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Article

Role of peroxisome proliferator‑activated receptor α in atherosclerosis

  • Authors:
    • Heng Cao
    • Gao Wen
    • Hongli Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai First People's Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200080, P.R. China
  • Pages: 1755-1760
    |
    Published online on: March 6, 2014
       https://doi.org/10.3892/mmr.2014.2020
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Abstract

Atherosclerosis is an inflammatory disease involving the immune response. In addition to lowering the cholesterol level, the peroxisome proliferator-activated receptor α (PPAR-α) can prevent atherosclerosis via its pleiotropic anti-inflammatory effects. However, the role of PPAR-α in modulating inflammatory progression of atherosclerosis has rarely been studied. Thus, we aimed to investigate the role of PPAR-α in atherosclerosis by evaluating the expression of inflammatory cytokines induced by PPAR-α in an in vivo rabbit model. New Zealand White rabbits were randomly divided into 5 groups: control, high-fat diet + balloon injury, high-fat diet + balloon injury + placebo, high-fat diet + balloon injury + fenofibrate, and high-fat diet + balloon injury + WY-14643. The femoral arteries of rabbits were balloon-injured after initiation of the high-fat diet and before administration of fenofibrate, WY-14643 or placebo solution. Atherosclerosis was induced by high-fat diet and balloon angioplasty, and the vessel wall lumen occlusion was determined by measuring the stenosis rate. PPAR-α gene expression was examined by quantitative polymerase chain reaction analysis. The cellular localization and distribution of PPAR-α was observed by immunohistochemistry, and its protein level was assessed by western blot analysis. The production of interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and P-selectin, which are major inflammatory factors involved in atherosclerosis, was monitored by an enzyme-linked immunosorbent assay (ELISA). Treatment with PPAR-α agonists (fenofibrate or WY-14643) reduced the vascular occlusion rate, as compared to the high‑fat diet + balloon injury and the placebo groups. Furthermore, the expression of PPAR-α at both the protein and the mRNA level was increased in the fenofibrate and WY-14643 groups. According to the results, the TNF-α and P-selectin levels were reduced in the fenofibrate and WY-14643 groups. These results suggest that PPAR-α activation can attenuate the effects of atherosclerosis by inhibiting the expression of major inflammatory factors in a rabbit atherosclerosis model.
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View References

1 

Ostrom MP, Gopal A, Ahmadi N, Nasir K, Yang E, Kakadiaris I, Flores F, Mao SS and Budoff MJ: Mortality incidence and the severity of coronary atherosclerosis assessed by computed tomography angiography. J Am Coll Cardiol. 52:1335–1343. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Mizuno Y, Jacob RF and Mason R: Inflammation and the development of atherosclerosis. J Atheroscler Thromb. 18:351–358. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Motojima K: Peroxisome proliferator-activated receptor (PPAR): structure, mechanisms of activation and diverse functions. Cell Struct Funct. 18:267–277. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Hiukka A, Maranghi M, Matikainen N and Taskinen MR: PPARα: an emerging therapeutic target in diabetic microvascular damage. Nat Rev Endocrinol. 6:454–463. 2010.

5 

Wilson JL, Duan R, El-Marakby A, Alhashim A and Lee DL: Peroxisome proliferator activated receptor-α agonist slows the progression of hypertension, attenuates plasma interleukin-6 levels and renal inflammatory markers in angiotensin II infused mice. PPAR Res. 2012:6459692012.

6 

Fruchart JC, Duriez P and Staels B: Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol. 10:245–257. 1999. View Article : Google Scholar

7 

Ding JL, Zhou ZG, Zhou XY, Zhou B, Wang L, Wang R, Zhan L, Sun XF and Li Y: Attenuation of acute pancreatitis by peroxisome proliferator-activated receptor-α in rats: the effect on Toll-like receptor signaling pathways. Pancreas. 42:114–122. 2013.

8 

Desvergne B and Wahli W: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 20:649–688. 1999.PubMed/NCBI

9 

Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ and Wahli W: The PPARalpha-leukotriene B4 pathway to inflammation control. Nature. 384:39–43. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Heun R, Kölsch H, Ibrahim-Verbaas CA, Combarros O, Aulchenko YS, Breteler M, Schuur M, van Duijn CM, Hammond N, Belbin O, Cortina-Borja M, Wilcock GK, Brown K, Barber R, Kehoe PG, Coto E, Alvarez V, Lehmann MG, Deloukas P, Mateo I, Morgan K, Warden DR, Smith AD and Lehmann DJ: Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer’s disease, observed by the epistasis project. Int J Mol Epidemiol Genet. 3:39–47. 2012.

