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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August-2014 Volume 10 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review)

Georgios D. Agrogiannis, Stavros Sifakis, Efstratios S. Patsouris, Anastasia E. Konstantinidou
Pages: 579-584
Published online on: 21 May 2014

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Article Open Access

Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo

Huaqi Zhu, Qiman Sun, Changjun Tan, Min Xu, Zhi Dai, Zheng Wang, Jia Fan, Jian Zhou
Pages: 585-592
Published online on: 05 June 2014

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Article Open Access

Use of lipolanthionine peptide, a toll-like receptor 2 inhibitor, enhances transdermal delivery efficiency

Bin Chen, Da-Lie Liu, Wen-Yan Pan, Xiao-Hui Yang, Jia‑Bao Shou, Ju-Hua Wu, Qing-Long Mao, Jia Wang
Pages: 593-598
Published online on: 20 May 2014

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Article Open Access

Early induction of oxidative stress in a mouse model of Alzheimer's disease with heme oxygenase activity

Sanli Xing, Dingzhu Shen, Chuan Chen, Jian Wang, Zhihua Yu
Pages: 599-604
Published online on: 20 May 2014

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Article

Human breast adipose‑derived stem cells: Characterization and differentiation into mammary gland‑like epithelial cells promoted by autologous activated platelet‑rich plasma

Shi-En Cui, Hong-Mian Li, Da-Lie Liu, Hua Nan, Kun-Ming  Xu, Pei-Ran Zhao, Shuang-Wu Liang
Pages: 605-614
Published online on: 28 May 2014

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Article Open Access

N‑acetylcysteine reduces oxidative stress, nuclear factor‑κB activity and cardiomyocyte apoptosis in heart failure

Xiao‑Yan Wu, An‑Yu Luo, Yi‑Rong Zhou, Jiang‑Hua Ren
Pages: 615-624
Published online on: 02 June 2014

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Article

Effect of autophagy inhibition on cell viability and cell cycle progression in MDA‑MB‑231 human breast cancer cells

Qiujun Liu, Xinli Shi, Xianyao Zhou, Da Wang, Li Wang, Changlong Li
Pages: 625-630
Published online on: 03 June 2014

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Article Open Access

Effect of siRNA against NF-κB on sepsis‑induced acute lung injury in a mouse model

Li-Yan Jin, Cong-Feng Li, Guang-Fa Zhu, Chun-Ting Wu, Jun Wang, Shu-Feng Yan
Pages: 631-637
Published online on: 05 June 2014

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Article

Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy

Ping He, Detian Li, Beiru Zhang
Pages: 638-644
Published online on: 06 June 2014

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Article Open Access

Dynamic expression patterns of ATF3 and p53 in the hippocampus of a pentylenetetrazole-induced kindling model

Dong-Xue Ding, Fa-Fa Tian, Jia-Ling Guo, Kai Li, Jing‑Xuan  He, Ming-Yu Song, Li Li, Xia Huang
Pages: 645-651
Published online on: 21 May 2014

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Article Open Access

Comparison of long non‑coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma

Su‑Qing Li, Feng Li, Yun Xiao, Chun‑Mei Wang, Lei Tuo, Jing Hu, Xiao‑Bin  Yang, Jin‑Song Wang, Wei‑Hong Shi, Xia Li, Xiu‑Feng Cao
Pages: 652-662
Published online on: 30 May 2014

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Article Open Access

Vasohibin‑2 promotes proliferation in human breast cancer cells via upregulation of fibroblast growth factor‑2 and growth/differentiation factor‑15 expression

Min Tu, Xian Liu, Bei Han, Qianqian Ge, Zhanjun Li, Zipeng Lu, Jishu Wei, Guoxin  Song, Baobao Cai, Nan Lv, Kuirong Jiang, Shui Wang, Yi Miao, Wentao Gao
Pages: 663-669
Published online on: 10 June 2014

