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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
May-2014 Volume 9 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)

Hiroshi Kobayashi, Shogo Imanaka, Haruki Nakamura, Ayumi Tsuji
Pages: 1483-1505
Published online on: 14 March 2014

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Review

Direct thrombin inhibitors: Patents 2002-2012 (Review)

Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng, Ji-Fu Wei
Pages: 1506-1514
Published online on: 06 March 2014

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Review Open Access

Limb-girdle muscular dystrophies: Where next after six decades from the first proposal (Review)

Omar A. Mahmood, Xin Mei Jiang
Pages: 1515-1532
Published online on: 13 March 2014

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Review

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer's disease (Review)

Zhiyou Cai
Pages: 1533-1541
Published online on: 11 March 2014

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Article

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury

Ye Cai, Hui Xu, Jia Yan, Lei Zhang, Yi Lu
Pages: 1542-1550
Published online on: 10 March 2014

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Article Open Access

A pivotal role of the vascular endothelial growth factor signaling pathway in the formation of venous hypertension-induced dural arteriovenous fistulas

Qiang Li, Qi Zhang, Qing-Hai Huang, Yi-Bin Fang, Zhao-Long Zhang, Yi Xu, Jian-Min Liu
Pages: 1551-1558
Published online on: 11 March 2014

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Article Open Access

Prognostic performance of a series of model for end‑stage liver disease and respective Δ scores in patients with hepatitis B acute-on-chronic liver failure

Yun-Hao Xun, Jun-Ping Shi, Chun-Qing Li, Dan Li, Wei-Zhen Shi, Qing-Chun Pan, Jian-Chun Guo, Guo-Qing Zang
Pages: 1559-1568
Published online on: 25 February 2014

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Article Open Access

Anti-inflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells

Han-Seok Choi, Hye Sook Seo, Soon Re Kim, Youn Kyung Choi, Yong-Cheol Shin, Seong-Gyu Ko
Pages: 1569-1574
Published online on: 10 March 2014

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Article Open Access

The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis

Jian Gong, Hong-Bo Meng, Jie Hua, Zhen-Shun Song, Zhi‑Gang He, Bo Zhou, Ming-Ping Qian
Pages: 1575-1582
Published online on: 14 March 2014

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Article

Mesenchymal stem cell-based developmental endothelial locus-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice

Yun-Feng Zhao, Wei Xiong, Xue-Ling Wu
Pages: 1583-1589
Published online on: 26 February 2014

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Article

Apelin-13 stimulates angiogenesis by promoting cross‑talk between AMP-activated protein kinase and Akt signaling in myocardial microvascular endothelial cells

Xiaoman Yang, Wei Zhu, Pu Zhang, Kankai Chen, Lijie Zhao, Jingbo Li, Meng Wei, Mingya Liu
Pages: 1590-1596
Published online on: 25 February 2014

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Article Open Access

Pilot genome-wide study of tandem 3' UTRs in esophageal cancer using high-throughput sequencing

Mingzhong Sun, Huixiang Ju, Zhongwei Zhou, Rong Zhu
Pages: 1597-1605
Published online on: 04 March 2014

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Article

c-Jun transactivates Puma gene expression to promote osteoarthritis

Huading Lu, Gang Hou, Yongkai Zhang, Yuhu Dai, Huiqing Zhao
Pages: 1606-1612
Published online on: 24 February 2014

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Article Open Access

KLF8 knockdown suppresses proliferation and invasion in human osteosarcoma cells

Feng Lin, Zan Shen, Li‑Na Tang, Shui‑Er Zheng, Yuan‑Jue Sun, Da‑Liu Min, Yang Yao
Pages: 1613-1617
Published online on: 07 March 2014

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Article Open Access

Phosphodiesterase 3A rs7134375 single nucleotide polymorphism and serum lipid levels

Wei Wang, Rui‑Xing Yin, Dong‑Feng Wu, Lynn Htet Htet Aung, Ping Huang, Xiao‑Na Zeng, Ke‑Ke Huang, Quan‑Zhen Lin, Jian Wu, Tao Guo
Pages: 1618-1628
Published online on: 04 March 2014

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Article

Impaired hematopoiesis and delayed thrombopoietic recovery following sublethal irradiation in SRC‑3 knockout mice

J. Jin, Y. Wang, J. Wang, Y. Xu, S. L. Chen, J. P. Wang, Y. P. Su
Pages: 1629-1633
Published online on: 12 March 2014

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Article Open Access

Retinol binding protein 4 promotes hyperinsulinism‑induced proliferation of rat aortic smooth muscle cells

Fei Li, Ke Xia, Md Sayed Ali Sheikh, Jinfang Cheng, Chuanchang Li, Tianlun Yang
Pages: 1634-1640
Published online on: 07 March 2014

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Article Open Access

F‑actin cytoskeleton reorganization is associated with hepatic stellate cell activation

