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2014-April Volume 9 Issue 4

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Article

Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii

  • Authors:
    • Chang‑Hwan Kim
    • Dong‑Jae Kim
    • Sang‑Jin Lee
    • Yu‑Jin Jeong
    • Min‑Jung Kang
    • Jun‑Young Lee
    • Jin‑A Choi
    • Sun‑Jung Kwon
    • Jae‑Hak Park
    • Jong‑Hwan Park
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151‑742, Republic of Korea, Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea, Department of Internal Medicine, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea
  • Pages: 1410-1414
    |
    Published online on: February 19, 2014
       https://doi.org/10.3892/mmr.2014.1966
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Abstract

Toll‑like receptor 2 (TLR2) has been identified as a sensor for bacterial lipoprotein. To determine the role of TLR2 in host defense against Acinetobacter baumannii infection, wild‑type (WT) and TLR2‑deficient mice were infected intranasally with A. baumannii. Body weight, cytokine and chemokine levels in bronchoalveolar (BAL) fluid and lung histopathology were examined. Body weight changes in TLR2‑deficient mice were comparable to those of WT mice throughout the experimental period. However, TLR2‑deficient mice exhibited an increased bacterial load in the lungs and increased levels of interleukin‑6 and chemokine (C‑X‑C motif) ligand 2 in BAL fluids compared with WT mice 1 day after infection. Histopathological features of lung tissue in WT and TLR2‑deficient mice were comparable between WT and TLR2‑deficient mice. Results of the present study demonstrate that TLR2 may have a minimal role in the host defense against A. baumannii at the early stages of infection.
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Copy and paste a formatted citation
Spandidos Publications style
Kim CH, Kim DJ, Lee SJ, Jeong YJ, Kang MJ, Lee JY, Choi JA, Kwon SJ, Park JH, Park JH, Park JH, et al: Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii. Mol Med Rep 9: 1410-1414, 2014.
APA
Kim, C., Kim, D., Lee, S., Jeong, Y., Kang, M., Lee, J. ... Park, J. (2014). Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii. Molecular Medicine Reports, 9, 1410-1414. https://doi.org/10.3892/mmr.2014.1966
MLA
Kim, C., Kim, D., Lee, S., Jeong, Y., Kang, M., Lee, J., Choi, J., Kwon, S., Park, J., Park, J."Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii". Molecular Medicine Reports 9.4 (2014): 1410-1414.
Chicago
Kim, C., Kim, D., Lee, S., Jeong, Y., Kang, M., Lee, J., Choi, J., Kwon, S., Park, J., Park, J."Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii". Molecular Medicine Reports 9, no. 4 (2014): 1410-1414. https://doi.org/10.3892/mmr.2014.1966
Copy and paste a formatted citation
x
Spandidos Publications style
Kim CH, Kim DJ, Lee SJ, Jeong YJ, Kang MJ, Lee JY, Choi JA, Kwon SJ, Park JH, Park JH, Park JH, et al: Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii. Mol Med Rep 9: 1410-1414, 2014.
APA
Kim, C., Kim, D., Lee, S., Jeong, Y., Kang, M., Lee, J. ... Park, J. (2014). Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii. Molecular Medicine Reports, 9, 1410-1414. https://doi.org/10.3892/mmr.2014.1966
MLA
Kim, C., Kim, D., Lee, S., Jeong, Y., Kang, M., Lee, J., Choi, J., Kwon, S., Park, J., Park, J."Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii". Molecular Medicine Reports 9.4 (2014): 1410-1414.
Chicago
Kim, C., Kim, D., Lee, S., Jeong, Y., Kang, M., Lee, J., Choi, J., Kwon, S., Park, J., Park, J."Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii". Molecular Medicine Reports 9, no. 4 (2014): 1410-1414. https://doi.org/10.3892/mmr.2014.1966
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