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Article

Mast cell activation and response to tolterodine in the rat urinary bladder in a chronic model of intravesical protamine sulfate and bacterial endotoxin-induced cystitis

Bo-Hwa Choi, Long-Hu Jin, Khae-Hawn Kim, Jee-Young Han, Ju‑Hee  Kang, Sang-Min Yoon, Chang-Shin Park, Tack Lee
Pages: 670-676
Published online on: 22 May 2014

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Article

Heat shock protein B6 potently increases non‑small cell lung cancer growth

Shaomu Chen, Haitao Huang, Jie Yao, Liangbin Pan, Haitao Ma
Pages: 677-682
Published online on: 15 May 2014

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Article

GLP-1 ameliorates the proliferation activity of INS-1 cells inhibited by intermittent high glucose concentrations through the regulation of cyclins

Zhen Zhang, Jing Li, Xinkui Jiang, Lei Yang, Lei Lei, Dehong Cai, Hua Zhang, Hong Chen
Pages: 683-688
Published online on: 22 May 2014

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Article

Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP‑2 and NF‑κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease

Ping Jiang, Chunbo Li, Zhenghua Xiang, Binghua Jiao
Pages: 689-694
Published online on: 20 May 2014

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Article

Peroxisome proliferator‑activated receptor γ agonist rosiglitazone inhibits migration and invasion of prostate cancer cells through inhibition of the CXCR4/CXCL12 axis

Liang Qin, Chen Gong, An‑Min Chen, Feng‑Jing Guo, Fei Xu, Ye Ren, Hui Liao
Pages: 695-700
Published online on: 13 May 2014

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Article

Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways

Zhe Xu, Yang Wang
Pages: 701-706
Published online on: 30 May 2014

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Article

MicroRNA‑21 inhibits SMAD7 expression through a target sequence in the 3' untranslated region and inhibits proliferation of renal tubular epithelial cells

Li Lin, Hua Gan, Han Zhang, Weixue Tang, Yue Sun, Xueqin Tang, Dequan Kong, Jiajun Zhou, Yuxuan Wang, Yanlin Zhu
Pages: 707-712
Published online on: 10 June 2014

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Article

Differential co‑expression analysis of a microarray gene expression profiles of pulmonary adenocarcinoma

Shijie Fu, Xufeng Pan, Wentao Fang
Pages: 713-718
Published online on: 05 June 2014

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Article

Necroptosis, a novel form of caspase-independent cell death, contributes to renal epithelial cell damage in an ATP-depleted renal ischemia model

Xinling Liang, Yuanhan Chen, Li Zhang, Fen Jiang, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Chunping Yu, Wei Shi
Pages: 719-724
Published online on: 13 May 2014

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Article

Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach

Jin-Hee Hwang, Kyu-Sup Lee, Jong-Kil Joo, Tao Wang, Jung-Bin Son, Jong‑Ha  Park, Dae-Youn Hwang, Man-Ho Choi, Hong-Gu Lee
Pages: 725-730
Published online on: 30 May 2014

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Article

Combination of aloe-emodin with radiation enhances radiation effects and improves differentiation in human cervical cancer cells

Jinghua Luo, Yong Yuan, Pengyu Chang, Dawei Li, Zhiqiang Liu, Yaqin Qu
Pages: 731-736
Published online on: 10 June 2014

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Article

Elevated expression of AKT2 correlates with disease severity and poor prognosis in human osteosarcoma

Yalong Zhu, Jianhua Zhou, Ying Ji, Baoqing Yu
Pages: 737-742
Published online on: 10 June 2014

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Article

Identification of two novel GATA6 mutations in patients with nonsyndromic conotruncal heart defects

Xike Wang, Wei Ji, Jian Wang, Pengjun Zhao, Ying Guo, Rang Xu, Sun Chen, Kun Sun
Pages: 743-748
Published online on: 16 May 2014

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Article

Evaluation of Jagged2 and Gli1 expression and their correlation with prognosis in human hepatocellular carcinoma

