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Article

Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach

  • Authors:
    • Jin-Hee Hwang
    • Kyu-Sup Lee
    • Jong-Kil Joo
    • Tao Wang
    • Jung-Bin Son
    • Jong‑Ha  Park
    • Dae-Youn Hwang
    • Man-Ho Choi
    • Hong-Gu Lee
  • View Affiliations / Copyright

    Affiliations: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, South Korea, Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Gyeongnam 626-770, South Korea, Department of Biomaterial Science, College of Natural Resources and Life Science, Pusan National University, Miryang 627-706, South Korea, Future Convergence Research Division, Korea Institute of Science and Technology, Seoul 136-791, South Korea
  • Pages: 725-730
    |
    Published online on: May 30, 2014
       https://doi.org/10.3892/mmr.2014.2291
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Abstract

The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis.
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1 

Sasson IE and Taylor HS: Stem cells and the pathogenesis of endometriosis. Ann NY Acad Sci. 1127:106–115. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Ozkan S, Murk W and Arici A: Endometriosis and infertility: epidemiology and evidence-based treatments. Ann NY Acad Sci. 1127:92–100. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Bulun SE: Endometriosis. N Engl J Med. 360:268–279. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Audebert A: Endometriosis coaching. Gynecol Obstet Fertil. 34:329–336. 2006.(In French).

5 

Bast RC Jr, Xu FJ, Yu YH, Barnhill S, Zhang Z and Mills GB: CA 125: the past and the future. Int J Biol Marker. 13:179–187. 1998.PubMed/NCBI

6 

Chen FP, Soong YK, Lee N and Lo SK: The use of serum CA-125 as a marker for endometriosis in patients with dysmenorrhea for monitoring therapy and for recurrence of endometriosis. Acta Obstet Gynecol Scand. 77:665–670. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Mihalyi A, Gevaert O, Kyama CM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert N, Vodolazkaia A, Fulop V and D’Hooghe TM: Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers. Hum Reprod. 25:654–664. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Nabeta M, Abe Y, Kagawa L, Haraguchi R, Kito K, Ueda N, Sugita A, Yokoyama M, Kusanagi Y and Ito M: Identification of anti-α-enolase autoantibody as a novel serum marker for endometriosis. Proteomics Clin Appl. 3:1201–1210. 2009.

9 

Nabeta M, Abe Y, Haraguchi R, Kito K, Kusanagi Y and Ito M: Serum anti-PDIK1L autoantibody as a novel marker for endometriosis. Fertil Steril. 94:2552–2557. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Nabeta M, Abe Y, Takaoka Y, Kusanagi Y and Ito M: Identification of anti-syntaxin 5 autoantibody as a novel serum marker of endometriosis. J Reprod Immunol. 91:48–55. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Eyster KM, Boles AL, Brannian JD and Hansen KA: DNA microarray analysis of gene expression markers of endometriosis. Fertil Steril. 77:38–42. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Arimoto T, Katagiri T, Oda K, Tsunoda T, Yasugi T, Osuga Y, Yoshikawa H, Nishii O, Yano T, Taketani Y and Nakamura Y: Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. Int J Oncol. 22:551–560. 2003.PubMed/NCBI

13 

Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, Taylor RN, Osteen K, Lessey BA and Giudice LC: Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology. 144:2870–2881. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Gupta S, Agarwal A, Sekhon L, Krajcir N, Cocuzza M and Falcone T: Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. Minerva Ginecol. 58:527–551. 2006.PubMed/NCBI