Xiaodong Cui, Xiaoyun Zhang, Qingling Yin, Aixia Meng, Shaojuan Su, Xu Jing, Hong Li, Xiumei Guan, Xin Li, Shunmei Liu, Min Cheng
Pages: 1641-1647
Published online on: 11 March 2014

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Article Open Access

Werner syndrome protein positively regulates XRCC4-like factor transcription

Dongyun Liu, Xiaoli Deng, Chongzhen Yuan, Lin Chen, Yusheng Cong, Xingzhi Xu
Pages: 1648-1652
Published online on: 10 March 2014

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Article

Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway

Wei-An Chang, En-Shyh Lin, Ming-Ju Tsai, Ming-Shyan Huang, Po-Lin Kuo
Pages: 1653-1659
Published online on: 06 March 2014

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Article

β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats

Heeok Hong, Chang‑Ju Kim, Jae‑Deung Kim, Jin‑Hee Seo
Pages: 1660-1666
Published online on: 04 March 2014

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Article

CD44 affects the expression level of FOS‑like antigen 1 in cervical cancer tissues

Songshu Xiao, Yanhong Zhou, Jianfa Jiang, Le Yuan, Min Xue
Pages: 1667-1674
Published online on: 06 March 2014

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Article

Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells

Li Luo, Lanhai Lü, Yinghong Lu, Lihong Zhang, Bofei Li, Kaihua Guo, Lizhi Chen, Yang Wang, Yijia Shao, Jie Xu
Pages: 1675-1680
Published online on: 06 March 2014

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Article

Allelic methylation status of CpG islands on chromosome 21q in patients with Trisomy 21

Yin‑Yin Xia, Yu‑Bing Ding, Xue‑Qing Liu, Xue‑Mei Chen, Shu‑Qun Cheng, Lian‑Bing Li, Ming‑Fu Ma, Jun‑Lin He, Ying‑Xiong Wang
Pages: 1681-1688
Published online on: 25 February 2014

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Article

Correlation between the overexpression of urokinase receptor isoform uPAR (D1D2) and hepatic cell malignant transformation

Yingqun Zhou, Xiaoping Lǚ, Shan Li, Lingling Zhan
Pages: 1689-1696
Published online on: 04 March 2014

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Article

Colon cancer cells treated with 5‑fluorouracil exhibit changes in polylactosamine‑type N‑glycans

Liping Gao, Li Shen, Meiyun Yu, Jianlong Ni, Xiaoxia Dong, Yinghui Zhou, Shiliang Wu
Pages: 1697-1702
Published online on: 05 March 2014

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Article

microRNA‑206 overexpression inhibits cellular proliferation and invasion of estrogen receptor α‑positive ovarian cancer cells Retraction in /10.3892/mmr.2021.12279

Shaoru Li, Yan Li, Zhengfang Wen, Fanjing Kong, Xinlei Guan, Wenhui Liu
Pages: 1703-1708
Published online on: 06 March 2014

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Article

Protective effects of daphnetin on sodium taurocholate‑induced severe acute pancreatitis in rats

Zhi-Yong Liu, Jiao Liu, Kai-Liang Zhao, Li-Kun Wang, Qiao Shi, Teng Zuo, Tian-Yi Liu, Liang Zhao, Wei-Xing Wang
Pages: 1709-1714
Published online on: 28 February 2014

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Article

Changes in the gene expression levels of microRNAs in the rat hippocampus by sevoflurane and propofol anesthesia

Gentaro Goto, Yoko Hori, Masashi Ishikawa, Shunsuke Tanaka, Atsuhiro Sakamoto
Pages: 1715-1722
Published online on: 11 March 2014

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Article

Caveolin 1 knockdown inhibits the proliferation, migration and invasion of human breast cancer BT474 cells

Rui Wang, Zhi Li, Hui Guo, Wei Shi, Yue Xin, Weilong Chang, Tao Huang
Pages: 1723-1728
Published online on: 06 March 2014

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Article

Prostaglandin E2 upregulates β1 integrin expression via the E prostanoid 1 receptor/nuclear factor κ‑light‑chain‑enhancer of activated B cells pathway in non‑small‑cell lung cancer cells

Xiaoming Bai, Qinyi Yang, Wei Shu, Jie Wang, Li Zhang, Juan Ma, Shukai Xia, Min Zhang, Shanyu Cheng, Yipin Wang, Jing Leng
Pages: 1729-1736
Published online on: 28 February 2014

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Article

Retinitis pigmentosa‑associated rhodopsin mutant T17M induces endoplasmic reticulum (ER) stress and sensitizes cells to ER stress-induced cell death

Haibo Jiang, Siqi Xiong, Xiaobo Xia
Pages: 1737-1742
Published online on: 26 February 2014

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Article

Role of Nogo‑A in the regulation of hepatocellular carcinoma SMMC‑7721 cell apoptosis

