Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
2014-February Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-February Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake

  • Authors:
    • Leticia Manuel‑Apolinar
    • Luisa Rocha
    • Leticia Damasio
    • Emiliano Tesoro‑Cruz
    • Arturo Zarate
  • View Affiliations / Copyright

    Affiliations: Endocrine Research Unit, National Medical Center, Mexican Social Security Institute, Mexico City, Mexico, Department of Pharmacobiology, Center for Research and Advanced Studies, Mexico City, Mexico, Department of Research and Animal Facility, INCMN, Mexico City, Mexico
    Copyright: © Manuel‑Apolinar et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 407-412
    |
    Published online on: December 10, 2013
       https://doi.org/10.3892/mmr.2013.1853
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Perturbations in the levels of serotonin expression have a significant impact on behavior and have been implicated in the pathogenesis of several neuropsychiatric disorders including anxiety, mood and appetite. Fetal programming is a risk factor for the development of metabolic diseases during adulthood. Moreover, previous studies have shown that serotonin (5‑HT), dopamine and leptin are important in energy balance. In the present study, the impact of maternal malnutrition‑induced prenatal undernutrition (UN) was investigated in mice and the expression of 5‑HT1A, dopamine (D)1, D2 and Ob‑Rb receptors was analyzed in the hypothalamus during adulthood. The UN group showed a low birth weight compared with the control group. With regard to receptor expression, 5‑HT1A in the UN group was increased in the hypothalamus and D1 was reduced, whereas D2 showed an increase from postnatal day (P)14 in the arcuate nucleus. Ob‑Rb receptor expression was increased in the hypothalamus at P14 and P90. These observations indicated that maternal caloric restriction programs a postnatal body weight gain in offspring with an increased food intake in early postnatal life which continues into adulthood. In addition, UN in mice was found to be affected by Ob‑Rb, 5‑HT1A and D1/2 receptor expression, indicating that these observations may be associated with hyperphagia and obesity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K and Clark PMS: Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 36:62–67. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Fontaine KR, Redden DT, Wang C, Westfall AO and Allison DB: Years of life lost due to obesity. JAMA. 289:187–193. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Poston L: Developmental programming and diabetes. The human experience and insight from animal models. Best Pract Res Clin Endocrinol Metab. 24:541–552. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Desai M, Gayle D, Babu J and Ross GM: Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition. Am J Physiol Regul Integr Comp Physiol. 288:R91–R96. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Hokken-Koelega AC, De Ridder MA, Lemmen RJ, Den Hartong H, De Muinck Keizer-Schrama SM and Drop SL: Children born small for gestation age: do they catch up? Pediatr Res. 38:267–271. 1995. View Article : Google Scholar

6 

Jones AP, Simson EL and Friedman MI: Gestational undernutrition and the development of obesity in rats. J Nutr. 114:1484–1492. 1984.PubMed/NCBI

7 

Vickers MH, Breier BH, Cutfield WS, Hofman PL and Gluckman PD: Fetal origin of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab. 279:E83–E87. 2000.PubMed/NCBI

8 

Begum G, Stevens A, Smith EB, Connor K, Challis JR, Bloomfield F and White A: Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning. FASEB J. 26:1694–1703. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Tamashiro K and Moran T: Perinatal environment and its influences on metabolic programming of offspring. Physiol Behav. 100:560–566. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Berger MA, Barros VG, Sarchi MI, Tarazi FI and Antonelli MC: Long-term effects of prenatal stress on dopamine and glutamate receptors in adult rat brain. Neurochem Res. 27:1525–1533. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Pôrto LC, Sardinha FL, Telles MM, Guimarães RB, Albuquerque KT, Andrade IS, Oyama LM, Nascimento CM, Santos OF and Ribeiro EB: Impairment of the serotonergic control of feeding in adult female rats exposed to intrauterine malnutrition. Br J Nutr. 101:1255–1261. 2009.PubMed/NCBI

12 

Manuel-Apolinar L, Zarate A, Rocha L and Hernández M: Fetal malnutrition affects hypothalamic leptin receptor expression after birth in male mice. Arch Med Res. 41:240–245. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Bauer A, Zilles K, Matusch A, Holzmann C, Riess O and von Hörsten S: Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington’s disease mutation. J Neurochem. 94:639–650. 2005.PubMed/NCBI

14 

Luna-Munguía H, Manuel-Apolinar L, Rocha L and Meneses A: 5-HT1A receptors expression during memory formation. Psychopharmacol. 181:309–318. 2005.PubMed/NCBI

15 

Díaz-Romero M, Arias-Montaño JA, Eguibar JR and Flores G: Enhanced binding of dopamine D1 receptors in caudate putamen subregions in High-Yawning Sprague-Dawley rats. Synapse. 56:69–73. 2005.PubMed/NCBI

