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Article

Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway

  • Authors:
    • Liang Qin
    • Ye Ren
    • An-Min Chen
    • Feng-Jing Guo
    • Fei Xu
    • Chen Gong
    • Peng Cheng
    • Yu Du
    • Hui Liao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 276-282
    |
    Published online on: April 29, 2014
       https://doi.org/10.3892/mmr.2014.2198
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Abstract

Vasculogenic mimicry (VM) describes functional vascular channels composed only of tumor cells and its presence predicts a poor prognosis for patients with prostate cancer. The present study demonstrated that prostate cancer PC-3 cells were able to form a patterned matrix or tubular VM in 3D cultures in vitro and rosiglitazone (RSG), the ligand of peroxisome proliferator-activated receptor γ (PPARγ) and effectively inhibited the formation of VM structures in a dose- and PPARγ‑dependent manner. In addition, RSG significantly inhibited prostate cancer cell migration and invasion. The inhibitory effect of RSG on VM formation could be at least partially explained by an RSG-driven downregulation of vascular endothelial growth factor (VEGF) levels and phosphorylation of AKT, which is known to be important in VM. Furthermore, the present study highlighted that VEGF and the phosphoinositide 3-kinase/AKT pathway exert a positive feedback regulation in the process of VM formation. These findings reveal new therapeutic potential for PPARγ ligands in anti‑cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Qin L, Ren Y, Chen A, Guo F, Xu F, Gong C, Cheng P, Du Y and Liao H: Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway. Mol Med Rep 10: 276-282, 2014.
APA
Qin, L., Ren, Y., Chen, A., Guo, F., Xu, F., Gong, C. ... Liao, H. (2014). Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway. Molecular Medicine Reports, 10, 276-282. https://doi.org/10.3892/mmr.2014.2198
MLA
Qin, L., Ren, Y., Chen, A., Guo, F., Xu, F., Gong, C., Cheng, P., Du, Y., Liao, H."Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway". Molecular Medicine Reports 10.1 (2014): 276-282.
Chicago
Qin, L., Ren, Y., Chen, A., Guo, F., Xu, F., Gong, C., Cheng, P., Du, Y., Liao, H."Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway". Molecular Medicine Reports 10, no. 1 (2014): 276-282. https://doi.org/10.3892/mmr.2014.2198
Copy and paste a formatted citation
x
Spandidos Publications style
Qin L, Ren Y, Chen A, Guo F, Xu F, Gong C, Cheng P, Du Y and Liao H: Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway. Mol Med Rep 10: 276-282, 2014.
APA
Qin, L., Ren, Y., Chen, A., Guo, F., Xu, F., Gong, C. ... Liao, H. (2014). Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway. Molecular Medicine Reports, 10, 276-282. https://doi.org/10.3892/mmr.2014.2198
MLA
Qin, L., Ren, Y., Chen, A., Guo, F., Xu, F., Gong, C., Cheng, P., Du, Y., Liao, H."Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway". Molecular Medicine Reports 10.1 (2014): 276-282.
Chicago
Qin, L., Ren, Y., Chen, A., Guo, F., Xu, F., Gong, C., Cheng, P., Du, Y., Liao, H."Peroxisome proliferator-activated receptor γ ligands inhibit VEGF-mediated vasculogenic mimicry of prostate cancer through the AKT signaling pathway". Molecular Medicine Reports 10, no. 1 (2014): 276-282. https://doi.org/10.3892/mmr.2014.2198
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