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Article

The incidence of mismatch repair gene defects in colorectal liver metastases

  • Authors:
    • Raul Alvarado‑Bachmann
    • Adrian Smith
    • Justin S. Gundara
    • Samuel  C.L. Kuo
    • Anthony J. Gill
    • Jaswinder S. Samra
    • Thomas J. Hugh
  • View Affiliations / Copyright

    Affiliations: Upper Gastrointestinal Surgical Unit, University of Sydney, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia, Department of Colorectal Surgery, University of Sydney, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia, Department of Anatomical Pathology, University of Sydney, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
  • Pages: 1003-1006
    |
    Published online on: May 21, 2014
       https://doi.org/10.3892/mmr.2014.2257
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Abstract

Knowledge of the molecular biology of primary colorectal cancer (CRC) has improved in recent years, and one reason for this is the identification of microsatellite instability (MSI), which occurs in up to 15% of sporadic CRC. However, less is known regarding the processes involved in colorectal liver metastases (CRLM). Increasing numbers of patients with CRLM are suitable for curative resection, so the identification of molecular markers may improve patient selection. The aim of the present study was to characterise the incidence of MSI in resected CRLM. Fifty‑one sequentially resected CRLM specimens were selected. Clinicopathologic data was collated and immunohistochemistry for MLH1 and MSH2 was performed on paraffin sections of the CRLM specimens. The association between abnormal staining and the clinicopathological data was examined. The median age of the subjects in the current study was 65 years, the average number of CRLM was 2 and the median overall survival time was 42.1 months post liver resection. None of the 50 resected specimens demonstrated abnormal staining for MLH1 or MSH2. Compared with the previously reported incidence of MSI in primary CRC, the low incidence of MSI in the current cohort of CRLM precludes its use as a marker for use in making clinical decisions regarding this condition.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2 

Wolpin BM and Mayer RJ: Systemic treatment of colorectal cancer. Gastroenterology. 134:1296–1310. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Cunningham JM, Kim CY, Christensen ER, Tester DJ, Parc Y, Burgart LJ, Halling KC, McDonnell SK, Schaid DJ, Walsh Vockley C, et al: The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet. 69:780–790. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Aaltonen LA, Peltomäki P, Leach FS, Sistonen P, Pylkkänen L, Mecklin JP, Järvinen H, Powell SM, Jen J, Hamilton SR, et al: Clues to the pathogenesis of familial colorectal cancer. Science. 260:812–816. 1993. View Article : Google Scholar : PubMed/NCBI

5 

Fong Y, Fortner J, Sun RL, Brennan MF and Blumgart LH: Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 230:309–321. 1999. View Article : Google Scholar

6 

Simmonds PC, Primrose JN, Colquitt JL, Garden OJ, Poston GJ and Rees M: Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer. 94:982–999. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Pawlik TM and Choti MA: Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastases. Curr Oncol Rep. 9:193–201. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Thorstensen L, Qvist H, Nesland JM, Giercksky KE and Lothe RA: Allelotype profiles of local recurrences and distant metastases from colorectal-cancer patients. Int J Cancer. 69:452–456. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Messick CA, Church J, Casey G and Kalady MF: Identification of the methylator (serrated) colorectal cancer phenotype through precursor serrated polyps. Dis Colon Rectum. 52:1535–1541. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Salahshor S, Kressner U, Fischer H, Lindmark G, Glimelius B, Pâhlman L and Lindblom A: Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor. Br J Cancer. 81:190–193. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AM and Bos JL: Genetic alterations during colorectal-tumor development. N Engl J Med. 319:525–532. 1988. View Article : Google Scholar : PubMed/NCBI

12 

Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell. 61:759–767. 1990. View Article : Google Scholar : PubMed/NCBI

13 

Leslie A, Carey FA, Pratt NR and Steele RJ: The colorectal adenoma-carcinoma sequence. Br J Surg. 89:845–860. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN and Srivastava S: A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 58:5248–5257. 1998.

15 

Walther A, Johnstone E, Swanton C, Midgley R, Tomlinson I and Kerr D: Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer. 9:489–499. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Poynter JN, Siegmund KD, Weisenberger DJ, et al; Colon Cancer Family Registry Investigators. Molecular characterisation of MSI-H colorectal cancer by MLH1 promoter methylation, immunohistochemistry and missmatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev. 17:3208–3215. 2008. View Article : Google Scholar

17 

Popat S, Hubner R and Houlston RS: Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol. 23:609–618. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Jover R, Payá A, Alenda C, Poveda MJ, Peiró G, Aranda FI and Pérez-Mateo M: Defective mismatch-repair colorectal cancer: clinicopathologic characteristics and usefulness of immunohistochemical analysis for diagnosis. Am J Clin Pathol. 122:389–394. 2004. View Article : Google Scholar

19 

Jover R, Zapater P, Castells A, et al; Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. The efficacy of adjuvant chemotherapy with 5-flourouracil in colorectal cancer depends on mismatch repair status. Eur J Cancer. 45:365–373. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Malesci A, Laghi L, Bianchi P, et al: Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer. Clin Cancer Res. 13:3831–3839. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Haddad R, Ogilvie RT, Croitoru M, Muniz V, Gryfe R, Pollet A, Shanmugathasan P, Fitzgerald T, Law CH, Hanna SS, et al: Microsatellite instability as a prognostic factor in resected colorectal cancer liver metastases. Ann Surg Oncol. 11:977–982. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Chen WS, Chen JY, Liu JM, Lin WC, King KL, Whang-Peng J and Yang WK: Microsatellite instability in sporadic-colon-cancer patients with and without liver metastases. Int J Cancer. 74:470–474. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Ishimaru G, Adachi J, Shiseki M, Yamaguchi N, Muto T and Yokota J: Microsatellite instability in primary and metastatic colorectal cancers. Int J Cancer. 64:153–157. 1995. View Article : Google Scholar : PubMed/NCBI

