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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-2014 Volume 9 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway

  • Authors:
    • Wei-An Chang
    • En-Shyh Lin
    • Ming-Ju Tsai
    • Ming-Shyan Huang
    • Po-Lin Kuo
  • View Affiliations / Copyright

    Affiliations: Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan R.O.C., Department of Beauty Science, National Taichung University of Science and Technology, Taichung 403, Taiwan R.O.C., Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan R.O.C.
  • Pages: 1653-1659
    |
    Published online on: March 6, 2014
       https://doi.org/10.3892/mmr.2014.2015
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Abstract

Lung cancer is currently the leading cause of cancer‑related mortality worldwide. In Taiwan, lung cancer is also the type of malignancy that is the major cause of cancer‑mortality. Investigating the mechanism of apoptosis of lung cancer cells is important in the treatment of lung cancer. In the present study, isolinderalactone was demonstrated to exhibit anticancer effects in A549 human non‑small cell lung cancer cells. The effect of isolinderalactone on apoptosis, cell cycle distribution p21 levels and the Fas receptor and soluble Fas ligand (sFasL) were assayed in order to determine the mechanism underlying the anticancer effect of isolinderalactone. It was demonstrated that isolinderalactone may induce p21 expression and then cause the cell cycle arrest of A549 cells. The data of the present study also revealed that the Fas/sFasL apoptotic system is significant in the mechanism of isolinderalactone‑induced apoptosis of A549 cells. These novel findings demonstrated that isolinderalactone may cause the cell cycle arrest of A549 cells by induction of p21, and induce apoptosis of A549 human non-small-cell lung carcinoma cells through the Fas/sFasL apoptotic system.
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1 

Herbst RS, Heymach JV and Lippman SM: Lung cancer. N Engl J Med. 359:1367–1380. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Gottschling S, Schnabel PA, Herth FJ and Herpel E: Are we missing the target? Cancer stem cells and drug resistance in non-small cell lung cancer. Cancer Genomics Proteomics. 9:275–286. 2012.PubMed/NCBI

3 

Spira A and Ettinger DS: Multidisciplinary management of lung cancer. N Engl J Med. 350:379–392. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Favaloro B, Allocati N, Graziano V, Di Ilio C and De Laurenzi V: Role of apoptosis in disease. Aging (Albany NY). 4:330–349. 2012.

5 

Ramakrishnan R and Gabrilovich DI: Novel mechanism of synergistic effects of conventional chemotherapy and immune therapy of cancer. Cancer Immunol Immunother. 62:405–410. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Chopin V, Toillon RA, Jouy N and Le Bourhis X: Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells. Br J Pharmacol. 135:79–86. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Ostrand-Rosenberg S, Sinha P, Chornoguz O and Ecker C: Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC). Cancer Immunol Immunother. 61:1319–1325. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Miller RE and Tuck KL: Reports on the distribution of aromatic cyanogenic glycosides in Australian tropical rainforest tree species of the Lauraceae and Sapindaceae. Phytochemistry. 92:146–152. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Gan LS, Zheng YL, Mo JX, Liu X, Li XH and Zhou CX: Sesquiterpene lactones from the root tubers of Lindera aggregata. J Nat Prod. 72:1497–1501. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Kobayashi W, Miyase T, Sano M, Umehara K, Warashina T and Noguchi H: Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill. Biol Pharm Bull. 25:1049–1052. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Wettersten HI, Hee Hwang S, Li C, et al: A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol Ther. 14:278–285. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Warfel NA and El-Deiry WS: p21WAF1 and tumourigenesis: 20 years after. Curr Opin Oncol. 25:52–58. 2013.PubMed/NCBI

13 

Gartel AL and Tyner AL: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther. 1:639–649. 2002.PubMed/NCBI

14 

Peter ME: Programmed cell death: Apoptosis meets necrosis. Nature. 471:310–312. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Liu YQ, Mu ZQ, You S, Tashiro S, Onodera S and Ikejima T: Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells. Biol Pharm Bull. 29:1873–1879. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Zhuang H, Gan Z, Jiang W, Zhang X and Hua ZC: Functional specific roles of FADD: comparative proteomic analyses from knockout cell lines. Mol Biosyst. 9:2063–2078. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Mou H, Zheng Y, Zhao P, Bao H, Fang W and Xu N: Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways. Toxicol In Vitro. 25:1027–1032. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chang W, Lin E, Tsai M, Huang M and Kuo P: Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway. Mol Med Rep 9: 1653-1659, 2014.
APA
Chang, W., Lin, E., Tsai, M., Huang, M., & Kuo, P. (2014). Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway. Molecular Medicine Reports, 9, 1653-1659. https://doi.org/10.3892/mmr.2014.2015
MLA
Chang, W., Lin, E., Tsai, M., Huang, M., Kuo, P."Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway". Molecular Medicine Reports 9.5 (2014): 1653-1659.
Chicago
Chang, W., Lin, E., Tsai, M., Huang, M., Kuo, P."Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway". Molecular Medicine Reports 9, no. 5 (2014): 1653-1659. https://doi.org/10.3892/mmr.2014.2015
Copy and paste a formatted citation
x
Spandidos Publications style
Chang W, Lin E, Tsai M, Huang M and Kuo P: Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway. Mol Med Rep 9: 1653-1659, 2014.
APA
Chang, W., Lin, E., Tsai, M., Huang, M., & Kuo, P. (2014). Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway. Molecular Medicine Reports, 9, 1653-1659. https://doi.org/10.3892/mmr.2014.2015
MLA
Chang, W., Lin, E., Tsai, M., Huang, M., Kuo, P."Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway". Molecular Medicine Reports 9.5 (2014): 1653-1659.
Chicago
Chang, W., Lin, E., Tsai, M., Huang, M., Kuo, P."Isolinderalactone inhibits proliferation of A549 human non‑small cell lung cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas receptor and soluble Fas ligand-mediated apoptotic pathway". Molecular Medicine Reports 9, no. 5 (2014): 1653-1659. https://doi.org/10.3892/mmr.2014.2015
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