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August-2014 Volume 10 Issue 2

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Article

Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer

  • Authors:
    • Min Du
    • Xiao‑Mei Su
    • Tao Zhang
    • Yong‑Jun Xing
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, PLA General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China, Affiliated Stomatological Hospital, PLA General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China
  • Pages: 1051-1055
    |
    Published online on: May 27, 2014
       https://doi.org/10.3892/mmr.2014.2276
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Abstract

Bone morphogenetic protein 2 (BMP2) is a growth factor that is involved in the development and progression of various types of cancer. However, the epigenetic regulation of the expression of BMP2 and the association between BMP2 expression and drug resistance in breast cancer remains to be elucidated. The present study reported that the expression of BMP2 was significantly decreased in primary breast cancer samples and the MCF‑7/ADR breast cancer mulitdrug resistance cell line, which was closely associated with its promoter DNA methylation status. The expression of BMP2 in MCF‑7/ADR cells markedly increased when treated with 5‑Aza‑2'‑deoxycytidine. Knockdown of BMP2 by specific small interfering RNA enhanced the chemoresistance of the MCF‑7 breast cancer cell line. These findings indicated that epigenetic silencing of BMP2 in breast cancer may be involved in breast cancer progression and drug resistance, and provided a novel prognostic marker and therapeutic strategy for breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Du M, Su XM, Zhang T and Xing YJ: Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer. Mol Med Rep 10: 1051-1055, 2014.
APA
Du, M., Su, X., Zhang, T., & Xing, Y. (2014). Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer. Molecular Medicine Reports, 10, 1051-1055. https://doi.org/10.3892/mmr.2014.2276
MLA
Du, M., Su, X., Zhang, T., Xing, Y."Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer". Molecular Medicine Reports 10.2 (2014): 1051-1055.
Chicago
Du, M., Su, X., Zhang, T., Xing, Y."Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer". Molecular Medicine Reports 10, no. 2 (2014): 1051-1055. https://doi.org/10.3892/mmr.2014.2276
Copy and paste a formatted citation
x
Spandidos Publications style
Du M, Su XM, Zhang T and Xing YJ: Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer. Mol Med Rep 10: 1051-1055, 2014.
APA
Du, M., Su, X., Zhang, T., & Xing, Y. (2014). Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer. Molecular Medicine Reports, 10, 1051-1055. https://doi.org/10.3892/mmr.2014.2276
MLA
Du, M., Su, X., Zhang, T., Xing, Y."Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer". Molecular Medicine Reports 10.2 (2014): 1051-1055.
Chicago
Du, M., Su, X., Zhang, T., Xing, Y."Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer". Molecular Medicine Reports 10, no. 2 (2014): 1051-1055. https://doi.org/10.3892/mmr.2014.2276
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