24 

Nicholl ID and Dunlop MG: Molecular markers of prognosis in colorectal cancer. J Natl Cancer Inst. 91:1267–1269. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Ding SF, Delhanty JD, Zografos G, Michail NE, Dooley JS and Habib NA: Chromosome allele loss in colorectal liver metastases and its association with clinical features. Br J Surg. 81:875–878. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Samowitz WS and Slattery ML: Regional reproducibility of microsatellite instability in sporadic colorectal cancer. Genes Chromosomes Cancer. 26:106–114. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Moslein G, Tester DJ, Lindor NM, Honchel R, Cunningham JM, French AJ, Halling KC, Schwab M, Goretzki P and Thibodeau SN: Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. Hum Mol Genet. 5:1245–1252. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Kochhar R, Halling KC, McDonnell S, Schaid DJ, French AJ, O’Connell MJ, Nagorney DM and Thibodeau SN: Allelic imbalance and microsatellite instability in resected Duke’s D colorectal cancer. Diagn Mol Pathol. 6:78–84. 1997.PubMed/NCBI

29 

Bendardaf R, Lamlum H, Ristamäki R, Korkeila E, Syrjänen K and Pyrhönen S: Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer. Tumour Biol. 28:212–220. 2007. View Article : Google Scholar

30 

Feeley KM, Fullard JF, Heneghan MA, Smith T, Maher M, Murphy RP and O’Gorman TA: Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis. J Pathol. 188:14–17. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Halling KC, French AJ, McDonnell SK, Burgart LJ, Schaid DJ, Peterson BJ, Moon-Tasson L, Mahoney MR, Sargent DJ, O’Connell MJ, et al: Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst. 91:1295–1303. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Lothe RA, Peltomäki P, Meling GI, Aaltonen LA, Nyström-Lahti M, Pylkkänen L, Heimdal K, Andersen TI, Møller P, Rognum TO, et al: Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res. 53:5849–5852. 1993.PubMed/NCBI

33 

Elsaleh H and Iacopetta B: Microsatellite instability is a predictive marker for survival benefit from adjuvant chemotherapy in a population-based series of stage III colorectal carcinoma. Clin Colorectal Cancer. 1:104–109. 2001. View Article : Google Scholar

34 

Des Guetz G, Uzzan B, Nicolas P, Schischmanoff O, Perret GY and Morere JF: Microsatellite instability does not predict the efficacy of chemotherapy in metastatic colorectal cancer. A systematic review and meta-analysis. Anticancer Res. 29:1615–1620. 2009.

35 

Huang J, Kuismanen SA, Liu T, Chadwick RB, Johnson CK, Stevens MW, Richards SK, Meek JE, Gao X, Wright FA, et al: MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer. Cancer Res. 61:1619–1623. 2001.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Alvarado‑Bachmann R, Smith A, Gundara JS, Kuo SC, Gill AJ, Samra JS and Hugh TJ: The incidence of mismatch repair gene defects in colorectal liver metastases. Mol Med Rep 10: 1003-1006, 2014.
APA
Alvarado‑Bachmann, R., Smith, A., Gundara, J.S., Kuo, S.C., Gill, A.J., Samra, J.S., & Hugh, T.J. (2014). The incidence of mismatch repair gene defects in colorectal liver metastases. Molecular Medicine Reports, 10, 1003-1006. https://doi.org/10.3892/mmr.2014.2257
MLA
Alvarado‑Bachmann, R., Smith, A., Gundara, J. S., Kuo, S. C., Gill, A. J., Samra, J. S., Hugh, T. J."The incidence of mismatch repair gene defects in colorectal liver metastases". Molecular Medicine Reports 10.2 (2014): 1003-1006.
Chicago
Alvarado‑Bachmann, R., Smith, A., Gundara, J. S., Kuo, S. C., Gill, A. J., Samra, J. S., Hugh, T. J."The incidence of mismatch repair gene defects in colorectal liver metastases". Molecular Medicine Reports 10, no. 2 (2014): 1003-1006. https://doi.org/10.3892/mmr.2014.2257
Copy and paste a formatted citation
x
Spandidos Publications style
Alvarado‑Bachmann R, Smith A, Gundara JS, Kuo SC, Gill AJ, Samra JS and Hugh TJ: The incidence of mismatch repair gene defects in colorectal liver metastases. Mol Med Rep 10: 1003-1006, 2014.
APA
Alvarado‑Bachmann, R., Smith, A., Gundara, J.S., Kuo, S.C., Gill, A.J., Samra, J.S., & Hugh, T.J. (2014). The incidence of mismatch repair gene defects in colorectal liver metastases. Molecular Medicine Reports, 10, 1003-1006. https://doi.org/10.3892/mmr.2014.2257
MLA
Alvarado‑Bachmann, R., Smith, A., Gundara, J. S., Kuo, S. C., Gill, A. J., Samra, J. S., Hugh, T. J."The incidence of mismatch repair gene defects in colorectal liver metastases". Molecular Medicine Reports 10.2 (2014): 1003-1006.
Chicago
Alvarado‑Bachmann, R., Smith, A., Gundara, J. S., Kuo, S. C., Gill, A. J., Samra, J. S., Hugh, T. J."The incidence of mismatch repair gene defects in colorectal liver metastases". Molecular Medicine Reports 10, no. 2 (2014): 1003-1006. https://doi.org/10.3892/mmr.2014.2257
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