Chun‑Qiu Hao, Yun Zhou, Jiu‑Ping Wang, Mei‑Jun Peng, Yu‑Mei Xie, Wen‑Zhen Kang, Li Sun, Ping‑Zhong Wang, Chun‑Ling Wan, Lin He, Lei Cai, Zhang‑Sheng Jia
Pages: 1743-1748
Published online on: 13 March 2014

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Article

Analysis of blood flow and local expression of angiogenesis‑associated growth factors in infected wounds treated with negative pressure wound therapy

Cheng‑Yan Xia, Ai‑Xi Yu, Baiwen Qi, Min Zhou, Zong‑Huan Li, Wei‑Yang Wang
Pages: 1749-1754
Published online on: 28 February 2014

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Article

Role of peroxisome proliferator‑activated receptor α in atherosclerosis

Heng Cao, Gao Wen, Hongli Li
Pages: 1755-1760
Published online on: 06 March 2014

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Article

Silencing ephrinB3 improves functional recovery following spinal cord injury

Yang Qu, Jianwu Zhao, Yang Wang, Zhongli Gao
Pages: 1761-1766
Published online on: 06 March 2014

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Article

Effects of canine myoblasts expressing human cartilage‑derived morphogenetic protein‑2 on the repair of meniscal fibrocartilage injury

Wen‑Hui Zhu, Yu‑Bin Wang, Liang Wang, Gu‑Feng Qiu, Liang‑Yu Lu
Pages: 1767-1772
Published online on: 13 March 2014

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Article

Cholera toxin, a typical protein kinase A activator, induces G1 phase growth arrest in human bladder transitional cell carcinoma cells via inhibiting the c‑Raf/MEK/ERK signaling pathway

Xiaoke Zheng, Yanqiu Ou, Minfeng Shu, Youqiong Wang, Yuxi  Zhou, Xingwen Su, Wenbo Zhu, Wei Yin, Shifeng Li, Pengxin  Qiu, Guangmei Yan, Jingxia Zhang, Jun Hu, Dong Xu
Pages: 1773-1779
Published online on: 14 March 2014

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Article

Translocation of protein kinase C δ contributes to the moderately high glucose‑, but not hypoxia‑induced proliferation in primary cultured human retinal endothelial cells

Zhao‑Chun Liu, En‑Hong Yu, Wei Liu, Xiao‑Chang Liu, Shi‑Bo Tang, Bang‑Hao Zhu
Pages: 1780-1786
Published online on: 13 March 2014

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Article

Targeting A549 lung adenocarcinoma cell growth and invasion with protease‑activated receptor‑1 siRNA

Zhuo Wu, Yanyan Zeng, Mingkang Zhong, Bin Wang
Pages: 1787-1793
Published online on: 06 March 2014

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Article

Transforming growth factor‑β1 in the microenvironment of ischemia reperfusion‑injured kidney enhances the chemotaxis of mesenchymal stem cells to stromal cell‑derived factor‑1 through upregulation of surface chemokine (C‑X‑C motif) receptor 4

Xiao‑Yun Si, Jing‑Jing Li, Tao Yao, Xiao‑Yan Wu
Pages: 1794-1798
Published online on: 26 February 2014

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Article

Mutation of isocitrate dehydrogenase 1 induces glioma cell proliferation via nuclear factor‑κB activation in a hypoxia‑inducible factor 1‑α dependent manner

GuoLiang Wang, Ke Sai, FangHe Gong, QunYing Yang, FuRong Chen, Jian Lin
Pages: 1799-1805
Published online on: 14 March 2014

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Article

Spatial expression of claudin family members in various organs of mice

Inho Hwang, Hyun Yang, Hong‑Seok Kang, Chang‑Hwan Ahn, Geun‑Shik Lee, Eui‑Ju Hong, Beum‑Soo An, Eui‑Bae Jeung
Pages: 1806-1812
Published online on: 10 March 2014

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Article

Inhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicity

Kun-Peng Wang, Yu Bai, Jian Wang, Jin-Zhen Zhang
Pages: 1813-1819
Published online on: 04 March 2014

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Article

MicroRNA‑125b suppresses the proliferation and osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells

Shi Chen, Liu Yang, Qiang Jie, Yan‑Shui Lin, Guo‑Lin Meng, Jin‑Zhu Fan, Jin‑Kang Zhang, Jing Fan, Zhuo‑Jing Luo, Jian Liu
Pages: 1820-1826
Published online on: 06 March 2014

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Article

Berberine ameliorates severe acute pancreatitis‑induced intestinal barrier dysfunction via a myosin light chain phosphorylation‑dependent pathway

Hong‑Yin Liang, Tao Chen, Hong‑Tao Yan, Zhu Huang, Li‑Jun Tang
Pages: 1827-1833
Published online on: 28 February 2014

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Article

IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868

Honglei Yin, Peicheng Li, Fudong Hu, Yakun Wang, Xiaoyan Chai, Yan Zhang
Pages: 1834-1838
Published online on: 14 March 2014

