Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2014 Volume 10 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2014 Volume 10 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation

  • Authors:
    • Hua He
    • Fei Chen
    • Wensi Ni
    • Jianhui Li
    • Yongjun Zhang
  • View Affiliations / Copyright

    Affiliations: Neonatology Department, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China
  • Pages: 269-275
    |
    Published online on: April 24, 2014
       https://doi.org/10.3892/mmr.2014.2188
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification with decreased numbers of alveoli and increased airspace. BPD, frequently suffered by very low birth weight infants, has been closely associated with intrauterine infection. However, the underlying mechanisms of BPD remain unclear. In the present study, it was identified that administration of intra-amniotic lipopolysaccharide (LPS) to pregnant rats on embryonal day 16.5 (E16.5) induced significant alveolarization arrest similar to that of BPD in neonatal pups, and theophylline injected subcutaneously into the newborns improved the pathological changes. To further investigate the underlying mechanism of the morphogenesis amelioration of theophylline, cytokine antibody arrays were performed with the lung lysates of neonatal rats. The results indicated that LPS upregulated a series of pro-inflammatory cytokines and theophylline significantly attenuated the expression levels of pro-inflammatory cytokines tumor necrosis factor‑α, macrophage inflammatory protein (MIP)-1α and MIP-2, and markedly elevated the production of tumor growth factor (TGF)-β family members TGF-β1, TGF-β2 and TGF-β3, which are anti‑inflammatory cytokines. Accordingly, it was hypothesized that theophylline may protect against BPD and improve chorioamnionitis‑induced alveolar arrest by regulating the balance between pro‑and anti-inflammatory cytokine expression.
View Figures

Figure 1

Figure 2

View References

1 

Choi CW, Kim BI, Hong JS, Kim EK, Kim HS and Choi JH: Bronchopulmonary dysplasia in a rat model induced by intra-amniotic inflammation and postnatal hyperoxia: morphometric aspects. Pediatr Res. 65:323–327. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Speer CP: Inflammation and bronchopulmonary dysplasia: A continuing story. Semin Fetal Neonatal Med. 11:354–362. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Jarreau PH, Fayon M, Baud O, Autret-Leca E, Danan M, de Verdelhan A and Castot A: The use of postnatal corticosteroid therapy in premature infants to prevent or treat bronchopulmonary dysplasia: current situation and recommendations. Arch Pediatr. 17:1480–1487. 2010.(In French).

4 

Grier DG and Halliday HL: Corticosteroids in the prevention and management of bronchopulmonary dysplasia. Semin Neonatol. 8:83–91. 2003. View Article : Google Scholar : PubMed/NCBI

5 

To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, Elliott WM, Hogg JC, Adcock IM and Barnes PJ: Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 182:897–904. 2010. View Article : Google Scholar

6 

Mascali JJ, Cvietusa P, Negri J and Borish L: Anti-inflammatory effects of theophylline: modulation of cytokine production. Ann Allergy Asthma Immunol. 77:34–38. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Zhu L, Li H, Tang J, Zhu J and Zhang Y: Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. Pediatr Pulmonol. 47:264–274. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Coalson JJ: Pathology of bronchopulmonary dysplasia. Semin Perinatol. 30:179–184. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Schreiber T, Niemann C, Schmidt B and Karzai W: A novel model of selective lung ventilation to investigate the long-term effects of ventilation-induced lung injury. Shock. 26:50–54. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR and Le Cras TD: Perinatal increases in TGF-α disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Am J Physiol Lung Cell Mol Physiol. 293:L314–L327. 2007.

11 

Kim N and Vu TH: Parabronchial smooth muscle cells and alveolar myofibroblasts in lung development. Birth Defects Res C Embryo Today. 78:80–89. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Bland RD: Neonatal chronic lung disease in the post-surfactant era. Biol Neonate. 88:181–191. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Vohr BR, Wright LL, Dusick AM, et al: Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993–1994. Pediatrics. 105:1216–1226. 2000.PubMed/NCBI

14 

Yoon BH, Romero R, Jun JK, et al: Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 177:825–830. 1997. View Article : Google Scholar

15 

Speer CP, Pabst MJ, Hedegaard HB, Rest RF and Johnston RB Jr: Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes: activity of neutrophil elastase and cathepsin G. J Immunol. 133:2151–2156. 1984.

