Inhibitory effects of Picrasma quassioides (D.Don) Benn. on airway inflammation in a murine model of allergic asthma

Shin,Na‑Rae; Shin,In‑Sik; Jeon,Chan‑Mi; Hong,Ju‑Mi; Oh,Sei‑Ryang; Hahn,Kyu‑Woung; Ahn,Kyung‑Seop

doi:10.3892/mmr.2014.2322

September-2014 Volume 10 Issue 3

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September-2014 Volume 10 Issue 3

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Article

Inhibitory effects of Picrasma quassioides (D.Don) Benn. on airway inflammation in a murine model of allergic asthma

Authors:
- Na‑Rae Shin
- In‑Sik Shin
- Chan‑Mi Jeon
- Ju‑Mi Hong
- Sei‑Ryang Oh
- Kyu‑Woung Hahn
- Kyung‑Seop Ahn
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Affiliations: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon‑gun, Chungbuk 363‑883, Republic of Korea, Department of Biological Sciences and Biotechnology, College of Life Science and Nano Technology, Hannam University, Daejeon 306‑791, Republic of Korea
Pages: 1495-1500
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Published online on: June 13, 2014

https://doi.org/10.3892/mmr.2014.2322
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Abstract

Picrasma quassioides (D.Don) Benn. (PQ) is used in traditional medicine for the treatment of inflammatory conditions, including gastritis. This study aimed to evaluate the inhibitory effects of PQ on the inflammatory responses in mice with allergic asthma induced by ovalbumin (OVA) and in lipopolysaccharide (LPS)‑stimulated RAW264.7 cells. To induce allergic asthma, the mice underwent OVA sensitization on days 0 and 14 and then were challenged with OVA from days 21‑23. The mice were administered 15 and 30 mg/kg doses of PQ 1 h prior to the OVA challenge. The PQ treatment decreased the inflammatory cell count in the bronchoalveolar lavage fluid of the mice and reduced the levels of interleukin (IL)‑4, IL‑5, IL‑13 and immunoglobulin (Ig)E when compared with those in the OVA group. The PQ treatment also reduced the airway hyperresponsiveness induced by the OVA challenge, attenuated the recruitment of inflammatory cells and the mucus production in the airways of the mice. In the LPS‑stimulated RAW264.7 cells, the PQ treatment reduced the overexpression of inducible nitric oxide synthase (iNOS). The results indicated that PQ inhibits inflammatory responses in mice with OVA‑sensitized/challenged allergic asthma and in LPS‑stimulated RAW264.7 cells. These effects were considered to be associated with the suppression of iNOS expression. Therefore, PQ may have the potential to treat airway inflammatory diseases, including allergic asthma.

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1	Prado CM, Martins MA and Tibério IF: Nitric oxide in asthma physiopathology. ISRN Allergy. 2011:8325602011. View Article : Google Scholar : PubMed/NCBI
2	Schuijs MJ, Willart MA, Hammad H and Lambrecht BN: Cytokine targets in airway inflammation. Curr Opin Pharmacol. 13:351–361. 2013. View Article : Google Scholar : PubMed/NCBI
3	Jiao WH, Gao H, Zhao F, Lin HW, Pan YM, Zhou GX and Yao XS: Anti-inflammatory alkaloids form the stems of Picrasma qussioides BENNET. Chem Pharm Bull (Tokyo). 59:359–364. 2011. View Article : Google Scholar
4	Yin Y, Lee SK and Wang MH: Isolation and biological activities of an alkaloid compound (3-methylcanthin-5,6-dione) from Picrasma quassiodes (D.Don) Benn. Nat Prod Sci. 17:5–9. 2011.
5	Liu JF, Shao M, Zhai DW, Liu K and Wu LJ: Protective effect of 4-methoxy-5-hyfuoxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis. Planta Med. 75:142–145. 2009. View Article : Google Scholar : PubMed/NCBI
6	Fan H, Qi D, Yang M, Fang H, Liu K and Zhao F: In vitro and in vivo anti-inflammatory effects of 4-methoxy-5-hydroxycanthin-6-one, natural alkaloid from Picrasma quassioides. Phytomedicine. 20:319–323. 2013. View Article : Google Scholar : PubMed/NCBI
7	Ra J, Lee S, Kim HJ, Jang YP, Ahn H and Kim J: Bambusae Caulis in Taeniam extract reduces ovalbumin-induced airway inflammation and T helper 2 responses in mice. J Ethnopharmacol. 128:241–247. 2010. View Article : Google Scholar : PubMed/NCBI
8	Nader MA, El-Awady MS, Shalaby AA and El-Aqamy DS: Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease. Naunyn Schmidebergs Arch Pharmacol. 385:909–919. 2012. View Article : Google Scholar : PubMed/NCBI
9	Lee MY, Shin IS, Jeon WY, Lim HS, Kim JH and Ha H: Pinellia ternate Breitenbach attenuates ovalbumin-induced allergic airway inflammation and mucus secretion in a murine model of asthma. Immunopharmacol Immunotoxicol. 35:410–418. 2013. View Article : Google Scholar
10	Schmudde I, Laumonnier Y and Köhl J: Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma. Semin Immunol. 25:2–11. 2013. View Article : Google Scholar : PubMed/NCBI
11	Shin IS, Lee MY, Lim HS, Ha H, Seo CS, Kim JC and Shin HK: An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma. PLoS One. 7:e457342012.PubMed/NCBI
12	Lee YT, Lee SS, Sun HL, Lu KH, Ku MS, Sheu JN, Ko JL and Lue KH: Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model. Cytokine. 61:237–244. 2013. View Article : Google Scholar : PubMed/NCBI
13	Simoes DC, Xanthou G, Petrochilou K, Panoutsakopoulou V, Roussos C and Gratziou C: Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma. Am J Respir Crit Care Med. 179:894–902. 2009. View Article : Google Scholar : PubMed/NCBI
14	Shen JJ, Chiang MS, Kuo ML, Leu YL, Hwang TL, Liou CJ and Huang WC: Partially purified extract and viscolin from Viscum coloratum attenuate airway inflammation and eosinophil infiltration in ovalbumin-sensitized mice. J Ethnopharmacol. 135:646–653. 2011.PubMed/NCBI
15	Koarai A, Ichinose M, Sugiura H, Tomaki M, Watanabe M, Yamagata S, Komaki Y, Shirato K and Hattori T: iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response. Eur Respir J. 20:609–616. 2002. View Article : Google Scholar
16	Deshane J, Zmijewski JW, Luther R, Gaggar A, Deshane R, Lai JF, Xu X, Spell M, Estell K, Weaver CT, Abraham E, Schwiebert LM and Chaplin DD: Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness. Mucosal Immunol. 4:503–518. 2011. View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inhibitory effects of Picrasma quassioides (D.Don) Benn. on airway inflammation in a murine model of allergic asthma

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