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Article

Study of the effect of miR‑124 and the SOX9 target gene in Hirschsprung's disease

Jie Mi, Dong Chen, Mei Wu, Weilin Wang, Hong Gao
Pages: 1839-1843
Published online on: 06 March 2014

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Article

Standardization of the methylation‑specific PCR method for analyzing BRCA1 and ER methylation

Vo Thi Thuong Lan, Ngo Thi Ha, Nguyen Quynh Uyen, Nguyen Thi Duong, Nguyen Thi Thu Huong, Ta Bich Thuan, Pham Anh Thuy Duong, Ta Van To
Pages: 1844-1850
Published online on: 26 February 2014

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Article

Ac‑hE‑18A‑NH2, a novel dual‑domain apolipoprotein mimetic peptide, inhibits apoptosis in macrophages by promoting cholesterol efflux

Qiong Xie, Feng Li, Shui‑Ping Zhao
Pages: 1851-1856
Published online on: 14 March 2014

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Article

C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension

Adnan Rafiq, Khursheed Aslam, Rouf Malik, Dil Afroze
Pages: 1857-1862
Published online on: 26 February 2014

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Article

Isoproterenol‑mediated heme oxygenase‑1 induction inhibits high mobility group box 1 protein release and protects against rat myocardial ischemia/reperfusion injury in vivo

Jichun Wang, Xiaorong Hu, Wenwen Fu, Jing Xie, Xiaoya Zhou, Hong Jiang
Pages: 1863-1868
Published online on: 07 March 2014

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Article

Protective effects of the SEPS1 gene on lipopolysaccharide-induced sepsis

Lei He, Bin Wang, Yuan Yao, Maosheng Su, Huanxian Ma, Ning Jia
Pages: 1869-1876
Published online on: 26 February 2014

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Article

ROCK1, a novel target of miR-145, promotes glioma cell invasion

Xin Wan, Quan Cheng, Renjun Peng, Zhiming Ma, Zigui Chen, Yiqiang Cao, Bing Jiang
Pages: 1877-1882
Published online on: 25 February 2014

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Article

Berberine induces double-strand DNA breaks in Rev3 deficient cells

Xiaojuan Hu, Xiaohua Wu, Yunfei Huang, Qingyi Tong, Shunichi Takeda, Yong Qing
Pages: 1883-1888
Published online on: 28 February 2014

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Article

Effect of 20-hydroxyeicosatetraenoic acid on biological behavior of human villous trophoblasts and uterine vascular smooth muscle cells

Shuaijun Lu, Changling Zhu, Anxiong Long, Longyi Tan, Qian Li, Yuli Zhu
Pages: 1889-1894
Published online on: 06 March 2014

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Article

Co-stimulation with stem cell factor and erythropoietin enhances migration of c-Kit expressing cervical cancer cells through the sustained activation of ERK1/2

Cristina Aguilar, Cecilia Aguilar, Rebeca Lopez-Marure, Alejandro Jiménez-Sánchez, Leticia Rocha-Zavaleta
Pages: 1895-1902
Published online on: 12 March 2014

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Article

p53 N‑terminal binding and stabilisation by PIAS3 inhibits MDM2‑induced p53 ubiquitination and regulates cell growth

Ziyi Zhao, Lan Wu, Huimin Shi, Chuanfang Wu
Pages: 1903-1908
Published online on: 27 February 2014

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Article

microRNA‑125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis

Lili Zhou, Haitao Bai, Chun Wang, Daolin Wei, Youwen Qin, Xiaowei Xu
Pages: 1909-1916
Published online on: 06 March 2014

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Article

microRNA‑9 attenuates amyloidβ‑induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2

Fei Chang, Lin‑Hong Zhang, Wu‑Ping Xu, Ping Jing, Pei‑Yan Zhan
Pages: 1917-1922
Published online on: 06 March 2014

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Article

β1‑adrenergic regulation of rapid component of delayed rectifier K+ currents in guinea‑pig cardiac myocytes

Sen Wang, Di Xu, Ting‑Ting Wu, Yan Guo, Yan‑Hong Chen, Jian‑Gang Zou
Pages: 1923-1928
Published online on: 10 March 2014

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Article

Phosphorylated Signal Transducer and Activator of Transcription 1 is a potential predictor of interferon response in patients with advanced renal cell carcinoma

Wei Li, Qiang Wei, Jianbo Liang
Pages: 1929-1934
Published online on: 13 March 2014

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Article

ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer

Xiaohong Lv, Yang Li, Ming Qian, Chengyuan Ma, Hongyu  Jing, Zhongmei Wen, Donghua Qian
Pages: 1935-1940
Published online on: 07 March 2014

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Hesperetin attenuates mitochondria-dependent apoptosis in lipopolysaccharide-induced H9C2 cardiomyocytes