11 

Lee JW, Bajwa PJ, Carson MJ, Jeske DR, Cong Y, Elson CO, Lytle C and Straus DS: Fenofibrate represses interleukin-17 and interferon-γ expression and improves colitis in interleukin-10-deficient mice. Gastroenterology. 133:108–123. 2007.PubMed/NCBI

12 

Liu Y, Jiang H, Liu W, Shang H, Tang Y, Zhu R and Li B: Effects of fluvastatin therapy on serum interleukin-18 and interleukin-10 levels in patients with acute coronary syndrome. Acta Cardiol. 65:285–289. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Miller AM, McPhaden AR, Preston A, Wadsworth RM and Wainwright CL: TNFα increases the inflammatory response to vascular balloon injury without accelerating neointimal formation. Atherosclerosis. 179:51–59. 2005.

14 

Mobarrez F, He S, Bröijersen A, Wiklund B, Antovic A, Antovic J, Egberg N, Jörneskog G and Wallén H: Atorvastatin reduces thrombin generation and expression of tissue factor, P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial occlusive disease. Thromb Haemost. 106:344–352. 2011. View Article : Google Scholar

15 

Jeanpierre E, Le Tourneau T, Zawadzki C, Van Belle E, Mouquet F, Susen S, Ezekowitz MD, Staels B, Jude B and Corseaux D: Beneficial effects of fenofibrate on plaque thrombogenicity and plaque stability in atherosclerotic rabbits. Cardiovasc Pathol. 18:140–147. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Yeh CH, Chen TP, Lee CH, Wu YC, Lin YM and Lin PJ: Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. Shock. 26:262–270. 2006. View Article : Google Scholar

17 

Buchanan MR and Brister SJ: Inhibition of chronic vessel wall intimal hyperplasia following acute anticoagulant treatment: Relative effects of heparin and dermatan sulphate. Thromb Res. 91:157–167. 1998. View Article : Google Scholar

18 

Jia XL, Li SY, Dang SS, Cheng YA, Zhang X, Wang WJ, Hughes CE and Caterson B: Increased expression of chondroitin sulphate proteoglycans in rat hepatocellular carcinoma tissues. World J Gastroenterol. 18:3962–3976. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Libby P, Ridker PM and Hansson GK: Progress and challenges in translating the biology of atherosclerosis. Nature. 473:317–325. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chamouton J and Latruffe N: PPARα/HNF4α interplay on diversified responsive elements. Relevance in the regulation of liver peroxisomal fatty acid catabolism. Curr Drug Metab. 13:1436–1453. 2012.

21 

Soulitzis N, Karyotis I, Delakas D and Spandidos DA: Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia. Int J Oncol. 29:305–314. 2006.PubMed/NCBI

22 

Baritaki S, Sifakis S, Huerta-Yepez S, Neonakis IK, Soufla G, Bonavida B and Spandidos DA: Overexpression of VEGF and TGF-β1 mRNA in Pap smears correlates with progression of cervical intraepithelial neoplasia to cancer: implication of YY1 in cervical tumorigenesis and HPV infection. Int J Oncol. 31:69–79. 2007.

23 

Arvanitis DA and Spandidos DA: Deregulation of the G1/S phase transition in cancer and squamous intraepithelial lesions of the uterine cervix: A case control study. Oncol Rep. 20:751–760. 2008.PubMed/NCBI

24 

Gervois P, Chopin-Delannoy S, Fadel A, Dubois G, Kosykh V, Fruchart JC, Najïb J, Laudet V and Staels B: Fibrates increase human REV-ERBα expression in liver via a novel peroxisome proliferator-activated receptor response element. Mol Endocrinol. 13:400–409. 1999.

