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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2014 Volume 10 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

Retinal ganglion cell death is triggered by paraptosis via reactive oxygen species production: A brief literature review presenting a novel hypothesis in glaucoma pathology

Yao Wang, Kun Xu, Hongbing Zhang, Junhong Zhao, Xiuping Zhu, Yangzheng Wang, Renyi Wu
Pages: 1179-1183
Published online on: 19 June 2014

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Article Open Access

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo Retraction in /10.3892/mmr.2018.8586

Xianqing Zhang, Xingbin Hu, Shijie Mu, Yonghua Zhan, Qunxing An, Zhixin Liu, Xiaofeng Huang
Pages: 1184-1194
Published online on: 14 July 2014

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Article Open Access

Pattern of microRNA expression associated with different stages of alcoholic liver disease in rat models

Yi-Peng Chen, Xi Jin, Mei Kong, You-Ming Li
Pages: 1195-1204
Published online on: 07 July 2014

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Article Open Access

Elevated expression of SLC34A2 inhibits the viability and invasion of A549 cells

Weihan Yang, Yu Wang, Qiang Pu, Sujuan Ye, Qingping Ma, Jiang Ren, Guoxing Zhong, Lunxu Liu, Wen Zhu
Pages: 1205-1214
Published online on: 14 July 2014

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Article Open Access

Elevated intracranial dopamine impairs the glutamate‑nitric oxide‑cyclic guanosine monophosphate pathway in cortical astrocytes in rats with minimal hepatic encephalopathy

Saidan Ding, Weilong Huang, Yiru Ye, Jianjing Yang, Jiangnan Hu, Xiaobin Wang, Leping Liu, Qin Lu, Yuanshao Lin
Pages: 1215-1224
Published online on: 16 July 2014

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Article

Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats

Jingwu Liao, Jingming Xie, Daqiang Lin, Ning Lu, Limin Guo, Weiqiang Li, Bo Pu, Yang Yang, Zhenlong Yang, Ying Zhang, Yueming Song
Pages: 1225-1230
Published online on: 25 June 2014

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Article

Diabetes mellitus potentiates diffuse large B‑cell lymphoma via high levels of CCL5

Jingcheng Zhang, Jia Luo, Fanrong Liu, Dongmei Wu, Qingling Zhong, Liangtao Zeng, Ziqing Wu, Tong Zhao, Liqing Wu, Hua Hao
Pages: 1231-1236
Published online on: 17 June 2014

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Article Open Access

Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non‑alcoholic fatty liver disease via adenosine monophosphate‑activated protein kinase pathway activation

Wei‑Ming Sun, Yu‑Ping Wang, Yong‑Qiang Duan, Hong‑Xia Shang, Wei‑Dong Cheng
Pages: 1237-1244
Published online on: 13 June 2014

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Article Open Access

A SNaPshot assay for the rapid and simple detection of hepatitis B virus genotypes

Guoqi Lai, Wenlu Zhang, Hong Tang, Tingting Zhao, Liwen  Wei, Ying Tao, Zengchan Wang, Ailong Huang
Pages: 1245-1251
Published online on: 14 July 2014

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Article

CD8+HLA-DR+ T cells are increased in patients with severe aplastic anemia

Limin Xing, Chunyan Liu, Rong Fu, Huaquan Wang, Jun Wang, Xiao Liu, Le Feng, Lijuan Li, Hui Liu, Honglei Wang, Tian Zhang, Zonghong Shao
Pages: 1252-1258
Published online on: 18 June 2014

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Article Open Access

Screening of hepatocyte proteins binding with C‑terminally truncated surface antigen middle protein of hepatitis B virus (MHBst167) by a yeast two‑hybrid system

Zhi Qun Li, Enqiang Linghu, Wan Jun, Jun Cheng
Pages: 1259-1263
Published online on: 26 June 2014

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Article Open Access

Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasis using high resolution melting analysis and direct sequencing

