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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2014 Volume 9 Issue 5

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

Hiroshi Kobayashi, Shogo Imanaka, Haruki Nakamura, Ayumi Tsuji
Pages: 1483-1505
Published online on: 14 March 2014

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Review

Direct thrombin inhibitors: Patents 2002-2012 (Review)

Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng, Ji-Fu Wei
Pages: 1506-1514
Published online on: 06 March 2014

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Review Open Access

Limb-girdle muscular dystrophies: Where next after six decades from the first proposal (Review)

Omar A. Mahmood, Xin Mei Jiang
Pages: 1515-1532
Published online on: 13 March 2014

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Review

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer's disease (Review)

Zhiyou Cai
Pages: 1533-1541
Published online on: 11 March 2014

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Article

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury

Ye Cai, Hui Xu, Jia Yan, Lei Zhang, Yi Lu
Pages: 1542-1550
Published online on: 10 March 2014

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Article Open Access

A pivotal role of the vascular endothelial growth factor signaling pathway in the formation of venous hypertension-induced dural arteriovenous fistulas

Qiang Li, Qi Zhang, Qing-Hai Huang, Yi-Bin Fang, Zhao-Long Zhang, Yi Xu, Jian-Min Liu
Pages: 1551-1558
Published online on: 11 March 2014

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Article Open Access

Prognostic performance of a series of model for end‑stage liver disease and respective Δ scores in patients with hepatitis B acute-on-chronic liver failure

Yun-Hao Xun, Jun-Ping Shi, Chun-Qing Li, Dan Li, Wei-Zhen Shi, Qing-Chun Pan, Jian-Chun Guo, Guo-Qing Zang
Pages: 1559-1568
Published online on: 25 February 2014

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Article Open Access

Anti-inflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells

Han-Seok Choi, Hye Sook Seo, Soon Re Kim, Youn Kyung Choi, Yong-Cheol Shin, Seong-Gyu Ko
Pages: 1569-1574
Published online on: 10 March 2014

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Article Open Access

The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis

Jian Gong, Hong-Bo Meng, Jie Hua, Zhen-Shun Song, Zhi‑Gang He, Bo Zhou, Ming-Ping Qian
Pages: 1575-1582
Published online on: 14 March 2014

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Article

Mesenchymal stem cell-based developmental endothelial locus-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice

Yun-Feng Zhao, Wei Xiong, Xue-Ling Wu
Pages: 1583-1589
Published online on: 26 February 2014

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Article

Apelin-13 stimulates angiogenesis by promoting cross‑talk between AMP-activated protein kinase and Akt signaling in myocardial microvascular endothelial cells

Xiaoman Yang, Wei Zhu, Pu Zhang, Kankai Chen, Lijie Zhao, Jingbo Li, Meng Wei, Mingya Liu
Pages: 1590-1596
Published online on: 25 February 2014

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Article Open Access

Pilot genome-wide study of tandem 3' UTRs in esophageal cancer using high-throughput sequencing

Mingzhong Sun, Huixiang Ju, Zhongwei Zhou, Rong Zhu
Pages: 1597-1605
Published online on: 04 March 2014

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Article

c-Jun transactivates Puma gene expression to promote osteoarthritis

Huading Lu, Gang Hou, Yongkai Zhang, Yuhu Dai, Huiqing Zhao
Pages: 1606-1612
Published online on: 24 February 2014

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Article Open Access

KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells

Feng Lin, Zan Shen, Li‑Na Tang, Shui‑Er Zheng, Yuan‑Jue Sun, Da‑Liu Min, Yang Yao
Pages: 1613-1617
Published online on: 07 March 2014

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Article Open Access

Phosphodiesterase 3A rs7134375 single nucleotide polymorphism and serum lipid levels

Wei Wang, Rui‑Xing Yin, Dong‑Feng Wu, Lynn Htet Htet Aung, Ping Huang, Xiao‑Na Zeng, Ke‑Ke Huang, Quan‑Zhen Lin, Jian Wu, Tao Guo
Pages: 1618-1628
Published online on: 04 March 2014

