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Article

IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways

Retraction in: /10.3892/mmr.2022.12868
  • Authors:
    • Honglei Yin
    • Peicheng Li
    • Fudong Hu
    • Yakun Wang
    • Xiaoyan Chai
    • Yan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology Ward 1, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. China, Department of Cardiology Ward 1, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. China
  • Pages: 1834-1838
    |
    Published online on: March 14, 2014
       https://doi.org/10.3892/mmr.2014.2051
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Abstract

The inflammatory response has adverse effects on left ventricular (LV) function and remodeling post-myocardial infarction (MI). Interleukin (IL)-33 is considered to have anti-inflammatory properties. The present study examined whether the suppression of inflammation with IL-33 was able to attenuate LV dysfunction and remodeling post-MI. The MI model was induced and the mice were treated with either saline or recombinant IL-33. Inflammatory mediators, LV functional changes and structural remodeling were evaluated. IL-33 significantly suppressed macrophage infiltration and the production of inflammatory cytokines in the myocardium. IL-33 treatment significantly improved LV function, reduced infarct size and infarct wall thinning. MI-induced activation of the p38 mitogen-activated protein kinase (p38 MAPK) and nuclear factor-κB (NF-κB) pathways was also suppressed. Our data demonstrated that IL-33 suppresses inflammatory responses and improved LV function and remodeling by inhibiting the p38 MAPK and NF-κB pathways. IL-33 may be a potential therapeutic target for heart dysfunction post-MI.
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1 

Binsalamah ZM, Paul A, Prakash S and Shum-Tim D: Nanomedicine in cardiovascular therapy: recent advancements. Expert Rev Cardiovasc Ther. 10:805–815. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Dhalla NS, Rangi S, Babick AP, Zieroth S and Elimban V: Cardiac remodeling and subcellular defects in heart failure due to myocardial infarction and aging. Heart Fail Rev. 17:671–681. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Nagai T and Komuro I: Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function. Am J Physiol Heart Circ Physiol. 303:H501–H512. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Timmers L, Sluijter JP, van Keulen JK, et al: Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res. 102:257–264. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Tao ZY, Cavasin MA, Yang F, Liu YH and Yang XP: Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice. Life Sci. 74:1561–1572. 2004. View Article : Google Scholar

6 

de Faire U and Frostegård J: Natural antibodies against phosphorylcholine in cardiovascular disease. Ann NY Acad Sci. 1173:292–300. 2009.PubMed/NCBI

7 

Sun M, Dawood F, Wen WH, et al: Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction. Circulation. 110:3221–3228. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Turner NA: Therapeutic regulation of cardiac fibroblast function: targeting stress-activated protein kinase pathways. Future Cardiol. 7:673–691. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Taube A, Schlich R, Sell H, Eckardt K and Eckel J: Inflammation and metabolic dysfunction: links to cardiovascular diseases. Am J Physiol Heart Circ Physiol. 302:H2148–H2165. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Kunes P, Holubcova Z, Kolackova M and Krejsek J: Interleukin-33, a novel member of the IL-1/IL-18 cytokine family, in cardiology and cardiac surgery. Thorac Cardiovasc Surg. 58:443–449. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Milovanovic M, Volarevic V, Radosavljevic G, et al: IL-33/ST2 axis in inflammation and immunopathology. Immunol Res. 52:89–99. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Ohno T, Morita H, Arae K, Matsumoto K and Nakae S: Interleukin-33 in allergy. Allergy. 67:1203–1214. 2012. View Article : Google Scholar

13 

Miller AM, Xu D, Asquith DL, et al: IL-33 reduces the development of atherosclerosis. J Exp Med. 205:339–346. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Krishnamurthy P, Subramanian V, Singh M and Singh K: Deficiency of beta1 integrins results in increased myocardial dysfunction after myocardial infarction. Heart. 92:1309–1315. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Hayashidani S, Tsutsui H, Ikeuchi M, et al: Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction. Am J Physiol Heart Circ Physiol. 285:H1229–H1235. 2003.PubMed/NCBI

16 

Subramanian V, Krishnamurthy P, Singh K and Singh M: Lack of osteopontin improves cardiac function in streptozotocin-induced diabetic mice. Am J Physiol Heart Circ Physiol. 292:H673–H683. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Ii M, Nishimura H, Iwakura A, et al: Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via ‘imported’ nitric oxide synthase activity. Circulation. 111:1114–1120. 2005.PubMed/NCBI

18 

Paulus WJ: Cytokines and heart failure. Heart Fail Monit. 1:50–56. 2000.