Guorui Hu, Ping He, Zhifeng Liu, Qian Chen, Bixia Zheng, Qihua Zhang
Pages: 1264-1274
Published online on: 20 June 2014

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Article Open Access

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1‑AS expression

Te Liu, Yongyi Huang, Jiulin Chen, Huiying Chi, Zhihua Yu, Jian Wang, Chuan Chen
Pages: 1275-1281
Published online on: 23 June 2014

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Article Open Access

Transforming growth factor‑β1 reduces apoptosis via autophagy activation in hepatic stellate cells

Mei‑Ya Fu, Ya‑Jun He, Xia Lv, Zhi‑He Liu, Yan Shen, Guo‑Rong  Ye, Yan‑Mei Deng, Jian‑Chang Shu
Pages: 1282-1288
Published online on: 15 July 2014

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Article

Galanin receptor 2 utilizes distinct signaling pathways to suppress cell proliferation and induce apoptosis in HNSCC

Takeharu Kanazawa, Kiyoshi Misawa, Yuki Misawa, Mikiko Maruta, Takayuki Uehara, Kazumi Kawada, Takafumi Nagatomo, Keiichi Ichimura
Pages: 1289-1294
Published online on: 04 July 2014

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Article

Silencing of hypoxia‑inducible adrenomedullin using RNA interference attenuates hepatocellular carcinoma cell growth in vivo

Fenbao Li, Ruimin Yang, Xizhong Zhang, Aiguang Liu, Yongli Zhao, Yingchang Guo
Pages: 1295-1302
Published online on: 13 June 2014

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Article

Carbon dioxide‑pneumoperitoneum in rats reduces ischemia/reperfusion‑induced hepatic apoptosis and inflammatory responses by stimulating sensory neurons

Miho Kawai, Juan Zhao, Hideyuki Ishiguro, Hiromitsu Takeyama
Pages: 1303-1308
Published online on: 16 June 2014

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Article

An improved method for guinea pig airway smooth muscle cell culture and the effect of SPFF on intracellular calcium

Jian Liu, Yuyang Zhang, Qian Li, Quankun Zhuang, Xiaojie Zhu, Li Pan, Maosheng Cheng
Pages: 1309-1314
Published online on: 15 July 2014

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Article

Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation

Dai‑Ying Zhou, Ning Ding, Zhi‑Yun Du, Xiao‑Xing Cui, Hong Wang, Xing‑Chuan Wei, Allan H. Conney, Kun Zhang, Xi Zheng
Pages: 1315-1322
Published online on: 14 July 2014

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Article

Melatonin synergized with cyclosporine A improves cardiac allograft survival by suppressing inflammation and apoptosis

Chen Liu, Tao Hong, Mengping Shao, Zhenghang Chen, Chunsheng Wang
Pages: 1323-1328
Published online on: 15 July 2014

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Article

Evaluation of vascular grafts based on polyvinyl alcohol cryogels

Maria Teresa Conconi, Luca Borgio, Rosa Di Liddo, Leonardo Sartore, Daniele Dalzoppo, Pietro Amistà, Silvano Lora, Pier Paolo Parnigotto, Claudio Grandi
Pages: 1329-1334
Published online on: 19 June 2014

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Article Open Access

Knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of the AKT pathway

Hai Lin, Li‑Hua Sun, Wei Han, Tie‑Ying He, Xin‑Jian Xu, Kun Cheng, Cheng Geng, Li‑Dan Su, Hao Wen, Xi‑Yan Wang, Qi‑Long Chen
Pages: 1335-1342
Published online on: 07 July 2014

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Article

Association of intercellular adhesion molecule‑1 gene polymorphism with coronary heart disease

Jun‑Yi Luo, Yi‑Tong Ma, Xiang Xie, Yi‑Ning Yang, Xiao‑Mei Li, Xiang Ma, Zixiang Yu, Bang‑Dang Chen, Fen Liu
Pages: 1343-1348
Published online on: 01 July 2014