Zheng Yang, Yuan Liu, Wei Deng, Jia Dai, Fangfang Li, Yuan Yuan, Qingqing Wu, Heng Zhou, Zhouyan Bian, Qizhu Tang
Pages: 1941-1946
Published online on: 04 March 2014

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Salvia miltiorrhiza increases the expression of transcription factor Foxp3 in experimental murine colitis

Dekui Xu, Hongbo Yu, Qinggong Yu, Simeng Wu, Dongmei Liu, Yan Lin, Ying Zhang, Changqing Zheng
Pages: 1947-1951
Published online on: 25 February 2014

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Embryo selection strategy in sibling oocytes: A novel approach to measuring the likelihood of single‑embryo transfer using a mouse embryo transfer model

Feng-Qin Xu, Rong Liu, Ying Ma, Li Liu, Ju-Yan Liang, Yan Ma
Pages: 1952-1958
Published online on: 28 February 2014

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Article

Long‑term treatment of spontaneously hypertensive rats with losartan and molecular basis of modulating Ito of ventricular myocytes

Hongming Zhang, Songlin Wu, Congxing Huang, Xiaoyan Li
Pages: 1959-1967
Published online on: 28 February 2014

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Article

Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats

Hao Xu, Ming Chen, Qianru Xu, Zhenlong Wang, Zhidong Qiu
Pages: 1968-1974
Published online on: 06 March 2014

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Article

Autophagy prevents doxorubicin‑induced apoptosis in osteosarcoma

Dongxu Zhao, Hongping Yuan, Fei Yi, Chunyang Meng, Qingsan Zhu
Pages: 1975-1981
Published online on: 14 March 2014

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FOXO3a-mediated suppression of the self-renewal capacity of sphere-forming cells derived from the ovarian cancer SKOV3 cell line by 7-difluoromethoxyl-5,4'-di-n-octyl genistein Corrigendum in /10.3892/mmr.2021.12449

Yingxia Ning, Chaoyuan Luo, Kaiqun Ren, Meifang Quan, Jianguo Cao
Pages: 1982-1988
Published online on: 06 March 2014

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Magnetic resonance imaging‑directed biopsy improves the prediction of prostate cancer aggressiveness compared with a 12‑core transrectal ultrasound‑guided prostate biopsy

Jie Zhang, Jianjun Xiu, Yin Dong, Muwen Wang, Xue Han, Yejun Qin, Zhaoqin Huang, Shifeng Cai, Xianshun Yuan, Qingwei Liu
Pages: 1989-1997
Published online on: 28 February 2014

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Human heat shock protein 27 exacerbates ischemia reperfusion injury in rats by reducing the number of T regulatory cells

Sunyi Ye, Chenxi Zhang, Jie Zhou, Jun Cheng, Zhen Lv, Lin Zhou, Haiyang Xie, Jian Wu, Shusen Zheng
Pages: 1998-2002
Published online on: 10 March 2014

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Article

Component analysis of Pu-erh and its anti-constipation effects

Guijie Li, Qiang Wang, Yu Qian, Yalin Zhou, Rui Wang, Xin Zhao
Pages: 2003-2009
Published online on: 05 March 2014

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Article

Hepatitis C virus core protein induces hypoxia‑inducible factor 1α-mediated vascular endothelial growth factor expression in Huh7.5.1 cells

Chengliang Zhu, Xinghui Liu, Shiqun Wang, Xiaohong Yan, Zhaoming Tang, Kailang Wu, Yan Li, Fang Liu
Pages: 2010-2014
Published online on: 11 March 2014

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Article

Decreased PPAR-γ expression in the conjunctiva and increased expression of TNF-α and IL-1β in the conjunctiva and tear fluid of dry eye mice

Yihui Chen, Xiaoyan Zhang, Ling Yang, Min Li, Bing Li, Weifang Wang, Minjie Sheng
Pages: 2015-2023
Published online on: 12 March 2014

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Telbivudine decreases proportion of peripheral blood CD4+CD25+CD127low T cells in parallel with inhibiting hepatitis B virus DNA

Zehui Yan, Jijun Zhou, Mengjun Zhang, Xiaolan Fu, Yuzhang Wu, Yuming Wang
Pages: 2024-2030
Published online on: 12 March 2014

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Article

Analysis of mutational characteristics of the drug‑resistant gene katG in multi-drug resistant Mycobacterium tuberculosis L‑form among patients with pneumoconiosis complicated with tuberculosis

Jun Lu, Shan Jiang, Qian‑Ying Liu, Shuai Ma, Ying Li, Chao‑Pin Li
Pages: 2031-2035
Published online on: 13 March 2014

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Journal Cover
October-2026 Volume 34 Issue 4

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article Open Access

Licoisoflavone A ameliorates adipose tissue dysfunction in diet‑induced obesity by promoting METTL3 expression

