Prognostic factors for renal allograft survival in patients with immunoglobulin A nephropathy: A case control study

Guo,Jun-Qi; Song,Bao-Lin; Wu,Zhi-Xian; Wu,Wei-Zhen; Luo,Liu-Tao; Chen,Xiao-Wen; He,Fu-Qiang; Zheng,Zhi-Yong; Yang,Shun-Liang; Tan,Jian-Ming

doi:10.3892/mmr.2014.1954

2014-April Volume 9 Issue 4

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2014-April Volume 9 Issue 4

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Article

Prognostic factors for renal allograft survival in patients with immunoglobulin A nephropathy: A case control study

Authors:
- Jun-Qi Guo
- Bao-Lin Song
- Zhi-Xian Wu
- Wei-Zhen Wu
- Liu-Tao Luo
- Xiao-Wen Chen
- Fu-Qiang He
- Zhi-Yong Zheng
- Shun-Liang Yang
- Jian-Ming Tan
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Affiliations: Organ Transplant Institute, Fuzhou General Hospital, Fujian Medical University and Fujian Key Laboratory of Transplant Biology, Fuzhou, Fujian 350025, P.R. China, Department of Urology, Jiaxing Traditional Chinese Medical Hospital, Jiaxing, Zhejiang 314000, P.R. China
Pages: 1179-1184
|
Published online on: February 17, 2014

https://doi.org/10.3892/mmr.2014.1954
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Abstract

The renal allograft survival rates of patients with immunoglobulin A nephropathy (IgAN), and patients with or without other glomerular diseases, have yet to be fully elucidated. In this study, the clinicopathological factors associated with long-term allograft survival for the prognosis of renal allograft recipients with IgAN were examined. All patients enrolled in this study were diagnosed with IgAN following clinical and pathological examinations. Patients underwent renal graft biopsy and were hospitalized at the Fuzhou General Hospital between June, 2004 and December, 2010. Common demographic and clinical indicators were recorded in patients who had graft loss and in those who had functional renal grafts. Forty-two of the 202 biopsy specimens (20.8%) met the diagnostic criteria for IgAN and were divided into two groups, the graft loss group (n=17) and the functional graft group (n=25). Patients were followed up for 1-257 months after kidney transplantation. The mean patient age was 40.6±9.3 years at the time of renal graft biopsy. Examination results indicated concomitant proteinuria and hematuria in 25 patients (59.5%) and proteinuria alone in six patients (14.3%). Graft loss occurred in 17 patients during the follow-up period. Comparison of the graft loss and the functional graft groups indicated that patients in the graft loss group were more likely to have proteinuria (P=0.047), high creatinine levels at the time of biopsy (P=0.009), low glomerular filtration rates (P=0.013), low serum total protein (P=0.01), a high Banff score (P=0.001), extensive glomerulosclerosis (P=0.002), a greater likelihood of crescent formation (P=0.01), severe tubular atrophy (P=0.013) and more extensive interstitial fibrosis (P=0.033). However, the two groups showed no significant differences in blood pressure, hematuria, BUN, UA, Hb, TG and CHO levels. The allograft survival rate of patients with IgAN was identified to be similar to that of patients with and without other glomerular diseases.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prognostic factors for renal allograft survival in patients with immunoglobulin A nephropathy: A case control study

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