Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2014 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2014 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats

  • Authors:
    • Heeok Hong
    • Chang‑Ju Kim
    • Jae‑Deung Kim
    • Jin‑Hee Seo
  • View Affiliations / Copyright

    Affiliations: Department of Medical Science, School of Medicine, Konkuk University, Seoul 143‑701, Republic of Korea, Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea, Department of Physical Education, Korea University, Seoul 136‑701, Republic of Korea, Division of Sports Science, Baekseok University, Cheonan 330‑704, Republic of Korea
  • Pages: 1660-1666
    |
    Published online on: March 4, 2014
       https://doi.org/10.3892/mmr.2014.2005
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Immediate‑early genes are involved in acute stress responses in the central nervous system. β‑glucan stimulates innate immune defenses, exerts an anti‑tumor response and increases resistance to a wide variety of types of infection. To date, the effect of β‑glucan on the expression of immediate‑early genes under stressful conditions has not been elucidated. In the present study, the effects of β‑glucan on the expression of the oncogenes c‑Fos and c‑Jun in the hypothalamus, dentate gyrus and dorsal raphe in rats following exhaustive treadmill running were investigated. Male Sprague Dawley rats were randomly divided into five groups (n=10 in each group) as follows: Control, exercise, exercise and 50 mg/kg β‑glucan treatment, exercise and 100 mg/kg β‑glucan treatment, and exercise and 200 mg/kg β‑glucan treatment. Rats in the β‑glucan‑treated groups were administered β‑glucan at the respective dose once per day for seven days. Rats in the exercise groups performed treadmill running once per day for six days. On the seventh day of the experiment, the time to exhaustion in response to treadmill running was determined for the exercise groups. The expression of c‑Fos and c‑Jun in the hypothalamus, dorsal raphe and hippocampus was enhanced by exhaustive treadmill running. Administration of β‑glucan resulted in an increase in the time to exhaustion and the suppression of the exercise‑induced increment in c‑Fos and c‑Jun expression. In conclusion, β‑glucan may exert an alleviating effect on exercise‑induced stress through the suppression of c‑Fos and c‑Jun expression in the brains of exhausted rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Schreiber SS, Tocco G, Shors TJ and Thompson RF: Activation of immediate early genes after acute stress. Neuroreport. 2:17–20. 1991. View Article : Google Scholar : PubMed/NCBI

2 

Honkaniemi J, Kainu T, Ceccatelli S, Rechardt L, Hökfelt T and Pelto-Huikko M: Fos and jun in rat central amygdaloid nucleus and paraventricular nucleus after stress. Neuroreport. 3:849–852. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Zamora-González EO, Santerre A, Palomera-Avalos V and Morales-Villagrán A: A chronic combinatory stress model that activates the HPA axis and avoids habituation in BALB/C mice. J Neurosci Methods. 213:70–75. 2013.PubMed/NCBI

4 

Imaki T, Shibasaki T, Chikada N, Harada S, Naruse M and Demura H: Different expression of immediate-early genes in the rat paraventricular nucleus induced by stress: relation to corticotropin-releasing factor gene transcription. Endocr J. 43:629–638. 1996. View Article : Google Scholar

5 

Singewald N, Salchner P and Sharp T: Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol Psychiatry. 53:275–283. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Soya H, Mukai A, Deocaris CC, Ohiwa N, Chang H, Nishijima T, Fujikawa T, Togashi K and Saito T: Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: establishment of a minimum running stress (MRS) rat model. Neurosci Res. 58:341–348. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Kovary K and Bravo R: Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations. Mol Cell Biol. 11:2451–2459. 1991.PubMed/NCBI

8 

Kovary K and Bravo R: The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol. 11:4466–4472. 1991.PubMed/NCBI

9 

Caubet JF: c-fos proto-oncogene expression in the nervous system during mouse development. Mol Cell Biol. 9:2269–2272. 1989.PubMed/NCBI

10 

Wilkinson DG, Bhatt S, Ryseck RP and Bravo R: Tissue-specific expression of c-jun and junB during organogenesis in the mouse. Development. 106:465–471. 1989.PubMed/NCBI

11 

Akins PT, Liu PK and Hsu CY: Immediate early gene expression in response to cerebral ischemia. Friend or foe? Stroke. 27:1682–1687. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Sheng M and Greenberg ME: The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron. 4:477–485. 1990. View Article : Google Scholar

13 

Jung JA, Yoo KS and Hwang KK: Changes of c-Fos immunoreactivity in midbrain by deep pain and effects of aspirin. Korean J Pediatr. 46:695–701. 2003.

