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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2014 Volume 10 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

DNA methylation profiles in ovarian cancer: Implication in diagnosis and therapy (Review)

Ourania Koukoura, Demetrios A. Spandidos, Alexandros Daponte, Stavros Sifakis
Pages: 3-9
Published online on: 08 May 2014

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Article Open Access

Monoglucosyl‑rutin as a potential radioprotector in mammalian cells

Shigeaki Sunada, Hiroshi Fujisawa, Ian M. Cartwright, Junko Maeda, Colleen A. Brents, Kazue Mizuno, Yasushi Aizawa, Takamitsu A. Kato, Mitsuru Uesaka
Pages: 10-14
Published online on: 24 April 2014

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Article Open Access

Atoh1 expression levels define the fate of rat cochlear nonsensory epithelial cells in vitro

Wen‑Wei Luo, Juan‑Mei Yang, Zhao Han, Ya‑Sheng Yuan, Hai‑Bin Sheng, Xiang Liu, Fang‑Lu Chi
Pages: 15-20
Published online on: 30 April 2014

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Article Open Access

Induction of E-cadherin+ human amniotic fluid cell differentiation into oocyte-like cells via culture in medium supplemented with follicular fluid

Te Liu, Yongyi Huang, Yanzhen Bu, Yanhui Zhao, Gang Zou, Zhixue Liu
Pages: 21-28
Published online on: 29 April 2014

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Article Open Access

Tetramethylpyrazine promotes the proliferation and migration of brain endothelial cells

Mingshun Zhang, Feng Gao, Fengmeng Teng, Chunbing Zhang
Pages: 29-32
Published online on: 24 April 2014

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Article Open Access

Colorectal polyp model established by transplacental BMP4 RNAi

Xin Jin, Zhongmei Chen, Li Xiang, Qing Luo, Zhenghua Guo, Xionghui Ding, Xianqing Jin
Pages: 33-38
Published online on: 07 May 2014

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Article Open Access

Epithelial‑mesenchymal transition and apoptosis of renal tubular epithelial cells are associated with disease progression in patients with IgA nephropathy

Junxia Yao, Zunji Ke, Xiaoyan Wang, Feng Peng, Bin Li, Renliang Wu
Pages: 39-44
Published online on: 24 April 2014

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Article Open Access

Complement anaphylatoxin C4a inhibits C5a-induced neointima formation following arterial injury

Yan Zhao, Heng Xu, Wenhui Yu, Bao-Dong Xie
Pages: 45-52
Published online on: 24 April 2014

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Article Open Access

Role and mechanism of Twist1 in modulating the chemosensitivity of FaDu cells

Sumei Lu, Liang Yu, Yakui Mu, Juke Ma, Jiajun Tian, Wei Xu, Haibo Wang
Pages: 53-60
Published online on: 06 May 2014

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Article Open Access

Hyperoxia arrests pulmonary development in newborn rats via disruption of endothelial tight junctions and downregulation of Cx40

Chong Li, Jianhua Fu, Hongyu Liu, Haiping Yang, Li Yao, Kai You, Xindong Xue
Pages: 61-67
Published online on: 28 April 2014

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Article Open Access

Multiple-locus variable number of tandem repeats analysis of Salmonella enterica serotype paratyphi A from Yuxi and comparison with isolates from the Chinese Medical Culture Collection Center

Yingbo Yao, Xiaoyan Cui, Qingshan Chen, Xinrong Huang, Bradley Elmore, Qing Pan, Shukun Wang, Jie Liu
Pages: 68-74
Published online on: 24 April 2014

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Article Open Access

An interspecies conserved motif of the mouse immune system-released activating agent (ISRAA) induces proliferative effects on human cells

Safa Taha, Mohamed Dahmani Fathallah, Moiz Bakhiet
Pages: 75-81
Published online on: 08 May 2014

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Article Open Access

KNDC1 knockdown protects human umbilical vein endothelial cells from senescence

Chunyan Zhang, Yong-Zhan Zhen, Ya-Jun Lin, Jiang Liu, Jie Wei, Rong Xu, Gang Hu
Pages: 82-88
Published online on: 30 April 2014

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Article

Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells

Qian Zheng, Yunyi Liu, Weiwei Liu, Fengyun Ma, Yi Zhou, Mingjie Chen, Junli Chang, Yuesheng Wang, Guangxiao Yang, Guangyuan He
Pages: 89-94
Published online on: 24 April 2014

