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Article

Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease

  • Authors:
    • Lei Li
    • Qing‑Guo Shi
    • Fang Lin
    • Yu‑Guang Liang
    • Li‑Jian Sun
    • Jin‑Song Mu
    • Yong‑Gang Wang
    • Hai‑Bin Su
    • Biao Xu
    • Cheng‑Cheng Ji
    • Hui‑Huang Huang
    • Ke Li
    • Hui‑Fen Wang
  • View Affiliations / Copyright

    Affiliations: The Medical College of Chinese PLA and PLA General Hospital, Beijing 100853, P.R. China, Department of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, P.R. China, Department of Intensive Care Unit, The 302 Military Hospital, Beijing 100039, P.R. China, Department of Pharmacology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, P.R. China
  • Pages: 831-836
    |
    Published online on: January 14, 2014
       https://doi.org/10.3892/mmr.2014.1898
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Abstract

Citrobacter rodentium (C. rodentium) infection is a widely used murine model to mimic human enteric bacteria infection and inflammatory bowel disease (IBD). In this model, interleukin (IL)‑17A plays critical roles in increasing chemokine and cytokine production in various tissues to recruit innate cells, including monocytes and neutrophils, to the local site of infection. However, the source of IL‑17A remains unclear, as the majority of cell types produce IL‑17A, including intestinal endothelium cells, innate immune cells and CD4+ T cells in disease development. In the current study, wild‑type B6 mice were treated with C. rodentium and the CD4+ Th17 cell subset was observed as being specifically increased in Peyer's patches (PP), but not in mesenteric draining lymph nodes. Furthermore, the research suggested that the differentiation and activation of Th17 cells in PP were dependent on the inflammatory cytokine IL‑6, as blocking IL‑6 signaling with neutralizing antibodies decreased Th17 cells and resulted in the mice being more susceptible to C. rodentium infection. These results confirmed that the Th17 cell subset was specifically activated in PP and demonstrated that IL‑6 is required in Th17 cell activation, which are important to the clinical treatment of IBD.
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Copy and paste a formatted citation
Spandidos Publications style
Li L, Shi QG, Lin F, Liang YG, Sun LJ, Mu JS, Wang YG, Su HB, Xu B, Ji CC, Ji CC, et al: Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease. Mol Med Rep 9: 831-836, 2014.
APA
Li, L., Shi, Q., Lin, F., Liang, Y., Sun, L., Mu, J. ... Wang, H. (2014). Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease. Molecular Medicine Reports, 9, 831-836. https://doi.org/10.3892/mmr.2014.1898
MLA
Li, L., Shi, Q., Lin, F., Liang, Y., Sun, L., Mu, J., Wang, Y., Su, H., Xu, B., Ji, C., Huang, H., Li, K., Wang, H."Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease". Molecular Medicine Reports 9.3 (2014): 831-836.
Chicago
Li, L., Shi, Q., Lin, F., Liang, Y., Sun, L., Mu, J., Wang, Y., Su, H., Xu, B., Ji, C., Huang, H., Li, K., Wang, H."Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease". Molecular Medicine Reports 9, no. 3 (2014): 831-836. https://doi.org/10.3892/mmr.2014.1898
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Shi QG, Lin F, Liang YG, Sun LJ, Mu JS, Wang YG, Su HB, Xu B, Ji CC, Ji CC, et al: Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease. Mol Med Rep 9: 831-836, 2014.
APA
Li, L., Shi, Q., Lin, F., Liang, Y., Sun, L., Mu, J. ... Wang, H. (2014). Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease. Molecular Medicine Reports, 9, 831-836. https://doi.org/10.3892/mmr.2014.1898
MLA
Li, L., Shi, Q., Lin, F., Liang, Y., Sun, L., Mu, J., Wang, Y., Su, H., Xu, B., Ji, C., Huang, H., Li, K., Wang, H."Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease". Molecular Medicine Reports 9.3 (2014): 831-836.
Chicago
Li, L., Shi, Q., Lin, F., Liang, Y., Sun, L., Mu, J., Wang, Y., Su, H., Xu, B., Ji, C., Huang, H., Li, K., Wang, H."Cytokine IL‑6 is required in Citrobacter rodentium infection‑induced intestinal Th17 responses and promotes IL‑22 expression in inflammatory bowel disease". Molecular Medicine Reports 9, no. 3 (2014): 831-836. https://doi.org/10.3892/mmr.2014.1898
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