Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection

Ma,Xiumin; Wang,Liang; Zhao,Hui; Pang,Nannan; Zhang,Fengbo; Jiang,Tao; Liu,Xuelei; Mamuti,Wulamu; Wen,Hao; Ding,Jianbing

doi:10.3892/mmr.2014.2170

July-2014 Volume 10 Issue 1

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July-2014 Volume 10 Issue 1

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Article

Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection

Authors:
- Xiumin Ma
- Liang Wang
- Hui Zhao
- Nannan Pang
- Fengbo Zhang
- Tao Jiang
- Xuelei Liu
- Wulamu Mamuti
- Hao Wen
- Jianbing Ding
View Affiliations / Copyright

Affiliations: State Key Laboratory Incubation Base of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
Pages: 236-240
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Published online on: April 24, 2014

https://doi.org/10.3892/mmr.2014.2170
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Abstract

The present study investigated the immunopathological effect of Echinococcus multilocularis (Em) using cytokine detection. Expression of the T‑helper (Th) 17‑cytokine, interleukin 17 (IL‑17), was observed using immunohistochemical staining, and levels of cytokines, including IL‑17, transforming growth factor β1 (TGF‑β1), IL‑6, interferon γ (IFN‑γ) and IL‑4, were assessed using ELISA at different stages of infection. IL‑17 expression occurred in hepatic cells at 1 month post‑infection, reached a maximum at 3 months post‑infection and then decreased gradually. Compared with the uninfected control, levels of the cytokines IL‑17, TGF‑β1, IL‑6, IFN‑γ and IL‑4 exhibited different dynamic patterns when infected with Em. In the immune response during the whole infection period, Th17 cells play an important role by secreting IL‑17, which may be involved in the Th1/Th2‑cell balance during the immune response. Th17 cells are associated with immunopathology in Em infection.

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