Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2014 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2014 Volume 9 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats

  • Authors:
    • Hao Xu
    • Ming Chen
    • Qianru Xu
    • Zhenlong Wang
    • Zhidong Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical College, Xiashan, Zhanjiang 524001, P.R. China
  • Pages: 1968-1974
    |
    Published online on: March 6, 2014
       https://doi.org/10.3892/mmr.2014.2014
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This study aimed to compare the effects of polypropylene (PP), lightweight PP (UP) and expanded polytetrafluorethylene (e-PTFE) hernia mesh on the reproductive function of adult male Sprague‑Dawley (SD) rats following open tension‑free hernioplasty. Forty adult SD rats were obtained and divided into five groups: A sham‑operated (FO) group, an e-PTFE mesh group, a PP mesh group, the UP mesh group and a normal control (NC) group (without any surgical manipulation). Ninety days following open tension-free hernioplasty, hematoxylin and eosin staining and immunhistochemistry were used to observe the pathological changes of the testicular tissue and to compare the expression of hypoxia-inducible factor-1α (HIF‑1α) in the rat testis, respectively. ELISA was used to analyze the serum concentration of antisperm antibodies (AsAbs) and routine semen testing was conducted to measure the percentage of grade a+b sperm from the epididymis. More than 50% of mesh adherence to the spermatic cord was observed in the PP and UP groups, and mild or no adhesion was observed in the NC, FO and e-PTFE groups. In the UP and PP groups, marked congestion of necrotic tissue was observed in the seminiferous tubule cavity, a significant reduction in the percentage of grade a+b sperm and a significant increase in the expression levels of AsAbs and HIF-α. It was concluded that the e-PTFE mesh exhibited a marginal effect on the reproductive function of rats compared with that of the PP and UP mesh and is more suitable for tension-free hernioplasty. The clinical significance of these results requires further elucidation with a multi-centered prospective study.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Eklund A, Carlsson P, Rosenblad A, et al: Long-term cost-minimization analysis comparing laparoscopic with open (Lichtenstein) inguinal hernia repair. Br J Surg. 97:765–771. 2010. View Article : Google Scholar : PubMed/NCBI

2 

López Cano M, Armengol Carrasco M, Quiles Pérez MT and Arbós Vía MA: Biological implants in abdominal wall hernia surgery. Cir Esp. 91:217–223. 2013.(In Spanish).

3 

Yazdankhah Kenary A, Afshin SN, Ahmadi Amoli H, et al: Randomized clinical trial comparing lightweight mesh with heavyweight mesh for primary inguinal hernia repair. Hernia. 17:471–477. 2013.PubMed/NCBI

4 

Nathan JD and Pappas TN: Inguinal hernia: an old condition with new solutions. Ann Surg. 238:S148–S157. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Birch C and Fynes MM: The role of synthetic and biological prostheses in reconstructive pelvic floor surgery. Curr Opin Obstet Gynecol. 14:527–535. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Shin D, Lipshultz LI, Goldstein M, et al: Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction: a preventable cause of obstructive azoospermia. Ann Surg. 241:553–558. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Suradom C and Palaphun J: The usage of two umbrella made-mesh plugs in herniorrhaphy: comparative study with Bassini and Lichtenstein method. J Med Assoc Thai. 94:1373–1379. 2011.PubMed/NCBI

8 

Kogan BA: Communicating hydrocele/hernia repair in children. BJU Int. 100:703–714. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Peiper C, Junge K, Klinge U, Strehlau E, Ottinger A and Schumpelick V: Is there a risk of infertility after inguinal mesh repair? Experimental studies in the pig and the rabbit. Hernia. 10:7–12. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Aydede H, Erhan Y, Sakarya A, Kara E, Ilkgül O and Can M: Effect of mesh and its localisation on testicular flow and spermatogenesis in patients with groin hernia. Acta Chir Belg. 103:607–610. 2003.PubMed/NCBI

11 

Goldenberg A and Paula JF: Effects of the polypropylene mesh implanted through inguinotomy in the spermatic funiculus, epididium and testis of dogs. Acta Cir Bras. 20:461–467. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Kolbe T and Lechner W: Influence of hernioplastic implants on male fertility in rats. J Biomed Mater Res B Appl Biomater. 81:435–440. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Peiper C, Junge K, Bühner A, Bassalay P and Schumpelick V: Load on the inguinal region under standard conditions in pigs. Eur J Surg. 167:356–361. 2001. View Article : Google Scholar : PubMed/NCBI

14 

LeBlanc KA, Booth WV, Whitaker JM and Baker D: In vivo study of meshes implanted over the inguinal ring and external iliac vessels in uncastrated pigs. Surg Endosc. 12:247–251. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Fernández-Braña M: Hypoxia: a therapeutic target. Clin Transl Oncol. 7:475–476. 2005.(In Spanish).

