double-blind, placebo-controlled clinical trial. J Med Food. 14:532–537. 2011. View Article : Google Scholar

6 

Soh JR, Kwon DY and Cha YS: Hepatic gene expression profiles are altered by dietary unsalted Korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity. J Nutr Metab. March 9–2011.(Epub ahead of print). View Article : Google Scholar

7 

Kim DJ, Jeong YJ, Kwon JH, Moon KD, Kim HJ, Jeon SM, Lee MK, Park YB and Choi MS: Beneficial effect of chungkukjang on regulating blood glucose and pancreatic β-cell functions in C75BL/Ksj-db/db mice. J Med Food. 11:215–223. 2008.PubMed/NCBI

8 

Kwon DY, Daily JW III, Kim HJ and Park S: Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr Res. 30:1–13. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Choi YH, Lim H, Heo MY, Kwon DY and Kim HP: Anti-imflammatory activity of the ethanol extract of Chungkukjang, Korean fermented bean: 5-lipoxygenase inhibition. J Med Food. 11:539–543. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Kim HB, Lee HS, Kim SJ, Yoo HJ, Hwang JS, Chen G and Youn HJ: Ethanol extract of fermented soybean, Chungkookjang, inhibits the apoptosis of mouse spleen, and thymus cells. J Microbiol. 45:256–261. 2007.PubMed/NCBI

11 

Singleton VL, Orthofer R and Lamuela-Raventos RM: Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol. 299:152–178. 1999. View Article : Google Scholar

12 

Meda A, Lamien CE, Romito M, Millogo J and Nacoulma OG: Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem. 91:571–577. 2005. View Article : Google Scholar

13 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976. View Article : Google Scholar : PubMed/NCBI

14 

Dubois M, Gilles KA, Hamilton JK, Rebers PA and Smith F: Colorimetric method for determination of sugars and related substances. Anal Biochem. 28:350–356. 1956.

15 

Zheng J, Jin Y and Row KH: Analysis of isoflavones from Korean and Chinese soybean and processed products by HPLC. J Kor Chem Soc. 49:349–354. 2005. View Article : Google Scholar

16 

Nareliya R and Kumar V: Biomechanical analysis of human femur bone. Int J Eng Sci Tech. 3:3090–3094. 2011.

17 

Daniels ME: Lilly’s Humatrope experience. Nat Biotechnol. 10:792–812. 1992.

18 

Powers M: Performance-enhancing drugs. Principles of Pharmacology for Athletic Trainers. Houglum JE and Harrelson GL: 2nd edition. SLACK Incorporated; Thorofare, NJ: pp. 331–332. 2005

19 

Kim JM, Kim SY, Jung EY, Bae SH and Suh HJ: Yeast hydrolysate induces longitudinal bone growth and growth hormone release in rats. Phytother Res. 23:731–736. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Shim SH, Lee EJ, Kim JS, Kang SS, Ha H, Lee HY, Kim C, Lee JH and Son KH: Rat growth-hormone release stimulators from fenugreek seeds. Chem Biodivers. 5:1753–1761. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Lee HY, Jung DY, Ha H, Kang SS, Kim JS and Kim C: Induction of growth hormone release by glycyrrhizae radix on rat. J Biochem Mol Biol. 40:979–985. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Postel-Vinay MC and Finidori J: Growth hormone receptor: structure and signal transduction. Eur J Endocrinol. 133:654–659. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Miquet JG, Muñoz MC, Giani JF, González L, Dominici FP, Bartke A, Turyn D and Sotelo AI: Ames dwarf (Prop1(df)/Prop1(df)) mice display increased sensitivity of the major GH-signaling pathways in liver and skeletal muscle. Growth Horm IGF Res. 20:118–126. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Nicholson KM and Anderson NG: The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14:381–395. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Nishimoto S and Nishida E: MAPK signalling: ERK5 versus ERK1/2. EMBO Rep. 7:782–786. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Wong RW and Rabie AB: Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation. Phytother Res. 24(Suppl 2): S155–S160. 2010.

27 

Potu BK, Rao MS, Kutty NG, Bhat KM, Chamallamudi MR and Nayak SR: Petroleum ether extract of Cissus quadrangularis (LINN) stimulates the growth of fetal bone during intra uterine developmental period: a morphometric analysis. Clinics (Sao Paulo). 63:815–820. 2008.

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Copy and paste a formatted citation
Spandidos Publications style
Hwang IS, Kim JE, Lee YJ, Kwak MH, Lee HG, Kim HS, Lee HS and Hwang DY: Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion. Mol Med Rep 9: 166-172, 2014.
APA
Hwang, I.S., Kim, J.E., Lee, Y.J., Kwak, M.H., Lee, H.G., Kim, H.S. ... Hwang, D.Y. (2014). Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion. Molecular Medicine Reports, 9, 166-172. https://doi.org/10.3892/mmr.2013.1757
MLA
Hwang, I. S., Kim, J. E., Lee, Y. J., Kwak, M. H., Lee, H. G., Kim, H. S., Lee, H. S., Hwang, D. Y."Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion". Molecular Medicine Reports 9.1 (2014): 166-172.
Chicago
Hwang, I. S., Kim, J. E., Lee, Y. J., Kwak, M. H., Lee, H. G., Kim, H. S., Lee, H. S., Hwang, D. Y."Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion". Molecular Medicine Reports 9, no. 1 (2014): 166-172. https://doi.org/10.3892/mmr.2013.1757
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang IS, Kim JE, Lee YJ, Kwak MH, Lee HG, Kim HS, Lee HS and Hwang DY: Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion. Mol Med Rep 9: 166-172, 2014.
APA
Hwang, I.S., Kim, J.E., Lee, Y.J., Kwak, M.H., Lee, H.G., Kim, H.S. ... Hwang, D.Y. (2014). Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion. Molecular Medicine Reports, 9, 166-172. https://doi.org/10.3892/mmr.2013.1757
MLA
Hwang, I. S., Kim, J. E., Lee, Y. J., Kwak, M. H., Lee, H. G., Kim, H. S., Lee, H. S., Hwang, D. Y."Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion". Molecular Medicine Reports 9.1 (2014): 166-172.
Chicago
Hwang, I. S., Kim, J. E., Lee, Y. J., Kwak, M. H., Lee, H. G., Kim, H. S., Lee, H. S., Hwang, D. Y."Growth sensitivity in the epiphyseal growth plate, liver and muscle of SD rats is significantly enhanced by treatment with a fermented soybean product (cheonggukjang) through stimulation of growth hormone secretion". Molecular Medicine Reports 9, no. 1 (2014): 166-172. https://doi.org/10.3892/mmr.2013.1757
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