Junli Zhang, Kangsheng Tu, Wei Yang, Chao Li, Yingmin Yao, Xin Zheng, Qingguang Liu
Pages: 749-754
Published online on: 16 May 2014

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Article

Cultivation and identification of rat bone marrow‑derived mesenchymal stem cells

Ke Song, Mengqi Huang, Qi Shi, Tianfeng Du, Yingguang Cao
Pages: 755-760
Published online on: 22 May 2014

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Article

Dynamic mitochondrial changes during differentiation of P19 embryonic carcinoma cells into cardiomyocytes

Jin Jin, Qin-Kao Xuan, Li-Juan Zhou, Chun-Mei Shi, Gui-Xian Song, Yan-Hui Sheng, Ling-Mei Qian
Pages: 761-766
Published online on: 10 June 2014

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Article

Screening and functional analysis of glioma‑related genes induced by candoxin

Lei Qiu, Xiang Zhang, Zuoquan Chen
Pages: 767-772
Published online on: 10 June 2014

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Article

Biphasic modulation of α-ENaC expression by lipopolysaccharide in vitro and in vivo

Shu-Jing Sheng, Yi-Chu Nie, Feng Lin, Pei-Bo Li, Meng‑Hua  Liu, Cheng-Shi Xie, Chao-Feng Long, Wei-Wei Su
Pages: 773-777
Published online on: 06 June 2014

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Article

Downregulation of TrkA protein expression by miRNA‑92a promotes the proliferation and migration of human neuroblastoma cells

Weiwei Liao, Hao Zhang, Chen Feng, Tianyou Wang, Yan Zhang, Suoqin Tang
Pages: 778-784
Published online on: 13 May 2014

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Article

A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer

Jinhua Luo, Qing Zhao, Wei Zhang, Zhuhong Zhang, Jing Gao, Chunyan Zhang, Yali Li, Yaping Tian
Pages: 785-791
Published online on: 27 May 2014

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Article

Co-treating mesenchymal stem cells with IL‑1β and TNF-α increases VCAM-1 expression and improves post-ischemic myocardial function

Chun-Miao Wang, Zeng Guo, Yang-Jing Xie, Yu-Yu Hao, Ji‑Min Sun, Jian Gu, Ai-Ling Wang
Pages: 792-798
Published online on: 13 May 2014

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Article

X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B ‘e’ antigen‑negative chronic hepatitis B

Fei Zhou, Hongzhi Xu, Meiya Chen, Hongmin Xiao, Zhiping Zhang, Yapi Lu, Jianlin Ren, Jing Dong
Pages: 799-803
Published online on: 20 May 2014

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Article

Expression and function of the ACE2/angiotensin(1-7)/Mas axis in osteosarcoma cell lines U-2 OS and MNNG-HOS

Stephan Albrecht Ender, Andrea Dallmer, Florian  Lässig, Uwe Lendeckel, Carmen Wolke
Pages: 804-810
Published online on: 22 May 2014

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Article

Complement component 3 is a prognostic factor of non‑small cell lung cancer

Kailong Lin, Siyi He, Luhang He, Junyin Chen, Xiaoming Cheng, Guoqiang Zhang, Bo Zhu
Pages: 811-817
Published online on: 13 May 2014

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Article Open Access

Liquiritin modulates ERK‑ and AKT/GSK‑3β‑dependent pathways to protect against glutamate‑induced cell damage in differentiated PC12 cells

Lesheng Teng, Qingfan Meng, Jiahui Lu, Jing Xie, Zhenzuo Wang, Yan Liu, Di Wang
Pages: 818-824
Published online on: 30 May 2014

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Article

Effects of human β-defensin-3 on biofilm formation‑regulating genes dltB and icaA in Staphylococcus aureus

Qiang Huang, Jun Fei, Hong-Jun Yu, Yuan-Bin Gou, Xian-Kai Huang
Pages: 825-831
Published online on: 10 June 2014