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Article

Application of two-dimensional electrophoresis and mass spectrometry to screen endometriosis‑related proteins

Hanikezi Tuerxun, Yanmei Zhang, Fei Ji, Aixingzi Aili, Xinhua Yang, Yan Ding
Pages: 95-100
Published online on: 15 April 2014

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Article

Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88‑dependent Toll-like receptor 4 signaling pathway

Zhuo Zhang, Ni Chen, Jin‑Bo Liu, Jian‑Bo Wu, Jing Zhang, Ying Zhang, Xian Jiang
Pages: 101-106
Published online on: 09 May 2014

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Article

Involvement of Rac in thromboxane A2‑induced human platelet activation: Regulation of sCD40 ligand release and PDGF‑AB secretion

Yasunari Kageyama, Tomoaki Doi, Rie Matsushima‑Nishiwaki, Yuko Iida, Shigeru Akamatsu, Akira Kondo, Gen Kuroyanagi, Naohiro Yamamoto, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Hiroki Iida, Osamu Kozawa, Shinji Ogura
Pages: 107-112
Published online on: 15 April 2014

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Article

Co‑expression network analysis of differentially expressed genes associated with metastasis in prolactin pituitary tumors

Wei Zhang, Zhenle Zang, Yechun Song, Hui Yang, Qing Yin
Pages: 113-118
Published online on: 15 April 2014

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Article

Analysis of differentially expressed genes between rheumatoid arthritis and osteoarthritis based on the gene co‑expression network

Qing‑You Lu, Qing‑Hui Han, Xia Li, Zeng‑Chun Li, Yu‑Tao Pan, Lin Liu, Qing‑Ge Fu
Pages: 119-124
Published online on: 24 April 2014

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Article

Suppressive effect of microRNA-126 on oral squamous cell carcinoma in vitro

Xiaolun Yang, Hanjiang Wu, Tianyou Ling
Pages: 125-130
Published online on: 24 April 2014

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Article

Prognostic significance of nemo‑like kinase in nasopharyngeal carcinoma

Size Chen, Zhijian Ma, Xuemei Chen, Jiren Zhang
Pages: 131-136
Published online on: 28 April 2014

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Article

Small interfering RNA targeting ILK inhibits EMT in human peritoneal mesothelial cells through phosphorylation of GSK‑3β

Lingrong Luo, Hong Liu, Zheng Dong, Lin Sun, Youming Peng, Fuyou Liu
Pages: 137-144
Published online on: 17 April 2014

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Article

Identification of microRNAs involved in growth arrest and cell death in hydrogen peroxide-treated human dermal papilla cells

Ok-Yeon Kim, Hwa Jun Cha, Kyu Joong Ahn, In-Sook An, Sungkwan An, Seunghee Bae
Pages: 145-154
Published online on: 16 April 2014

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Article

microRNA‑145 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1 Retraction in /10.3892/mmr.2022.12790

Pengfei Lei, Jie Xie, Long Wang, Xucheng Yang, Zixun Dai, Yihe Hu
Pages: 155-160
Published online on: 28 April 2014

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Article

MicroRNA‑21 regulation of the progression of viral myocarditis to dilated cardiomyopathy

Hong‑Fei Xu, Yu‑Jie Ding, Zhi‑Xiang Zhang, Zu‑Feng Wang, Cheng‑Liang Luo, Bei‑Xu Li, Yi‑Wen Shen, Lu‑Yang Tao, Zi‑Qin Zhao
Pages: 161-168
Published online on: 02 May 2014

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Article

Knockdown of IRX2 inhibits osteosarcoma cell proliferation and invasion by the AKT/MMP9 signaling pathway

Tielong Liu, Weiwei Zhou, Fei Zhang, Guodong Shi, Honglin Teng, Jianru Xiao, Yan Wang
Pages: 169-174
Published online on: 07 May 2014

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Article

Clinical and pathological features of patients with nemaline myopathy

Xi Yin, Chuan Qiang Pu, Qian Wang, Jie Xiao Liu, Yan Ling Mao
Pages: 175-182
Published online on: 24 April 2014

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Article

Tumoricidal activity of combining the agonistic DR5 antibody D-6 with cisplatin in C30 cisplatin‑resistant ovarian cancer in vitro and in vivo

Yan Huang, Baoquan Liang, Qin Jiang, Chen Chen, Kun Yang, Chunmei Li, Ai Zheng
Pages: 183-190
Published online on: 28 April 2014