25 

Stoll G and Bendszus M: Inflammation and atherosclerosis novel insights into plaque formation and destabilization. Stroke. 37:1923–1932. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Liu Y, Li D, Chen J, Xie J, Bandyopadhyay S, Zhang D, Nemarkommula AR, Liu H, Mehta JL and Hermonat PL: Inhibition of atherogenesis in LDLR knockout mice by systemic delivery of adeno-associated virus type 2-hIL-10. Atherosclerosis. 188:19–27. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Kleemann R, Zadelaar S and Kooistra T: Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc Res. 79:360–376. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Di Paola R, Impellizzeri D, Torre A, Mazzon E, Cappellani A, Faggio C, Esposito E, Trischitta F and Cuzzocrea S: Effects of palmitoylethanolamide on intestinal injury and inflammation caused by ischemia-reperfusion in mice. J Leukoc Biol. 91:911–920. 2012.PubMed/NCBI

29 

Standage SW, Caldwell CC, Zingarelli B and Wong HR: Reduced peroxisome proliferator-activated receptor α expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock. 37:164–169. 2012.

30 

Salagianni M, Galani IE, Lundberg AM, Davos CH, Varela A, Gavriil A, Lyytikäinen LP, Lehtimäki T, Sigala F, Folkersen L, Gorgoulis V, Lenglet S, Montecucco F, Mach F, Hedin U, Hansson GK, Monaco C and Andreakos E: Toll-like receptor 7 protects from atherosclerosis by constraining ‘inflammatory’ macrophage activation. Circulation. 126:952–962. 2012.PubMed/NCBI

31 

Zhou B, Pan Y, Hu Z, Wang X, Han J, Zhou Q, Zhai Z and Wang Y: All-trans-retinoic acid ameliorated high fat diet-induced atherosclerosis in rabbits by inhibiting platelet activation and inflammation. J Biomed Biotechnol. 2012:2596932012. View Article : Google Scholar : PubMed/NCBI

32 

Trompet S, Pons D, De Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Hyland M, Gaw A, Macfarlane PW, Packard CJ, Norrie J, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG and Jukema JW: Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study. Ann NY Acad Sci. 1100:189–198. 2007. View Article : Google Scholar

33 

van Exel E, Gussekloo J, de Craen A, Bootsma-van der Wiel A, Frölich M and Westendorp R: Inflammation and stroke: the Leiden 85-Plus Study. Stroke. 33:1135–1138. 2002.PubMed/NCBI

34 

Lakoski SG, Liu Y, Brosnihan KB and Herrington DM: Interleukin-10 concentration and coronary heart disease (CHD) event risk in the estrogen replacement and atherosclerosis (ERA) study. Atherosclerosis. 197:443–447. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao H, Wen G and Li H: Role of peroxisome proliferator‑activated receptor α in atherosclerosis. Mol Med Rep 9: 1755-1760, 2014.
APA
Cao, H., Wen, G., & Li, H. (2014). Role of peroxisome proliferator‑activated receptor α in atherosclerosis. Molecular Medicine Reports, 9, 1755-1760. https://doi.org/10.3892/mmr.2014.2020
MLA
Cao, H., Wen, G., Li, H."Role of peroxisome proliferator‑activated receptor α in atherosclerosis". Molecular Medicine Reports 9.5 (2014): 1755-1760.
Chicago
Cao, H., Wen, G., Li, H."Role of peroxisome proliferator‑activated receptor α in atherosclerosis". Molecular Medicine Reports 9, no. 5 (2014): 1755-1760. https://doi.org/10.3892/mmr.2014.2020
Copy and paste a formatted citation
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Spandidos Publications style
Cao H, Wen G and Li H: Role of peroxisome proliferator‑activated receptor α in atherosclerosis. Mol Med Rep 9: 1755-1760, 2014.
APA
Cao, H., Wen, G., & Li, H. (2014). Role of peroxisome proliferator‑activated receptor α in atherosclerosis. Molecular Medicine Reports, 9, 1755-1760. https://doi.org/10.3892/mmr.2014.2020
MLA
Cao, H., Wen, G., Li, H."Role of peroxisome proliferator‑activated receptor α in atherosclerosis". Molecular Medicine Reports 9.5 (2014): 1755-1760.
Chicago
Cao, H., Wen, G., Li, H."Role of peroxisome proliferator‑activated receptor α in atherosclerosis". Molecular Medicine Reports 9, no. 5 (2014): 1755-1760. https://doi.org/10.3892/mmr.2014.2020
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