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Article

Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC‑3 knockout mice

J. Jin, Y. Wang, J. Wang, Y. Xu, S. L. Chen, J. P. Wang, Y. P. Su
Pages: 1629-1633
Published online on: 12 March 2014

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Article Open Access

Retinol binding protein 4 promotes hyperinsulinism‑induced proliferation of rat aortic smooth muscle cells

Fei Li, Ke Xia, Md Sayed Ali Sheikh, Jinfang Cheng, Chuanchang Li, Tianlun Yang
Pages: 1634-1640
Published online on: 07 March 2014

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Article Open Access

F‑actin cytoskeleton reorganization is associated with hepatic stellate cell activation

Xiaodong Cui, Xiaoyun Zhang, Qingling Yin, Aixia Meng, Shaojuan Su, Xu Jing, Hong Li, Xiumei Guan, Xin Li, Shunmei Liu, Min Cheng
Pages: 1641-1647
Published online on: 11 March 2014

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Article Open Access

Werner syndrome protein positively regulates XRCC4-like factor transcription

Dongyun Liu, Xiaoli Deng, Chongzhen Yuan, Lin Chen, Yusheng Cong, Xingzhi Xu
Pages: 1648-1652
Published online on: 10 March 2014

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Article

Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway

Wei-An Chang, En-Shyh Lin, Ming-Ju Tsai, Ming-Shyan Huang, Po-Lin Kuo
Pages: 1653-1659
Published online on: 06 March 2014

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Article

β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats

Heeok Hong, Chang‑Ju Kim, Jae‑Deung Kim, Jin‑Hee Seo
Pages: 1660-1666
Published online on: 04 March 2014

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Article

CD44 affects the expression level of FOS‑like antigen 1 in cervical cancer tissues

Songshu Xiao, Yanhong Zhou, Jianfa Jiang, Le Yuan, Min Xue
Pages: 1667-1674
Published online on: 06 March 2014

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Article

Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells

Li Luo, Lanhai Lü, Yinghong Lu, Lihong Zhang, Bofei Li, Kaihua Guo, Lizhi Chen, Yang Wang, Yijia Shao, Jie Xu
Pages: 1675-1680
Published online on: 06 March 2014

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Article

Allelic methylation status of CpG islands on chromosome 21q in patients with Trisomy 21

Yin‑Yin Xia, Yu‑Bing Ding, Xue‑Qing Liu, Xue‑Mei Chen, Shu‑Qun Cheng, Lian‑Bing Li, Ming‑Fu Ma, Jun‑Lin He, Ying‑Xiong Wang
Pages: 1681-1688
Published online on: 25 February 2014

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Article

Correlation between the overexpression of urokinase receptor isoform uPAR (D1D2) and hepatic cell malignant transformation

Yingqun Zhou, Xiaoping Lǚ, Shan Li, Lingling Zhan
Pages: 1689-1696
Published online on: 04 March 2014

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Article

Colon cancer cells treated with 5‑fluorouracil exhibit changes in polylactosamine‑type N‑glycans

Liping Gao, Li Shen, Meiyun Yu, Jianlong Ni, Xiaoxia Dong, Yinghui Zhou, Shiliang Wu
Pages: 1697-1702
Published online on: 05 March 2014

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Article

microRNA‑206 overexpression inhibits cellular proliferation and invasion of estrogen receptor α‑positive ovarian cancer cells Retraction in /10.3892/mmr.2021.12279

Shaoru Li, Yan Li, Zhengfang Wen, Fanjing Kong, Xinlei Guan, Wenhui Liu
Pages: 1703-1708
Published online on: 06 March 2014

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Article

Protective effects of daphnetin on sodium taurocholate‑induced severe acute pancreatitis in rats

Zhi-Yong Liu, Jiao Liu, Kai-Liang Zhao, Li-Kun Wang, Qiao Shi, Teng Zuo, Tian-Yi Liu, Liang Zhao, Wei-Xing Wang
Pages: 1709-1714
Published online on: 28 February 2014

