Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells

Park,Seon-Young; Kim,Ji-Young; Lee,Su-Mi; Jun,Chung-Hwan; Cho,Sung-Bum; Park,Chang-Hwan; Joo,Young‑Eun; Kim,Hyun-Soo; Choi,Sung-Kyu; Rew,Jong-Sun

doi:10.3892/mmr.2013.1849

2014-February Volume 9 Issue 2

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2014-February Volume 9 Issue 2

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Article

Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells

Authors:
- Seon-Young Park
- Ji-Young Kim
- Su-Mi Lee
- Chung-Hwan Jun
- Sung-Bum Cho
- Chang-Hwan Park
- Young‑Eun Joo
- Hyun-Soo Kim
- Sung-Kyu Choi
- Jong-Sun Rew
View Affiliations / Copyright

Affiliations: Department of Internal Medicine, Chonnam National University Hospital, Dong-ku, Gwangju 501-757, Republic of Korea
Pages: 499-502
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Published online on: December 9, 2013

https://doi.org/10.3892/mmr.2013.1849
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Abstract

Capsaicin is known to have tumor suppressive effects. However, the molecular mechanisms and targets of capsaicin involved in exerting anticancer activity are complex and remain to be clarified. The aim of the current study was to investigate the effects of capsaicin on human gastric cancer cells (AGS cells) and demonstrate that capsaicin induced apoptosis in AGS cells. Results of the MTT assay and flow cytometry revealed that capsaicin potentially inhibited the proliferation of AGS cells and induced apoptosis in vitro in a dose-dependent manner. Cleaved caspase-3 was increased and Bcl-2 was reduced by treatment with capsaicin in AGS cells. Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells. The results of this study suggest that capsaicin may serve as an anti-tumorigenic agent in human gastric cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells

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Abstract

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