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2014-March Volume 9 Issue 3

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Article

P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier

  • Authors:
    • Pei‑Liang Dong
    • Hua Han
    • Tian‑Yu Zhang
    • Bingyou Yang
    • Qiu‑Hong Wang
    • Gao‑Wa Eerdun

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Chinese Materia Medica of Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Pharmacology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China
  • Pages: 985-988
    |
    Published online on: December 27, 2013
       https://doi.org/10.3892/mmr.2013.1880
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Abstract

Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. The aim of the present study was to investigate the role of P‑glycoprotein in the transport of dauricine across the blood‑brain barrier by pre‑treatment with the P‑glycoprotein inhibitor verapamil. Sprague Dawley rats were divided into a verapamil group (pretreated with verapamil at a dose of 20 mg/kg) and a control group (pretreated with the same volume of normal saline). After 90 min, the animals were injected intravenously with dauricine (10 mg/kg). At 15, 30 and 60 min after dauricine administration, the levels of dauricine in the blood and brain were detected by high‑performance liquid chromatography. Compared with the control group, the dauricine concentration in the brains of the rats in the verapamil group was significantly increased. Furthermore, the brain‑plasma ratio of dauricine in the rats pretreated with verapamil was significantly higher than that of the animals in the control group. However, there was no difference identified between dauricine levels in the plasma of the verapamil and the control groups. The results indicated that dauricine is able to pass the blood‑brain barrier, and that P‑glycoprotein has an important role in the transportation of dauricine across the blood‑brain barrier.
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Copy and paste a formatted citation
Spandidos Publications style
Dong PL, Han H, Zhang TY, Yang B, Wang QH and Eerdun GW: P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier. Mol Med Rep 9: 985-988, 2014.
APA
Dong, P., Han, H., Zhang, T., Yang, B., Wang, Q., & Eerdun, G. (2014). P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier. Molecular Medicine Reports, 9, 985-988. https://doi.org/10.3892/mmr.2013.1880
MLA
Dong, P., Han, H., Zhang, T., Yang, B., Wang, Q., Eerdun, G."P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier". Molecular Medicine Reports 9.3 (2014): 985-988.
Chicago
Dong, P., Han, H., Zhang, T., Yang, B., Wang, Q., Eerdun, G."P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier". Molecular Medicine Reports 9, no. 3 (2014): 985-988. https://doi.org/10.3892/mmr.2013.1880
Copy and paste a formatted citation
x
Spandidos Publications style
Dong PL, Han H, Zhang TY, Yang B, Wang QH and Eerdun GW: P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier. Mol Med Rep 9: 985-988, 2014.
APA
Dong, P., Han, H., Zhang, T., Yang, B., Wang, Q., & Eerdun, G. (2014). P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier. Molecular Medicine Reports, 9, 985-988. https://doi.org/10.3892/mmr.2013.1880
MLA
Dong, P., Han, H., Zhang, T., Yang, B., Wang, Q., Eerdun, G."P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier". Molecular Medicine Reports 9.3 (2014): 985-988.
Chicago
Dong, P., Han, H., Zhang, T., Yang, B., Wang, Q., Eerdun, G."P‑glycoprotein inhibition increases the transport of dauricine across the blood‑brain barrier". Molecular Medicine Reports 9, no. 3 (2014): 985-988. https://doi.org/10.3892/mmr.2013.1880
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