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Article

Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer

  • Authors:
    • Jihong Feng
    • Zhongxue Fu
    • Jinbao Guo
    • Weidong Lu
    • Kunming Wen
    • Wangsheng Chen
    • Hao Wang
    • Jilai Wei
    • Shouru Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China, The Affiliated Hospital, Zunyi Medical College, Zunyi, Guizhou 563003, P.R. China, The Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan 266003, P.R. China
  • Pages: 867-873
    |
    Published online on: June 10, 2014
       https://doi.org/10.3892/mmr.2014.2316
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Abstract

Although human peroxiredoxin 2 (PRDX2) has been implicated in tumor progression (e.g., invasion and metastasis), little is known regarding its role in the epithelial‑mesenchymal transition (EMT) process during tumorigenesis. The present study offers the first evidence, to the best of our knowledge, that the antioxidant enzyme PRDX2 has an important role in regulating the EMT process. It was demonstrated that overexpression of PRDX2 leads to changes in cell morphology in vitro and potent inhibition of the transforming growth factor (TGF)‑β1‑induced EMT and cell migration of colorectal cancer (CRC) cells. Furthermore, PRDX2 regulates the expression of EMT markers, EMT‑related transcription factors and metastasis‑related factors in CRC cells. These results provide new insight into the role of PRDX2 in regulating EMT, cell migration and metastasis of CRC cells. It was concluded that the upregulation of PRDX2 may be correlated with EMT and contributes to the pathogenesis of CRC by inhibiting EMT, cell migration and metastasis. Taken together, these findings suggest that PRDX2 may be a key regulator of invasion and metastasis by inhibiting EMT of CRC cells, and also identifies a therapeutic strategy to effectively decrease the lethality of highly malignant types of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Feng J, Fu Z, Guo J, Lu W, Wen K, Chen W, Wang H, Wei J and Zhang S: Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. Mol Med Rep 10: 867-873, 2014.
APA
Feng, J., Fu, Z., Guo, J., Lu, W., Wen, K., Chen, W. ... Zhang, S. (2014). Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. Molecular Medicine Reports, 10, 867-873. https://doi.org/10.3892/mmr.2014.2316
MLA
Feng, J., Fu, Z., Guo, J., Lu, W., Wen, K., Chen, W., Wang, H., Wei, J., Zhang, S."Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer". Molecular Medicine Reports 10.2 (2014): 867-873.
Chicago
Feng, J., Fu, Z., Guo, J., Lu, W., Wen, K., Chen, W., Wang, H., Wei, J., Zhang, S."Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer". Molecular Medicine Reports 10, no. 2 (2014): 867-873. https://doi.org/10.3892/mmr.2014.2316
Copy and paste a formatted citation
x
Spandidos Publications style
Feng J, Fu Z, Guo J, Lu W, Wen K, Chen W, Wang H, Wei J and Zhang S: Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. Mol Med Rep 10: 867-873, 2014.
APA
Feng, J., Fu, Z., Guo, J., Lu, W., Wen, K., Chen, W. ... Zhang, S. (2014). Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. Molecular Medicine Reports, 10, 867-873. https://doi.org/10.3892/mmr.2014.2316
MLA
Feng, J., Fu, Z., Guo, J., Lu, W., Wen, K., Chen, W., Wang, H., Wei, J., Zhang, S."Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer". Molecular Medicine Reports 10.2 (2014): 867-873.
Chicago
Feng, J., Fu, Z., Guo, J., Lu, W., Wen, K., Chen, W., Wang, H., Wei, J., Zhang, S."Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer". Molecular Medicine Reports 10, no. 2 (2014): 867-873. https://doi.org/10.3892/mmr.2014.2316
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