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Article

Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart

  • Authors:
    • Xiaoqiang Cong
    • Ying Li
    • Na Lu
    • Yajian Dai
    • Huijie Zhang
    • Xin Zhao
    • Ya Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Bethune First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Emergency Internal Medicine, The People's Hospital of Jilin Province, Changchun, Jilin 130021, P.R. China, Department of Internal Medicine, The Friendship Hospital of Linjiang, Linjiang, Jilin 134600, P.R. China, Department of Nutrition and Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 2528-2532
    |
    Published online on: March 28, 2014
       https://doi.org/10.3892/mmr.2014.2090
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Abstract

The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor‑α (TNF‑α) induction in an ischemia/reperfusion‑injured rat heart model. The rats were randomly exposed to sham surgery, myocardial ischemia/reperfusion (MI/R) alone, MI/R + Res, MI/R + Res + L‑NG‑nitroarginine methyl ester (L‑NAME) and MI/R + Res + methylene blue (MB). The results demonstrated that compared with MI/R, Res reduced the myocardial infarct area, myocardial myeloperoxidase levels, serum creatinine kinase and lactate dehydrogenase levels, and serum and myocardial TNF‑α production. All the effects of Res demonstrated were inhibited by L‑NAME (a nitric oxide (NO) synthase inhibitor) and MB [a cyclic guanosine monophosphate (cGMP) inhibitor]. Thus, Res produces cardioprotective and anti‑inflammatory effects. These effects may be associated with an increase in NO production, the inhibition of neutrophil accumulation, TNF‑α induction and cGMP signaling pathways in myocardium subjected to MI/R.
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Copy and paste a formatted citation
Spandidos Publications style
Cong X, Li Y, Lu N, Dai Y, Zhang H, Zhao X and Liu Y: Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart. Mol Med Rep 9: 2528-2532, 2014.
APA
Cong, X., Li, Y., Lu, N., Dai, Y., Zhang, H., Zhao, X., & Liu, Y. (2014). Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart. Molecular Medicine Reports, 9, 2528-2532. https://doi.org/10.3892/mmr.2014.2090
MLA
Cong, X., Li, Y., Lu, N., Dai, Y., Zhang, H., Zhao, X., Liu, Y."Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart". Molecular Medicine Reports 9.6 (2014): 2528-2532.
Chicago
Cong, X., Li, Y., Lu, N., Dai, Y., Zhang, H., Zhao, X., Liu, Y."Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart". Molecular Medicine Reports 9, no. 6 (2014): 2528-2532. https://doi.org/10.3892/mmr.2014.2090
Copy and paste a formatted citation
x
Spandidos Publications style
Cong X, Li Y, Lu N, Dai Y, Zhang H, Zhao X and Liu Y: Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart. Mol Med Rep 9: 2528-2532, 2014.
APA
Cong, X., Li, Y., Lu, N., Dai, Y., Zhang, H., Zhao, X., & Liu, Y. (2014). Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart. Molecular Medicine Reports, 9, 2528-2532. https://doi.org/10.3892/mmr.2014.2090
MLA
Cong, X., Li, Y., Lu, N., Dai, Y., Zhang, H., Zhao, X., Liu, Y."Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart". Molecular Medicine Reports 9.6 (2014): 2528-2532.
Chicago
Cong, X., Li, Y., Lu, N., Dai, Y., Zhang, H., Zhao, X., Liu, Y."Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart". Molecular Medicine Reports 9, no. 6 (2014): 2528-2532. https://doi.org/10.3892/mmr.2014.2090
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