19 

McKinsey TA: Targeting inflammation in heart failure with histone deacetylase inhibitors. Mol Med. 17:434–441. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Rui T, Zhang J, Xu X, Yao Y, Kao R and Martin CM: Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus. Cardiovasc Res. 94:370–378. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Zhang HF, Xie SL, Chen YX, et al: Altered serum levels of IL-33 in patients with advanced systolic chronic heart failure: correlation with oxidative stress. J Transl Med. 10:1202012. View Article : Google Scholar : PubMed/NCBI

22 

Aukrust P, Yndestad A, Damås JK and Gullestad L: Inflammation and chronic heart failure-potential therapeutic role of intravenous immunoglobulin. Autoimmun Rev. 3:221–227. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Suzuki K, Murtuza B, Smolenski RT, et al: Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation. 104:I308–I313. 2001. View Article : Google Scholar

24 

Wang M, Tsai BM, Turrentine MW, Mahomed Y, Brown JW and Meldrum DR: p38 mitogen activated protein kinase mediates both death signaling and functional depression in the heart. Ann Thorac Surg. 80:2235–2241. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Li Z, Ma JY, Kerr I, et al: Selective inhibition of p38alpha MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury. Am J Physiol Heart Circ Physiol. 291:H1972–H1977. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Ling H, Gray CB, Zambon AC, et al: Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB. Circ Res. 112:935–944. 2013.

27 

Kim YS, Kim JS, Kwon JS, et al: BAY 11-7082, a nuclear factor-κB inhibitor, reduces inflammation and apoptosis in a rat cardiac ischemia-reperfusion injury model. Int Heart J. 51:348–353. 2010.

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Copy and paste a formatted citation
Spandidos Publications style
Yin H, Li P, Hu F, Wang Y, Chai X and Zhang Y: IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868. Mol Med Rep 9: 1834-1838, 2014.
APA
Yin, H., Li, P., Hu, F., Wang, Y., Chai, X., & Zhang, Y. (2014). IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868. Molecular Medicine Reports, 9, 1834-1838. https://doi.org/10.3892/mmr.2014.2051
MLA
Yin, H., Li, P., Hu, F., Wang, Y., Chai, X., Zhang, Y."IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868". Molecular Medicine Reports 9.5 (2014): 1834-1838.
Chicago
Yin, H., Li, P., Hu, F., Wang, Y., Chai, X., Zhang, Y."IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868". Molecular Medicine Reports 9, no. 5 (2014): 1834-1838. https://doi.org/10.3892/mmr.2014.2051
Copy and paste a formatted citation
x
Spandidos Publications style
Yin H, Li P, Hu F, Wang Y, Chai X and Zhang Y: IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868. Mol Med Rep 9: 1834-1838, 2014.
APA
Yin, H., Li, P., Hu, F., Wang, Y., Chai, X., & Zhang, Y. (2014). IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868. Molecular Medicine Reports, 9, 1834-1838. https://doi.org/10.3892/mmr.2014.2051
MLA
Yin, H., Li, P., Hu, F., Wang, Y., Chai, X., Zhang, Y."IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868". Molecular Medicine Reports 9.5 (2014): 1834-1838.
Chicago
Yin, H., Li, P., Hu, F., Wang, Y., Chai, X., Zhang, Y."IL-33 attenuates cardiac remodeling following myocardial infarction via inhibition of the p38 MAPK and NF-κB pathways Retraction in /10.3892/mmr.2022.12868". Molecular Medicine Reports 9, no. 5 (2014): 1834-1838. https://doi.org/10.3892/mmr.2014.2051
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