Shuangxi Tu, Xiaodan Wang, Zhenbo Wang, Haojun Tang, Kai Yin, Xiao Zhu
Article Number: 296
Published online on: 03 September 2026

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Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review)

Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima
Article Number: 295
Published online on: 03 September 2026

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From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review)

Yuying Li, Ling Wei, Fang Sun, Huixia Wu, Xijun Sun, Yirong Gan, Xiaohua Kong
Article Number: 294
Published online on: 03 September 2026

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Resurrection biology: Melatonin as a modulator of anastasis (Review)

Alexandros Georgiou, Russel J. Reiter, Vassilis Zoumpourlis, Demetrios A. Spandidos
Article Number: 293
Published online on: 02 September 2026

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Correction Open Access

[Corrigendum] CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma

Qianle Yu, Kai Gao
Article Number: 292
Published online on: 01 September 2026

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Natural medicine‑empowered treatment of depression via restoring neurogenesis (Review)

Xiufen Zhong, Jingtao Gui
Article Number: 291
Published online on: 28 August 2026

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Article Open Access

POU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy

Yongbo Ma, Xiaozhe Chen, Zixian Liu, Yulong Ma, Chunlei Hou, Yunfeng Li, Mingtai Gui, Bo Lu, Deyu Fu, Mingzhu Wang
Article Number: 290
Published online on: 26 August 2026

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[Corrigendum] Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication

Guili Wang, Gaowei Ren, Xin Cui, Zhitao Lu, Yanping Ma, Ying Qi, Yujing Huang, Zhongyang Liu, Zhengrong Sun, Qiang Ruan
Article Number: 289
Published online on: 24 August 2026

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Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review)

Laifeng Wu, Lingchen Liao, Ziwei Xia, Qiao Zeng, An Huang, Zhiyong Cao
Article Number: 288
Published online on: 21 August 2026

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Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review)

Xi Wang, Baojun Duan, Jun Bai, Huitong Liu
Article Number: 287
Published online on: 20 August 2026

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Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review)

Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li
Article Number: 286
Published online on: 20 August 2026

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Article Open Access

Inhibition of Dyrk1a attenuates type 1 diabetic cardiomyopathy via anti‑ferroptosis

Junjian Chen, Wanyi Zhang, Tao Hong, Junsheng Wang, Chuan Chen, Ying Zhang, Mi Hu, Ning You, Jietao Huang
Article Number: 285
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons 

Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Yu
Article Number: 284
Published online on: 20 August 2026

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Deubiquitinating enzymes in kidney diseases: Molecular mechanisms, pathological roles and therapeutic opportunities (Review)

Qianqian Li, Yufang Ni, Zhaoyang Li, Jianchun Li, Li Wang
Article Number: 283
Published online on: 18 August 2026

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Biological mechanisms of atropine in myopia control (Review)

Qin Zhu, Guanglong Zhou, Lingguo Wang, Xuejiao Li, Zhijuan Hua, Jie Yin, Jieying Zhang, Yuan Zhou, Xiaofan Zhang, Allison Wilde, Yingting Zhu, Liping Xue
Article Number: 282
Published online on: 18 August 2026

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Article Open Access

6'‑O‑Caffeoylarbutin attenuates experimental hyperuricemia by regulating renal and intestinal urate transport, intestinal barrier integrity, and gut microbiota

Xuezhi Yu, Yang Zhang, Konchun Sun, Rui Yang, Xingde Li, Xiuzhen Chen, Tiantian Li, Xiaolei Yang, Ming Li, Lu Liu, Fei Li, Baochun Shen
Article Number: 281
Published online on: 18 August 2026

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Retraction Open Access

[Retracted] Aberrant expression of miR‑130a‑3p in ankylosing spondylitis and its role in regulating T‑cell survival  

Fengju Li, Dingran Si, Xuejun Guo, Ningru Guo, Dandan Li, Liujing Zhang, Xianan Jian, Jiasheng Ma
Article Number: 280
Published online on: 17 August 2026

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Article Open Access

Uric acid enhances tumor stemness in breast cancer cells by upregulating GMPS

Zhiying Wang, Mingzhang Huang, Yuanqi Zhang, Siqi Huang, Wei Lei, Xiaorong Shui
Article Number: 279
Published online on: 13 August 2026

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Article Open Access

Construction and validation of a nomogram for the diagnosis of postmenopausal osteoporosis

Le-Yi Huang, Yao Chen, Lin-Ran Song, Zhuo-Lin Zhong, Kamran Ali, Hui-Min Li, Qing-Feng Hu, Hong-Hua Hu
Article Number: 278
Published online on: 13 August 2026

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Expression of Concern Open Access

[Expression of Concern] MicroRNA‑145‑5p suppresses fascin to inhibit the invasion and migration of cervical carcinoma cells

Shufang He, Guiyuan Yu, Ke Peng, Sisun Liu
Article Number: 277
Published online on: 12 August 2026

