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Article

Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells

  • Authors:
    • María B. Pastrian
    • Fanny Guzmán
    • Juan Garona
    • Marina Pifano
    • Giselle V. Ripoll
    • Osvaldo Cascone
    • Graciela N. Ciccia
    • Fernando Albericio
    • Daniel E. Gómez
    • Daniel F. Alonso
    • Nancy B. Iannucci
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina, Biotechnology Nucleus, Pontifical Catholic University of Valparaiso, Valparaiso, Chile, Laboratory of Molecular Oncology, Quilmes National University, Buenos Aires, Argentina, Therapeutic Peptides Research and Development Laboratory, Chemo‑Romikin, Buenos Aires, Argentina, Institute for Research in Biomedicine, Barcelona Science Park, Barcelona, Spain
  • Pages: 2568-2572
    |
    Published online on: April 11, 2014
       https://doi.org/10.3892/mmr.2014.2140
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Abstract

The synthetic nonapeptide 1‑desamino‑8‑D‑arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure‑antiproliferative activity relationship analysis of dDAVP was performed using the alanine scanning technique on the aggressive MDA‑MB‑231 human breast carcinoma cell line. The results from this analysis demonstrated that the amino acids located at the loop of dDAVP are important for the antiproliferative activity of dDAVP, highlighting the key role of the N‑terminal region of the peptide in the interaction with the tumor cell surface receptor. The findings from this study present novel strategies for designing improved compounds with enhanced stability for cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Pastrian MB, Guzmán F, Garona J, Pifano M, Ripoll GV, Cascone O, Ciccia GN, Albericio F, Gómez DE, Alonso DF, Alonso DF, et al: Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells. Mol Med Rep 9: 2568-2572, 2014.
APA
Pastrian, M.B., Guzmán, F., Garona, J., Pifano, M., Ripoll, G.V., Cascone, O. ... Iannucci, N.B. (2014). Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells. Molecular Medicine Reports, 9, 2568-2572. https://doi.org/10.3892/mmr.2014.2140
MLA
Pastrian, M. B., Guzmán, F., Garona, J., Pifano, M., Ripoll, G. V., Cascone, O., Ciccia, G. N., Albericio, F., Gómez, D. E., Alonso, D. F., Iannucci, N. B."Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells". Molecular Medicine Reports 9.6 (2014): 2568-2572.
Chicago
Pastrian, M. B., Guzmán, F., Garona, J., Pifano, M., Ripoll, G. V., Cascone, O., Ciccia, G. N., Albericio, F., Gómez, D. E., Alonso, D. F., Iannucci, N. B."Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells". Molecular Medicine Reports 9, no. 6 (2014): 2568-2572. https://doi.org/10.3892/mmr.2014.2140
Copy and paste a formatted citation
x
Spandidos Publications style
Pastrian MB, Guzmán F, Garona J, Pifano M, Ripoll GV, Cascone O, Ciccia GN, Albericio F, Gómez DE, Alonso DF, Alonso DF, et al: Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells. Mol Med Rep 9: 2568-2572, 2014.
APA
Pastrian, M.B., Guzmán, F., Garona, J., Pifano, M., Ripoll, G.V., Cascone, O. ... Iannucci, N.B. (2014). Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells. Molecular Medicine Reports, 9, 2568-2572. https://doi.org/10.3892/mmr.2014.2140
MLA
Pastrian, M. B., Guzmán, F., Garona, J., Pifano, M., Ripoll, G. V., Cascone, O., Ciccia, G. N., Albericio, F., Gómez, D. E., Alonso, D. F., Iannucci, N. B."Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells". Molecular Medicine Reports 9.6 (2014): 2568-2572.
Chicago
Pastrian, M. B., Guzmán, F., Garona, J., Pifano, M., Ripoll, G. V., Cascone, O., Ciccia, G. N., Albericio, F., Gómez, D. E., Alonso, D. F., Iannucci, N. B."Structure‑activity relationship of 1‑desamino‑8‑D‑arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor‑expressing cancer cells". Molecular Medicine Reports 9, no. 6 (2014): 2568-2572. https://doi.org/10.3892/mmr.2014.2140
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