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2014-April Volume 9 Issue 4

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Article

microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression

  • Authors:
    • Wei Li
    • Huiping Ma
    • Ji Sun
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Shandong 272000, P.R. China, Department of Respiration, The First People's Hospital of Jining, Shandong 272000, P.R. China, Department of Otolaryngology, Head and Neck Surgery, Harbin Medical University Cancer Institute and Hospital, Heilongjiang 150081, P.R. China
  • Pages: 1293-1298
    |
    Published online on: January 30, 2014
       https://doi.org/10.3892/mmr.2014.1929
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Abstract

A family of small non‑coding RNAs, ~22 nt in length, known as microRNAs (miRNAs), regulating ~30% of all human gene expression, have been reported to be involved in the pathogenesis of a number of types of cancers, including laryngeal squamous cell carcinoma (LSCC). In the current study, miR‑34a and miR‑34c were observed to be downregulated in human LSCC tissues. Ectopic expression of miR‑34a and miR‑34c in Hep‑2 cells significantly induced the cell proliferation and migration ability in vitro. UDP‑N‑acetyl‑α‑D‑galactosamine:polypeptide‑N‑acetylgalactosaminyltransferase 7 (GALNT7), whose expression is negatively regulated by miR‑34a and miR‑34c in Hep‑2 cells, is confirmed to be a novel direct target gene of miR‑34a and miR‑34c. In conclusion, the current results suggest that miR‑34a and miR‑34c may function as tumor suppressors in LSCC through downregulation of GALNT7. The study of miR‑34a, miR‑34c and its novel target, GALNT7, may serve as novel potential makers for LSCC therapy.
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1 

Breving K and Esquela-Kerscher A: The complexities of microRNA regulation: mirandering around the rules. Int J Biochem Cell Biol. 42:1316–1329. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Kim VN: Small RNAs: classification, biogenesis, and function. Mol Cells. 19:1–15. 2005.PubMed/NCBI

3 

Garzon R, Calin GA and Croce CM: MicroRNAs in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar

4 

Mao L, Hong WK and Papadimitrakopoulou VA: Focus on head and neck cancer. Cancer Cell. 5:311–316. 2004. View Article : Google Scholar

5 

Licitra L, Bernier J, Grandi C, et al: Cancer of the larynx. Crit Rev Oncol Hematol. 47:65–80. 2003. View Article : Google Scholar

6 

Vokes EE, Weichselbaum RR, Lippman SM and Hong WK: Head and neck cancer. N Engl J Med. 328:184–194. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Tivnan A, Tracey L, Buckley PG, Alcock LC, Davidoff AM and Stallings RL: MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma. BMC Cancer. 11:332011. View Article : Google Scholar : PubMed/NCBI

8 

Cai KM, Bao XL, Kong XH, et al: Hsa-miR-34c suppresses growth and invasion of human laryngeal carcinoma cells via targeting c-Met. Int J Mol Med. 25:565–571. 2010.PubMed/NCBI

9 

Chen C, Ridzon DA, Broomer AJ, et al: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 33:e1792005. View Article : Google Scholar : PubMed/NCBI

10 

Peng RQ, Wan HY, Li HF, Liu M, Li X and Tang H: MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7. J Biol Chem. 287:14301–14309. 2012.PubMed/NCBI

11 

Liu M, Wu H, Liu T, et al: Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. Cell Res. 19:828–837. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Peter ME: Targeting of mRNAs by multiple miRNAs: the next step. Oncogene. 29:2161–2164. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Hobert O: miRNAs play a tune. Cell. 131:22–24. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Gaziel-Sovran A, Segura MF, Di Micco R, et al: miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell. 20:104–118. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science. 294:853–858. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Johnson SM, Grosshans H, Shingara J, et al: RAS is regulated by the let-7 microRNA family. Cell. 120:635–647. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Hayashita Y, Osada H, Tatematsu Y, et al: A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 65:9628–9632. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Tazawa H, Tsuchiya N, Izumiya M and Nakagama H: Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA. 104:15472–15477. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Ji Q, Hao X, Zhang M, et al: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One. 4:e68162009. View Article : Google Scholar : PubMed/NCBI

21 

Pang RT, Leung CO, Ye TM, et al: MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis. 31:1037–1044. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Li N, Fu H, Tie Y, et al: miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Lett. 275:44–53. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Yamakuchi M, Ferlito M and Lowenstein CJ: miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA. 105:13421–13426. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Welch C, Chen Y and Stallings RL: MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene. 26:5017–5022. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Wei JS, Song YK, Durinck S, et al: The MYCN oncogene is a direct target of miR-34a. Oncogene. 27:5204–5213. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Sun F, Fu H, Liu Q, et al: Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett. 582:1564–1568. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Bommer GT, Gerin I, Feng Y, et al: p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol. 17:1298–1307. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Liu H, Brannon AR, Reddy AR, et al: Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell renal cell carcinoma. BMC Syst Biol. 4:512010. View Article : Google Scholar : PubMed/NCBI

29 

Luan S, Sun L and Huang F: MicroRNA-34a: a novel tumor suppressor in p53-mutant glioma cell line U251. Arch Med Res. 41:67–74. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Ten Hagen KG, Fritz TA and Tabak LA: All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases. Glycobiology. 13:1R–16R. 2003.PubMed/NCBI

31 

Casey RC, Oegema TR Jr, Skubitz KM, Pambuccian SE, Grindle SM and Skubitz AP: Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells. Clin Exp Metastasis. 20:143–152. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Kahai S, Lee SC, Lee DY, et al: MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. PLoS One. 4:e75352009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li W, Ma H and Sun J: microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression. Mol Med Rep 9: 1293-1298, 2014.
APA
Li, W., Ma, H., & Sun, J. (2014). microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression. Molecular Medicine Reports, 9, 1293-1298. https://doi.org/10.3892/mmr.2014.1929
MLA
Li, W., Ma, H., Sun, J."microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression". Molecular Medicine Reports 9.4 (2014): 1293-1298.
Chicago
Li, W., Ma, H., Sun, J."microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression". Molecular Medicine Reports 9, no. 4 (2014): 1293-1298. https://doi.org/10.3892/mmr.2014.1929
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Ma H and Sun J: microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression. Mol Med Rep 9: 1293-1298, 2014.
APA
Li, W., Ma, H., & Sun, J. (2014). microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression. Molecular Medicine Reports, 9, 1293-1298. https://doi.org/10.3892/mmr.2014.1929
MLA
Li, W., Ma, H., Sun, J."microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression". Molecular Medicine Reports 9.4 (2014): 1293-1298.
Chicago
Li, W., Ma, H., Sun, J."microRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression". Molecular Medicine Reports 9, no. 4 (2014): 1293-1298. https://doi.org/10.3892/mmr.2014.1929
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