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Review

Research progress on drugs targeting mitochondria‑associated membranes for the treatment of atherosclerosis (Review)

Shaoying An, Wenhui Sun, Lizhou Shi, Hai Chen, Zhongcheng Mo
Article Number: 276
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis

Liang Hao, Yuying Wan, Juhua Xiao, Qiang Tang, Huan Deng, Lu Chen
Article Number: 275
Published online on: 10 August 2026

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Article Open Access

Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu
Article Number: 274
Published online on: 06 August 2026

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Mitochondrial quality control in acute liver injury and its therapeutic implications (Review)

Ziqiang Chen, Yunhe Wang, Yijing Li, Gang Cong, Yunhang Chu, Yunhui Bai, Yishuo Zhang, Liya Zhou
Article Number: 273
Published online on: 05 August 2026

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Article Open Access

STC1 promotes osteogenic differentiation and represses inflammation via inhibition of NF‑κB signaling in mesenchymal stromal cells

Chen Yang, Xin Li, Peng Wang, Yitong Chen, Erli Wu, Qian Chen, Jing Hu, Fu Zheng, Lamu Gongsang, Jiayu Li, Mengyuan Zhang, Jing Zhou, Bing Han, Amr A. Badreldin, Yuka Miyamoto, Jin Koo Kim, Insoon Chang, Jia Chang, Paul H. Krebsbach, Liyuan Huang, Xiaoping Xu, Xiaoyan Chen, Peng Deng, Qianming Chen, Lijie Fan
Article Number: 272
Published online on: 05 August 2026

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Review Open Access

Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review)

Teng Sun, Lei Ye
Article Number: 271
Published online on: 04 August 2026

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Review Open Access

Role of microbial metabolites in the pathogenesis of hypertensive disorders of pregnancy: From short‑chain fatty acids to tryptophan metabolites (Review)

Fengyun Gao, Lili Wang, Guiyun Teng, Liqiong Shang
Article Number: 270
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Tumor promoter role of miR‑647 in gastric cancer via repression of TP73

Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
Article Number: 269
Published online on: 03 August 2026

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Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review)

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu
Article Number: 268
Published online on: 31 July 2026

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Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review)

Liqi Zhang, Shuxia Yang, Huiyan Wu, Hong Zhou
Article Number: 267
Published online on: 30 July 2026

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Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

Rongtou Huang, Danning Mo, Huitian Huang, Minmin Zhang, Wenhong Yu, Buqing Cao
Article Number: 266
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses

Yubo Xiao, Min Feng, Haiying Ran, Xiao Han, Xuegang Li
Article Number: 265
Published online on: 29 July 2026

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Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review)

Xiaona Wang, Hua Du, Yingxu Shi
Article Number: 264
Published online on: 28 July 2026

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Association between periodontitis and heart failure: Mechanisms and clinical implications (Review)

Xinyue Zhang, Xiaoli An
Article Number: 263
Published online on: 28 July 2026

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Article Open Access

Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene CLOCK

Jiawen Yu, Chunmei Qian, Renye Que, Yi Zhou
Article Number: 262
Published online on: 28 July 2026

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Retraction Open Access

[Retracted] PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells

Jinhua Lu, Shengyou Lin, Zechen Lin, Xianlei Lin, Yuezhong Shen, Jingyang Su
Article Number: 261
Published online on: 27 July 2026

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Article Open Access

UBE2A as a prognostic indicator across human cancers: Insights from multi‑omics and immune landscape analyses

Yun Wen, Pengfei Luo
Article Number: 260
Published online on: 23 July 2026

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Journal Cover
November-2026 Volume 34 Issue 5

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Journal Metrics

Impact Factor: 5.0

CiteScore: 7.3

CiteScore Rank: Q1: #83/351 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review)

Yuwen Zeng, Yutong Yan, Shiye Wu, Wanshan Wu, Ke Chen, Youyi Lai, Qing Ye, Nan Zhang, Yuanyuan Zhou
Article Number: 320
Published online on: 23 September 2026

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Lactylation in gastric cancer: From mechanisms to clinical applications (Review)

Yuliang Fang, Peng Chen, Yuhong Gao, Yanpiao Li, Xue Li
Article Number: 319
Published online on: 23 September 2026

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Article Open Access

Sleep deprivation exacerbates lens‑induced myopia in association with ERK/NF‑κB pathway activation

Xueli Yang, Zhou Zhang, Chengbai Zhu, Jianbo Li, Wenting Gong, Ruirui Yang, Lipeng Guan
Article Number: 318
Published online on: 22 September 2026

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Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review)

Yuanshe Huang, Zhenjun Xi, Jingxin Mao, Xiaobing Li
Article Number: 317
Published online on: 21 September 2026

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[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells

Long-Qiao Cao, Ya-Nan Wang, Ming Liang, Mei-Zhou Pan
Article Number: 316
Published online on: 21 September 2026

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Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review)

