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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June-2014 Volume 9 Issue 6

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Association of glycogen synthase kinase‑3β with Parkinson's disease (Review)

Da‑Wei Li, Zhi‑Qiang Liu, Wei Chen, Min Yao, Guang‑Ren Li
Pages: 2043-2050
Published online on: 28 March 2014

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Review

Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (Review)

Chen Liang, Ying-Yi Li
Pages: 2051-2060
Published online on: 11 April 2014

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Article Open Access

Effect of gender differences on the regulation of renal ischemia‑reperfusion‑induced inflammation in mice

Kyung Pyo Kang, Jung Eun Lee, Ae Sin Lee, Yu Jin Jung, Dal Kim, Sik Lee, Hong Pil Hwang, Won Kim, Sung Kwang Park
Pages: 2061-2068
Published online on: 28 March 2014

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Article Open Access

Enhanced efficacy of combination therapy with adeno‑associated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma

Sha-Sha He, Qin-Jie Wu, Chang Yang Gong, Shun-Tao Luo, Shuang Zhang, Meng Li, Lian Lu, Yu-Quan Wei, Li Yang
Pages: 2069-2076
Published online on: 04 April 2014

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Article Open Access

Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation

Yung‑Luen Yu, Giou‑Teng Yiang, Pei‑Lun Chou, Hsu‑Hung Tseng, Tsai‑Kun Wu, Yu‑Ting Hung, Pei‑Shiuan Lin, Shu‑Yu Lin, Hsiao‑Chun Liu, Wei‑Jung Chang, Chyou‑Wei Wei
Pages: 2077-2084
Published online on: 28 March 2014

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Article

MicroRNA‑518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus

Chun Zhao, Ting Zhang, Zhonghua Shi, Hongjuan Ding, Xiufeng Ling
Pages: 2085-2090
Published online on: 17 March 2014

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Article

Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model

Zhi Chen, Qingge Fu, Baoliang Shen, Xuan Huang, Kun Wang, Ping He, Fengning Li, Fan Zhang, Hongxing Shen
Pages: 2091-2096
Published online on: 08 April 2014

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Article Open Access

Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis

Si Qin, Ju Wen, Xiao-Chun Bai, Tian-Yu Chen, Rong-Chang Zheng, Gui‑Bin Zhou, Jing Ma, Jie-Ying Feng, Bi-Ling Zhong, Yi-Ming Li
Pages: 2097-2104
Published online on: 09 April 2014

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Article Open Access

Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma

Xuanwei Wang, Jingyu Du, Pengcheng Gu, Rilong Jin, Xiangjin Lin
Pages: 2105-2110
Published online on: 02 April 2014

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Article Open Access

Identification of differentially expressed genes involved in transient regeneration of the neonatal C57BL/6J mouse heart by digital gene expression profiling

Ming Liu, Jin‑Gai Zhu, Zhang‑Bin Yu, Gui‑Xian Song, Ya‑Hui Shen, Yao‑Qiu Liu, Chun Zhu, Ling‑Mei Qian
Pages: 2111-2116
Published online on: 02 April 2014

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Article Open Access

Enrichment and characterization of cancer stem‑like cells from a cervical cancer cell line

Li Wang, Huijie Guo, Caiyu Lin, Liuqi Yang, Xiujie Wang
Pages: 2117-2123
Published online on: 20 March 2014

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Article Open Access

Preconditioned hyperbaric oxygenation protects skin flap grafts in rats against ischemia/reperfusion injury

Nan Kang, Yong Hai, Fang Liang, Chun‑Jin Gao, Xue‑Hua Liu
Pages: 2124-2130
Published online on: 24 March 2014

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Article Open Access

Astragaloside Ⅳ reduces the expression level of P‑glycoprotein in multidrug‑resistant human hepatic cancer cell lines

Pei‑Pei Wang, Du‑Juan Xu, Can Huang, Wei‑Ping Wang, Wen‑Ke Xu
Pages: 2131-2137
Published online on: 27 March 2014

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Article Open Access

Correlation of CTGF gene promoter methylation with CTGF expression in type 2 diabetes mellitus with or without nephropathy

Hao Zhang, Xu Cai, Bin Yi, Jing Huang, Jianwen Wang, Jian Sun
Pages: 2138-2144
Published online on: 24 March 2014

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Article Open Access

β-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/β-catenin signaling inhibits hepatic stellate cell activation