16 

Yoon BH, Romero R, Jun JK, et al: Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 177:825–830. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M and Berry SM: The fetal inflammatory response syndrome. Am J Obstet Gynecol. 179:194–202. 1998. View Article : Google Scholar

18 

Arnon S, Grigg J and Silverman M: Pulmonary inflammatory cells in ventilated preterm infants: effect of surfactant treatment. Arch Dis Child. 69:44–48. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Kotecha S, Chan B, Azam N, Silverman M and Shaw RJ: Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage of premature infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 72:F90–F96. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Kotecha S, Mildner RJ, Prince LR, et al: The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants. Thorax. 58:961–967. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Jones CA, Cayabyab RG, Kwong KY, et al: Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr Res. 39:966–975. 1996. View Article : Google Scholar

22 

Kaneko Y, Takashima K, Suzuki N and Yamana K: Effects of theophylline on chronic inflammatory lung injury induced by LPS exposure in guinea pigs. Allergol Int. 56:445–456. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Ito K, Lim S, Caramori G, et al: A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci USA. 99:8921–8926. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Liang B, Jiang S, Zhang Z, et al: Anti-inflammatory effects of theophylline: modulation of immune functions during murine leukemia virus infection. Immunopharmacol Immunotoxicol. 23:307–319. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Ezeamuzie CI and Shihab PK: Interactions between theophylline and salbutamol on cytokine release in human monocytes. J Pharmacol Exp Ther. 334:302–309. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Marwick JA, Caramori G, Stevenson CS, et al: Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med. 179:542–548. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Bonner JC: The epidermal growth factor receptor at the crossroads of airway remodeling. Am J Physiol Lung Cell Mol Physiol. 283:L528–L530. 2002.PubMed/NCBI

28 

Lutgens E, Gijbels M, Smook M, Heeringa P, Gotwals P, Koteliansky VE and Daemen MJ: Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler Thromb Vasc Biol. 22:975–982. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Shull MM, Ormsby I, Kier AB, et al: Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 359:693–699. 1992. View Article : Google Scholar : PubMed/NCBI

30 

Lan HY: Diverse roles of TGF-β/Smads in renal fibrosis and inflammation. Int J Biol Sci. 7:1056–1067. 2011.

31 

Kitamura H, Cambier S, Somanath S, et al: Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J Clin Invest. 121:2863–2875. 2011.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He H, Chen F, Ni W, Li J and Zhang Y: Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation. Mol Med Rep 10: 269-275, 2014.
APA
He, H., Chen, F., Ni, W., Li, J., & Zhang, Y. (2014). Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation. Molecular Medicine Reports, 10, 269-275. https://doi.org/10.3892/mmr.2014.2188
MLA
He, H., Chen, F., Ni, W., Li, J., Zhang, Y."Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation". Molecular Medicine Reports 10.1 (2014): 269-275.
Chicago
He, H., Chen, F., Ni, W., Li, J., Zhang, Y."Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation". Molecular Medicine Reports 10, no. 1 (2014): 269-275. https://doi.org/10.3892/mmr.2014.2188
Copy and paste a formatted citation
x
Spandidos Publications style
He H, Chen F, Ni W, Li J and Zhang Y: Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation. Mol Med Rep 10: 269-275, 2014.
APA
He, H., Chen, F., Ni, W., Li, J., & Zhang, Y. (2014). Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation. Molecular Medicine Reports, 10, 269-275. https://doi.org/10.3892/mmr.2014.2188
MLA
He, H., Chen, F., Ni, W., Li, J., Zhang, Y."Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation". Molecular Medicine Reports 10.1 (2014): 269-275.
Chicago
He, H., Chen, F., Ni, W., Li, J., Zhang, Y."Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation". Molecular Medicine Reports 10, no. 1 (2014): 269-275. https://doi.org/10.3892/mmr.2014.2188
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team