16 

Harder T, Rodekamp E, Schellong K, Dudenhausen JW and Plagemann A: Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. Am J Epidemiol. 165:849–857. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Stevens A, Begum G and White A: Epigenetic changes in the hypothalamic pro-opiomelanocortin gene: a mechanism linking maternal undernutrition to obesity in the offspring? Eur J Pharmacol. 660:194–201. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Hales CN and Barker DJP: The thrifty phenotype hypothesis. Br Med Bull. 60:5–20. 2001. View Article : Google Scholar

19 

Ozanne SE, Lewis R, Jennings BJ and Hales CN: Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet. Clin Sci (Lond). 106:141–145. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Jousse C, Parry L, Lambert-Langlais S, Maurin AC, Averous J, Bruhat A, Carraro V, et al: Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB J. 25:3271–3278. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Kwak SH, Park BL, Kim H, German MS, Go MJ, Jung HS, et al: Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity. Obesity (Silver Spring). 20:233–238. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C and López M: Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB J. 24:2670–2679. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Bina KG and Cincotta AH: Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob mice. Neuroendocrinol. 71:68–78. 2000. View Article : Google Scholar

24 

Schwartz MW, Woods SC, Porte D Jr, Seeley RJ and Baskin DG: Central nervous system control of food intake. Nature. 404:661–671. 2000.PubMed/NCBI

25 

Davis JD and Smith GP: Learning to sham feed: behavioral adjustments to loss of physiological postingestional stimuli. Am J Physiol. 259:R1228–R1235. 1990.PubMed/NCBI

26 

Smith GP: The controls of eating: a shift from nutritional homeostasis to behavioral neuroscience. Nutrition. 16:814–820. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Schellekens H, Clarke G, Jeffery IB, Dinan TG and Cryan JF: Dynamic 5-HT2C receptor editing in a mouse model of obesity. PLos One. 7:e322662012. View Article : Google Scholar : PubMed/NCBI

28 

Dryden S, Burns SJ, Frankish HM and Williams G: Increased hypothalamic neuropeptide Y concentration or hyperphagia in streptozotocin-diabetic rats are not mediated by glucocorticoids. Eur J Pharmacol. 340:221–225. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Dryden S, Pickavance L, Frankish HM and Williams G: Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats. Brain Res. 690:185–188. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Pfaffly J, Michaelides M, Wang GJ, Pessin JE, Volkow ND and Thanos PK: Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice. Synapse. 64:503–510. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Sullivan EL, Smith MS and Grove KL: Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood. Neuroendocrinology. 93:1–8. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Sullivan EL, Grayson B, Takahashi D, Robertson N, Maier A, Bethea CL, Smit MS, Coleman K and Grove KL: Chronic consumption of a high-fat diet during pregnancy causes perturbations in in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring. J Neurosci. 30:3826–3830. 2010. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Manuel‑Apolinar L, Rocha L, Damasio L, Tesoro‑Cruz E and Zarate A: Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake. Mol Med Rep 9: 407-412, 2014.
APA
Manuel‑Apolinar, L., Rocha, L., Damasio, L., Tesoro‑Cruz, E., & Zarate, A. (2014). Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake. Molecular Medicine Reports, 9, 407-412. https://doi.org/10.3892/mmr.2013.1853
MLA
Manuel‑Apolinar, L., Rocha, L., Damasio, L., Tesoro‑Cruz, E., Zarate, A."Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake". Molecular Medicine Reports 9.2 (2014): 407-412.
Chicago
Manuel‑Apolinar, L., Rocha, L., Damasio, L., Tesoro‑Cruz, E., Zarate, A."Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake". Molecular Medicine Reports 9, no. 2 (2014): 407-412. https://doi.org/10.3892/mmr.2013.1853
Copy and paste a formatted citation
x
Spandidos Publications style
Manuel‑Apolinar L, Rocha L, Damasio L, Tesoro‑Cruz E and Zarate A: Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake. Mol Med Rep 9: 407-412, 2014.
APA
Manuel‑Apolinar, L., Rocha, L., Damasio, L., Tesoro‑Cruz, E., & Zarate, A. (2014). Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake. Molecular Medicine Reports, 9, 407-412. https://doi.org/10.3892/mmr.2013.1853
MLA
Manuel‑Apolinar, L., Rocha, L., Damasio, L., Tesoro‑Cruz, E., Zarate, A."Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake". Molecular Medicine Reports 9.2 (2014): 407-412.
Chicago
Manuel‑Apolinar, L., Rocha, L., Damasio, L., Tesoro‑Cruz, E., Zarate, A."Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake". Molecular Medicine Reports 9, no. 2 (2014): 407-412. https://doi.org/10.3892/mmr.2013.1853
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team