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Article

Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells

Retraction in: /10.3892/mmr.2025.13628
  • Authors:
    • Rong Li
    • Yinhai Zhao
    • Jin Chen
    • Songjun Shao
    • Xiujuan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Pathophysiology, Guangdong Medical College, Zhanjiang, Guangdong 524023, P.R. China, Department of Physiology, Guangdong Medical College, Zhanjiang, Guangdong 524023, P.R. China
  • Pages: 413-418
    |
    Published online on: December 2, 2013
       https://doi.org/10.3892/mmr.2013.1836
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Abstract

Fisetin (3,3',4',7-tetrahydroxyflavone) has been reported to possess certain anticancer properties. It may inhibit tumor cell proliferation, metastasis and induce apoptosis. However, the effects of fisetin in preventing the metastasis of nasopharyngeal carcinoma (NPC) cells remain to be determined. The epithelial-mesenchymal transition (EMT) is involved in several metastatic malignancies including NPC. It has been reported that the Epstein-Barr virus latent membrane protein-1 (LMP1) induced EMT and is associated with the metastasis of NPC. The aim of this study was to examine the effects of fisetin in preventing the migration and invasion of LMP1-expressing NPC cells (CNE1-LMP1 cells), as well as to investigate whether fisetin may inhibit the molecular changes associated with EMT induced by LMP1. The investigation demonstrated that fisetin suppressed the migration and invasion of CNE1-LMP1 cells under non-cytotoxic concentrations. Fisetin inhibited molecular changes associated with EMT induced by LMP1, upregulated the epithelial marker, E-cadherin protein, and downregulated the mesenchymal marker, vimentin protein, levels. Fisetin also significantly reduced the levels of Twist protein, an EMT regulator. The investigation suggested that fisetin inhibits the migration and invasion of LMP1-positive NPC cells, and the molecular mechanism involves fisetin reversing the EMT induced by LMP1 and downregulates the expression of Twist. This study indicated that fisetin serves as a potential candidate for the treatment of cancer metastasis.
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1 

Wakisaka N and Pagano JS: Epstein-Barr virus induces invasion and metastasis factors. Anticancer Res. 23:2133–2138. 2003.PubMed/NCBI

2 

Horikawa T, Yoshizaki T, Kondo S, et al: Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma. Br J Cancer. 104:1160–1167. 2011. View Article : Google Scholar

3 

Liu HP, Chen CC, Wu CC, et al: Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. PLoS Pathog. 8:e10026902012. View Article : Google Scholar : PubMed/NCBI

4 

Chou YC, Chen CL, Yeh TH, et al: Involvement of recepteur d’origine nantais receptor tyrosine kinase in Epstein-Barr virus-associated nasopharyngeal carcinoma and its metastasis. Am J Pathol. 181:1773–1781. 2012.

5 

Horikawa T, Yang J, Kondo S, et al: Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res. 67:1970–1978. 2007. View Article : Google Scholar

6 

Thiery JP, Acloque H, Huang RY, et al: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Yang J and Weinberg RA: Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 14:818–829. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Yang J, Mani SA, Donaher JL, et al: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Elias MC, Tozer KR, Silber JR, et al: TWIST is expressed in human gliomas and promotes invasion. Neoplasia. 7:824–837. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Luo GQ, Li JH, Wen JF, et al: Effect and mechanism of the Twist gene on invasion and metastasis of gastric carcinoma cells. World J Gastroenterol. 14:2487–2493. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Jia J, Zhang W, Liu JY, Chen G, et al: Epithelial mesenchymal transition is required for acquisition of anoikis resistance and metastatic potential in adenoid cystic carcinoma. PLoS One. 7:e515492012. View Article : Google Scholar : PubMed/NCBI

12 

Murtaza I, Adhami VM, Hafeez BB, et al: Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB. Int J Cancer. 125:2465–2473. 2009. View Article : Google Scholar

13 

Li J, Cheng Y, Qu W, et al: Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells. Basic Clin Pharmacol Toxicol. 108:84–93. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Ying TH, Yang SF, Tsai SJ, et al: Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway. Arch Toxicol. 86:263–273. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Khan N, Asim M, Afaq F, et al: A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. Cancer Res. 68:8555–8563. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Zheng H, Li LL, Hu DS, et al: Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immunol. 4:185–196. 2007.PubMed/NCBI

17 

Chen Y and Chen XY: Effect of Epstein-Barr virus latent membrane protein 1 (LMP1) on apoptosis of nasopharyngeal carcinoma cell line CNE1. Ai Zheng. 21:498–503. 2002.(In Chinese).

18 

Guo L, Tang M, Yang L, et al: Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma. Int J Mol Med. 29:574–580. 2012.PubMed/NCBI

19 

Lo KW, To KF and Huang DP: Focus on nasopharyngeal carcinoma. Cancer Cell. 5:423–428. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Brabletz T: EMT and MET in metastasis: where are the cancer stem cells? Cancer Cell. 22:699–701. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Ploenes T, Scholtes B, Krohn A, et al: CC-chemokine ligand 18 induces epithelial to mesenchymal transition in lung cancer A549 cells and elevates the invasive potential. PLoS One. 8:e530682013. View Article : Google Scholar : PubMed/NCBI

22 

Klein CA: Cancer. The metastasis cascade. Science. 321:1785–1787. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Sánchez-García I: The crossroads of oncogenesis and metastasis. N Engl J Med. 360:297–299. 2009.PubMed/NCBI

24 

Wang WS, Yang XS, Xia M, et al: Silencing of twist expression by RNA interference suppresses epithelial-mesenchymal transition, invasion, and metastasis of ovarian cancer. Asian Pac J Cancer Prev. 13:4435–4439. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Zhang L, Yang M, Gan L, et al: DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis. Int J Biol Sci. 8:1178–1187. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li R, Zhao Y, Chen J, Shao S and Zhang X: Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628. Mol Med Rep 9: 413-418, 2014.
APA
Li, R., Zhao, Y., Chen, J., Shao, S., & Zhang, X. (2014). Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628. Molecular Medicine Reports, 9, 413-418. https://doi.org/10.3892/mmr.2013.1836
MLA
Li, R., Zhao, Y., Chen, J., Shao, S., Zhang, X."Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628". Molecular Medicine Reports 9.2 (2014): 413-418.
Chicago
Li, R., Zhao, Y., Chen, J., Shao, S., Zhang, X."Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628". Molecular Medicine Reports 9, no. 2 (2014): 413-418. https://doi.org/10.3892/mmr.2013.1836
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Zhao Y, Chen J, Shao S and Zhang X: Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628. Mol Med Rep 9: 413-418, 2014.
APA
Li, R., Zhao, Y., Chen, J., Shao, S., & Zhang, X. (2014). Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628. Molecular Medicine Reports, 9, 413-418. https://doi.org/10.3892/mmr.2013.1836
MLA
Li, R., Zhao, Y., Chen, J., Shao, S., Zhang, X."Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628". Molecular Medicine Reports 9.2 (2014): 413-418.
Chicago
Li, R., Zhao, Y., Chen, J., Shao, S., Zhang, X."Fisetin inhibits migration, invasion and epithelial-mesenchymal transition of LMP1-positive nasopharyngeal carcinoma cells Retraction in /10.3892/mmr.2025.13628". Molecular Medicine Reports 9, no. 2 (2014): 413-418. https://doi.org/10.3892/mmr.2013.1836
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