Wen-Song Ge, Yao-Jun Wang, Jian-Xin Wu, Jian-Gao Fan, Ying-Wei Chen, Liang Zhu
Pages: 2145-2151
Published online on: 01 April 2014

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Article Open Access

Highly efficient release of simvastatin from simvastatin‑loaded calcium sulphate scaffolds enhances segmental bone regeneration in rabbits

Xin Huang, Zhongming Huang, Weixu Li
Pages: 2152-2158
Published online on: 01 April 2014

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Article

Invadopodia are essential in transurothelial invasion during the muscle invasion of bladder cancer cells

Kengo Imanishi, Mihoko Sutoh Yoneyama, Shingo Hatakeyama, Hayato Yamamoto, Takuya Koie, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Toshiya Nakamura, Chikara Ohyama, Shigeru Tsuboi
Pages: 2159-2165
Published online on: 03 April 2014

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Article Open Access

Autophagy in human articular chondrocytes is cytoprotective following glucocorticoid stimulation

Ning Liu, Wenbo Wang, Zhe Zhao, Tao Zhang, Yuwen Song
Pages: 2166-2172
Published online on: 01 April 2014

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Article Open Access

Gene silencing of NOB1 by lentivirus suppresses growth and migration of human osteosarcoma cells Corrigendum in /10.3892/mmr.2022.12909

Bingpeng Chen, Jingjing Liu, Dankai Wu, Yanguo Qin, Chuangang Peng, Chen Li, Jincheng Wang
Pages: 2173-2179
Published online on: 04 April 2014

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Article Open Access

Angiotensin-(1-7) and angiotensin Ⅱ induce the transdifferentiation of human endometrial epithelial cells in vitro

Tieying Shan, Lei Zhang, Chunfang Zhao, Wei Chen, Yanan Zhang, Guiying Li
Pages: 2180-2186
Published online on: 09 April 2014

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Article

A novel mild variant of osteogenesis imperfecta type I caused by a Gly1088Glu mutation in COL1A1

Xin‑Yi Xia, Wei‑Wei Li, Na Li, Qiu‑Yue Wu, Ying‑Xia Cui, Xiao‑Jun Li
Pages: 2187-2190
Published online on: 28 March 2014

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Article

Spectroscopic investigations of the interaction of the anti‑hypertension drug valsartan with human serum albumin

Jian Jing, Xin Qu, Zhi Tu, Chenhoo Zheng, Zhicheng Zheng
Pages: 2191-2196
Published online on: 09 April 2014

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Article

Resveratrol protects primary cortical neuron cultures from transient oxygen‑glucose deprivation by inhibiting MMP‑9

Dakuan Gao, Tao Huang, Xiaofan Jiang, Shijie Hu, Lei Zhang, Zhou Fei
Pages: 2197-2204
Published online on: 28 March 2014

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Article Open Access

Module-based functional pathway enrichment analysis of a protein‑protein interaction network to study the effects of intestinal microbiota depletion in mice

Zhen‑Yi Jia, Yang Xia, Danian Tong, Jing Yao, Hong‑Qi Chen, Jun Yang
Pages: 2205-2212
Published online on: 09 April 2014

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Article

microRNA‑21 protects against ischemia‑reperfusion and hypoxia‑reperfusion‑induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt‑dependent mechanism

Qiong Yang, Kan Yang, Anying Li
Pages: 2213-2220
Published online on: 24 March 2014

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Article

Protective effect of fluvastatin on influenza virus infection

Jing Peng, Dingmei Zhang, Yu Ma, Guoling Wang, Zhongmin Guo, Jiahai Lu
Pages: 2221-2226
Published online on: 27 March 2014

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Article

Nicorandil attenuates endothelial VCAM‑1 expression via thioredoxin production in diabetic rats induced by streptozotocin

Lihua Liu, Yun Liu, Benling Qi, Qinqin Wu, Yuanyuan Li, Zhaohui Wang
Pages: 2227-2232
Published online on: 24 March 2014

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Article

Receptors of the Notch signaling pathway are associated with hemorrhage of brain arteriovenous malformations

Shu Li, Rong Wang, Yajie Wang, Haowen Li, Jian Zheng, Ran Duan, Jizong Zhao
Pages: 2233-2238
Published online on: 18 March 2014

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Article

Construction and characterization of a Vibrio cholerae serogroup O139 vaccine candidate by genetic engineering

Cancan Cheng, Yanyan Zhou, Biao Kan, Qian Wang, Yongyu Rui
Pages: 2239-2244
Published online on: 24 March 2014