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Article

Nuclear factor-κB is involved in the protocadherin-10-mediated pro-apoptotic effect in multiple myeloma

Zhen Li, Zesong Yang, Xi Peng, Ying Li, Qiong Liu, Jianbin Chen
Pages: 832-838
Published online on: 29 May 2014

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Article

Activated δ‑opioid receptors inhibit hydrogen peroxide‑induced apoptosis in liver cancer cells through the PKC/ERK signaling pathway

Kaiqi Jia, Deguang Sun, Sunbin Ling, Yu Tian, Xuejun Yang, Jidong Sui, Bo Tang, Liming Wang
Pages: 839-847
Published online on: 05 June 2014

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Article

Talen-mediated girdin knockout downregulates cell proliferation, migration and invasion in human esophageal carcinoma ECA109 cells Retraction in /10.3892/mmr.2021.12318

Ke Cao, Wenting Jiang, Peiguo Cao, Qiong Zou, Sheng Xiao, Jianda Zhou, Chenghui Huang
Pages: 848-854
Published online on: 26 May 2014

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Article

microRNA‑25 promotes osteosarcoma cell proliferation by targeting the cell‑cycle inhibitor p27

Xiu‑Hui Wang, Pan Cai, Ming‑Hui Wang, Zhe Wang
Pages: 855-859
Published online on: 21 May 2014

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Article

Flotillin-1 expression in human clear-cell renal cell carcinoma is associated with cancer progression and poor patient survival

Yiyan Zhang, Jijun Li, Yan Song, Fengkun Chen, Yin Pei, Fenghua Yao
Pages: 860-866
Published online on: 10 June 2014

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Article

Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer

Jihong Feng, Zhongxue Fu, Jinbao Guo, Weidong Lu, Kunming Wen, Wangsheng Chen, Hao Wang, Jilai Wei, Shouru Zhang
Pages: 867-873
Published online on: 10 June 2014

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Article

Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells

Kai Liu, Xilin Song, Heng Ma, Liqing Liu, Xiaowen Wen, Jianyong Yu, Longgang Wang, Sanyuan Hu
Pages: 874-880
Published online on: 10 June 2014

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Article

Glucocorticoids induce apoptosis by inhibiting microRNA cluster miR‑17‑92 expression in chondrocytic cells

Wenhua Xing, Lixia Hao, Xuejun Yang, Feng Li, Hongjun Huo
Pages: 881-886
Published online on: 20 May 2014

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Article

Differential expression of stromal aromatase in obese females is regulated by DNA methylation

Xian‑Cheng Zeng, Xiang Ao, Hai‑Feng Yang, Guang‑Xian  Zhang, Wen‑Hong Li, Qi‑Long Liu, Yue‑Liang Tang, Yi‑Cheng Xie, Wen‑Guang  He, Yan‑Nian Huang, Lei Zhang, Rong‑Jiang Li
Pages: 887-890
Published online on: 27 May 2014

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Article

Tumor suppressor candidate gene, NDRG2 is frequently inactivated in human glioblastoma multiforme

Bin Zhou, Zhuo Tang, Yanchun Deng, Shuangxing Hou, Nan Liu, Wei Lin, Xinping Liu, Libo Yao
Pages: 891-896
Published online on: 14 May 2014

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Article

O-GlcNAcylation is increased in prostate cancer tissues and enhances malignancy of prostate cancer cells

Yuchao Gu, Jiangang Gao, Cuifang Han, Xinling Zhang, Haiyan Liu, Leina Ma, Xiaoqing Sun, Wengong Yu
Pages: 897-904
Published online on: 26 May 2014

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Article

Restoration of adiponectin expression via the ERK pathway in TNFα-treated 3T3-L1 adipocytes

Eugene Chang, Jung Mook Choi, Won Jun Kim, Eun-Jung Rhee, Ki Won Oh, Won-Young Lee, Se Eun Park, Sung Woo Park, Cheol-Young Park
Pages: 905-910
Published online on: 28 May 2014

