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Article

Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage

  • Authors:
    • Min Jeong Kim
    • Hye Hyeon Lee
    • Jin Woo Jeong
    • Min Jeong Seo
    • Byoung Won Kang
    • Jeong Uck Park
    • Kyoung-Sook Kim
    • Young-Su Cho
    • Kwon-Il Seo
    • Gi-Young Kim
    • Jung-In Kim
    • Yung Hyun Choi
    • Yong Kee Jeong
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnology, Dong-A University, Saha‑gu, Busan 604-714, Republic of Korea, Center for Core Research Facilities, Daegu Gyeongbuk Institute of Science and Technology, Dalseong‑gun, Daegu 711-873, Republic of Korea, Medi-Farm Industrialization Research Center, Dong-A University, Saha‑gu, Busan 604-714, Republic of Korea, Department of Food and Nutrition, Sunchon National University, Sunchon, Jeollanam‑do 540-950, Republic of Korea, Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju-si, Jeju 690-756, Republic of Korea, School of Food and Life Sciences, Inje University, Gimhae, Gyeongsang 621-749, Republic of Korea, Department of Biochemistry, Dongeui University College of Oriental Medicine, Busanjin-gu, Busan 614-052, Republic of Korea
  • Pages: 1197-1203
    |
    Published online on: January 28, 2014
       https://doi.org/10.3892/mmr.2014.1922
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Abstract

The anti-inflammatory mechanism of 5‑hydroxy-3,6,7,8,3',4'‑hexamethoxyflavone (5HHMF), a polyhydroxyflavone isolated from the marine algae Hizikia fusiforme, was investigated in RAW 264.7 murine macrophage cells. Western blot and reverse transcriptase PCR analyses indicated that adding 5HHMF to cultured cells significantly reduced the production of nitric oxide and prostaglandin E2 and downregulated inducible nitric oxide synthase (iNOS) and cyclooxygenase‑2 (COX‑2) expression in lipopolysaccharide (LPS)‑stimulated RAW 264.7 cells. In addition, 5HHMF inhibited the release of pro‑inflammatory cytokines, such as tumor necrosis factor‑α and interleukin‑1β, and decreased the transcriptional levels. In particular, 5HHMF significantly inhibited the LPS‑induced nuclear factor‑κB (NF‑κB) translocation from the cytosol to the nucleus, which was associated with the abrogation of inhibitory IκBα degradation and subsequent decreases in nuclear p65 levels. In conclusion, these results suggested that the anti‑inflammatory activities of 5HHMF may be attributed to the inhibition of iNOS, COX‑2 and cytokine expression by attenuating NF‑κB activation via IκBα degradation in macrophages.
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1 

Andreasen AS, Krabbe KS, Krogh-Madsen R, Taudorf S, Pedersen BK and Møller K: Human endotoxemia as a model of systemic inflammation. Curr Med Chem. 15:1697–1705. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Aderem A: Role of Toll-like receptors in inflammatory response in macrophages. Crit Care Med. 29(Suppl 7): S16–S18. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Ritchlin CT, Haas-Smith SA, Li P, Hicks DG and Schwarz EM: Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest. 111:821–831. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Brown MD and Sacks DB: Compartmentalised MAPK pathways. Handb Exp Pharmacol. 186:205–235. 2008. View Article : Google Scholar

5 

Ci X, Song Y, Zeng F, Zhang X, Li H, Wang X, Cui J and Deng X: Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK. Biochem Biophys Res Commun. 372:73–77. 2008.PubMed/NCBI

6 

Liu RH and Hotchkiss JH: Potential genotoxicity of chronically elevated nitric oxide: a review. Mutat Res. 339:73–89. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Siebenlist U, Franzoso G and Brown K: Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol. 10:405–455. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Zhang X, Li H, Feng H, Xiong H, Zhang L, Song Y, Yu L and Deng X: Valnemulin downregulates nitric oxide, prostaglandin E2, and cytokine production via inhibition of NF-kappaB and MAPK activity. Int Immunopharmacol. 9:810–816. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Edwards MR, Bartlett NW, Clarke D, Birrell M, Belvisi M and Johnston SL: Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease. Pharmacol Ther. 121:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Ghosh S and Hayden MS: New regulators of NF-kappaB in inflammation. Nat Rev Immunol. 8:837–848. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Wong ET and Tergaonkar V: Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential. Clin Sci (Lond). 116:451–465. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Barak V, Kalickman I, Halperin T, Birkenfeld S and Ginsburg I: PADMA-28, a Tibetan herbal preparation is an inhibitor of inflammatory cytokine production. Eur Cytokine Netw. 15:203–209. 2004.PubMed/NCBI