Shuo Cao, Mo Yang, Siyu Qu, Jinsong Wu, Jiaheng Li, Ying Zhao
Article Number: 315
Published online on: 17 September 2026

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Demethylase FTO attenuates atherosclerotic plaque via upregulating ABCA1 and ABCG1 expression by targeting ATG5

Fengxia Guo, Mei He, Yaonan Li, Kangning Zhu, Bing Hu
Article Number: 314
Published online on: 16 September 2026

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Correction Open Access

[Corrigendum] Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Article Number: 313
Published online on: 16 September 2026

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Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

Changshun Chen, Xingxi Hu, Sixing Wei, Yongcheng Deng, Qinggang Zhao, Ge Chen, Zhong Cheng, Jianhua Ji, Jinyi Gu
Article Number: 312
Published online on: 15 September 2026

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Therapeutic effects of exosome‑based hyperin delivery in a cyclophosphamide‑induced mouse model of diminished ovarian reserve

Yi Ying, Yue Wu, Ji Zhou, Yaming Wang, Hongtao Yin, Gang Lu, Ruolang Pan, Liangzhong Lv
Article Number: 311
Published online on: 15 September 2026

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Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review)

Xin Dong, Yongkun Hou, Jingjing Shao, Haixia Zhu, Jibin Liu
Article Number: 310
Published online on: 15 September 2026

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Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review)

Shilong Meng, Xinlei Fu, Yawei Xu, Zhiliang Peng, Xu Zhang, Yanguang Cao, Binbin Tang, Xiaolin Shi, Kang Liu
Article Number: 309
Published online on: 15 September 2026

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Article Open Access

High‑fat diet exacerbates hepatic and adipose insulin signaling impairment and ovarian lesions in a rat model of letrozole‑induced polycystic ovary syndrome

Sunju So, Sujin Kwon, La Yoon Choi, Dae Yong Kim, Mi Hye Kim
Article Number: 308
Published online on: 15 September 2026

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Retraction Open Access

[Retracted] RNAi‑mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non‑small lung cancer in vitro and in vivo

Liang Chang, Fangchao Gong, Youbin Cui
Article Number: 307
Published online on: 14 September 2026

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Article Open Access

A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer

Wenwen Chang, Jiaxin Yuan, Huilin Zhang, Ying Yu, Yan Ma, Mingyue Li, Wenjing Li, Hongxia Yan, Chongran Sun, Peng Zhang, Yang Tian, Feng Guo, Pan Li, Yang Sun
Article Number: 306
Published online on: 11 September 2026

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Research advances in the microbiota‑gut‑brain axis and Parkinson's disease (Review)

Yangping Meng, Qian Liu, Hao Zou, Xingyu Zhu, Xinxin Mi, Sitong Li, Yutian Xia, Yucheng Ma, Qianyu Yang, Jiaxin Peng, Junrui Li, Xingliang Liu, Junli Chen
Article Number: 305
Published online on: 10 September 2026

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Article Open Access

Ameliorative effects of Paulownia tomentosa flower absolute on atopic dermatitis‑related responses in mast cells and keratinocytes and its chemical composition

Da Yeon Yoo, Kyung Jong Won, Do Yoon Kim, Yoon Yi Kim, Ji Hye Bae, Ji Seong Yun, Hwan Myung Lee
Article Number: 304
Published online on: 10 September 2026

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Retraction Open Access

[Retracted] PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Jin
Article Number: 303
Published online on: 10 September 2026

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Article Open Access

KIF4A drives esophageal squamous cell carcinoma via Wnt/β‑catenin signaling and predicts poor prognosis

Jialong Chen, Tong Wang, Da Wang, Weiguo Liu, Chunlai Liu, Yang Yang, Xiangfu Sun, Lei Zhou
Article Number: 302
Published online on: 08 September 2026

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Review Open Access

Research progress of aptamers in the diagnosis and treatment of colorectal cancer (Review)

Yiwen Li, Penghui Yan, Ji Zhang, Binghui Wu, Min Li, Baoliang Bao
Article Number: 301
Published online on: 08 September 2026

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Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

Mary-Lyn Eichhorn, Anna M. Dmitrieva, Lydia Meder
Article Number: 300
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway

Xiaohui Zhao, Dayu Zhou, Yunen Liu, Chun Li, Xiaoguang Zhao, Ying Li, Wei Li
Article Number: 299
Published online on: 07 September 2026

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Review Open Access

Multi‑omics approaches to decipher the molecular mechanisms of exercise‑mediated bone protection: From mechanistic insights to personalized exercise prescription (Review)

Bin Tian, Xuesong Chen, Xin Kang
Article Number: 298
Published online on: 03 September 2026

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Retraction Open Access

[Retracted] MicroRNA‑27a promotes tumorigenesis via targeting AKT in triple negative breast cancer

Jing Wu, Zhihui Sun, Huijie Sun, Yanhua Li
Article Number: 297
Published online on: 03 September 2026

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