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Article

Protective effect of fluvastatin on influenza virus infection

  • Authors:
    • Jing Peng
    • Dingmei Zhang
    • Yu Ma
    • Guoling Wang
    • Zhongmin Guo
    • Jiahai Lu
  • View Affiliations / Copyright

    Affiliations: School of Public Health, State Ministry of Education, Key Laboratory of Tropical Diseases Control Research, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China, Haizhu Center for Disease Control and Prevention, Guangzhou, Guangdong 510288, P.R. China, Experimental Animal Center, Sun Yat‑sen University, Guangzhou, Guangdong 510080, PR China
  • Pages: 2221-2226
    |
    Published online on: March 27, 2014
       https://doi.org/10.3892/mmr.2014.2076
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Abstract

Statins are 3‑hydroxy‑3‑methylglutaryl coenzyme A reductase inhibitors and have pleiotropic effects. It has been suggested that statins may be a potential treatment during the next influenza pandemic. In a previous study we found that a statin/caffeine combination protects BALB/c mice against Influenza A, subtypes haemagglutinin type 5 and neuraminidase type 1 (H5N1), H3N2 and H1N1 infection. The effect of statins alone on influenza virus infection, however, is not known. In this study, it was investigated whether fluvastatin is capable of inhibiting influenza A virus replication in vitro. The results demonstrated that the synthesis of viral RNA and protein was affected by fluvastatin treatment. Virus production was markedly reduced when fluvastatin was administered simultaneously with the virus; however, a greater inhibition was observed when fluvastatin was added following viral adsorption. The selectivity index [SI; 50% cytotoxic concentration (CC50)/50% inhibition concentration (IC50)], however, was only 21. It was further demonstrated that fluvastatin protects host cells against influenza‑induced inflammation by reducing the production of tumour necrosis factor‑α, interleukin 8 and interferon γ. In conclusion, the results demonstrated that fluvastatin exerted a minor inhibitory effect on influenza virus infection, which involved anti‑inflammatory activities.
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Copy and paste a formatted citation
Spandidos Publications style
Peng J, Zhang D, Ma Y, Wang G, Guo Z and Lu J: Protective effect of fluvastatin on influenza virus infection. Mol Med Rep 9: 2221-2226, 2014.
APA
Peng, J., Zhang, D., Ma, Y., Wang, G., Guo, Z., & Lu, J. (2014). Protective effect of fluvastatin on influenza virus infection. Molecular Medicine Reports, 9, 2221-2226. https://doi.org/10.3892/mmr.2014.2076
MLA
Peng, J., Zhang, D., Ma, Y., Wang, G., Guo, Z., Lu, J."Protective effect of fluvastatin on influenza virus infection". Molecular Medicine Reports 9.6 (2014): 2221-2226.
Chicago
Peng, J., Zhang, D., Ma, Y., Wang, G., Guo, Z., Lu, J."Protective effect of fluvastatin on influenza virus infection". Molecular Medicine Reports 9, no. 6 (2014): 2221-2226. https://doi.org/10.3892/mmr.2014.2076
Copy and paste a formatted citation
x
Spandidos Publications style
Peng J, Zhang D, Ma Y, Wang G, Guo Z and Lu J: Protective effect of fluvastatin on influenza virus infection. Mol Med Rep 9: 2221-2226, 2014.
APA
Peng, J., Zhang, D., Ma, Y., Wang, G., Guo, Z., & Lu, J. (2014). Protective effect of fluvastatin on influenza virus infection. Molecular Medicine Reports, 9, 2221-2226. https://doi.org/10.3892/mmr.2014.2076
MLA
Peng, J., Zhang, D., Ma, Y., Wang, G., Guo, Z., Lu, J."Protective effect of fluvastatin on influenza virus infection". Molecular Medicine Reports 9.6 (2014): 2221-2226.
Chicago
Peng, J., Zhang, D., Ma, Y., Wang, G., Guo, Z., Lu, J."Protective effect of fluvastatin on influenza virus infection". Molecular Medicine Reports 9, no. 6 (2014): 2221-2226. https://doi.org/10.3892/mmr.2014.2076
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