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Article

Complement component 3 is a prognostic factor of non‑small cell lung cancer

  • Authors:
    • Kailong Lin
    • Siyi He
    • Luhang He
    • Junyin Chen
    • Xiaoming Cheng
    • Guoqiang Zhang
    • Bo Zhu
  • View Affiliations / Copyright

    Affiliations: Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China, Institute of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China, Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China, Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 811-817
    |
    Published online on: May 13, 2014
       https://doi.org/10.3892/mmr.2014.2230
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Abstract

Lung cancer is the leading cause of cancer‑related mortality worldwide. The complement component 3 (C3) is a central protein of the complement system, expressed in numerous cancer tissues and considered crucial for tumor progression. This study aimed to investigate the prognostic value of C3 in non‑small cell lung cancer (NSCLC) and the underlying mechanisms. We used immunohistochemistry to observe the expression of C3 in malignant pulmonary lesion specimens from biopsy of 80 patients with NSCLC at stages I‑III, who underwent lobectomy. We further assessed the correlation between C3 expression and a number of clinical features, as well as its prognostic value. To investigate the mechanism by which C3 exerts its effects, the correlation of C3 expression to T lymphocyte infiltration was also assessed. There was no significant correlation between the C3 level and clinical features such as gender, smoking status, degree of differentiation, histological type and malignant tumor stage based on the TNM classification system, while a significant correlation was found to age. However, analysis of overall survival (OS) and disease‑free survival (DFS) rates showed that low C3 expression was related to poor prognosis. Univariate survival analysis revealed that C3 level and TNM stage are independent prognostic factors. Multivariate analysis demonstrated that the low level of C3 and TNM stage are also associated with poor prognosis. Furthermore, in tissues from biopsies, the C3 level positively correlated to the number of infiltrated CD4+ and CD8+ T lymphocytes (P<0.01). These findings indicate that C3 is a valuable marker for prognostic evaluation of NSCLC and may be considered as a therapeutic target for the treatment of lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lin K, He S, He L, Chen J, Cheng X, Zhang G and Zhu B: Complement component 3 is a prognostic factor of non‑small cell lung cancer. Mol Med Rep 10: 811-817, 2014.
APA
Lin, K., He, S., He, L., Chen, J., Cheng, X., Zhang, G., & Zhu, B. (2014). Complement component 3 is a prognostic factor of non‑small cell lung cancer. Molecular Medicine Reports, 10, 811-817. https://doi.org/10.3892/mmr.2014.2230
MLA
Lin, K., He, S., He, L., Chen, J., Cheng, X., Zhang, G., Zhu, B."Complement component 3 is a prognostic factor of non‑small cell lung cancer". Molecular Medicine Reports 10.2 (2014): 811-817.
Chicago
Lin, K., He, S., He, L., Chen, J., Cheng, X., Zhang, G., Zhu, B."Complement component 3 is a prognostic factor of non‑small cell lung cancer". Molecular Medicine Reports 10, no. 2 (2014): 811-817. https://doi.org/10.3892/mmr.2014.2230
Copy and paste a formatted citation
x
Spandidos Publications style
Lin K, He S, He L, Chen J, Cheng X, Zhang G and Zhu B: Complement component 3 is a prognostic factor of non‑small cell lung cancer. Mol Med Rep 10: 811-817, 2014.
APA
Lin, K., He, S., He, L., Chen, J., Cheng, X., Zhang, G., & Zhu, B. (2014). Complement component 3 is a prognostic factor of non‑small cell lung cancer. Molecular Medicine Reports, 10, 811-817. https://doi.org/10.3892/mmr.2014.2230
MLA
Lin, K., He, S., He, L., Chen, J., Cheng, X., Zhang, G., Zhu, B."Complement component 3 is a prognostic factor of non‑small cell lung cancer". Molecular Medicine Reports 10.2 (2014): 811-817.
Chicago
Lin, K., He, S., He, L., Chen, J., Cheng, X., Zhang, G., Zhu, B."Complement component 3 is a prognostic factor of non‑small cell lung cancer". Molecular Medicine Reports 10, no. 2 (2014): 811-817. https://doi.org/10.3892/mmr.2014.2230
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