T regulatory lymphocytes in patients with endometriosis

Gogacz,Marek; Winkler,Izabela; Bojarska‑Junak,Agnieszka; Tabarkiewicz,Jacek; Semczuk,Andrzej; Rechberger,Tomasz; Adamiak,Aneta

doi:10.3892/mmr.2014.2294

August-2014 Volume 10 Issue 2

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August-2014 Volume 10 Issue 2

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Article

T regulatory lymphocytes in patients with endometriosis

Authors:
- Marek Gogacz
- Izabela Winkler
- Agnieszka Bojarska‑Junak
- Jacek Tabarkiewicz
- Andrzej Semczuk
- Tomasz Rechberger
- Aneta Adamiak
View Affiliations / Copyright

Affiliations: Second Department of Gynaecology, Medical University of Lublin, Lublin 20‑954, Poland, Department of Clinical Immunology, Medical University, Lublin 20‑093, Poland
Pages: 1072-1076
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Published online on: June 2, 2014

https://doi.org/10.3892/mmr.2014.2294
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Abstract

The present study aimed to investigate the presence of T regulatory cells (Tregs) in the peripheral blood (PB) and peritoneal fluid (PF) in females with endometriosis. The present study included 42 patients who underwent laparoscopy between 2010 and 2011. Flow cytometry was used to determine the percentage of Tregs in the PF and PB of the patients. No significant difference was observed in the percentage of Tregs in the patients in the endometriosis group compared with those in the control group in the PF (9.1±5.4 vs. 9.1±3.8%) or the PB (6.5±3.2 vs. 6.5±3.7%). However, the percentage of Tregs was found to be higher in the PF compared with the PB in the patients in the endometriosis and control groups, but significance was found only in those in the control group. Furthermore, no significant difference was observed in the Treg concentration in the patients with early stage (I/II) endometriosis compared with those with late stage (III/IV) endometriosis. Moreover, no significant correlation was found between the percentage of Tregs and the white blood cell count, lymphocyte count or CA125 concentration in the patients. These findings suggest that the local host‑defense mechanism is deficient in patients with endometriosis, thus endometriosis should not be treated as an autoimmune condition.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

T regulatory lymphocytes in patients with endometriosis

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Abstract

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