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Article

Prognostic value of PPM1D in 800 gastric cancer patients

Dan Ma, Chao-Jun Zhang, Zu-Lin Chen, Hua Yang
Pages: 191-194
Published online on: 24 April 2014

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Article

Impact of estrogen-related receptor α on the biological characteristics of rat mandibular condylar chondrocytes

Xin Chen, Chuan Cai, Jing Liu, Li Wen, Xi Wang, Yin Ding
Pages: 195-202
Published online on: 02 May 2014

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Article

Activation of STAT5 contributes to proliferation in U87 human glioblastoma multiforme cells

Cui Feng, Shouqiang Cao
Pages: 203-210
Published online on: 08 May 2014

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Article

Sanguinarine protects against pressure overload‑induced cardiac remodeling via inhibition of nuclear factor-κB activation

Wei Deng, Yi Fang, Yuan Liu, Heng Zhou, Zhihong Cheng, Yang Zhang, Di Sun, Mengying He, Yafen Lin, Rui Zhang, Jieyu Zhang, Wei Li, Qizhu Tang
Pages: 211-216
Published online on: 02 May 2014

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Article

Gene profiling in the dynamic regulation of the lifespan of the myelin sheath structure in the optic nerve of rats

Fang Xie, Han Fu, Jiu‑Cong Zhang, Xue‑Feng Chen, Xiao‑Liang Wang, Jun Chen
Pages: 217-222
Published online on: 09 May 2014

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Article

Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes

Guangfeng Xu, Chunmei Shi, Chenbo Ji, Guixian Song, Ling Chen, Lei Yang, Yaping Zhao, Xirong Guo
Pages: 223-228
Published online on: 02 May 2014

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Article

Identification of the typical miRNAs and target genes in hepatocellular carcinoma

Keqiang Han, Jing Li, Hongzhi Zhao, Ping Liang, Xiaobing Huang, Lu Zheng, Yuming Li, Tonghan Yang, Liang Wang
Pages: 229-235
Published online on: 28 April 2014

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Article

Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection

Xiumin Ma, Liang Wang, Hui Zhao, Nannan Pang, Fengbo Zhang, Tao Jiang, Xuelei Liu, Wulamu Mamuti, Hao Wen, Jianbing Ding
Pages: 236-240
Published online on: 24 April 2014

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Article

RNA‑seq analysis of synovial fibroblasts in human rheumatoid arthritis

Xiuhui Wang, Shengli Xia, Beigang Fu
Pages: 241-247
Published online on: 24 April 2014

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Article

Effect of Gua Lou Gui Zhi decoction on focal cerebral ischemia‑reperfusion injury through regulating the expression of excitatory amino acids and their receptors

Xianwen Chen, Huang Li, Mingqing Huang, Mei Huang, Wei Xu, Kedan Chu, Lidian Chen, Yuqin Zhang
Pages: 248-254
Published online on: 28 April 2014

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Article

Localization and expression patterns of prolactin‑like protein J in mouse testis

Qiaozhen Yang, Jie Hao, Miao He, Maoxin Chen, Gang Li
Pages: 255-261
Published online on: 07 May 2014

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Article

Lycopene inhibits neointimal hyperplasia through regulating lipid metabolism and suppressing oxidative stress

Min Mao, Han Lei, Qing Liu, Rui He, Zhong Zuo, Nan Zhang, Chao Zhou
Pages: 262-268
Published online on: 24 April 2014

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Article

Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation

Hua He, Fei Chen, Wensi Ni, Jianhui Li, Yongjun Zhang
Pages: 269-275
Published online on: 24 April 2014

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Article

Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway

Liang Qin, Ye Ren, An-Min Chen, Feng-Jing Guo, Fei Xu, Chen Gong, Peng Cheng, Yu Du, Hui Liao
Pages: 276-282
Published online on: 29 April 2014

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Article

miR‑20a is an independent prognostic factor in colorectal cancer and is involved in cell metastasis

Guang‑Jun Zhang, Yu Li, He Zhou, Hua‑Xu Xiao, Tong Zhou
Pages: 283-291
Published online on: 15 April 2014

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Article

microRNAs mediate oleic acid-induced acute lung injury in rats using an alternative injury mechanism

Sang Mook Lee, Hyunsoo Choi, Geumjin Yang, Ki Cheol Park, Sikyoung Jeong, Sungyoup Hong
Pages: 292-300
Published online on: 15 April 2014

