Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2014 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2014 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

CDK3 expression and its clinical significance in human nasopharyngeal carcinoma

  • Authors:
    • Liang Wang
    • Hong‑Yi Hu
    • Yi‑Ling Lin
    • Zhi‑Xiang Zhao
    • Lu Tan
    • Peng Yu
    • Hui‑Juan Wan
    • Zhe Jin
    • Duo Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Basic Medicine, School of Medicine, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China, Department of Otolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China
  • Pages: 2582-2586
    |
    Published online on: March 31, 2014
       https://doi.org/10.3892/mmr.2014.2095
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to investigate the expression of cyclin‑dependent kinase 3 (CDK3) in human nasopharyngeal carcinoma (NPC) and to evaluate its association with the clinicopathological characteristics of patients with NPC. CDK3 expression was examined in three NPC cell lines and one nasopharyngeal epithelial cell line by western blot analysis and in 94 specimens of NPC and 40 specimens of inflamed nasopharyngeal tissue by immunohistochemistry staining. CDK3 was overexpressed in the three NPC cell lines, 5‑8F, CNE1 and CNE2, compared with the NP‑69 nasopharyngeal epithelial cell line, and was primarily expressed in the cytoplasm. The frequency of CDK3 expression was significantly higher in NPC specimens (67%) compared with inflamed nasopharyngeal tissue specimens (12.5%; P<0.001). CDK3 expression was associated with the degree of infiltration, lymph node metastasis and tumor node metastasis clinical staging, respectively, (P<0.001) in patients with NPC. These results revealed that the expression of CDK3 is associated with the progression of NPC, and may be a potential biomarker for prediction of the prognosis of patients with NPC.
View Figures

Figure 1

Figure 2

View References

1 

Mutirangura A, Tanunyutthawongese C, Pornthanakasem W, et al: Genomic alterations in nasopharyngeal carcinoma: loss of heterozygosity and Epstein-Barr virus infection. Br J Cancer. 76:770–776. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Wee JT, Ha TC, Loong SL and Qian CN: Is nasopharyngeal cancer really a ‘Cantonese cancer’? Chin J Cancer. 29:517–526. 2010.

3 

No authors listed. Cancer incidence in five continents. VII. IARC Sci Publ; pp. i–xxxiv. pp. 1–1240. 1997

4 

Chow E, Payne D, O’Sullivan B, et al: Radiotherapy alone in patients with advanced nasopharyngeal cancer: comparison with an intergroup study. Is combined modality treatment really necessary? Radiother Oncol. 63:269–274. 2002. View Article : Google Scholar

5 

al-Sarraf M and McLaughlin PW: Nasopharynx carcinoma: choice of treatment. Int J Radiat Oncol Biol Phys. 33:761–763. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Chua DT, Sham JS and Au GK: A phase II study of capecitabine in patients with recurrent and metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy. Oral Oncol. 39:361–366. 2003. View Article : Google Scholar

7 

Meyerson M, Enders GH, Wu CL, et al: A family of human cdc2-related protein kinases. EMBO J. 11:2909–2917. 1992.PubMed/NCBI

8 

Miyata Y, Liu Y, Jankovic V, et al: Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Stem Cells. 28:308–317. 2010.PubMed/NCBI

9 

Rao HV, Thirumangalakudi L and Grammas P: Cyclin C and cyclin dependent kinases 1, 2 and 3 in thrombin-induced neuronal cell cycle progression and apoptosis. Neurosci Lett. 450:347–350. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Sage J, Miller AL, Pérez-Mancera PA, Wysocki JM and Jacks T: Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 424:223–228. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Hofmann F and Livingston DM: Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. Genes Dev. 10:851–861. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Ren S and Rollins BJ: Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell. 117:239–251. 2004. View Article : Google Scholar : PubMed/NCBI

13 

van den Heuvel S and Harlow E: Distinct roles for cyclin-dependent kinases in cell cycle control. Science. 262:2050–2054. 1993.PubMed/NCBI

14 

Lee JY, Jeong W, Kim JH, et al: Distinct expression pattern and post-transcriptional regulation of cell cycle genes in the glandular epithelia of avian ovarian carcinomas. PLoS One. 7:e515922012. View Article : Google Scholar

15 

Zheng D, Cho YY, Lau AT, et al: Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res. 68:7650–7660. 2008. View Article : Google Scholar

16 

Cho YY, Tang F, Yao K, et al: Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation. Cancer Res. 69:272–281. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Bullrich F, MacLachlan TK, Sang N, et al: Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. Cancer Res. 55:1199–1205. 1995.PubMed/NCBI

18 

Mao YP, Li WF, Chen L, et al: A clinical verification of the Chinese 2008 staging system for nasopharyngeal carcinoma. Ai Zheng. 28:1022–1028. 2009.(In Chinese).

