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2014-April Volume 9 Issue 4

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Article

Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway

  • Authors:
    • Yuqiang Ji
    • Zhao Zhao
    • Tianzhi Cai
    • Pengkang Yang
    • Manli Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, First Hospital of Xi'an, Xi'an, Shaanxi 710002, P.R. China, Department of Cardiovascular Medicine, The Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P.R. China
  • Pages: 1254-1258
    |
    Published online on: February 17, 2014
       https://doi.org/10.3892/mmr.2014.1956
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Abstract

Clinically, diabetes mellitus is closely associated with and induces certain cardiovascular diseases. The aim of this study was to investigate endoplasmic reticulum (ER) stress-associated apoptosis of diabetic cardiomyopathy (DCM), and explore the protective mechanism of liraglutide. The DCM model was established with a high-fat diet and streptozotocin (STZ). Cardiac function was detected by echocardiogram examination and hematoxylin-eosin staining. ER stress unfolded protein response (UPR) hallmarks [inositol-requiring enzyme‑α (IRE-α), p-Perk and ATF6] and transcription factors were detected with western blotting. Apoptosis inducers CHOP, c-Jun amino terminal kinase (JNK) and casapse-12 were also examined with western blotting. The results indicated that liraglutide is capable of improving cardiac function in DCM rats (P<0.05). IRE-α expression was significantly increased in the DCM group compared with the control group (P<0.05), and liraglutide is capable of decreasing IRE-α expression. X-box transcription factor-1 (XBP-1) was significantly spliced in the model group, and downregulated in the liraglutide-treated group. CHOP protein was upregulated in the DCM group, but inactivated by liraglutide treatment. In conclusion, liraglutide is capable of protecting DCM and blocking CHOP-mediated ER stress by inhibiting the IRE-α UPR pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Ji Y, Zhao Z, Cai T, Yang P and Cheng M: Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway. Mol Med Rep 9: 1254-1258, 2014.
APA
Ji, Y., Zhao, Z., Cai, T., Yang, P., & Cheng, M. (2014). Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway. Molecular Medicine Reports, 9, 1254-1258. https://doi.org/10.3892/mmr.2014.1956
MLA
Ji, Y., Zhao, Z., Cai, T., Yang, P., Cheng, M."Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway". Molecular Medicine Reports 9.4 (2014): 1254-1258.
Chicago
Ji, Y., Zhao, Z., Cai, T., Yang, P., Cheng, M."Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway". Molecular Medicine Reports 9, no. 4 (2014): 1254-1258. https://doi.org/10.3892/mmr.2014.1956
Copy and paste a formatted citation
x
Spandidos Publications style
Ji Y, Zhao Z, Cai T, Yang P and Cheng M: Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway. Mol Med Rep 9: 1254-1258, 2014.
APA
Ji, Y., Zhao, Z., Cai, T., Yang, P., & Cheng, M. (2014). Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway. Molecular Medicine Reports, 9, 1254-1258. https://doi.org/10.3892/mmr.2014.1956
MLA
Ji, Y., Zhao, Z., Cai, T., Yang, P., Cheng, M."Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway". Molecular Medicine Reports 9.4 (2014): 1254-1258.
Chicago
Ji, Y., Zhao, Z., Cai, T., Yang, P., Cheng, M."Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP‑triggered apoptosis via the inhibition of the IRE-α pathway". Molecular Medicine Reports 9, no. 4 (2014): 1254-1258. https://doi.org/10.3892/mmr.2014.1956
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