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Article

Pingyangmycin stimulates apoptosis in human hemangioma‑derived endothelial cells through activation of the p53 pathway

Jun‑Bo Tu, Quan‑Yan Li, Fei Jiang, Xiao‑Yi Hu, Rui‑Zhao Ma, Qiang Dong, Hao Zhang, Parukjan Pattar, Shi‑Xian Li
Pages: 301-305
Published online on: 24 April 2014

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Article

Anti-fibrotic effects of specific-siRNA targeting of the receptor for advanced glycation end products in a rat model of experimental hepatic fibrosis

Xiao-Gang Cai, Jin-Rong Xia, Wei-Dong Li, Feng-Lin Lu, Juan Liu, Qin Lu, Hong Zhi
Pages: 306-314
Published online on: 02 May 2014

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Article

microRNA-200c downregulates XIAP expression to suppress proliferation and promote apoptosis of triple-negative breast cancer cells

Yi Ren, Xuedong Han, Kun Yu, Su'an Sun, Linlin Zhen, Zhi Li, Shui Wang
Pages: 315-321
Published online on: 08 May 2014

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Article

Fms-related tyrosine kinase 3 ligand promotes proliferation of placenta amnion and chorion mesenchymal stem cells in vitro

Fang Li, Yunyun Xu, Xiaoxia Xu, Biao Xu, Juan Zhao, Xueguang Zhang
Pages: 322-328
Published online on: 08 May 2014

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Article

Generation of liver-specific TGF-α and c-Myc-overexpressing fibroblasts for future creation of a liver cancer porcine model

Jeeyoung Kim, Huijeong Ahn, Heung-Myong Woo, Eunsong Lee, Geun-Shik Lee
Pages: 329-335
Published online on: 07 May 2014

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Article

AP‑4 predicts poor prognosis in non‑small cell lung cancer

Hai Gong, Shaorong Han, Hui Yao, Hui Zhao, Yanming Wang
Pages: 336-340
Published online on: 02 May 2014

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Article

Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression

Min Lv, Yan Li, Ming-Hua Ji, Ming Zhuang, Jin-Hai Tang
Pages: 341-346
Published online on: 17 April 2014

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Article

Therapeutic effects of sorafenib on the A549/DDP human lung adenocarcinoma cell line in vitro

Xiang‑Qi Chen, Yu‑Lan Wang, Zhi‑Ying Li, Ting‑Yan Lin
Pages: 347-352
Published online on: 24 April 2014

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Article

Signal transduction mechanism of the NZW type IL‑10R1 and the effect on B lymphocyte function

Cheng Diao, Zanmei Qi, Shuyan Du, Xinzhe Cai, Yi Jiang
Pages: 353-358
Published online on: 15 April 2014

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Article

Increased circulating T‑helper 22 cells in patients with dilated cardiomyopathy

Qing Kong, Xiaomo Li, Weifeng Wu, Fan Yang, Yanli Liu, Wenyin Lai, Xiaofen Pan, Mengsha Gao, Yimin Xue
Pages: 359-364
Published online on: 15 April 2014

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Article

Saikosaponin‑d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase

Min Yao, Jingbo Yang, Lanqing Cao, Lian Zhang, Shanshan Qu, Hongwen Gao
Pages: 365-372
Published online on: 15 April 2014

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Article

Effect of peroxisome proliferator-activated receptor γ on the cholesterol efflux of peritoneal macrophages in inflammation

Kun He, Yue Li, Kang Yang, Jian-Ping Gong, Pei-Zhi Li
Pages: 373-378
Published online on: 29 April 2014

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Article

Prevalence and range of GJB2 and SLC26A4 mutations in patients with autosomal recessive non‑syndromic hearing loss

Hua Jiang, Jia Chen, Xin‑Ji Shan, Ying Li, Jian‑Guo He, Bei‑Bei Yang
Pages: 379-386
Published online on: 15 April 2014

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Article

Role of CIP2A in the antitumor effect of bortezomib in colon cancer

Yayun Ding, Yueguo Wang, Shaoqing Ju, Xinghua  Wu, Wencai Zhu, Feng Shi, Liping Mao
Pages: 387-392
Published online on: 24 April 2014

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Article

microRNA‑145 inhibits cell proliferation, migration and invasion by targeting matrix metallopeptidase-11 in renal cell carcinoma

