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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2014 Volume 9 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

Hiroshi Kobayashi, Shogo Imanaka, Haruki Nakamura, Ayumi Tsuji
Pages: 1483-1505
Published online on: 14 March 2014

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Review

Direct thrombin inhibitors: Patents 2002-2012 (Review)

Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng, Ji-Fu Wei
Pages: 1506-1514
Published online on: 06 March 2014

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Review Open Access

Limb-girdle muscular dystrophies: Where next after six decades from the first proposal (Review)

Omar A. Mahmood, Xin Mei Jiang
Pages: 1515-1532
Published online on: 13 March 2014

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Review

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer's disease (Review)

Zhiyou Cai
Pages: 1533-1541
Published online on: 11 March 2014

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Article

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury

Ye Cai, Hui Xu, Jia Yan, Lei Zhang, Yi Lu
Pages: 1542-1550
Published online on: 10 March 2014

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Article Open Access

A pivotal role of the vascular endothelial growth factor signaling pathway in the formation of venous hypertension-induced dural arteriovenous fistulas

Qiang Li, Qi Zhang, Qing-Hai Huang, Yi-Bin Fang, Zhao-Long Zhang, Yi Xu, Jian-Min Liu
Pages: 1551-1558
Published online on: 11 March 2014

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Article Open Access

Prognostic performance of a series of model for end‑stage liver disease and respective Δ scores in patients with hepatitis B acute-on-chronic liver failure

Yun-Hao Xun, Jun-Ping Shi, Chun-Qing Li, Dan Li, Wei-Zhen Shi, Qing-Chun Pan, Jian-Chun Guo, Guo-Qing Zang
Pages: 1559-1568
Published online on: 25 February 2014

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Article Open Access

Anti-inflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells

Han-Seok Choi, Hye Sook Seo, Soon Re Kim, Youn Kyung Choi, Yong-Cheol Shin, Seong-Gyu Ko
Pages: 1569-1574
Published online on: 10 March 2014

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Article Open Access

The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis

Jian Gong, Hong-Bo Meng, Jie Hua, Zhen-Shun Song, Zhi‑Gang He, Bo Zhou, Ming-Ping Qian
Pages: 1575-1582
Published online on: 14 March 2014

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Article

Mesenchymal stem cell-based developmental endothelial locus-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice

Yun-Feng Zhao, Wei Xiong, Xue-Ling Wu
Pages: 1583-1589
Published online on: 26 February 2014

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Article

Apelin-13 stimulates angiogenesis by promoting cross‑talk between AMP-activated protein kinase and Akt signaling in myocardial microvascular endothelial cells

Xiaoman Yang, Wei Zhu, Pu Zhang, Kankai Chen, Lijie Zhao, Jingbo Li, Meng Wei, Mingya Liu
Pages: 1590-1596
Published online on: 25 February 2014

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Article Open Access

Pilot genome-wide study of tandem 3' UTRs in esophageal cancer using high-throughput sequencing

Mingzhong Sun, Huixiang Ju, Zhongwei Zhou, Rong Zhu
Pages: 1597-1605
Published online on: 04 March 2014

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Article

c-Jun transactivates Puma gene expression to promote osteoarthritis

Huading Lu, Gang Hou, Yongkai Zhang, Yuhu Dai, Huiqing Zhao
Pages: 1606-1612
Published online on: 24 February 2014

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Article Open Access

KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells

Feng Lin, Zan Shen, Li‑Na Tang, Shui‑Er Zheng, Yuan‑Jue Sun, Da‑Liu Min, Yang Yao
Pages: 1613-1617
Published online on: 07 March 2014

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Article Open Access

Phosphodiesterase 3A rs7134375 single nucleotide polymorphism and serum lipid levels

Wei Wang, Rui‑Xing Yin, Dong‑Feng Wu, Lynn Htet Htet Aung, Ping Huang, Xiao‑Na Zeng, Ke‑Ke Huang, Quan‑Zhen Lin, Jian Wu, Tao Guo
Pages: 1618-1628
Published online on: 04 March 2014