19 

Malumbres M and Barbacid M: Mammalian cyclin-dependent kinases. Trends Biochem Sci. 30:630–641. 2005. View Article : Google Scholar

20 

Schang LM, Bantly A and Schaffer PA: Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4. J Virol. 76:7724–7735. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Keezer SM and Gilbert DM: Evidence for a pre-restriction point Cdk3 activity. J Cell Biochem. 85:545–552. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Braun K, Hölzl G, Soucek T, Geisen C, Möröy T and Hengstschläger M: Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. Oncogene. 17:2259–2269. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Alessandrini A, Chiaur DS and Pagano M: Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia. 11:342–345. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Baba Y, Tsukuda M, Mochimatsu I, et al: Reduced expression of p16 and p27 proteins in nasopharyngeal carcinoma. Cancer Detect Prev. 25:414–419. 2001.PubMed/NCBI

25 

Pan Y, Zhang Q, Tian L, et al: Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma. Cancer Res. 72:1890–1900. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Shih LC, Tsai CW, Tsai MH, et al: Association of cyclin D1 genotypes with nasopharyngeal carcinoma risk. Anticancer Res. 32:1093–1098. 2012.PubMed/NCBI

27 

Acikalin MF, Etiz D, Gurbuz MK, Ozudogru E, Canaz F and Colak E: Prognostic significance of galectin-3 and cyclin D1 expression in undifferentiated nasopharyngeal carcinoma. Med Oncol. 29:742–749. 2012. View Article : Google Scholar

28 

Hung MC and Link W: Protein localization in disease and therapy. J Cell Sci. 124:3381–3392. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Shapiro GI: Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol. 24:1770–1783. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Yang ES and Burnstein KL: Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm. J Biol Chem. 278:46862–46868. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Flores O, Wang Z, Knudsen KE and Burnstein KL: Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition. Endocrinology. 151:896–908. 2010. View Article : Google Scholar

32 

Bryja V, Pacherník J, Vondrácek J, et al: Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin. Cell Prolif. 41:875–893. 2008. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang L, Hu HY, Lin YL, Zhao ZX, Tan L, Yu P, Wan HJ, Jin Z and Zheng D: CDK3 expression and its clinical significance in human nasopharyngeal carcinoma. Mol Med Rep 9: 2582-2586, 2014.
APA
Wang, L., Hu, H., Lin, Y., Zhao, Z., Tan, L., Yu, P. ... Zheng, D. (2014). CDK3 expression and its clinical significance in human nasopharyngeal carcinoma. Molecular Medicine Reports, 9, 2582-2586. https://doi.org/10.3892/mmr.2014.2095
MLA
Wang, L., Hu, H., Lin, Y., Zhao, Z., Tan, L., Yu, P., Wan, H., Jin, Z., Zheng, D."CDK3 expression and its clinical significance in human nasopharyngeal carcinoma". Molecular Medicine Reports 9.6 (2014): 2582-2586.
Chicago
Wang, L., Hu, H., Lin, Y., Zhao, Z., Tan, L., Yu, P., Wan, H., Jin, Z., Zheng, D."CDK3 expression and its clinical significance in human nasopharyngeal carcinoma". Molecular Medicine Reports 9, no. 6 (2014): 2582-2586. https://doi.org/10.3892/mmr.2014.2095
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Hu HY, Lin YL, Zhao ZX, Tan L, Yu P, Wan HJ, Jin Z and Zheng D: CDK3 expression and its clinical significance in human nasopharyngeal carcinoma. Mol Med Rep 9: 2582-2586, 2014.
APA
Wang, L., Hu, H., Lin, Y., Zhao, Z., Tan, L., Yu, P. ... Zheng, D. (2014). CDK3 expression and its clinical significance in human nasopharyngeal carcinoma. Molecular Medicine Reports, 9, 2582-2586. https://doi.org/10.3892/mmr.2014.2095
MLA
Wang, L., Hu, H., Lin, Y., Zhao, Z., Tan, L., Yu, P., Wan, H., Jin, Z., Zheng, D."CDK3 expression and its clinical significance in human nasopharyngeal carcinoma". Molecular Medicine Reports 9.6 (2014): 2582-2586.
Chicago
Wang, L., Hu, H., Lin, Y., Zhao, Z., Tan, L., Yu, P., Wan, H., Jin, Z., Zheng, D."CDK3 expression and its clinical significance in human nasopharyngeal carcinoma". Molecular Medicine Reports 9, no. 6 (2014): 2582-2586. https://doi.org/10.3892/mmr.2014.2095
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team