13 

Chi YS, Lim H, Park H and Kim HP: Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem Pharmacol. 66:1271–1278. 2003.PubMed/NCBI

14 

Genovese MC: Biologic therapies in clinical development for the treatment of rheumatoid arthritis. J Clin Rheumatol. 11:S45–S54. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Kim KI, Seo HD, Lee HS, Jo HY and Yang HC: Studies on the blood anticoagulant polysaccharide isolated from hot water extracts of Hizikia fusiforme. Korean J Food Sci Nutr. 27:1204–1210. 1998.

16 

Nagai T and Yukimoto T: Preparation and functional properties of beverages made from sea algae. Food Chem. 81:327–332. 2003. View Article : Google Scholar

17 

Okai Y, Okai KH, Ishizaka S, Ohtani K, Yuasa IS and Yamashita U: Possible immunodulating activities in extract of edible brown alga Hizikia fusiforme (Hiziki). J Food Agricul. 76:56–62. 1998. View Article : Google Scholar

18 

Yan X, Chuda Y, Suzuki M and Nagata T: Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed. Biosci Biotechnol Biochem. 63:605–607. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Kim MJ, Lee HH, Seo MJ, Kang BW, Park JU, Kim KS, Kim KY, Joo WH, Choi YH, Cho YS and Jeong YK: Identification of 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone from Hizikia fusiforme involved in the induction of the apoptosis mediators in human AGS carcinoma cells. J Microbiol Biotechnol. 22:1665–1672. 2012.

20 

Pan MH, Lai YS, Lai CS, Wang YJ, Li S, Lo CY, Dushenkov S and Ho CT: 5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone induces apoptosis through reactive oxygen species production, growth arrest and DNA damage-inducible gene 153 expression, and caspase activation in human leukemia cells. J Agric Food Chem. 55:5081–5091. 2007.

21 

Sergeev IN, Li S, Colby J, Ho CT and Dushenkov S: Polymethoxylated flavones induce Ca2+-mediated apoptosis in breast cancer cells. Life Sci. 80:245–253. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Bae DS, Kim YH, Pan CH, Nho CW, Samdan J, Yansan J and Lee JK: Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages. BMB Rep. 5:108–113. 2012.PubMed/NCBI

23 

Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K and Shin SY: A new synthetic chalcone derivative, 2-hydroxy-3′,5,5′-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells. Exp Mol Med. 44:369–377. 2012.PubMed/NCBI

24 

Guo LY, Hung TM, Bae KH, Shin EM, Zhou HY, Hong YN, Kang SS, Kim HP and Kim YS: Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. Eur J Pharmacol. 591:293–299. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Southan GJ and Szabó C: Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol. 51:383–394. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S and Howells L: Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene. 18:6013–6020. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Sarkar D, Saha P, Gamre S, Bhattacharjee S, Hariharan C, Ganguly S, Sen R, Mandal G, Chattopadhyay S, Majumdar S and Chatterjee M: Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-kappaB pathway. Int Immunopharmacol. 8:1264–1271. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Tao JY, Zheng GH, Zhao L, Wu JG, Zhang XY, Zhang SL, Huang ZJ, Xiong FL and Li CM: Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells. J Ethnopharmacol. 123:97–105. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Van Q, Nayak BN, Reimer M, Jones PJ, Fulcher RG and Rempel CB: Anti-inflammatory effect of Inonotus obliquus, Polygala senega L, and Viburnum trilobum in a cell screening assay. J Ethnopharmacol. 125:487–493. 2009.