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Article

Changes in the gene expression levels of microRNAs in the rat hippocampus by sevoflurane and propofol anesthesia

Gentaro Goto, Yoko Hori, Masashi Ishikawa, Shunsuke Tanaka, Atsuhiro Sakamoto
Pages: 1715-1722
Published online on: 11 March 2014

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Article

Caveolin 1 knockdown inhibits the proliferation, migration and invasion of human breast cancer BT474 cells

Rui Wang, Zhi Li, Hui Guo, Wei Shi, Yue Xin, Weilong Chang, Tao Huang
Pages: 1723-1728
Published online on: 06 March 2014

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Article

Prostaglandin E2 upregulates β1 integrin expression via the E prostanoid 1 receptor/nuclear factor κ‑light‑chain‑enhancer of activated B cells pathway in non‑small‑cell lung cancer cells

Xiaoming Bai, Qinyi Yang, Wei Shu, Jie Wang, Li Zhang, Juan Ma, Shukai Xia, Min Zhang, Shanyu Cheng, Yipin Wang, Jing Leng
Pages: 1729-1736
Published online on: 28 February 2014

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Article

Retinitis pigmentosa‑associated rhodopsin mutant T17M induces endoplasmic reticulum (ER) stress and sensitizes cells to ER stress-induced cell death

Haibo Jiang, Siqi Xiong, Xiaobo Xia
Pages: 1737-1742
Published online on: 26 February 2014

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Article

Role of Nogo‑A in the regulation of hepatocellular carcinoma SMMC‑7721 cell apoptosis

Chun‑Qiu Hao, Yun Zhou, Jiu‑Ping Wang, Mei‑Jun Peng, Yu‑Mei Xie, Wen‑Zhen Kang, Li Sun, Ping‑Zhong Wang, Chun‑Ling Wan, Lin He, Lei Cai, Zhang‑Sheng Jia
Pages: 1743-1748
Published online on: 13 March 2014

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Article

Analysis of blood flow and local expression of angiogenesis‑associated growth factors in infected wounds treated with negative pressure wound therapy

Cheng‑Yan Xia, Ai‑Xi Yu, Baiwen Qi, Min Zhou, Zong‑Huan Li, Wei‑Yang Wang
Pages: 1749-1754
Published online on: 28 February 2014

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Article

Role of peroxisome proliferator‑activated receptor α in atherosclerosis

Heng Cao, Gao Wen, Hongli Li
Pages: 1755-1760
Published online on: 06 March 2014

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Article

Silencing ephrinB3 improves functional recovery following spinal cord injury

Yang Qu, Jianwu Zhao, Yang Wang, Zhongli Gao
Pages: 1761-1766
Published online on: 06 March 2014

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Article

Effects of canine myoblasts expressing human cartilage‑derived morphogenetic protein‑2 on the repair of meniscal fibrocartilage injury

Wen‑Hui Zhu, Yu‑Bin Wang, Liang Wang, Gu‑Feng Qiu, Liang‑Yu Lu
Pages: 1767-1772
Published online on: 13 March 2014

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Article

Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c‑Raf/MEK/ERK signaling pathway

Xiaoke Zheng, Yanqiu Ou, Minfeng Shu, Youqiong Wang, Yuxi  Zhou, Xingwen Su, Wenbo Zhu, Wei Yin, Shifeng Li, Pengxin  Qiu, Guangmei Yan, Jingxia Zhang, Jun Hu, Dong Xu
Pages: 1773-1779
Published online on: 14 March 2014

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Article

Translocation of protein kinase C δ contributes to the moderately high glucose‑, but not hypoxia‑induced proliferation in primary cultured human retinal endothelial cells

Zhao‑Chun Liu, En‑Hong Yu, Wei Liu, Xiao‑Chang Liu, Shi‑Bo Tang, Bang‑Hao Zhu
Pages: 1780-1786
Published online on: 13 March 2014

