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August-2014 Volume 10 Issue 2

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Article

Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells

  • Authors:
    • Kai Liu
    • Xilin Song
    • Heng Ma
    • Liqing Liu
    • Xiaowen Wen
    • Jianyong Yu
    • Longgang Wang
    • Sanyuan Hu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China
  • Pages: 874-880
    |
    Published online on: June 10, 2014
       https://doi.org/10.3892/mmr.2014.2305
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Abstract

The upregulation of bone morphogenetic protein and activin membrane‑bound inhibitor (BAMBI) has been observed in several types of malignant cancer, including thyroid, ovarian, liver and colorectal cancer. However, the pathological role and the regulatory mechanism of BAMBI in gastric cancer remain to be elucidated. The present study revealed that the expression of BAMBI was upregulated in gastric cancer tissue, and was correlated with tumor metastasis, disease recurrence and low survival rates in patients. Knockdown of BAMBI in aggressive gastric cancer cell lines significantly inhibited their malignant behavior, including in vitro invasion and cell proliferation. β‑catenin expression was downregulated as a result of knocking down of BAMBI, and TGF-β was downregulated in a similar manner. These results demonstrated the association between BAMBI expression and gastric cancer progression, and indicate a promising direction for developing novel strategies to improve the prognosis and therapy of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu K, Song X, Ma H, Liu L, Wen X, Yu J, Wang L and Hu S: Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells. Mol Med Rep 10: 874-880, 2014.
APA
Liu, K., Song, X., Ma, H., Liu, L., Wen, X., Yu, J. ... Hu, S. (2014). Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells. Molecular Medicine Reports, 10, 874-880. https://doi.org/10.3892/mmr.2014.2305
MLA
Liu, K., Song, X., Ma, H., Liu, L., Wen, X., Yu, J., Wang, L., Hu, S."Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells". Molecular Medicine Reports 10.2 (2014): 874-880.
Chicago
Liu, K., Song, X., Ma, H., Liu, L., Wen, X., Yu, J., Wang, L., Hu, S."Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells". Molecular Medicine Reports 10, no. 2 (2014): 874-880. https://doi.org/10.3892/mmr.2014.2305
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Song X, Ma H, Liu L, Wen X, Yu J, Wang L and Hu S: Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells. Mol Med Rep 10: 874-880, 2014.
APA
Liu, K., Song, X., Ma, H., Liu, L., Wen, X., Yu, J. ... Hu, S. (2014). Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells. Molecular Medicine Reports, 10, 874-880. https://doi.org/10.3892/mmr.2014.2305
MLA
Liu, K., Song, X., Ma, H., Liu, L., Wen, X., Yu, J., Wang, L., Hu, S."Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells". Molecular Medicine Reports 10.2 (2014): 874-880.
Chicago
Liu, K., Song, X., Ma, H., Liu, L., Wen, X., Yu, J., Wang, L., Hu, S."Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells". Molecular Medicine Reports 10, no. 2 (2014): 874-880. https://doi.org/10.3892/mmr.2014.2305
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