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Article

B16 cell lysates plus polyinosinic-cytidylic acid effectively eradicate melanoma in a mouse model by acting as a prophylactic vaccine

Biwen Lin, Hua Zhao, Jianfeng Fan, Fang Xie, Wenjuan Wang, Xiangyu Ding
Pages: 911-916
Published online on: 15 May 2014

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Article

Salidroside blocks the proliferation of pulmonary artery smooth muscle cells induced by platelet‑derived growth factor‑BB

Changgui Chen, Yanhong Tang, Wei Deng, Congxin Huang, Tianyi Wu
Pages: 917-922
Published online on: 14 May 2014

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Article

Spinal leptin contributes to the development of morphine antinociceptive tolerance by activating the STAT3-NMDA receptor pathway in rats

Fen Hu, Yu Cui, Ruixian Guo, Jingfu Chen, Runming Guo, Ning Shen, Xiaoxiao Hua, Liqiu Mo, Jianqiang Feng
Pages: 923-930
Published online on: 20 May 2014

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Article

Combined gefitinib and pemetrexed overcome the acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

Min Wu, Yuan Yuan, Yue-Yin Pan, Ying Zhang
Pages: 931-938
Published online on: 16 May 2014

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Article

Expression of breast cancer resistance protein in peripheral T cell subsets from HIV‑1‑infected patients with antiretroviral therapy

Jiu‑Cong Zhang, Zhi‑Yun Deng, Yong Wang, Fang Xie, Li Sun, Fang‑Xin Zhang
Pages: 939-946
Published online on: 29 May 2014

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Article

Aberrant DNA methylation of the PDGF gene in homocysteine‑mediated VSMC proliferation and its underlying mechanism

Xue‑Bo Han, Hui‑Ping Zhang, Cheng‑Jian Cao, Yan‑Hua Wang, Jue Tian, Xiao‑Ling Yang, An‑Ning Yang, Jie Wang, Yi‑Deng Jiang, Hua Xu
Pages: 947-954
Published online on: 20 May 2014

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Article

Downregulation of β-catenin and Akt signaling is responsible for poor proliferation of the late passage of bone marrow mesenchymal stem cells

Junfang Wu, Jie Niu, Xiaopeng Li, Tongming Ren, Fenxi Zhang
Pages: 955-958
Published online on: 29 May 2014

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Article

Reduced levels of interleukin‑1 receptor antagonist act as a marker for pneumonia in the elderly

Lijie Zhao, Lina Wang, Xiaoyan Zhang, Lili Sun, Dan Sun, Tingli Sun
Pages: 959-964
Published online on: 29 May 2014

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Article

1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone exhibits a potent radiosensitizing effect with induced oncosis in human nasopharyngeal carcinoma cells

Huaxin Hou, Danrong Li, Wei Jiang, Yan Liang, Donglian Chen, Yuanyuan Mo
Pages: 965-970
Published online on: 10 June 2014

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Article

Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction

Jiansuo Zhou, Jie Zhang
Pages: 971-976
Published online on: 16 May 2014

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Article

Peripheral Foxp3+ regulatory T cells and natural killer group 2, member D expression levels in natural killer cells of patients with colorectal cancer

Yajuan Shen, Qian Wang, Yuanying Qi, Bin Cui, Zhifen Zhang, Jingran Su, Xiaowen Liu, Chao Lu, Hui Ye, Ying Ju, Zhiming Lu
Pages: 977-982
Published online on: 13 May 2014

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Article

Effects of bacteria‑mediated reprogramming and antibiotic pretreatment on the course of colitis in mice

Roman Gardlik, Alexandra Wagnerova, Peter Celec
Pages: 983-988
Published online on: 16 May 2014

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Decreased V?8.2 T?cells in neonatal rats exposed prenatally to Staphylococcal enterotoxin B are further deleted by restimulation in an in vitro cultured thymus