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Article

Targeting A549 lung adenocarcinoma cell growth and invasion with protease‑activated receptor‑1 siRNA

Zhuo Wu, Yanyan Zeng, Mingkang Zhong, Bin Wang
Pages: 1787-1793
Published online on: 06 March 2014

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Article

Transforming growth factor‑β1 in the microenvironment of ischemia reperfusion‑injured kidney enhances the chemotaxis of mesenchymal stem cells to stromal cell‑derived factor‑1 through upregulation of surface chemokine (C‑X‑C motif) receptor 4

Xiao‑Yun Si, Jing‑Jing Li, Tao Yao, Xiao‑Yan Wu
Pages: 1794-1798
Published online on: 26 February 2014

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Article

Mutation of isocitrate dehydrogenase 1 induces glioma cell proliferation via nuclear factor‑κB activation in a hypoxia‑inducible factor 1‑α dependent manner

GuoLiang Wang, Ke Sai, FangHe Gong, QunYing Yang, FuRong Chen, Jian Lin
Pages: 1799-1805
Published online on: 14 March 2014

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Article

Spatial expression of claudin family members in various organs of mice

Inho Hwang, Hyun Yang, Hong‑Seok Kang, Chang‑Hwan Ahn, Geun‑Shik Lee, Eui‑Ju Hong, Beum‑Soo An, Eui‑Bae Jeung
Pages: 1806-1812
Published online on: 10 March 2014

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Article

Inhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicity

Kun-Peng Wang, Yu Bai, Jian Wang, Jin-Zhen Zhang
Pages: 1813-1819
Published online on: 04 March 2014

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Article

MicroRNA‑125b suppresses the proliferation and osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells

Shi Chen, Liu Yang, Qiang Jie, Yan‑Shui Lin, Guo‑Lin Meng, Jin‑Zhu Fan, Jin‑Kang Zhang, Jing Fan, Zhuo‑Jing Luo, Jian Liu
Pages: 1820-1826
Published online on: 06 March 2014

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Article

Berberine ameliorates severe acute pancreatitis‑induced intestinal barrier dysfunction via a myosin light chain phosphorylation‑dependent pathway

Hong‑Yin Liang, Tao Chen, Hong‑Tao Yan, Zhu Huang, Li‑Jun Tang
Pages: 1827-1833
Published online on: 28 February 2014

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Article

IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868

Honglei Yin, Peicheng Li, Fudong Hu, Yakun Wang, Xiaoyan Chai, Yan Zhang
Pages: 1834-1838
Published online on: 14 March 2014

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Article

Study of the effect of miR‑124 and the SOX9 target gene in Hirschsprung's disease

Jie Mi, Dong Chen, Mei Wu, Weilin Wang, Hong Gao
Pages: 1839-1843
Published online on: 06 March 2014

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Article

Standardization of the methylation‑specific PCR method for analyzing BRCA1 and ER methylation

Vo Thi Thuong Lan, Ngo Thi Ha, Nguyen Quynh Uyen, Nguyen Thi Duong, Nguyen Thi Thu Huong, Ta Bich Thuan, Pham Anh Thuy Duong, Ta Van To
Pages: 1844-1850
Published online on: 26 February 2014

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Article

Ac‑hE‑18A‑NH2, a novel dual‑domain apolipoprotein mimetic peptide, inhibits apoptosis in macrophages by promoting cholesterol efflux

Qiong Xie, Feng Li, Shui‑Ping Zhao
Pages: 1851-1856
Published online on: 14 March 2014

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Article

C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension

Adnan Rafiq, Khursheed Aslam, Rouf Malik, Dil Afroze
Pages: 1857-1862
Published online on: 26 February 2014

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Article

Isoproterenol‑mediated heme oxygenase‑1 induction inhibits high mobility group box 1 protein release and protects against rat myocardial ischemia/reperfusion injury in vivo

Jichun Wang, Xiaorong Hu, Wenwen Fu, Jing Xie, Xiaoya Zhou, Hong Jiang
Pages: 1863-1868
Published online on: 07 March 2014

