Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2014 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2014 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism

  • Authors:
    • Qiong Yang
    • Kan Yang
    • Anying Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
  • Pages: 2213-2220
    |
    Published online on: March 24, 2014
       https://doi.org/10.3892/mmr.2014.2068
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Myocardial tissue injury caused by ischemia and hypoxia is a major cause of fatal diseases, including coronary atherosclerosis resulting from myocardial infarction and stroke. A number of microRNAs have been demonstrated to function as protectors against ischemia‑reperfusion (I/R) and/or hypoxia‑reperfusion (H/R)‑induced myocardial injury, including microRNA‑21 (miR‑21). However, the protective mechanism of miR‑21 has not been fully elucidated. The present study demonstrated that miR‑21 had an anti‑apoptotic role in I/R‑induced myocardial damage in vivo and in H/R‑induced H9C2 cell death in vitro. Of note, the present study indicates that a common molecular mechanism is likely to exist in I/R‑ and H/R‑induced cardiocyte apoptosis. During I/R and H/R, forced expression of miR‑21 upregulated the Akt signaling activity via suppressing the expression of phosphatase and tensin homolog (PTEN) and the increased activity of Akt signaling further inhibited apoptosis partially by increasing the ratio of B‑cell lymphoma 2(Bcl‑2)/Bcl‑2‑associated X protein, which further suppressed the expression of caspase‑3. In conclusion, to the best of our knowledge, it was shown for the first time that miR‑21 had a protective role in I/R‑ and H/R‑induced cardiocyte apoptosis via the PTEN/Akt‑dependent mechanism. The present study indicates that miR‑21 may be a promising agent for the treatment of I/R and H/R‑induced myocardial injury.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ganguly R, Lytwyn MS and Pierce GN: Differential effects of trans and polyunsaturated fatty acids on ischemia/reperfusion injury and its associated cardiovascular disease states. Curr Pharm Des. Apr 10–2013.(Epub ahead of print).

2 

Kalogeris T, Baines CP, Krenz M and Korthuis RJ: Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 298:229–317. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Xu T, Li D and Jiang D: Targeting cell signaling and apoptotic pathways by luteolin: cardioprotective role in rat cardiomyocytes following ischemia/reperfusion. Nutrients. 4:2008–2019. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Guo W, Kan JT, Cheng ZY, et al: Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxid Med Cell Longev. 2012:8780522012.PubMed/NCBI

5 

Ha T, Liu L, Kelley J, Kao R, Williams D and Li C: Toll-like receptors: new players in myocardial ischemia/reperfusion injury. Antioxid Redox Signal. 15:1875–1893. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Young RW: Hyperoxia: a review of the risks and benefits in adult cardiac surgery. J Extra Corpor Technol. 44:241–249. 2012.PubMed/NCBI

7 

Nagai T, Anzai T, Kaneko H, et al: Impact of systemic acidosis on the development of malignant ventricular arrhythmias after reperfusion therapy for ST-elevation myocardial infarction. Circ J. 74:1808–1814. 2010. View Article : Google Scholar

8 

Porrello ER: microRNAs in cardiac development and regeneration. Clin Sci (Lond). 125:151–166. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Chen LJ, Lim SH, Yeh YT, Lien SC and Chiu JJ: Roles of microRNAs in atherosclerosis and restenosis. J Biomed Sci. 19:792012. View Article : Google Scholar : PubMed/NCBI

10 

Zhu H and Fan GC: Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovasc Res. 94:284–292. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Yang KC, Ku YC, Lovett M and Nerbonne JM: Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3Kalpha signaling in cardiac hypertrophy. J Mol Cell Cardiol. 53:101–112. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Cheng Y and Zhang C: MicroRNA-21 in cardiovascular disease. J Cardiovasc Transl Res. 3:251–255. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Hers I, Vincent EE and Tavare JM: Akt signalling in health and disease. Cell Signal. 23:1515–1527. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Tomek M, Akiyama T and Dass CR: Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy. J Pharm Pharmacol. 64:1695–1702. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Zakeri Z and Lockshin RA: Cell death: history and future. Adv Exp Med Biol. 615:1–11. 2008. View Article : Google Scholar