30 

Yun KJ, Kim JY, Kim JB, Lee KW, Jeong SY, Park HJ, Jung HJ, Cho YW, Yun K and Lee KT: Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. Int Immunopharmacol. 8:431–441. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Aggarwal BB and Natarajan K: Tumor necrosis factors: developments during the last decade. Eur Cytokine Netw. 7:93–124. 1996.PubMed/NCBI

32 

Lee HS, Ryu DS, Lee GS and Lee DS: Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: suppression of NF-kappaB activation and MAPK signaling. J Ethnopharmacol. 140:271–276. 2012.PubMed/NCBI

33 

Kim YG, Ohta T, Takahashi T, Kushiro A, Nomoto K, Yokokura T, Okada N and Danbara H: Probiotic Lactobacillus casei activates innate immunity via NF-kappaB and p38 MAP kinase signaling pathways. Microbes Infect. 8:994–1005. 2006.

34 

Rajapakse N, Kim MM, Mendis E and Kim SK: Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-kappaB signaling. Immunology. 123:348–357. 2008.

35 

Lee SJ, Bai SK, Lee KS, Namkoong S, Na HJ, Ha KS, Han JA, Yim SV, Chang K, Kwon YG, et al: Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing IκB kinase-dependent NF-kappaB activation. Mol Cells. 16:97–105. 2003.PubMed/NCBI

36 

Abraham E: Nuclear factor-kappaB and its role in sepsis-associated organ failure. J Infect Dis. 187(Suppl 2): S364–S369. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim MJ, Lee HH, Jeong JW, Seo MJ, Kang BW, Park JU, Kim K, Cho Y, Seo K, Kim G, Kim G, et al: Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage. Mol Med Rep 9: 1197-1203, 2014.
APA
Kim, M.J., Lee, H.H., Jeong, J.W., Seo, M.J., Kang, B.W., Park, J.U. ... Jeong, Y.K. (2014). Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage. Molecular Medicine Reports, 9, 1197-1203. https://doi.org/10.3892/mmr.2014.1922
MLA
Kim, M. J., Lee, H. H., Jeong, J. W., Seo, M. J., Kang, B. W., Park, J. U., Kim, K., Cho, Y., Seo, K., Kim, G., Kim, J., Choi, Y. H., Jeong, Y. K."Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage". Molecular Medicine Reports 9.4 (2014): 1197-1203.
Chicago
Kim, M. J., Lee, H. H., Jeong, J. W., Seo, M. J., Kang, B. W., Park, J. U., Kim, K., Cho, Y., Seo, K., Kim, G., Kim, J., Choi, Y. H., Jeong, Y. K."Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage". Molecular Medicine Reports 9, no. 4 (2014): 1197-1203. https://doi.org/10.3892/mmr.2014.1922
Copy and paste a formatted citation
x
Spandidos Publications style
Kim MJ, Lee HH, Jeong JW, Seo MJ, Kang BW, Park JU, Kim K, Cho Y, Seo K, Kim G, Kim G, et al: Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage. Mol Med Rep 9: 1197-1203, 2014.
APA
Kim, M.J., Lee, H.H., Jeong, J.W., Seo, M.J., Kang, B.W., Park, J.U. ... Jeong, Y.K. (2014). Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage. Molecular Medicine Reports, 9, 1197-1203. https://doi.org/10.3892/mmr.2014.1922
MLA
Kim, M. J., Lee, H. H., Jeong, J. W., Seo, M. J., Kang, B. W., Park, J. U., Kim, K., Cho, Y., Seo, K., Kim, G., Kim, J., Choi, Y. H., Jeong, Y. K."Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage". Molecular Medicine Reports 9.4 (2014): 1197-1203.
Chicago
Kim, M. J., Lee, H. H., Jeong, J. W., Seo, M. J., Kang, B. W., Park, J. U., Kim, K., Cho, Y., Seo, K., Kim, G., Kim, J., Choi, Y. H., Jeong, Y. K."Anti-inflammatory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone via NF-κB inactivation in lipopolysaccharide-stimulated RAW 264.7 macrophage". Molecular Medicine Reports 9, no. 4 (2014): 1197-1203. https://doi.org/10.3892/mmr.2014.1922
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