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Article

Protective effects of the SEPS1 gene on lipopolysaccharide-induced sepsis

Lei He, Bin Wang, Yuan Yao, Maosheng Su, Huanxian Ma, Ning Jia
Pages: 1869-1876
Published online on: 26 February 2014

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Article

ROCK1, a novel target of miR-145, promotes glioma cell invasion

Xin Wan, Quan Cheng, Renjun Peng, Zhiming Ma, Zigui Chen, Yiqiang Cao, Bing Jiang
Pages: 1877-1882
Published online on: 25 February 2014

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Article

Berberine induces double-strand DNA breaks in Rev3 deficient cells

Xiaojuan Hu, Xiaohua Wu, Yunfei Huang, Qingyi Tong, Shunichi Takeda, Yong Qing
Pages: 1883-1888
Published online on: 28 February 2014

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Article

Effect of 20-hydroxyeicosatetraenoic acid on biological behavior of human villous trophoblasts and uterine vascular smooth muscle cells

Shuaijun Lu, Changling Zhu, Anxiong Long, Longyi Tan, Qian Li, Yuli Zhu
Pages: 1889-1894
Published online on: 06 March 2014

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Article

Co-stimulation with stem cell factor and erythropoietin enhances migration of c-Kit expressing cervical cancer cells through the sustained activation of ERK1/2

Cristina Aguilar, Cecilia Aguilar, Rebeca Lopez-Marure, Alejandro Jiménez-Sánchez, Leticia Rocha-Zavaleta
Pages: 1895-1902
Published online on: 12 March 2014

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Article

p53 N‑terminal binding and stabilisation by PIAS3 inhibits MDM2‑induced p53 ubiquitination and regulates cell growth

Ziyi Zhao, Lan Wu, Huimin Shi, Chuanfang Wu
Pages: 1903-1908
Published online on: 27 February 2014

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Article

microRNA‑125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis

Lili Zhou, Haitao Bai, Chun Wang, Daolin Wei, Youwen Qin, Xiaowei Xu
Pages: 1909-1916
Published online on: 06 March 2014

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Article

microRNA‑9 attenuates amyloidβ‑induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2

Fei Chang, Lin‑Hong Zhang, Wu‑Ping Xu, Ping Jing, Pei‑Yan Zhan
Pages: 1917-1922
Published online on: 06 March 2014

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Article

β1‑adrenergic regulation of rapid component of delayed rectifier K+ currents in guinea‑pig cardiac myocytes

Sen Wang, Di Xu, Ting‑Ting Wu, Yan Guo, Yan‑Hong Chen, Jian‑Gang Zou
Pages: 1923-1928
Published online on: 10 March 2014

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Article

Phosphorylated Signal Transducer and Activator of Transcription 1 is a potential predictor of interferon response in patients with advanced renal cell carcinoma

Wei Li, Qiang Wei, Jianbo Liang
Pages: 1929-1934
Published online on: 13 March 2014

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Article

ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer

Xiaohong Lv, Yang Li, Ming Qian, Chengyuan Ma, Hongyu  Jing, Zhongmei Wen, Donghua Qian
Pages: 1935-1940
Published online on: 07 March 2014

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Hesperetin attenuates mitochondria-dependent apoptosis in lipopolysaccharide-induced H9C2 cardiomyocytes

Zheng Yang, Yuan Liu, Wei Deng, Jia Dai, Fangfang Li, Yuan Yuan, Qingqing Wu, Heng Zhou, Zhouyan Bian, Qizhu Tang
Pages: 1941-1946
Published online on: 04 March 2014

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Salvia miltiorrhiza increases the expression of transcription factor Foxp3 in experimental murine colitis

Dekui Xu, Hongbo Yu, Qinggong Yu, Simeng Wu, Dongmei Liu, Yan Lin, Ying Zhang, Changqing Zheng
Pages: 1947-1951
Published online on: 25 February 2014

