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Article

Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells

Corrigendum in: /10.3892/mmr.2020.11616
  • Authors:
    • Yang Li
    • Chengyuan Ma
    • Ming Qian
    • Zhongmei Wen
    • Hongyu Jing
    • Donghua Qian
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Prosthodontics, Stomatological Hospital, Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 763-767
    |
    Published online on: December 9, 2013
       https://doi.org/10.3892/mmr.2013.1850
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Abstract

Butein is a flavonoid isolated from the bark of Rhus verniciflua Stokes and the flowers of Butea monosperma, and is known to be a potential therapeutic drug for treating inflammation and cancer. Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX‑2, has been observed in lung cancer tissue. The aim of the present study was to investigate expression alteration of COX‑2 in A549 lung cancer cells following butein treatment at the mRNA and protein levels by quantitative polymerase chain reaction and western blotting, respectively. It was observed that COX‑2 mRNA and protein levels were significantly downregulated in the butein treatment group in comparison with the control group (P<0.05). In addition, the effects of butein on proliferation and apoptosis were evaluated. The data demonstrated that butein induces cell‑cycle arrest and apoptosis in human lung cancer cells. These results indicated that butein may be a promising candidate drug for lung cancer treatment.
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1 

Szuster-Ciesielska A, Plewka K and Kandefer-Szerszeń M: Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. Pharmacol Rep. 63:1109–1123. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Martineau L: Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation. Biochim Biophys Acta. 1820:133–150. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Khan N, Adhami VM, Afaq F and Mukhtar H: Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo. Antioxid Redox Signal. 16:1195–1204. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Son YO, Lee KY, Lee JC, Jang HS, Kim JG, Jeon YM and Jang YS: Selective antiproliferative and apoptotic effects of flavonoids purified from Rhus verniciflua Stokes on normal versus transformed hepatic cell lines. Toxicol Lett. 155:115–125. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Moon DO, Kim MO, Choi YH, Hyun JW, Chang WY and Kim GY: Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. Cancer Lett. 288:204–213. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Pandey MK, Sung B, Ahn KS and Aggarwal BB: Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Mol Pharmacol. 75:525–533. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Moon DO, Kim MO, Lee JD, Choi YH and Kim GY: Butein suppresses c-Myc dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells. Cancer Lett. 286:172–179. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Kim N: Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Arch Pharm Res. 31:1179–1186. 2008. View Article : Google Scholar

9 

Samoszuk M, Tan J and Chorn G: The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. BMC Complement Altern Med. 5:52005. View Article : Google Scholar

10 

Prosperi JR, Mallery SR, Kigerl KA, Erfurt AA and Robertson FM: Invasive and angiogenic phenotype of MCF-7 human breast tumor cells expressing human cyclooxygenase-2. Prostaglandins Other Lipid Mediat. 73:249–264. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Takahashi Y, Kawahara F, Noguchi M, Miwa K, Sato H, Seiki M, Inoue H, Tanabe T and Yoshimoto T: Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2. FEBS Lett. 460:145–148. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Trifan OC and Hla T: Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. J Cell Mol Med. 7:207–222. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Nakatsugi S, Ohta T, Kawamori T, Mutoh M, Tanigawa T, Watanabe K, Sugie S, Sugimura T and Wakabayashi K: Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis in rats. Jpn J Cancer Res. 91:886–892. 2000.PubMed/NCBI

14 

Kim PK, Park SY, Koty PP, Hua Y, Luketich JD and Billiar TR: Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells. J Thorac Cardiovasc Surg. 125:1336–1342. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Cheng YL, Chang WL, Lee SC, Liu YG, Lin HC, Chen CJ, Yen CY, Yu DS, Lin SZ and Harn HJ: Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci. 73:2383–2394. 2003. View Article : Google Scholar

16 

Kim NY, Pae HO, Oh GS, Kang TH, Kim YC, Rhew HY and Chung HT: Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol Toxicol. 88:261–266. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Iwashita K, Kobori M, Yamaki K and Tsushida T: Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci Biotechnol Biochem. 64:1813–1820. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Wang Y, Chan FL, Chen S and Leung LK: The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. Life Sci. 77:39–51. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Yit CC and Das NP: Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett. 82:65–72. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Jang HS, Kook SH, Son YO, Kim JG, Jeon YM, Jang YS, Choi KC, Kim J, Han SK, Lee KY, et al: Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim Biophys Acta. 1726:309–316. 2005.PubMed/NCBI

21 

Lee SH, Seo GS, Kim H and Sohn DH: 2′,4′,6′-Tris(methoxy-methoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway. Biochem Pharmacol. 72:1322–1333. 2006.

22 

Dempke W, Rie C, Grothey A and Schmoll HJ: Cyclooxygenase-2: a novel target for cancer chemotherapy? J Cancer Res Clin Oncol. 127:411–417. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Williams CS, Mann M and DuBois RN: The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 18:7908–7916. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Denkert C, Köbel M, Pest S, Koch I, Berger S, Schwabe M, Siegert A, Reles A, Klosterhalfen B and Hauptmann S: Expression of cyclooxygenase-2 is an independent prognostic factor in human ovarian carcinoma. Am J Pathol. 160:893–903. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Erkinheimo TL, Lassus H, Finne P, van Rees BP, Leminen A, Ylikorkala O, Haglund C, Butzow R and Ristimäki A: Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. Clin Cancer Res. 10:538–545. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Li S, Miner K, Fannin R, Carl Barrett J and Davis BJ: Cyclooxygenase-1 and 2 in normal and malignant human ovarian epithelium. Gynecol Oncol. 92:622–627. 2004. View Article : Google Scholar

27 

Arico S, Pattingre S, Bauvy C, Gane P, Barbat A, Codogno P and Ogier-Denis E: Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem. 277:27613–27621. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Ma C, Qian M, Wen Z, Jing H and Qian D: Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616. Mol Med Rep 9: 763-767, 2014.
APA
Li, Y., Ma, C., Qian, M., Wen, Z., Jing, H., & Qian, D. (2014). Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616. Molecular Medicine Reports, 9, 763-767. https://doi.org/10.3892/mmr.2013.1850
MLA
Li, Y., Ma, C., Qian, M., Wen, Z., Jing, H., Qian, D."Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616". Molecular Medicine Reports 9.2 (2014): 763-767.
Chicago
Li, Y., Ma, C., Qian, M., Wen, Z., Jing, H., Qian, D."Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616". Molecular Medicine Reports 9, no. 2 (2014): 763-767. https://doi.org/10.3892/mmr.2013.1850
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Ma C, Qian M, Wen Z, Jing H and Qian D: Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616. Mol Med Rep 9: 763-767, 2014.
APA
Li, Y., Ma, C., Qian, M., Wen, Z., Jing, H., & Qian, D. (2014). Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616. Molecular Medicine Reports, 9, 763-767. https://doi.org/10.3892/mmr.2013.1850
MLA
Li, Y., Ma, C., Qian, M., Wen, Z., Jing, H., Qian, D."Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616". Molecular Medicine Reports 9.2 (2014): 763-767.
Chicago
Li, Y., Ma, C., Qian, M., Wen, Z., Jing, H., Qian, D."Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells Corrigendum in /10.3892/mmr.2020.11616". Molecular Medicine Reports 9, no. 2 (2014): 763-767. https://doi.org/10.3892/mmr.2013.1850
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