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Article

TPX2 regulates tumor growth in human cervical carcinoma cells

  • Authors:
    • Peiyue Jiang
    • Kexin Shen
    • Xuerui Wang
    • Haiqin Song
    • Ying Yue
    • Tongjun Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecological Oncology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
  • Pages: 2347-2351
    |
    Published online on: April 2, 2014
       https://doi.org/10.3892/mmr.2014.2106
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Abstract

The targeting protein for the Xenopus kinesin‑like protein 2 (TPX2), a microtubule-associated protein, has been utilized as a tool to evaluate, more precisely, the proliferative behavior of tumor cells. The abnormal expression of TPX2 in a variety of malignant tumor types has been reported, however less is known about its role in cervical cancer. In the present study, the association between TPX2 expression and the biological behavior of cervical cancer, was investigated. Immunohistochemistry and RT-PCR were used to detect the expression of TPX2 in cervical cancer tissues. The inhibitory effect of TPX2-siRNA on the growth of SiHa human cervical carcinoma cells was studied in vitro. TPX2 expression was identified as significantly higher in cervical carcinoma compared with the control, normal cervical tissues. TPX2 siRNA transfected into SiHa cells induced apoptosis and inhibited cell proliferation and invasion. Similar results were obtained by in vivo transplantation, as TPX2 siRNA transfection significantly reduced tumor growth of the xenograft in nude mice. The results demonstrated that TPX2 is important in the regulation of tumor growth in cervical cancer and therefore may be a potential therapeutic target as a novel treatment strategy.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang P, Shen K, Wang X, Song H, Yue Y and Liu T: TPX2 regulates tumor growth in human cervical carcinoma cells. Mol Med Rep 9: 2347-2351, 2014.
APA
Jiang, P., Shen, K., Wang, X., Song, H., Yue, Y., & Liu, T. (2014). TPX2 regulates tumor growth in human cervical carcinoma cells. Molecular Medicine Reports, 9, 2347-2351. https://doi.org/10.3892/mmr.2014.2106
MLA
Jiang, P., Shen, K., Wang, X., Song, H., Yue, Y., Liu, T."TPX2 regulates tumor growth in human cervical carcinoma cells". Molecular Medicine Reports 9.6 (2014): 2347-2351.
Chicago
Jiang, P., Shen, K., Wang, X., Song, H., Yue, Y., Liu, T."TPX2 regulates tumor growth in human cervical carcinoma cells". Molecular Medicine Reports 9, no. 6 (2014): 2347-2351. https://doi.org/10.3892/mmr.2014.2106
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang P, Shen K, Wang X, Song H, Yue Y and Liu T: TPX2 regulates tumor growth in human cervical carcinoma cells. Mol Med Rep 9: 2347-2351, 2014.
APA
Jiang, P., Shen, K., Wang, X., Song, H., Yue, Y., & Liu, T. (2014). TPX2 regulates tumor growth in human cervical carcinoma cells. Molecular Medicine Reports, 9, 2347-2351. https://doi.org/10.3892/mmr.2014.2106
MLA
Jiang, P., Shen, K., Wang, X., Song, H., Yue, Y., Liu, T."TPX2 regulates tumor growth in human cervical carcinoma cells". Molecular Medicine Reports 9.6 (2014): 2347-2351.
Chicago
Jiang, P., Shen, K., Wang, X., Song, H., Yue, Y., Liu, T."TPX2 regulates tumor growth in human cervical carcinoma cells". Molecular Medicine Reports 9, no. 6 (2014): 2347-2351. https://doi.org/10.3892/mmr.2014.2106
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