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Embryo selection strategy in sibling oocytes: A novel approach to measuring the likelihood of single‑embryo transfer using a mouse embryo transfer model

Feng-Qin Xu, Rong Liu, Ying Ma, Li Liu, Ju-Yan Liang, Yan Ma
Pages: 1952-1958
Published online on: 28 February 2014

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Long‑term treatment of spontaneously hypertensive rats with losartan and molecular basis of modulating Ito of ventricular myocytes

Hongming Zhang, Songlin Wu, Congxing Huang, Xiaoyan Li
Pages: 1959-1967
Published online on: 28 February 2014

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Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats

Hao Xu, Ming Chen, Qianru Xu, Zhenlong Wang, Zhidong Qiu
Pages: 1968-1974
Published online on: 06 March 2014

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Autophagy prevents doxorubicin‑induced apoptosis in osteosarcoma

Dongxu Zhao, Hongping Yuan, Fei Yi, Chunyang Meng, Qingsan Zhu
Pages: 1975-1981
Published online on: 14 March 2014

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FOXO3a-mediated suppression of the self-renewal capacity of sphere-forming cells derived from the ovarian cancer SKOV3 cell line by 7-difluoromethoxyl-5,4'-di-n-octyl genistein Corrigendum in /10.3892/mmr.2021.12449

Yingxia Ning, Chaoyuan Luo, Kaiqun Ren, Meifang Quan, Jianguo Cao
Pages: 1982-1988
Published online on: 06 March 2014

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Magnetic resonance imaging‑directed biopsy improves the prediction of prostate cancer aggressiveness compared with a 12‑core transrectal ultrasound‑guided prostate biopsy

Jie Zhang, Jianjun Xiu, Yin Dong, Muwen Wang, Xue Han, Yejun Qin, Zhaoqin Huang, Shifeng Cai, Xianshun Yuan, Qingwei Liu
Pages: 1989-1997
Published online on: 28 February 2014

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Human heat shock protein 27 exacerbates ischemia reperfusion injury in rats by reducing the number of T regulatory cells

Sunyi Ye, Chenxi Zhang, Jie Zhou, Jun Cheng, Zhen Lv, Lin Zhou, Haiyang Xie, Jian Wu, Shusen Zheng
Pages: 1998-2002
Published online on: 10 March 2014

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Component analysis of Pu-erh and its anti-constipation effects

Guijie Li, Qiang Wang, Yu Qian, Yalin Zhou, Rui Wang, Xin Zhao
Pages: 2003-2009
Published online on: 05 March 2014

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Hepatitis C virus core protein induces hypoxia‑inducible factor 1α-mediated vascular endothelial growth factor expression in Huh7.5.1 cells

Chengliang Zhu, Xinghui Liu, Shiqun Wang, Xiaohong Yan, Zhaoming Tang, Kailang Wu, Yan Li, Fang Liu
Pages: 2010-2014
Published online on: 11 March 2014

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Decreased PPAR-γ expression in the conjunctiva and increased expression of TNF-α and IL-1β in the conjunctiva and tear fluid of dry eye mice

Yihui Chen, Xiaoyan Zhang, Ling Yang, Min Li, Bing Li, Weifang Wang, Minjie Sheng
Pages: 2015-2023
Published online on: 12 March 2014

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Telbivudine decreases proportion of peripheral blood CD4+CD25+CD127low T cells in parallel with inhibiting hepatitis B virus DNA

Zehui Yan, Jijun Zhou, Mengjun Zhang, Xiaolan Fu, Yuzhang Wu, Yuming Wang
Pages: 2024-2030
Published online on: 12 March 2014

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Analysis of mutational characteristics of the drug‑resistant gene katG in multi-drug resistant Mycobacterium tuberculosis L‑form among patients with pneumoconiosis complicated with tuberculosis

Jun Lu, Shan Jiang, Qian‑Ying Liu, Shuai Ma, Ying Li, Chao‑Pin Li
Pages: 2031-2035
Published online on: 13 March 2014

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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