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Article

Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC‑3 knockout mice

J. Jin, Y. Wang, J. Wang, Y. Xu, S. L. Chen, J. P. Wang, Y. P. Su
Pages: 1629-1633
Published online on: 12 March 2014

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Article Open Access

Retinol binding protein 4 promotes hyperinsulinism‑induced proliferation of rat aortic smooth muscle cells

Fei Li, Ke Xia, Md Sayed Ali Sheikh, Jinfang Cheng, Chuanchang Li, Tianlun Yang
Pages: 1634-1640
Published online on: 07 March 2014

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Article Open Access

F‑actin cytoskeleton reorganization is associated with hepatic stellate cell activation

Xiaodong Cui, Xiaoyun Zhang, Qingling Yin, Aixia Meng, Shaojuan Su, Xu Jing, Hong Li, Xiumei Guan, Xin Li, Shunmei Liu, Min Cheng
Pages: 1641-1647
Published online on: 11 March 2014

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Article Open Access

Werner syndrome protein positively regulates XRCC4-like factor transcription

Dongyun Liu, Xiaoli Deng, Chongzhen Yuan, Lin Chen, Yusheng Cong, Xingzhi Xu
Pages: 1648-1652
Published online on: 10 March 2014

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Article

Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway

Wei-An Chang, En-Shyh Lin, Ming-Ju Tsai, Ming-Shyan Huang, Po-Lin Kuo
Pages: 1653-1659
Published online on: 06 March 2014

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Article

β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats

Heeok Hong, Chang‑Ju Kim, Jae‑Deung Kim, Jin‑Hee Seo
Pages: 1660-1666
Published online on: 04 March 2014

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Article

CD44 affects the expression level of FOS‑like antigen 1 in cervical cancer tissues

Songshu Xiao, Yanhong Zhou, Jianfa Jiang, Le Yuan, Min Xue
Pages: 1667-1674
Published online on: 06 March 2014

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Article

Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells

Li Luo, Lanhai Lü, Yinghong Lu, Lihong Zhang, Bofei Li, Kaihua Guo, Lizhi Chen, Yang Wang, Yijia Shao, Jie Xu
Pages: 1675-1680
Published online on: 06 March 2014

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Article

Allelic methylation status of CpG islands on chromosome 21q in patients with Trisomy 21

Yin‑Yin Xia, Yu‑Bing Ding, Xue‑Qing Liu, Xue‑Mei Chen, Shu‑Qun Cheng, Lian‑Bing Li, Ming‑Fu Ma, Jun‑Lin He, Ying‑Xiong Wang
Pages: 1681-1688
Published online on: 25 February 2014

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Article

Correlation between the overexpression of urokinase receptor isoform uPAR (D1D2) and hepatic cell malignant transformation

Yingqun Zhou, Xiaoping Lǚ, Shan Li, Lingling Zhan
Pages: 1689-1696
Published online on: 04 March 2014

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Article

Colon cancer cells treated with 5‑fluorouracil exhibit changes in polylactosamine‑type N‑glycans

Liping Gao, Li Shen, Meiyun Yu, Jianlong Ni, Xiaoxia Dong, Yinghui Zhou, Shiliang Wu
Pages: 1697-1702
Published online on: 05 March 2014

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Article

microRNA‑206 overexpression inhibits cellular proliferation and invasion of estrogen receptor α‑positive ovarian cancer cells Retraction in /10.3892/mmr.2021.12279

Shaoru Li, Yan Li, Zhengfang Wen, Fanjing Kong, Xinlei Guan, Wenhui Liu
Pages: 1703-1708
Published online on: 06 March 2014

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Article

Protective effects of daphnetin on sodium taurocholate‑induced severe acute pancreatitis in rats

Zhi-Yong Liu, Jiao Liu, Kai-Liang Zhao, Li-Kun Wang, Qiao Shi, Teng Zuo, Tian-Yi Liu, Liang Zhao, Wei-Xing Wang
Pages: 1709-1714
Published online on: 28 February 2014

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Article

Changes in the gene expression levels of microRNAs in the rat hippocampus by sevoflurane and propofol anesthesia