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Article

Exogenous IL-10 induces corneal transplantation immune tolerance by a mechanism associated with the altered Th1/Th2 cytokine ratio and the increased expression of TGF-β

Bing Li, Lihua Tian, Yumei Diao, Xue Li, Liying Zhao, Xuefeng Wang
Pages: 2245-2250
Published online on: 27 March 2014

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Article

Effect of metformin on apoptosis, cell cycle arrest migration and invasion of A498 cells

Zhiqing Fang, Xiulian Xu, Zunlin Zhou, Zhonghua Xu, Zhaoxu Liu
Pages: 2251-2256
Published online on: 31 March 2014

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Article

Genetic alterations following ionizing radiation in human ovarian cancer‑derived endothelial cells

Ting Liu, Xuelian Du, Xiugui Sheng
Pages: 2257-2264
Published online on: 31 March 2014

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Article

Paris saponin I induces apoptosis via increasing the Bax/Bcl‑2 ratio and caspase‑3 expression in gefitinib‑resistant non‑small cell lung cancer in vitro and in vivo

Hao Jiang, Peng‑Jun Zhao, Dan Su, Jianguo Feng, Sheng‑Lin Ma
Pages: 2265-2272
Published online on: 02 April 2014

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Article

Safety assessment of So‑cheong‑ryong‑tang: Subchronic toxicity study in Crl:CD Sprague Dawley rats

Mee‑Young Lee, Chang‑Seob Seo, Shin‑Woo Cha, Hyeun‑Kyoo Shin
Pages: 2273-2282
Published online on: 03 April 2014

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Article

Novel tumor-suppressor gene epidermal growth factor‑containing fibulin‑like extracellular matrix protein 1 is epigenetically silenced and associated with invasion and metastasis in human gastric cancer

Xin-Jiang Zhu, Jian Liu, Xiao-Yang Xu, Chun-Dong Zhang, Dong-Qiu Dai
Pages: 2283-2292
Published online on: 09 April 2014

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Article

Intraperitoneal administration of the globular adiponectin gene ameliorates diabetic nephropathy in Wistar rats

Fang Yuan, Ying‑Hong Liu, Fu‑You Liu, You‑Ming Peng, Jun‑Wei Tian
Pages: 2293-2300
Published online on: 09 April 2014

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Article

Induced production of anti-etanercept antibody in collagen-induced arthritis

Hyoju Yi, Juryun Kim, Hyerin Jung, Yeri Alice Rim, Youngkyun Kim, Seung Min Jung, Sung-Hwan Park, Ji Hyeon Ju
Pages: 2301-2308
Published online on: 09 April 2014

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Article

Autophagy may protect MC3T3-E1 cells from fluoride-induced apoptosis

Min Wei, Dongmei Duan, Yujie Liu, Zhigang Wang, Zhongli Li
Pages: 2309-2315
Published online on: 28 March 2014

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Article

Signal tranducers and activators of transcription: Expression and function in anti‑neutrophil cytoplasmic antibody‑associated vasculitis

Benjamin Wilde, André Hoerning, Andreas Kribben, Oliver Witzke, Sebastian Dolff
Pages: 2316-2320
Published online on: 20 March 2014

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Article

Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells

Jianmei Wan, Shitao Zou, Mengshang Hu, Ran Zhu, Jiaying Xu, Yang Jiao, Saijun Fan
Pages: 2321-2327
Published online on: 28 March 2014

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Article

Evaluation of the effect of static magnetic fields combined with human hepatocyte growth factor on human satellite cell cultures

Richard Birk, Ulrich Sommer, Anne Faber, Christoph Aderhold, Johannes  D. Schulz, Karl Hörmann, Ulrich Reinhart Goessler, Jens Stern-Straeter
Pages: 2328-2334
Published online on: 28 March 2014

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Article

Expression of hormone receptors, Bcl‑2, Cox‑2 and Ki67 in benign endometrial polyps and their association with obesity

Anderson Pinheiro, Armando Antunes, Liliana Andrade, Louise De Brot, Aarão Mendes Pinto‑Neto, Lúcia Costa‑Paiva
Pages: 2335-2341
Published online on: 09 April 2014

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Article

Screening of hepatocyte proteins binding with the middle surface protein of the hepatitis B virus by the yeast two‑hybrid system

Zhiqun Li, Enqiang Linghu, Jun Cheng
Pages: 2342-2346
Published online on: 24 March 2014