15 

Zhang H, Niu Y, Feng J, Guo H, Ye X and Cui H: Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls. Fertil Steril. 86:274–282. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Ferrero S, Gillott DJ, Remorgida V, Anserini P, Leung KY, Ragni N and Grudzinskas JG: Proteomic analysis of peritoneal fluid in women with endometriosis. J Proteome Res. 6:3402–3411. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Fowler PA, Tattum J, Bhattacharya S, Klonisch T, Hombach-Klonisch S, Gazvani R, Lea RG, Miller I, Simpson WG and Cash P: An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease. Proteomics. 7:130–142. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Ametzazurra A, Matorras R, García-Velasco JA, Prieto B, Simón L, Martínez A and Nagore D: Endometrial fluid is a specific and non-invasive biological sample for protein biomarker identification in endometriosis. Hum Reprod. 24:954–965. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Somigliana E, Viganò P, Rossi G, Carinelli S, Vignali M and Panina-Bordignon P: Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis. Hum Reprod. 14:2944–2950. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Wang T, Lee HG, Hwang JH, Oh JJ, Lim JN, Kang HS, Joo JK and Lee KS: Myoglobin: a promising exogenous reference marker using in proteomics analysis. Food Sci Biotechnol. 22:393–398. 2013. View Article : Google Scholar

21 

Hwang JH, Oh JJ, Wang T, Jin YC, Lee JS, Choi JR, Lee KS, Joo JK and Lee HG: Identification of biomarkers for endometriosis in eutopic endometrial cells from patients with endometriosis using a proteomics approach. Mol Med Rep. 8:183–188. 2013.PubMed/NCBI

22 

Galle PC: Clinical presentation and diagnosis of endometriosis. Obstet Gynecol Clin North Am. 16:29–42. 1989.PubMed/NCBI

23 

Mol BW, Bayram N, Lijmer JG, Wiegerinck MA, Bongers MY, van der Veen F and Bossuyt PM: The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis. Fertil Steril. 70:1101–1108. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Moore J, Copley S, Morris J, Lindsell D, Golding S and Kennedy S: A systematic review of the accuracy of ultrasound in the diagnosis of endometriosis. Ultrasound Obstet Gynecol. 20:630–634. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Slobodianik NH, Feliu MS, Perris P, Barbeito S, Strasnoy I, Franchello A and Ferraro M: Inflammatory biomarker profile in children with cystic fibrosis: preliminary study. Proc Nutr Soc. 69:354–356. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Cocciolo A, Di Domenico F, Coccia R, Fiorini A, Cai J, Pierce WM, Mecocci P, Butterfield DA and Perluigi M: Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics. Free Radic Biol Med. 53:1868–1876. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Iborra A, Palacio JR and Martinez P: Oxidative stress and autoimmune response in the infertile woman. Chem Immunol Allergy. 88:150–162. 2005.PubMed/NCBI

28 

Sohal RS: Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med. 33:37–44. 2002.PubMed/NCBI

29 

Carvalho LF, Samadder AN, Agarwal A, Fernandes LF and Abrão MS: Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch Gynecol Obstet. 286:1033–1040. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hwang J, Lee K, Joo J, Wang T, Son J, Park JH, Hwang D, Choi M and Lee H: Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach. Mol Med Rep 10: 725-730, 2014.
APA
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J. ... Lee, H. (2014). Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach. Molecular Medicine Reports, 10, 725-730. https://doi.org/10.3892/mmr.2014.2291
MLA
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J., Hwang, D., Choi, M., Lee, H."Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach". Molecular Medicine Reports 10.2 (2014): 725-730.
Chicago
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J., Hwang, D., Choi, M., Lee, H."Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach". Molecular Medicine Reports 10, no. 2 (2014): 725-730. https://doi.org/10.3892/mmr.2014.2291
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang J, Lee K, Joo J, Wang T, Son J, Park JH, Hwang D, Choi M and Lee H: Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach. Mol Med Rep 10: 725-730, 2014.
APA
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J. ... Lee, H. (2014). Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach. Molecular Medicine Reports, 10, 725-730. https://doi.org/10.3892/mmr.2014.2291
MLA
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J., Hwang, D., Choi, M., Lee, H."Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach". Molecular Medicine Reports 10.2 (2014): 725-730.
Chicago
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J., Hwang, D., Choi, M., Lee, H."Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach". Molecular Medicine Reports 10, no. 2 (2014): 725-730. https://doi.org/10.3892/mmr.2014.2291
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