Wen‑Xuan Yang, Xiang Zhu, Feng‑Ling Yu, Tao Zhang, Na Lin, Ting‑Ting  Liu, Fang‑Fang Zhao, Yong Liu, Hui Xia, Jun‑Chang Guan
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Published online on: 26 May 2014

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Overexpression of microRNA-125b sensitizes human hepatocellular carcinoma cells to 5-fluorouracil through inhibition of glycolysis by targeting hexokinase II

Jian-Xin Jiang, Shan Gao, Yao-Zhen Pan, Chao Yu, Cheng-Yi Sun
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The incidence of mismatch repair gene defects in colorectal liver metastases

Raul Alvarado‑Bachmann, Adrian Smith, Justin S. Gundara, Samuel  C.L. Kuo, Anthony J. Gill, Jaswinder S. Samra, Thomas J. Hugh
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Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factor-κB signaling pathway

Kyu-Shik Lee, Do-Hyung Lee, So-Young Chun, Kyung-Soo Nam
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Expression of growth‑regulated oncogene‑1, hepatocyte growth factor, platelet‑derived growth factor‑AA and soluble E‑selectin and their association with high‑risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Ye Zhang, Jian‑Zhong Wu, Yong‑Qin Yang, Rong Ma, Jun‑Ying Zhang, Ji‑Feng Feng
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Effect of arazyme on the lipopolysaccharide‑induced inflammatory response in human endothelial cells

In Sik Kim, Eun Ju Yang, Dong‑Ha Shin, Kwang‑Hee Son, Ho‑Yong Park, Ji‑Sook Lee
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Effect of the Wnt1/β-catenin signalling pathway on human embryonic pulmonary fibroblasts

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Correlation between the genetic variations in interleukin 28B and chronic hepatitis C virus genotypes in the Chinese population

Xiao-Rong Mao, Li-Ting Zhang, Hong Chen, Ping Xiao, You-Cheng Zhang
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Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest

Bo Liu, Yue-Qiu Gao, Xiao-Min Wang, Yu-Chun Wang, Li-Qi Fu
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Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer

Min Du, Xiao‑Mei Su, Tao Zhang, Yong‑Jun Xing
Pages: 1051-1055
Published online on: 27 May 2014

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MUC1 and maltose‑binding protein recombinant fusion protein combined with Bacillus Calmette‑Guerin induces MUC1‑specific and nonspecific anti‑tumor immunity in mice

Fang Fang, Jichun Ma, Weihua Ni, Fengli Wang, Xiaxia Sun, Yingying Li, Qiongshu Li, Fei Xie, Juan Wang, Ruiping Zhai, Zhonghui Liu, Sunjun Gao, Guixiang Tai
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Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-κB pathway

Tao Huang, Dakuan Gao, Xiaofan Jiang, Shijie Hu, Lei Zhang, Zhou Fei
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T regulatory lymphocytes in patients with endometriosis

Marek Gogacz, Izabela Winkler, Agnieszka Bojarska‑Junak, Jacek Tabarkiewicz, Andrzej Semczuk, Tomasz Rechberger, Aneta Adamiak
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Anti‑inflammatory effects of Perilla frutescens leaf extract on lipopolysaccharide‑stimulated RAW264.7 cells

Bee‑Piao Huang, Chun‑Hsiang Lin, Yi‑Ching Chen, Shao‑Hsuan Kao
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Published online on: 05 June 2014

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Pioglitazone inhibits the expression of matrix metalloproteinase-9, a protein involved in diabetes-associated wound healing

Jun Zhang, Xiaoyuan Huang, Lingfeng Wang
Pages: 1084-1088
Published online on: 28 May 2014

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HSP70 inhibits high glucose-induced Smad3 activation and attenuates epithelial-to-mesenchymal transition of peritoneal mesothelial cells

Jun Liu, Jinfang Bao, Jing Hao, Yan Peng, Fuyuan Hong
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Efficacy of switching from premixed insulin to insulin glargine regimen in Type 2 diabetes mellitus patients with different islet functions