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Article

TPX2 regulates tumor growth in human cervical carcinoma cells

Peiyue Jiang, Kexin Shen, Xuerui Wang, Haiqin Song, Ying Yue, Tongjun Liu
Pages: 2347-2351
Published online on: 02 April 2014

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Article

Effects of alcohol on intestinal epithelial barrier permeability and expression of tight junction‑associated proteins

Ying Wang, Jing Tong, Bing Chang, Baifang Wang, Dai Zhang, Bingyuan Wang
Pages: 2352-2356
Published online on: 09 April 2014

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Article

Y-27632 inhibits ethanol-induced increase in intestinal epithelial barrier permeability

Jing Tong, Ying Wang, Bing Chang, Dai Zhang, Bingyuan Wang
Pages: 2357-2361
Published online on: 18 March 2014

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Article

α‑spinasterol from Melandrium firmum attenuates benign prostatic hyperplasia in a rat model

Mee‑Young Lee, In‑Sik Shin, Hwangbo Kyoung, Chang‑Seob  Seo, Jong-Keun Son, Hyeun‑Kyoo Shin
Pages: 2362-2366
Published online on: 28 March 2014

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Article

Decreased expression of Dkk1 and Dkk3 in human clear cell renal cell carcinoma

Chang‑Cheng Guo, Xiao‑Long Zhang, Bin Yang, Jiang  Geng, Bo Peng, Jun‑Hua Zheng
Pages: 2367-2373
Published online on: 27 March 2014

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Article

B‑cell translocation 1 gene inhibits cellular metastasis‑associated behavior in breast cancer

Wei Li, Shi‑Tao Zou, Ran Zhu, Jian‑Mei Wan, Yan Xu, Hao‑Rong Wu
Pages: 2374-2380
Published online on: 04 April 2014

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Article

Fuzheng Qingjie recipe induces apoptosis in HepG2 cells via P38 MAPK activation and the mitochondria-dependent apoptotic pathway

Xu-Zheng Chen, Jin-Nong Li, You-Quan Zhang, Zhi-Yun Cao, Zhi‑Zhen Liu, Su-Qing Wang, Lian-Ming Liao, Jian Du
Pages: 2381-2387
Published online on: 11 April 2014

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Article

Expression of mammalian target of rapamycin in atherosclerotic plaques is decreased under diabetic conditions: A mechanism for rapamycin resistance

Yan Zhang, Qiang Wang, Dachun Yang, De Li, Bing Tang, Yongjian Yang, Shuangtao Ma
Pages: 2388-2392
Published online on: 11 April 2014

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Article

miR‑22 inhibits proliferation and invasion in estrogen receptor α-positive endometrial endometrioid carcinomas cells Retraction in /10.3892/mmr.2021.12280

Shaoru Li, Ruili Hu, Chuanhong Wang, Fang Guo, Xiaoli Li, Shijin Wang
Pages: 2393-2399
Published online on: 08 April 2014

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Article

Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells

Yu‑Qi Wang, Wei‑Min Dai, Xiang‑Yang Chu, Bo Yang, Ming Zhao, Yu'e Sun
Pages: 2400-2404
Published online on: 27 March 2014

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Article

Selective β2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac

Hossein Mostafavi, Mojtaba Khaksarian, Mohammad Taghi Joghataei, Masoud Soleimani, Gholamreza Hassanzadeh, Sanaz Eftekhari, Mansooreh Soleimani, Kazem Mousavizadeh, Hajar Estiri, Sedighesadat Ahmadi, Mahmoud Reza Hadjighassem
Pages: 2405-2410
Published online on: 08 April 2014

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Article

Unc5D regulates p53‑dependent apoptosis in neuroblastoma cells

Hong Wang, Qiong Wu, Shuang Li, Bin Zhang, Zuofei Chi, Liangchun Hao
Pages: 2411-2416
Published online on: 01 April 2014

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Article

Antitumor activity of combination treatment with gefitinib and docetaxel in EGFR‑TKI‑sensitive, primary resistant and acquired resistant human non‑small cell lung cancer cells

Min Wu, Yuan Yuan, Yue‑Yin Pan, Ying Zhang
Pages: 2417-2422
Published online on: 28 March 2014

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Article

ERCC1 siRNA ameliorates drug resistance to cisplatin in gastric carcinoma cell lines

Wei Li, ZhiGang Jie, ZhengRong Li, Yi Liu, Quan Gan, YiQiu Mao, XueMin Wang
Pages: 2423-2428
Published online on: 03 April 2014