16 

Anderson DJ and Alexander NJ: Consequences of autoimmunity to sperm antigens in vasectomized men. Clin Obstet Gynaecol. 6:425–442. 1979.PubMed/NCBI

17 

Silich RC and McSherry CK: Spermatic granuloma. An uncommon complication of the tension-free hernia repair. Surg Endosc. 10:537–539. 1996.PubMed/NCBI

18 

Walker AP, Henderson J and Condon RE: Double-layer protheses for repair of abdominal wall defects in rabbit model. J Surg Res. 55:32–37. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Johnsen SG: Testicular biopsy score count - a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones. 1:2–25. 1970. View Article : Google Scholar : PubMed/NCBI

20 

Xue J, Yang J, Yan J, et al: Abnormalities of the testes and semen parameters in clinical varicocele. Nan Fang Yi Ke Da Xue Xue Bao. 32:439–442. 2012.PubMed/NCBI

21 

Zendejas B, Ramirez T, Jones T, et al: Incidence of inguinal hernia repairs in Olmsted County, MN: a population-based study. Ann Surg. 257:520–526. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Bierca J, Kosim A, Kołodziejczak M, Zmora J and Kultys E: Effectiveness of Lichtenstein repairs in planned treatment of giant inguinal hernia - own experience. Wideochir Inne Tech Malo Inwazyjne. 8:36–42. 2013.PubMed/NCBI

23 

Pielaciński K, Szczepanik AB, Misiak A and Wróblewski T: Randomized clinical trial comparing inguinal hernia repair with Lichtenstein technique using non-absorbable or partially absorbable mesh. Preliminary report. Wideochir Inne Tech Malo Inwazyjne. 6:190–206. 2011.

24 

Wang WJ, Chen JZ, Fang Q, Li JF, Jin PF and Li ZT: Comparison of the effects of laparoscopic hernia repair and lichtenstein tension-free hernia repair. J Laparoendosc Adv Surg Tech A. 23:301–305. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Junge K, Binnebösel M, Kauffmann C, et al: Damage to the spermatic cord by the Lichtenstein and TAPP procedures in a pig model. Surg Endosc. 25:146–152. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Da Silva N, Silberstein C, Beaulieu V, et al: Postnatal expression of aquaporins in epithelial cells of the rat epididymis. Biol Reprod. 74:427–438. 2006.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu H, Chen M, Xu Q, Wang Z and Qiu Z: Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats. Mol Med Rep 9: 1968-1974, 2014.
APA
Xu, H., Chen, M., Xu, Q., Wang, Z., & Qiu, Z. (2014). Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats. Molecular Medicine Reports, 9, 1968-1974. https://doi.org/10.3892/mmr.2014.2014
MLA
Xu, H., Chen, M., Xu, Q., Wang, Z., Qiu, Z."Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats". Molecular Medicine Reports 9.5 (2014): 1968-1974.
Chicago
Xu, H., Chen, M., Xu, Q., Wang, Z., Qiu, Z."Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats". Molecular Medicine Reports 9, no. 5 (2014): 1968-1974. https://doi.org/10.3892/mmr.2014.2014
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Chen M, Xu Q, Wang Z and Qiu Z: Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats. Mol Med Rep 9: 1968-1974, 2014.
APA
Xu, H., Chen, M., Xu, Q., Wang, Z., & Qiu, Z. (2014). Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats. Molecular Medicine Reports, 9, 1968-1974. https://doi.org/10.3892/mmr.2014.2014
MLA
Xu, H., Chen, M., Xu, Q., Wang, Z., Qiu, Z."Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats". Molecular Medicine Reports 9.5 (2014): 1968-1974.
Chicago
Xu, H., Chen, M., Xu, Q., Wang, Z., Qiu, Z."Application of tension-free hernioplasty with hernia meshes of different materials and the postoperative effects on the reproductive function of male rats". Molecular Medicine Reports 9, no. 5 (2014): 1968-1974. https://doi.org/10.3892/mmr.2014.2014
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team