Gentaro Goto, Yoko Hori, Masashi Ishikawa, Shunsuke Tanaka, Atsuhiro Sakamoto
Pages: 1715-1722
Published online on: 11 March 2014

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Article

Caveolin 1 knockdown inhibits the proliferation, migration and invasion of human breast cancer BT474 cells

Rui Wang, Zhi Li, Hui Guo, Wei Shi, Yue Xin, Weilong Chang, Tao Huang
Pages: 1723-1728
Published online on: 06 March 2014

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Article

Prostaglandin E2 upregulates β1 integrin expression via the E prostanoid 1 receptor/nuclear factor κ‑light‑chain‑enhancer of activated B cells pathway in non‑small‑cell lung cancer cells

Xiaoming Bai, Qinyi Yang, Wei Shu, Jie Wang, Li Zhang, Juan Ma, Shukai Xia, Min Zhang, Shanyu Cheng, Yipin Wang, Jing Leng
Pages: 1729-1736
Published online on: 28 February 2014

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Article

Retinitis pigmentosa‑associated rhodopsin mutant T17M induces endoplasmic reticulum (ER) stress and sensitizes cells to ER stress-induced cell death

Haibo Jiang, Siqi Xiong, Xiaobo Xia
Pages: 1737-1742
Published online on: 26 February 2014

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Article

Role of Nogo‑A in the regulation of hepatocellular carcinoma SMMC‑7721 cell apoptosis

Chun‑Qiu Hao, Yun Zhou, Jiu‑Ping Wang, Mei‑Jun Peng, Yu‑Mei Xie, Wen‑Zhen Kang, Li Sun, Ping‑Zhong Wang, Chun‑Ling Wan, Lin He, Lei Cai, Zhang‑Sheng Jia
Pages: 1743-1748
Published online on: 13 March 2014

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Article

Analysis of blood flow and local expression of angiogenesis‑associated growth factors in infected wounds treated with negative pressure wound therapy

Cheng‑Yan Xia, Ai‑Xi Yu, Baiwen Qi, Min Zhou, Zong‑Huan Li, Wei‑Yang Wang
Pages: 1749-1754
Published online on: 28 February 2014

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Article

Role of peroxisome proliferator‑activated receptor α in atherosclerosis

Heng Cao, Gao Wen, Hongli Li
Pages: 1755-1760
Published online on: 06 March 2014

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Article

Silencing ephrinB3 improves functional recovery following spinal cord injury

Yang Qu, Jianwu Zhao, Yang Wang, Zhongli Gao
Pages: 1761-1766
Published online on: 06 March 2014

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Article

Effects of canine myoblasts expressing human cartilage‑derived morphogenetic protein‑2 on the repair of meniscal fibrocartilage injury

Wen‑Hui Zhu, Yu‑Bin Wang, Liang Wang, Gu‑Feng Qiu, Liang‑Yu Lu
Pages: 1767-1772
Published online on: 13 March 2014

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Article

Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c‑Raf/MEK/ERK signaling pathway

Xiaoke Zheng, Yanqiu Ou, Minfeng Shu, Youqiong Wang, Yuxi  Zhou, Xingwen Su, Wenbo Zhu, Wei Yin, Shifeng Li, Pengxin  Qiu, Guangmei Yan, Jingxia Zhang, Jun Hu, Dong Xu
Pages: 1773-1779
Published online on: 14 March 2014

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Article

Translocation of protein kinase C δ contributes to the moderately high glucose‑, but not hypoxia‑induced proliferation in primary cultured human retinal endothelial cells

Zhao‑Chun Liu, En‑Hong Yu, Wei Liu, Xiao‑Chang Liu, Shi‑Bo Tang, Bang‑Hao Zhu
Pages: 1780-1786
Published online on: 13 March 2014

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Article

Targeting A549 lung adenocarcinoma cell growth and invasion with protease‑activated receptor‑1 siRNA

Zhuo Wu, Yanyan Zeng, Mingkang Zhong, Bin Wang
Pages: 1787-1793
Published online on: 06 March 2014