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Article

Baicalein pretreatment confers cardioprotection against acute myocardial infarction by activating the endothelial nitric oxide synthase signaling pathway and inhibiting oxidative stress

Shengyu Tan, Shenghua Zhou, Yingquan Luo
Pages: 2429-2434
Published online on: 28 March 2014

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Article

Post‑conditioning with sevoflurane induces heme oxygenase‑1 expression via the PI3K/Akt pathway in lipopolysaccharide‑induced acute lung injury

Shuangping Zhao, Jiao Wu, Lemeng Zhang, Yuhang Ai
Pages: 2435-2440
Published online on: 31 March 2014

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Article

Changes in mood states and salivary cortisol levels following two months of training in elite female water polo players

Donatella Di Corrado, Tiziano Agostini, Marco Bonifazi, Vincenzo Perciavalle
Pages: 2441-2446
Published online on: 04 April 2014

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Article

Cryptotanshinone inhibits lung tumorigenesis and induces apoptosis in cancer cells in vitro and in vivo

Liang Chen, Hui-Juan Wang, Wenli Xie, Yunyi Yao, Yan-Shan Zhang, Huiling Wang
Pages: 2447-2452
Published online on: 31 March 2014

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Article

Effect of the human SOD1‑G93A gene on the Nrf2/ARE signaling pathway in NSC‑34 cells

Fumin Wang, Yucheng Lu, Faying Qi, Quanping Su, Long  Wang, Cuiping You, Fengyuan Che, Jixu Yu
Pages: 2453-2458
Published online on: 28 March 2014

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Article

Association between common genetic variants of α2A-, α2B‑ and α2C-adrenoceptors and the risk of silent brain infarction

Jung O Kim, Young Joo Jeon, Ok Joon Kim, Seung Hun Oh, Hyun Sook Kim, Byoung Soo Shin, Doyeun Oh, Eo Jin Kim, Yun Kyung Cho, Nam Keun Kim
Pages: 2459-2466
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Inhibition of the endogenous CSE/H2S system contributes to hypoxia and serum deprivation‑induced apoptosis in mesenchymal stem cells

Congsheng Li, Zeng Guo, Birong Guo, Yangjing Xie, Jing Yang, Ailing Wang
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Expression of integrin β1 and its significance in squamous cell carcinoma of the cervix

Ping Zhan, Ling Liu, Bin Liu, Xi‑Guang Mao
Pages: 2473-2478
Published online on: 09 April 2014

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Rapid screening for sickle cell disease by polymerase chain reaction-high resolution melting analysis

Liang Yue, Min Lin, Jiang-Tao Chen, Xiao-Fen Zhan, De-Shang Zhong, Santiago-M. Monte-Nguba, Pei-Fen Liu, Xue-Fen Pan, Jiang-Hua Huang, Xi Wang, Juan Carlos Salas Ehapo, Urbano Monsuy Eyi, Hui-Tian Yang, Li-Ye Yang
Pages: 2479-2484
Published online on: 09 April 2014

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Opposite effects of the gap junction blocker octanol on focal cerebral ischemia occluded for different durations

Wenting Ding, Lequan Zhou, Wei Liu, Li Guan, Xiaoying Li, Haimei  Liu, Fuman Yan, Jinwen Xu, Weiyong Zeng, Min Qiu
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Published online on: 27 March 2014

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microRNA-133b downregulation and inhibition of cell proliferation, migration and invasion by targeting matrix metallopeptidase‑9 in renal cell carcinoma

Deyao Wu, Huixing Pan, Yunfeng Zhou, Jian Zhou, Yuanfeng Fan, Ping Qu
Pages: 2491-2498
Published online on: 04 April 2014

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Silencing of cyclooxygenase‑2 inhibits the growth, invasion and migration of ovarian cancer cells

Yang Lin, Manhua Cui, Tianmin Xu, Wei Yu, Lihui Zhang
Pages: 2499-2504
Published online on: 09 April 2014

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Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2

Ling Liu, Jingkai Zhang, Meiling Li, Xiaohong Zhang, Jinlu Zhang, Zhenjing Li, Likui Wang, Jihui Wu, Cheng Luo
Pages: 2505-2511
Published online on: 17 March 2014

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ABCG5/8 variants are associated with susceptibility to coronary heart disease

