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Article

Spatial expression of claudin family members in various organs of mice

  • Authors:
    • Inho Hwang
    • Hyun Yang
    • Hong‑Seok Kang
    • Chang‑Hwan Ahn
    • Geun‑Shik Lee
    • Eui‑Ju Hong
    • Beum‑Soo An
    • Eui‑Bae Jeung
  • View Affiliations / Copyright

    Affiliations: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361‑763, Republic of Korea, Laboratory of Veterinary Physiology, College of Veterinary Medicine, Kangwon National University, Chuncheon, Gangwon 200‑701, Republic of Korea, Department of Biomaterials Science, College of National Resources and Life Science, Pusan National University, Miryang, Pusan 627‑706, Republic of Korea
  • Pages: 1806-1812
    |
    Published online on: March 10, 2014
       https://doi.org/10.3892/mmr.2014.2031
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Abstract

Claudins (CLDNs) are tetraspan transmembrane proteins, which are components of tight junctions. The CLDN family is composed of 27 members that are responsible for paracellular transport and certain CLDNs form charge‑selective ion channels. CLDNs have two extracellular loops, and the charge of the first extracellular loop determines the ion selectivity of each CLDN. Although the expression and function of each CLDN have been previously investigated, the distribution of CLDNs in various target organs remains to be determined. In the present study, the tissue‑specific mRNA distribution of CLDNs (1‑5, 7‑8, 10a and b, 11‑12, 14‑17 and 19) in the duodenum, ileum, colon, kidney, liver and lung were defined. Among the tested CLDNs, CLDN1, 2, 12 and 16 were selected for further investiagtion. It was observed that CLDN1, CLDN2 and CLDN12 transcripts and proteins were particularly abundant in the investigated organs. Notably, immune‑reactive CLDN16 was detected in a tissue‑specific manner and shown in the renal tubules and portal vein. The tested CLDNs were localized to intercellular apical junctions in the epithelium of the intestine, renal tubule and bronchus. Based on this novel information, the presence of several types of CLDNs is of interest as CLDNs may promote or dampen the paracellular diffusion of specific ions.
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1 

Wen H, Watry DD, Marcondes MC and Fox HS: Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5. Mol Cell Biol. 24:8408–8417. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Amasheh S, Meiri N, Gitter AH, et al: Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci. 115:4969–4976. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Hou J, Paul DL and Goodenough DA: Paracellin-1 and the modulation of ion selectivity of tight junctions. J Cell Sci. 118:5109–5118. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Colegio OR, Van Itallie C, Rahner C and Anderson JM: Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol. 284:C1346–C1354. 2003. View Article : Google Scholar

5 

Alexandre MD, Jeansonne BG, Renegar RH, Tatum R and Chen YH: The first extracellular domain of claudin-7 affects paracellular Cl- permeability. Biochem Biophys Res Commun. 357:87–91. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Van Itallie CM, Rogan S, Yu A, Vidal LS, Holmes J and Anderson JM: Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities. Am J Physiol Renal Physiol. 291:F1288–F1299. 2006.PubMed/NCBI

7 

Van Itallie CM and Anderson JM: Claudins and epithelial paracellular transport. Annu Rev Physiol. 68:403–429. 2006.PubMed/NCBI

8 

Krug SM, Günzel D, Conrad MP, et al: Charge-selective claudin channels. Ann NY Acad Sci. 1257:20–28. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Schulzke JD, Günzel D, John LJ and Fromm M: Perspectives on tight junction research. Ann NY Acad Sci. 1257:1–19. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Günzel D, Stuiver M, Kausalya PJ, et al: Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. J Cell Sci. 122:1507–1517. 2009.PubMed/NCBI

11 

Myal Y, Leygue E and Blanchard AA: Claudin 1 in breast tumorigenesis: revelation of a possible novel ‘claudin high’ subset of breast cancers. J Biomed Biotechnol. 2010:9568972010.PubMed/NCBI

12 

Inai T, Kobayashi J and Shibata Y: Claudin-1 contributes to the epithelial barrier function in MDCK cells. Eur J Cell Biol. 78:849–855. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Weber CR, Nalle SC, Tretiakova M, Rubin DT and Turner JR: Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest. 88:1110–1120. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Van Itallie C, Rahner C and Anderson JM: Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest. 107:1319–1327. 2001.PubMed/NCBI