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Article

Transforming growth factor‑β1 in the microenvironment of ischemia reperfusion‑injured kidney enhances the chemotaxis of mesenchymal stem cells to stromal cell‑derived factor‑1 through upregulation of surface chemokine (C‑X‑C motif) receptor 4

Xiao‑Yun Si, Jing‑Jing Li, Tao Yao, Xiao‑Yan Wu
Pages: 1794-1798
Published online on: 26 February 2014

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Article

Mutation of isocitrate dehydrogenase 1 induces glioma cell proliferation via nuclear factor‑κB activation in a hypoxia‑inducible factor 1‑α dependent manner

GuoLiang Wang, Ke Sai, FangHe Gong, QunYing Yang, FuRong Chen, Jian Lin
Pages: 1799-1805
Published online on: 14 March 2014

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Article

Spatial expression of claudin family members in various organs of mice

Inho Hwang, Hyun Yang, Hong‑Seok Kang, Chang‑Hwan Ahn, Geun‑Shik Lee, Eui‑Ju Hong, Beum‑Soo An, Eui‑Bae Jeung
Pages: 1806-1812
Published online on: 10 March 2014

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Article

Inhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicity

Kun-Peng Wang, Yu Bai, Jian Wang, Jin-Zhen Zhang
Pages: 1813-1819
Published online on: 04 March 2014

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Article

MicroRNA‑125b suppresses the proliferation and osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells

Shi Chen, Liu Yang, Qiang Jie, Yan‑Shui Lin, Guo‑Lin Meng, Jin‑Zhu Fan, Jin‑Kang Zhang, Jing Fan, Zhuo‑Jing Luo, Jian Liu
Pages: 1820-1826
Published online on: 06 March 2014

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Article

Berberine ameliorates severe acute pancreatitis‑induced intestinal barrier dysfunction via a myosin light chain phosphorylation‑dependent pathway

Hong‑Yin Liang, Tao Chen, Hong‑Tao Yan, Zhu Huang, Li‑Jun Tang
Pages: 1827-1833
Published online on: 28 February 2014

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Article

IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868

Honglei Yin, Peicheng Li, Fudong Hu, Yakun Wang, Xiaoyan Chai, Yan Zhang
Pages: 1834-1838
Published online on: 14 March 2014

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Article

Study of the effect of miR‑124 and the SOX9 target gene in Hirschsprung's disease

Jie Mi, Dong Chen, Mei Wu, Weilin Wang, Hong Gao
Pages: 1839-1843
Published online on: 06 March 2014

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Article

Standardization of the methylation‑specific PCR method for analyzing BRCA1 and ER methylation

Vo Thi Thuong Lan, Ngo Thi Ha, Nguyen Quynh Uyen, Nguyen Thi Duong, Nguyen Thi Thu Huong, Ta Bich Thuan, Pham Anh Thuy Duong, Ta Van To
Pages: 1844-1850
Published online on: 26 February 2014

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Article

Ac‑hE‑18A‑NH2, a novel dual‑domain apolipoprotein mimetic peptide, inhibits apoptosis in macrophages by promoting cholesterol efflux

Qiong Xie, Feng Li, Shui‑Ping Zhao
Pages: 1851-1856
Published online on: 14 March 2014

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Article

C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension

Adnan Rafiq, Khursheed Aslam, Rouf Malik, Dil Afroze
Pages: 1857-1862
Published online on: 26 February 2014

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Article

Isoproterenol‑mediated heme oxygenase‑1 induction inhibits high mobility group box 1 protein release and protects against rat myocardial ischemia/reperfusion injury in vivo

Jichun Wang, Xiaorong Hu, Wenwen Fu, Jing Xie, Xiaoya Zhou, Hong Jiang
Pages: 1863-1868
Published online on: 07 March 2014

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Article

Protective effects of the SEPS1 gene on lipopolysaccharide-induced sepsis

Lei He, Bin Wang, Yuan Yao, Maosheng Su, Huanxian Ma, Ning Jia
Pages: 1869-1876
Published online on: 26 February 2014