Ge Wu, Gui-Bin Li, Ming Yao, Dong-Qing Zhang, Bin Dai, Chuan-Jing Ju, Ming Han
Pages: 2512-2520
Published online on: 01 April 2014

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Effects of partial deletion of the wzm and wzt genes on lipopolysaccharide synthesis and virulence of Brucella abortus S19

Xiuran Wang, Lin Wang, Tiancheng Lu, Yanling Yang, Si  Chen, Rui Zhang, Xulong  Lang, Guangmou  Yan, Jing  Qian, Xiaoxu Wang, Lingyi Meng, Xinglong Wang
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Published online on: 02 April 2014

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Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart

Xiaoqiang Cong, Ying Li, Na Lu, Yajian Dai, Huijie Zhang, Xin Zhao, Ya Liu
Pages: 2528-2532
Published online on: 28 March 2014

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Ursolic acid suppresses growth and adrenocorticotrophic hormone secretion in AtT20 cells as a potential agent targeting adrenocorticotrophic hormone‑producing pituitary adenoma

Ying‑Ying Gong, Yuan‑Yuan Liu, Shuang Yu, Xiao‑Nan Zhu, Xiao‑Pei Cao, Hai‑Peng Xiao
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Published online on: 27 March 2014

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GPC5, a tumor suppressor, is regulated by miR‑620 in lung adenocarcinoma

Zhengyuan Zhao, Chengguang Han, Juntao Liu, Changlei Wang, Yi Wang, Liya Cheng
Pages: 2540-2546
Published online on: 28 March 2014

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Involvement of β‑catenin in matrine‑induced autophagy and apoptosis in WB‑F344 cells

Bu‑Shan Xie, Xing‑Xing He, Zheng‑Lin Ai, Shu‑Kun Yao
Pages: 2547-2553
Published online on: 02 April 2014

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Chronic leucine exposure results in reduced but reversible glucose-stimulated insulin secretion in INS-1 cells

Xiujuan Zhang, Wenxia Han, Xiuyun Jiang, Min Li, Ling Gao, Jia Jun Zhao
Pages: 2554-2558
Published online on: 08 April 2014

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Enhancement of transfection efficiency with NLS and SPB‑NLS

Jian Lin, Tao Qin, Li Qi Zhu, Qiang Zhang, Qing Hua Yu, Qian Yang
Pages: 2559-2567
Published online on: 08 April 2014

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Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells

María B. Pastrian, Fanny Guzmán, Juan Garona, Marina Pifano, Giselle V. Ripoll, Osvaldo Cascone, Graciela N. Ciccia, Fernando Albericio, Daniel E. Gómez, Daniel F. Alonso, Nancy B. Iannucci
Pages: 2568-2572
Published online on: 11 April 2014

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Neuroprotective effect of Atractylodes macrocephalaon polysaccharides in vitro on neuronal apoptosis induced by hypoxia

Wei‑Xu Hu, Qin Xiang, Zhu Wen, Dan He, Xiao‑Mu Wu, Guo‑Zhu Hu
Pages: 2573-2581
Published online on: 02 April 2014

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CDK3 expression and its clinical significance in human nasopharyngeal carcinoma

Liang Wang, Hong‑Yi Hu, Yi‑Ling Lin, Zhi‑Xiang Zhao, Lu Tan, Peng Yu, Hui‑Juan Wan, Zhe Jin, Duo Zheng
Pages: 2582-2586
Published online on: 31 March 2014

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MG132 reverse the malignant characteristics of hypopharyngeal cancer

Juke Ma, Liang Yu, Jiajun Tian, Yakui Mu, Zhenghua Lv, Jidong Zou, Jianfeng Li, Haibo Wang, Wei Xu
Pages: 2587-2591
Published online on: 01 April 2014

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Anti‑inflammatory effect of resveratrol on adjuvant arthritis rats with abnormal immunological function via the reduction of cyclooxygenase‑2 and prostaglandin E2

Xiaoyu Chen, Jinseng Lu, Mei An, Zhongfei Ma, Hexiang Zong, Jun Yang
Pages: 2592-2598
Published online on: 24 March 2014

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Melatonin reduces inflammation and recovers endogenous ghrelin in acute necrotizing pancreatitis in rats

Zhi‑Hai Liang, Meng‑Bin Qin, Guo‑Du Tang, Hui‑Ying Yang, Juan Su, Jie‑An Huang
Pages: 2599-2605
Published online on: 09 April 2014

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January-2026 Volume 33 Issue 1

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CiteScore: 8.5

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Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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