14 

Seo JH, Kim TW, Kim CJ, Sung YH and Lee SJ: Treadmill exercise during pregnancy ameliorates post-traumatic stress disorder-induced anxiety-like responses in maternal rats. Mol Med Rep. 7:389–395. 2013.PubMed/NCBI

15 

Kohut ML, Boehm GW and Moynihan JA: Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection. J Appl Physiol (1985). 90:678–684. 2001.PubMed/NCBI

16 

Pedersen BK and Hoffman-Goetz L: Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev. 80:1055–1081. 2000.PubMed/NCBI

17 

Hong JA, Chung SH, Lee JS, Kim SS, Shin HD, Kim H, Jang MH, Lee TH, Lim BV, Kim YP and Kim CJ: Effects of Paeonia radix on 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats. Biol Pharm Bull. 26:166–169. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Lim BV, Jang MH, Shin MC, Kim HB, Kim YJ, Kim YP, Chung JH, Kim H, Shin MS, Kim SS, et al: Caffeine inhibits exercise-induced increase in tryptophan hydroxylase expression in dorsal and median raphe of Sprague-Dawley rats. Neurosci Lett. 308:25–28. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Seo JH, Sung YH, Kim KJ, Shin MS, Lee EK and Kim CJ: Effects of Phellinus linteus administration on serotonin synthesis in the brain and expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats. J Nutr Sci Vitaminol (Tokyo). 57:95–103. 2011.

20 

Lee MK, Lim HH, Song YK, Ko IG, Kim H, Shin MS, Lee TH, Kim CJ, Joo KJ, Park JK and Choi HH: Effects of the mixture of red ginseng and Paeonia radix on the treadmill running and swimming exercise in rats. J Exerc Nutr Biochem. 10:255–263. 2006.(In Korean).

21 

Mantovani MS, Bellini MF, Angeli JP, Oliveira RJ, Silva AF and Ribeiro LR: beta-Glucans in promoting health: prevention against mutation and cancer. Mutat Res. 658:154–161. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, Deponti WK, Kalbfleisch JH, et al: Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther. 314:1079–1086. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Hong F, Yan J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung NK and Ross GD: Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol. 173:797–806. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Neumann-Haefelin T, Wiessner C, Vogel P, Back T and Hossmann KA: Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia. J Cereb Blood Flow Metab. 14:206–216. 1994. View Article : Google Scholar

25 

Hiroi N, Brown JR, Haile CN, Ye H, Greenberg ME and Nestler EJ: FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects. Proc Natl Acad Sci USA. 94:10397–10402. 1997.PubMed/NCBI

26 

Dragunow M and Faull R: The use of c-Fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods. 29:261–265. 1989. View Article : Google Scholar : PubMed/NCBI

27 

Ko IG, Kim SE, Kim CJ, Jung JH, Lee SJ, Kim DH, Lee KY and Kim KH: Effect of treadmill exercise on leak-point pressure and neuronal activation in brain of rats with stress urinary incontinence. Int Neurourol J. 14:141–148. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Hoene M, Franken H, Fritsche L, Lehmann R, Pohl AK, Häring HU, Zell A, Schleicher ED and Weigert C: Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in the liver of mice is related to plasma glucose levels after acute exercise. Diabetologia. 53:1131–1141. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Han SB, Lee CW, Jeon YJ, Hong ND, Yoo ID, Yang KH and Kim HM: The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis. Immunopharmacology. 41:157–164. 1999. View Article : Google Scholar

30 

Song YS, Kim SH, Sa JH, Jin C, Lim CJ and Park EH: Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus. J Ethnopharmacol. 88:113–116. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Kim SH, Song YS, Kim SK, Kim BC, Lim CJ and Park EH: Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus. J Ethnopharmacol. 93:141–146. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Zaidman BZ, Yassin M, Mahajna J and Wasser SP: Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol. 67:453–468. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Majtan J: Pleuran (β-glucan from Pleurotus ostreatus): an effective nutritional supplement against upper respiratory tract infections? Med Sport Sci. 59:57–61. 2012.

34 

Carpenter KC, Breslin WL, Davidson T, Adams A and McFarlin BK: Baker’s yeast β-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk? Br J Nutr. 109:478–486. 2013.

35 

Xu C, Lv J, Lo YM, Cui SW, Hu X and Fan M: Effects of oat β-glucan on endurance exercise and its anti-fatigue properties in trained rats. Carbohydr Polym. 92:1159–1165. 2013.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hong H, Kim CJ, Kim JD and Seo JH: β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats. Mol Med Rep 9: 1660-1666, 2014.
APA
Hong, H., Kim, C., Kim, J., & Seo, J. (2014). β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats. Molecular Medicine Reports, 9, 1660-1666. https://doi.org/10.3892/mmr.2014.2005
MLA
Hong, H., Kim, C., Kim, J., Seo, J."β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats". Molecular Medicine Reports 9.5 (2014): 1660-1666.
Chicago
Hong, H., Kim, C., Kim, J., Seo, J."β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats". Molecular Medicine Reports 9, no. 5 (2014): 1660-1666. https://doi.org/10.3892/mmr.2014.2005
Copy and paste a formatted citation
x
Spandidos Publications style
Hong H, Kim CJ, Kim JD and Seo JH: β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats. Mol Med Rep 9: 1660-1666, 2014.
APA
Hong, H., Kim, C., Kim, J., & Seo, J. (2014). β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats. Molecular Medicine Reports, 9, 1660-1666. https://doi.org/10.3892/mmr.2014.2005
MLA
Hong, H., Kim, C., Kim, J., Seo, J."β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats". Molecular Medicine Reports 9.5 (2014): 1660-1666.
Chicago
Hong, H., Kim, C., Kim, J., Seo, J."β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats". Molecular Medicine Reports 9, no. 5 (2014): 1660-1666. https://doi.org/10.3892/mmr.2014.2005
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team