Deyao Wu, Min Li, Linmao Wang, Yunfeng Zhou, Jian Zhou, Huixing Pan, Ping Qu
Pages: 393-398
Published online on: 15 April 2014

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Article

PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells Retraction in /10.3892/mmr.2021.12299

Quan Cheng, Hui Cao, Zigui Chen, Zhiming Ma, Xin Wan, Renjun Peng, Bing Jiang
Pages: 399-404
Published online on: 15 April 2014

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Article

Substituted 3‑acyl‑2‑phenylamino‑1,4‑naphthoquinones intercalate into DNA and cause genotoxicity through the increased generation of reactive oxygen species culminating in cell death

Mirelle Sifroni Farias, Claus Tröger Pich, Maicon Roberto Kviecinski, Nádia Cristina Falcão Bucker, Karina Bettega Felipe, Fabiana Ourique Da Silva, Tânia Mara Fisher Günther, João Francisco Correia, David Ríos, Julio Benites, Jaime A. Valderrama, Pedro Buc Calderon, Rozangela Curi Pedrosa
Pages: 405-410
Published online on: 16 April 2014

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Article

Temozolomide induces autophagy via ATM‑AMPK‑ULK1 pathways in glioma

Yuhui Zou, Qiong Wang, Bingling Li, Bing Xie, Weimin Wang
Pages: 411-416
Published online on: 15 April 2014

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Article

Sperm‑associated antigen 9 promotes astrocytoma cell invasion through the upregulation of podocalyxin

Jiaode Jiang, Yunsheng Liu, Wenhua Fang, Feng Liu
Pages: 417-422
Published online on: 24 April 2014

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Article

Regulation of the HMOX1 gene by the transcription factor AP-2δ with unique DNA binding site

Liyun Sun, Yuxia Zhao, Shaohua Gu, Yumin Mao, Chaoneng Ji, Xiujuan Xin
Pages: 423-428
Published online on: 28 April 2014

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Article

Therapeutic effect of Zeng Ye decoction on primary Sjögren's syndrome via upregulation of aquaporin‑1 and aquaporin‑5 expression levels

Xiaodan Wu, Changhong Ren, Hongwei Zhou, Lin Zhang, Cheng Juan, Yong Yang
Pages: 429-434
Published online on: 02 May 2014

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Association between CLOCK, PER3 and CCRN4L with non‑small cell lung cancer in Brazilian patients

Patricia Couto, Debora Miranda, Renalice Vieira, Alyne Vilhena, Luiz De Marco, Luciana Bastos‑Rodrigues
Pages: 435-440
Published online on: 08 May 2014

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Novel curcumin analogue IHCH exhibits potent anti‑proliferative effects by inducing autophagy in A549 lung cancer cells

Guang‑Zhou Zhou, Su‑Li Xu, Gang‑Chun Sun, Xiao‑Bing Chen
Pages: 441-446
Published online on: 24 April 2014

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Anti‑inflammatory effects of triptolide by inhibiting the NF‑κB signalling pathway in LPS‑induced acute lung injury in a murine model

Xian Wang, Lei Zhang, Wei Duan, Bin Liu, Ping Gong, Yusong Ding, Xiongwen Wu
Pages: 447-452
Published online on: 28 April 2014

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Inhibition of the Jagged/Notch pathway inhibits retinoblastoma cell proliferation via suppressing the PI3K/Akt, Src, p38MAPK and Wnt/β‑catenin signaling pathways

Wei Xiao, Xiaoyun Chen, Mingguang He
Pages: 453-458
Published online on: 06 May 2014

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Effects of normal aging on myelin sheath ultrastructures in the somatic sensorimotor system of rats

Fang Xie, Ping Liang, Han Fu, Jiu‑Cong Zhang, Jun Chen
Pages: 459-466
Published online on: 09 May 2014

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FOXP1 has a low expression in human gliomas and its overexpression inhibits proliferation, invasion and migration of human glioma U251 cells

Liang Xue, Shuyuan Yue, Jianning Zhang
Pages: 467-472
Published online on: 29 April 2014

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MicroRNA‑195 inhibits colorectal cancer cell proliferation, colony‑formation and invasion through targeting CARMA3

Ling Wang, Liyuan Qian, Xiaorong Li, Jin Yan
Pages: 473-478
Published online on: 24 April 2014

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Differentially‑expressed genes identified by suppression subtractive hybridization in the bone marrow hematopoietic stem cells of patients with psoriasis

