Effects of normal aging on myelin sheath ultrastructures in the somatic sensorimotor system of rats

  • Authors:
    • Fang Xie
    • Ping Liang
    • Han Fu
    • Jiu‑Cong Zhang
    • Jun Chen
  • View Affiliations

  • Published online on: May 9, 2014     https://doi.org/10.3892/mmr.2014.2228
  • Pages: 459-466
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Abstract

Previous studies have presented qualitative and quantitative data regarding the morphological changes that occur peripherally in myelin sheaths and nerve fibers of rats during their lifespan. However, studies on ultrastructural features of myelinated fibers (MFs) in the central nervous system (CNS) remain limited. In the present study, morphological analyses of the somatic sensorimotor MFs in rats at time‑points between postnatal day 14 and postnatal month (PNM) 26 were conducted using electron microscopy. Significant alterations in the myelin sheath were observed in the sensorimotor system of aging and aged rats, which became aggravated with age. The ultrastructural pattern of myelin lamellae also exhibited age dependence. The transformation of the myelin intraperiod line from complete to incomplete fusion occurred after PNM 5, leading to an expansion of periodicity in myelin lamellae. These pathological changes in the myelin structure occurred very early and showed a significant correlation with age, indicating that myelin was the part of the CNS with the highest susceptibility to the influence of aging, and may be the main target of aging effects. In addition to the myelin breakdown, continued myelin production and remyelination were observed in the aging sensorimotor system, suggesting the presence of endogenous mechanisms of myelin repair.
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July-2014
Volume 10 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Xie F, Liang P, Fu H, Zhang JC and Chen J: Effects of normal aging on myelin sheath ultrastructures in the somatic sensorimotor system of rats. Mol Med Rep 10: 459-466, 2014
APA
Xie, F., Liang, P., Fu, H., Zhang, J., & Chen, J. (2014). Effects of normal aging on myelin sheath ultrastructures in the somatic sensorimotor system of rats. Molecular Medicine Reports, 10, 459-466. https://doi.org/10.3892/mmr.2014.2228
MLA
Xie, F., Liang, P., Fu, H., Zhang, J., Chen, J."Effects of normal aging on myelin sheath ultrastructures in the somatic sensorimotor system of rats". Molecular Medicine Reports 10.1 (2014): 459-466.
Chicago
Xie, F., Liang, P., Fu, H., Zhang, J., Chen, J."Effects of normal aging on myelin sheath ultrastructures in the somatic sensorimotor system of rats". Molecular Medicine Reports 10, no. 1 (2014): 459-466. https://doi.org/10.3892/mmr.2014.2228