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Article

ROCK1, a novel target of miR-145, promotes glioma cell invasion

Xin Wan, Quan Cheng, Renjun Peng, Zhiming Ma, Zigui Chen, Yiqiang Cao, Bing Jiang
Pages: 1877-1882
Published online on: 25 February 2014

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Article

Berberine induces double-strand DNA breaks in Rev3 deficient cells

Xiaojuan Hu, Xiaohua Wu, Yunfei Huang, Qingyi Tong, Shunichi Takeda, Yong Qing
Pages: 1883-1888
Published online on: 28 February 2014

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Article

Effect of 20-hydroxyeicosatetraenoic acid on biological behavior of human villous trophoblasts and uterine vascular smooth muscle cells

Shuaijun Lu, Changling Zhu, Anxiong Long, Longyi Tan, Qian Li, Yuli Zhu
Pages: 1889-1894
Published online on: 06 March 2014

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Article

Co-stimulation with stem cell factor and erythropoietin enhances migration of c-Kit expressing cervical cancer cells through the sustained activation of ERK1/2

Cristina Aguilar, Cecilia Aguilar, Rebeca Lopez-Marure, Alejandro Jiménez-Sánchez, Leticia Rocha-Zavaleta
Pages: 1895-1902
Published online on: 12 March 2014

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Article

p53 N‑terminal binding and stabilisation by PIAS3 inhibits MDM2‑induced p53 ubiquitination and regulates cell growth

Ziyi Zhao, Lan Wu, Huimin Shi, Chuanfang Wu
Pages: 1903-1908
Published online on: 27 February 2014

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Article

microRNA‑125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis

Lili Zhou, Haitao Bai, Chun Wang, Daolin Wei, Youwen Qin, Xiaowei Xu
Pages: 1909-1916
Published online on: 06 March 2014

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Article

microRNA‑9 attenuates amyloidβ‑induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2

Fei Chang, Lin‑Hong Zhang, Wu‑Ping Xu, Ping Jing, Pei‑Yan Zhan
Pages: 1917-1922
Published online on: 06 March 2014

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Article

β1‑adrenergic regulation of rapid component of delayed rectifier K+ currents in guinea‑pig cardiac myocytes

Sen Wang, Di Xu, Ting‑Ting Wu, Yan Guo, Yan‑Hong Chen, Jian‑Gang Zou
Pages: 1923-1928
Published online on: 10 March 2014

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Article

Phosphorylated Signal Transducer and Activator of Transcription 1 is a potential predictor of interferon response in patients with advanced renal cell carcinoma

Wei Li, Qiang Wei, Jianbo Liang
Pages: 1929-1934
Published online on: 13 March 2014

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Article

ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer

Xiaohong Lv, Yang Li, Ming Qian, Chengyuan Ma, Hongyu  Jing, Zhongmei Wen, Donghua Qian
Pages: 1935-1940
Published online on: 07 March 2014

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Hesperetin attenuates mitochondria-dependent apoptosis in lipopolysaccharide-induced H9C2 cardiomyocytes

Zheng Yang, Yuan Liu, Wei Deng, Jia Dai, Fangfang Li, Yuan Yuan, Qingqing Wu, Heng Zhou, Zhouyan Bian, Qizhu Tang
Pages: 1941-1946
Published online on: 04 March 2014

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Salvia miltiorrhiza increases the expression of transcription factor Foxp3 in experimental murine colitis

Dekui Xu, Hongbo Yu, Qinggong Yu, Simeng Wu, Dongmei Liu, Yan Lin, Ying Zhang, Changqing Zheng
Pages: 1947-1951
Published online on: 25 February 2014

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Embryo selection strategy in sibling oocytes: A novel approach to measuring the likelihood of single‑embryo transfer using a mouse embryo transfer model

Feng-Qin Xu, Rong Liu, Ying Ma, Li Liu, Ju-Yan Liang, Yan Ma
Pages: 1952-1958
Published online on: 28 February 2014

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Long‑term treatment of spontaneously hypertensive rats with losartan and molecular basis of modulating Ito of ventricular myocytes