Yong-Bo Wang, Shuang Wang, Ran Bai, Jian-Ling Du, Qian Xing, Ying Ba, Yu Yang, Xue-Yan Zhang, Chun-Hong Shi, Jun-Jie Yao
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Published online on: 22 May 2014

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Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells

Zonggang Xie, Ye Xie, Youjia Xu, Haibin Zhou, Wei Xu, Qirong Dong
Pages: 1103-1107
Published online on: 29 May 2014

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Dual‑sensitive HRE/Egr1 promoter regulates Smac overexpression and enhances radiation‑induced A549 human lung adenocarcinoma cell death under hypoxia

Chang‑Feng Li, Li‑Bo Chen, Dan‑Dan Li, Lei Yang, Bao‑Gang Zhang, Jing‑Peng Jin, Ying Zhang, Bin Zhang
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Expression of latent membrane proteins in Epstein‑Barr virus-transformed lymphocytes in vitro

Yunlian Tang, Chunyan Luo, Ailan Cheng, Suli Lu, Jinhua Xu, Ting Fu, Runliang Gan
Pages: 1117-1121
Published online on: 10 June 2014

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β-Elemene inhibits proliferation through crosstalk between glia maturation factor β and extracellular signal‑regulated kinase 1/2 and impairs drug resistance to temozolomide in glioblastoma cells

Ting-Zhun Zhu, Xiao-Ming Li, Li-Han Luo, Ying-Hui  Xu, Peng Cao, Yang Liu, Guo-Biao Liang
Pages: 1122-1128
Published online on: 27 May 2014

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Interference of Skp2 effectively inhibits the development and metastasis of colon carcinoma

Haijin Chen, Xiaodong Mo, Jinlong Yu, Shuxin Huang, Zonghai Huang, Liping Gao
Pages: 1129-1135
Published online on: 10 June 2014

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Generation of transgenic fibroblasts expressing pancreas‑specific and doxycycline-inducible ICER Iγ for the establishment of a porcine model of human diabetes mellitus

Hee Young Kang, Eui-Man Jung, Eui-Ju Hong, Sang-Hwan Hyun, Woo-Suk Hwang, Eui-Bae Jeung
Pages: 1136-1142
Published online on: 20 May 2014

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Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury in H9c2 cells through activation of the NF‑E2‑related factor 2/heme oxygenase 1 signaling pathway

Qiang Xie, Xue‑Xiang Li, Peng Zhang, Jin‑Cao Li, Ying Cheng, Yan‑Ling  Feng, Bing‑Sheng Huang, Yu‑Feng Zhuo, Guo‑Hua Xu
Pages: 1143-1149
Published online on: 29 May 2014

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Chlamydia pneumoniae disrupts lipid metabolism in human umbilical vein endothelial cells

Shan Sun, Bei Cheng, Xiaohua Wu, Qinqin Wu, Benling Qi, Jianping Wu, Ping He
Pages: 1150-1156
Published online on: 03 June 2014

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Measurement of hydroxyproline in collagen with three different methods

Bing Qiu, Fengxiang Wei, Xiuzhi Sun, Xi Wang, Binhong Duan, Chunlin  Shi, Jianying  Zhang, Jiye Zhang, Wenliang Qiu, Wenling Mu
Pages: 1157-1163
Published online on: 23 May 2014

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Expression of obesity‑related miR‑1908 in human adipocytes is regulated by adipokines, free fatty acids and hormones

Xinye Jiang, Lei Yang, Lingxia Pang, Ling Chen, Xirong Guo, Chenbo Ji, Chunmei Shi, Yuhui Ni
Pages: 1164-1169
Published online on: 05 June 2014

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[Retracted] Generation of induced pluripotent stem cells using skin fibroblasts from patients with myocardial infarction under feeder-free conditions

Jun-Quan Li, Ming Cheng, Wei-Chen Tian, Jian Zhang
Pages: 1170-1170
Published online on: 27 May 2014

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Article Number: 51
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Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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