Zhenying Zhang, Zhen Yu, Pan Tian, Suchun Hou, Shixin Han, Xuejing Tan, Yongjun Piao, Xiaoming Liu
Pages: 479-485
Published online on: 02 May 2014

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Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair

Xiao‑Yu Wu, Che Chen, Xue‑Quan Yao, Qin‑Hong Cao, Zhe Xu, Wei‑Su Li, Fu‑Kun Liu, Gang Li
Pages: 486-490
Published online on: 24 April 2014

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Ocular albinism type 1‑induced melanoma cell migration is mediated through the RAS/RAF/MEK/ERK signaling pathway

Jun Bai, Xin Xie, Yun Lei, Gaili An, Li He, Xiaopeng Lv
Pages: 491-495
Published online on: 15 April 2014

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Identification of genetic variants of lecithin cholesterol acyltransferase in individuals with high HDL‑C levels

Mohsen Naseri, Mehdi Hedayati, Maryam Sadat Daneshpour, Fatemeh Bandarian, Fereidoun Azizi
Pages: 496-502
Published online on: 24 April 2014

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Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma

Ku Jung Kwon, Seunghee Bae, Karam Kim, In Sook An, Kyu Joong Ahn, Sungkwan An, Hwa Jun Cha
Pages: 503-507
Published online on: 16 April 2014

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Cartilage tissue engineering using PHBV and PHBV/Bioglass scaffolds

Mingshu Zhou, Dong Yu
Pages: 508-514
Published online on: 15 April 2014

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Baicalein increases the cytotoxicity of cisplatin by enhancing gap junction intercellular communication

Yiwen Wang, Qin Wang, Suzhi Zhang, Yuan Zhang, Liang Tao
Pages: 515-521
Published online on: 16 April 2014

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Faecal calprotectin as a novel biomarker for differentiating between inflammatory bowel disease and irritable bowel syndrome

Ming‑Hui Chang, Jen‑Wei Chou, Shan‑Ming Chen, Ming‑Chang Tsai, Yu‑Shu Sun, Chun‑Che Lin, Ching‑Pin Lin
Pages: 522-526
Published online on: 24 April 2014

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miR‑376b‑5p regulates angiogenesis in cerebral ischemia

Ling‑Juan Li, Qing Huang, Ning Zhang, Gui-Bin Wang, Yun‑Hai Liu
Pages: 527-535
Published online on: 24 April 2014

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Remote ischemic postconditioning protects the heart by upregulating ALDH2 expression levels through the PI3K/Akt signaling pathway

Ying Yu, Xian‑Jie Jia, Qiao‑Feng Zong, Guan‑Jun Zhang, Hong‑Wei Ye, Jie Hu, Qin Gao, Su‑Dong Guan
Pages: 536-542
Published online on: 15 April 2014

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Phenethyl isothiocyanate inhibits growth of human chronic myeloid leukemia K562 cells via reactive oxygen species generation and caspases

Yating Wang, Sixi Wei, Jishi Wang, Qin Fang, Qixiang Chai
Pages: 543-549
Published online on: 24 April 2014

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MicroRNA-155 inhibits migration of trophoblast cells and contributes to the pathogenesis of severe preeclampsia by regulating endothelial nitric oxide synthase

Xuelan Li, Chunfang Li, Xin Dong, Wenli Gou
Pages: 550-554
Published online on: 06 May 2014

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Hepatoprotective effects of erythropoietin on D‑galactosamine/lipopolysaccharide‑induced fulminant hepatic failure in mice

Xue‑Fei Yang, Yi He, Hai‑Yuan Li, Xin Liu, Huan Chen, Jian‑Bang Liu, Wen‑Jun Ji, Bing Wang, Li‑Na Chen
Pages: 555-559
Published online on: 24 April 2014

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Cardioprotective effects of phosphocreatine on myocardial cell ultrastructure and calcium-sensing receptor expression in the acute period following high level spinal cord injury

Hui Chen, Chao Gong, Cheng Ma, Xiaoni Zhang, Lishuang Xu, Caizhu Lin
Pages: 560-566
Published online on: 08 May 2014

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Preparation and characterization of luteinising‑hormone releasing hormone nanoliposomal microbubbles specifically targeting ovarian cancer cells in vitro

Jinyi Zhang, Sisun Liu, Yuanfang Zhu, Liping Zhang, Wenjuan Li, Fen Wang, Shuying Huang
Pages: 567-571
Published online on: 06 May 2014

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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