Hongming Zhang, Songlin Wu, Congxing Huang, Xiaoyan Li
Pages: 1959-1967
Published online on: 28 February 2014

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Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats

Hao Xu, Ming Chen, Qianru Xu, Zhenlong Wang, Zhidong Qiu
Pages: 1968-1974
Published online on: 06 March 2014

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Autophagy prevents doxorubicin‑induced apoptosis in osteosarcoma

Dongxu Zhao, Hongping Yuan, Fei Yi, Chunyang Meng, Qingsan Zhu
Pages: 1975-1981
Published online on: 14 March 2014

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FOXO3a-mediated suppression of the self-renewal capacity of sphere-forming cells derived from the ovarian cancer SKOV3 cell line by 7-difluoromethoxyl-5,4'-di-n-octyl genistein Corrigendum in /10.3892/mmr.2021.12449

Yingxia Ning, Chaoyuan Luo, Kaiqun Ren, Meifang Quan, Jianguo Cao
Pages: 1982-1988
Published online on: 06 March 2014

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Article

Magnetic resonance imaging‑directed biopsy improves the prediction of prostate cancer aggressiveness compared with a 12‑core transrectal ultrasound‑guided prostate biopsy

Jie Zhang, Jianjun Xiu, Yin Dong, Muwen Wang, Xue Han, Yejun Qin, Zhaoqin Huang, Shifeng Cai, Xianshun Yuan, Qingwei Liu
Pages: 1989-1997
Published online on: 28 February 2014

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Human heat shock protein 27 exacerbates ischemia reperfusion injury in rats by reducing the number of T regulatory cells

Sunyi Ye, Chenxi Zhang, Jie Zhou, Jun Cheng, Zhen Lv, Lin Zhou, Haiyang Xie, Jian Wu, Shusen Zheng
Pages: 1998-2002
Published online on: 10 March 2014

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Component analysis of Pu-erh and its anti-constipation effects

Guijie Li, Qiang Wang, Yu Qian, Yalin Zhou, Rui Wang, Xin Zhao
Pages: 2003-2009
Published online on: 05 March 2014

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Hepatitis C virus core protein induces hypoxia‑inducible factor 1α-mediated vascular endothelial growth factor expression in Huh7.5.1 cells

Chengliang Zhu, Xinghui Liu, Shiqun Wang, Xiaohong Yan, Zhaoming Tang, Kailang Wu, Yan Li, Fang Liu
Pages: 2010-2014
Published online on: 11 March 2014

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Decreased PPAR-γ expression in the conjunctiva and increased expression of TNF-α and IL-1β in the conjunctiva and tear fluid of dry eye mice

Yihui Chen, Xiaoyan Zhang, Ling Yang, Min Li, Bing Li, Weifang Wang, Minjie Sheng
Pages: 2015-2023
Published online on: 12 March 2014

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Telbivudine decreases proportion of peripheral blood CD4+CD25+CD127low T cells in parallel with inhibiting hepatitis B virus DNA

Zehui Yan, Jijun Zhou, Mengjun Zhang, Xiaolan Fu, Yuzhang Wu, Yuming Wang
Pages: 2024-2030
Published online on: 12 March 2014

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Article

Analysis of mutational characteristics of the drug‑resistant gene katG in multi-drug resistant Mycobacterium tuberculosis L‑form among patients with pneumoconiosis complicated with tuberculosis

Jun Lu, Shan Jiang, Qian‑Ying Liu, Shuai Ma, Ying Li, Chao‑Pin Li
Pages: 2031-2035
Published online on: 13 March 2014

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

ISX promotes tumor migration and invasion in lung cancer by upregulating COL1A1 in vitro

Yihe Ma, Ye Chen, Yuhui Liang, Yun Huang, Miao Gong, Lifeng Tian, Xiaojun Xiao, Jingyan Liu, Qinmiao Huang
Article Number: 77
Published online on: 31 December 2025

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Role and mechanism of miR‑222‑5p in endothelial cell apoptosis

Shimeng Wang, Boxin Zhao, Ying Cui, Lin Gui, Jingyao Fan, Lijuan Huang
Article Number: 76
Published online on: 31 December 2025