15 

Hou J, Renigunta A, Yang J and Waldegger S: Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci USA. 107:18010–18015. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Fujita H, Sugimoto K, Inatomi S, et al: Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell. 19:1912–1921. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Hou J, Renigunta A, Konrad M, et al: Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J Clin Invest. 118:619–628. 2008.PubMed/NCBI

18 

Chao YC, Pan SH, Yang SC, et al: Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma. Am J Respir Crit Care Med. 179:123–133. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Kitajiri SI, Furuse M, Morita K, et al: Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. Hear Res. 187:25–34. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Zhu Y, Brännström M, Janson PO and Sundfeldt K: Differences in expression patterns of the tight junction proteins, claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours. Int J Cancer. 118:1884–1891. 2006. View Article : Google Scholar

21 

Furuse M, Furuse K, Sasaki H and Tsukita S: Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol. 153:263–272. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Reyes JL, Lamas M, Martin D, et al: The renal segmental distribution of claudins changes with development. Kidney Int. 62:476–487. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Rahner C, Mitic LL and Anderson JM: Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology. 120:411–422. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Wolburg H, Wolburg-Buchholz K, Liebner S and Engelhardt B: Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse. Neurosci Lett. 307:77–80. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Muto S, Hata M, Taniguchi J, et al: Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci USA. 107:8011–8016. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Hawkins BT and Davis TP: The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev. 57:173–185. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Belanger M, Asashima T, Ohtsuki S, Yamaguchi H, Ito S and Terasaki T: Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. Neurochem Int. 50:95–101. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Fujita H, Chiba H, Yokozaki H, et al: Differential expression and subcellular localization of claudin-7, -8, -12, -13 and -15 along the mouse intestine. J Histochem Cytochem. 54:933–944. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Brandner JM, McIntyre M, Kief S, Wladykowski E and Moll I: Expression and localization of tight junction-associated proteins in human hair follicles. Arch Dermatol Res. 295:211–221. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Simon DB, Lu Y, Choate KA, et al: Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. 285:103–106. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Konrad M, Schaller A, Seelow D, et al: Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet. 79:949–957. 2006.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hwang I, Yang H, Kang HS, Ahn CH, Lee GS, Hong EJ, An BS and Jeung EB: Spatial expression of claudin family members in various organs of mice. Mol Med Rep 9: 1806-1812, 2014.
APA
Hwang, I., Yang, H., Kang, H., Ahn, C., Lee, G., Hong, E. ... Jeung, E. (2014). Spatial expression of claudin family members in various organs of mice. Molecular Medicine Reports, 9, 1806-1812. https://doi.org/10.3892/mmr.2014.2031
MLA
Hwang, I., Yang, H., Kang, H., Ahn, C., Lee, G., Hong, E., An, B., Jeung, E."Spatial expression of claudin family members in various organs of mice". Molecular Medicine Reports 9.5 (2014): 1806-1812.
Chicago
Hwang, I., Yang, H., Kang, H., Ahn, C., Lee, G., Hong, E., An, B., Jeung, E."Spatial expression of claudin family members in various organs of mice". Molecular Medicine Reports 9, no. 5 (2014): 1806-1812. https://doi.org/10.3892/mmr.2014.2031
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang I, Yang H, Kang HS, Ahn CH, Lee GS, Hong EJ, An BS and Jeung EB: Spatial expression of claudin family members in various organs of mice. Mol Med Rep 9: 1806-1812, 2014.
APA
Hwang, I., Yang, H., Kang, H., Ahn, C., Lee, G., Hong, E. ... Jeung, E. (2014). Spatial expression of claudin family members in various organs of mice. Molecular Medicine Reports, 9, 1806-1812. https://doi.org/10.3892/mmr.2014.2031
MLA
Hwang, I., Yang, H., Kang, H., Ahn, C., Lee, G., Hong, E., An, B., Jeung, E."Spatial expression of claudin family members in various organs of mice". Molecular Medicine Reports 9.5 (2014): 1806-1812.
Chicago
Hwang, I., Yang, H., Kang, H., Ahn, C., Lee, G., Hong, E., An, B., Jeung, E."Spatial expression of claudin family members in various organs of mice". Molecular Medicine Reports 9, no. 5 (2014): 1806-1812. https://doi.org/10.3892/mmr.2014.2031
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