16 

Cheng Y, Ji R, Yue J, et al: MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol. 170:1831–1840. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Qin Y, Yu Y, Dong H, Bian X, Guo X and Dong S: MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis. Int J Med Sci. 9:413–423. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Sayed D, He M, Hong C, et al: MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem. 285:20281–20290. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Cheng Y, Liu X, Zhang S, Lin Y, Yang J and Zhang C: MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4. J Mol Cell Cardiol. 47:5–14. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Liu CZ, Liu W, Zheng Y, et al: PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma. Chin Med Sci J. 27:65–72. 2012.PubMed/NCBI

21 

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 133:647–658. 2007. View Article : Google Scholar : PubMed/NCBI

22 

McCubrey JA, Steelman LS, Chappell WH, et al: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget. 3:1068–1111. 2012.PubMed/NCBI

23 

Tang Y and Wang MH: MicroRNA-21 protects cardiomyocytes from tumor necrosis factor-alpha induced apoptosis in vitro via modulating PTEN/AKT/FOXO3a pathway. Chinese Journal of Cardiovascular Diseases. 41:135–142. 2013.(In Chinese).

24 

Ma YX, Guo Z and Sun T: CGRP inhibits norepinephrine induced apoptosis with restoration of Bcl-2/Bax in cultured cardiomyocytes of rat. Neurosci Lett. 549:130–134. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Xu XP, Zhai D, Kim E, et al: Three-dimensional structure of Bax-mediated pores in membrane bilayers. Cell Death Dis. 4:e6832013. View Article : Google Scholar : PubMed/NCBI

26 

Walensky LD and Gavathiotis E: BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. Trends Biochem Sci. 36:642–652. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Renault TT and Manon S: Bax: Addressed to kill. Biochimie. 93:1379–1391. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Fiandalo MV and Kyprianou N: Caspase control: protagonists of cancer cell apoptosis. Exp Oncol. 34:165–175. 2012.PubMed/NCBI

29 

Snigdha S, Smith ED, Prieto GA and Cotman CW: Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull. 28:14–24. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Poreba M, Strózyk A, Salvesen GS and Drag M: Caspase substrates and inhibitors. Cold Spring Harb Perspect Biol. 5:a0086802013. View Article : Google Scholar : PubMed/NCBI

31 

Kale J, Liu Q, Leber B and Andrews DW: Shedding light on apoptosis at subcellular membranes. Cell. 151:1179–1184. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang Q, Yang K and Li A: microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism. Mol Med Rep 9: 2213-2220, 2014.
APA
Yang, Q., Yang, K., & Li, A. (2014). microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism. Molecular Medicine Reports, 9, 2213-2220. https://doi.org/10.3892/mmr.2014.2068
MLA
Yang, Q., Yang, K., Li, A."microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism". Molecular Medicine Reports 9.6 (2014): 2213-2220.
Chicago
Yang, Q., Yang, K., Li, A."microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism". Molecular Medicine Reports 9, no. 6 (2014): 2213-2220. https://doi.org/10.3892/mmr.2014.2068
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Q, Yang K and Li A: microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism. Mol Med Rep 9: 2213-2220, 2014.
APA
Yang, Q., Yang, K., & Li, A. (2014). microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism. Molecular Medicine Reports, 9, 2213-2220. https://doi.org/10.3892/mmr.2014.2068
MLA
Yang, Q., Yang, K., Li, A."microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism". Molecular Medicine Reports 9.6 (2014): 2213-2220.
Chicago
Yang, Q., Yang, K., Li, A."microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism". Molecular Medicine Reports 9, no. 6 (2014): 2213-2220. https://doi.org/10.3892/mmr.2014.2068
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team