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Expression of Concern Open Access

[Expression of Concern] MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA

Shijuan Zhan, Chunfeng Wang, Fangqing Yin
Article Number: 75
Published online on: 22 December 2025

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Melatonin induces autophagy in neuroblastoma by alleviating Pak2‑mediated endoplasmic reticulum stress

Qian-Qi Qiu, Na Zhang, Ying-Yi Xu, Jing-Wen Qin, Gao-Feng Yu, Xing-Rong Song
Article Number: 74
Published online on: 22 December 2025

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ST3Gal1 modulates intestinal barrier function and impacts human ulcerative colitis

Yin Tian, Yun Liu, Yangyang Shang, Lijian Ran, Li Liu, Rongquan Wang, Jun Ye
Article Number: 73
Published online on: 18 December 2025

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Mechanistic study of miR‑369‑3p in regulating the Wnt/β‑catenin signaling pathway via targeting SPTBN1 in inflammatory response and bone destruction of rheumatoid arthritis

Aihong Wu, Yuan Wang, Feifei Liu, Zhoufang Cao, Shuhui Du, Mengyu Sun
Article Number: 72
Published online on: 18 December 2025

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CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation

Qingbo Shao, Ji Zhang, Huaying Wang
Article Number: 71
Published online on: 17 December 2025

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Expression of Concern Open Access

[Expression of Concern] Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

Feng He, Xiu-Mei Cheng, Wen-Long Gu
Article Number: 70
Published online on: 17 December 2025

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Aggravated effects of human parvovirus B19 NS1 protein on bleomycin‑induced pulmonary fibrosis

Tsai-Ching Hsu, Chih-Chen Tzang, Chia-Wei Kuo, Zhi-Han Wen, Der-Yuan Chen, Bor-Show Tzang
Article Number: 69
Published online on: 16 December 2025

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Review Open Access

Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions (Review)

Pai Zhang, Yabin Cui, Chunyan Liu, Chengji Cui, Shoulin Zhang, Yue Zhang, Fan Li
Article Number: 68
Published online on: 16 December 2025

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Retraction Open Access

[Retracted] N‑Myc downstream‑regulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis

Jie Huang, Zhou Wu, Guangxiu Wang, Yingxian Cai, Minshan Cai, Yaozhang Li
Article Number: 67
Published online on: 15 December 2025

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Review Open Access

Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review)

Ziling Qin, Ranran Chen, Dianrong Song
Article Number: 66
Published online on: 11 December 2025

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Review Open Access

Gut microbiota as a multifaceted modulator of prostate cancer: Mechanistic insights, therapeutic opportunities and clinical challenges (Review)

Zhenming Hao, Yongqiang Xie, Ru Zhang, Hui Sang, Luxi Li, Yulin Liu, Jinbo Hu, Jijun Wang, Keqiang Chai, Qiang Zhao
Article Number: 65
Published online on: 11 December 2025

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Expression of Concern Open Access

[Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis

Yi Han, Xiaoyan Wang, Enqiang Mao, Boyong Shen, Liang Huang
Article Number: 64
Published online on: 10 December 2025

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Influence and treatment of insulin receptor substrate/PI3K/Akt‑mediated insulin resistance in diabetes mellitus (Review)

Weikang Tang, Huixia Liu, Xuan Li, Siyao Deng, Changyu Gao
Article Number: 63
Published online on: 09 December 2025

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Retraction Open Access

[Retracted] Long non‑coding RNA ANRIL knockdown suppresses apoptosis and pro‑inflammatory cytokines while enhancing neurite outgrowth via binding microRNA‑125a in a cellular model of Alzheimer’s disease

Bingling Zhou, Lijuan Li, Xin Qiu, Jiashun Wu, Lei Xu, Wei Shao
Article Number: 62
Published online on: 08 December 2025

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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Article Open Access

ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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Article

MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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Correction Open Access

[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Article Open Access

Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Article Open Access

Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Review Open Access

Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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Article Open Access

lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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Journal Cover
March-2026 Volume 33 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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