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Article

Platelet‑derived growth factor promotes osteoblast proliferation by activating G‑protein‑coupled receptor kinase interactor‑1

You Wu, Ying Zhang, Qingshui Yin, Hong Xia, Jiajia Wang
Pages: 1349-1354
Published online on: 14 July 2014

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Article

Bioactive components of Glycyrrhiza uralensis mediate drug functions and properties through regulation of CYP450 enzymes

Hao Chen, Xiaomei Zhang, Yifan Feng, Wen Rui, Zhongfeng Shi, Lirong Wu
Pages: 1355-1362
Published online on: 16 June 2014

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Article

Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes

Hwa Jun Cha, Ghang Tai Lee, Kwang Sik Lee, Kun Kook Lee, Jin Tae Hong, Na Kyeong Lee, Soo-Yeon Kim, Bo Mi Lee, In-Sook An, Hyung Jin Hahn, Kyu Joong Ahn, Su-Jae Lee, Sungkwan An, Seunghee Bae
Pages: 1363-1370
Published online on: 13 June 2014

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Article Open Access

Tumor necrosis factor-α induces interleukin-34 expression through nuclear factor‑κB activation in MC3T3-E1 osteoblastic cells

Yaqiong Yu, Di Yang, Lihong Qiu, Hirohiko Okamura, Jiajie Guo, Tatsuji Haneji
Pages: 1371-1376
Published online on: 25 June 2014

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Article

MicroRNA‑10a enhances the metastatic potential of cervical cancer cells by targeting phosphatase and tensin homologue

Tianhe Zeng, Guiling Li
Pages: 1377-1382
Published online on: 09 July 2014

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Article

(-)-Epigallocatechin gallate selectively inhibits adenosine diphosphate‑stimulated human platelet activation: Suppression of heat shock protein 27 phosphorylation via p38 mitogen‑activated protein kinase

Yuko Iida, Tomoaki Doi, Rie Matsushima-Nishiwaki, Haruhiko Tokuda, Shinji Ogura, Osamu Kozawa, Hiroki Iida
Pages: 1383-1388
Published online on: 16 July 2014

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Article

RNA interference targeting inhibition of S100A4 suppresses cell growth and promotes apoptosis in human laryngeal carcinoma Hep‑2 cells

Jia Liu, Shuang Fu, Yingqi Xu, Zhihong Zheng
Pages: 1389-1394
Published online on: 19 June 2014

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Article

Variation in Sp1 binding sites correlates with expression of survivin in breast cancer

Qing Xu, Mei Liu, Ningzhi Xu, Hongxia Zhu
Pages: 1395-1399
Published online on: 10 July 2014

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Article

Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats

Yu‑Qing Chen, Ling Rong, Jian‑Ou Qiao
Pages: 1400-1408
Published online on: 16 June 2014

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Article

Midkine and syndecan‑1 levels correlate with the progression of malignant gastric cardiac adenocarcinoma

Xiu‑Feng Hu, Jun Yao, She‑Gan Gao, Yan‑Tong Yang, Xiu‑Qing Peng, Xiao‑Shan Feng
Pages: 1409-1415
Published online on: 09 July 2014

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Article

Platelet-derived growth factor-β expression in rabbit models of cerebral vasospasm following subarachnoid hemorrhage

Hong-Kai Cui, Rui-Fang Yan, Xiao-Li Ding, Peng Zhao, Qing-Wu Wu, Hong-Po Wang, Hai-Xia Qin, Jian-Fei Tu, Rui-Min Yang
Pages: 1416-1422
Published online on: 20 June 2014

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Article

A familial late‑onset hereditary ataxia mimicking pontocerebellar hypoplasia caused by a novel TSEN54 mutation

Yi Qian, Haiyong Wang, Tao Jin, Yiqing Wang, Lizheng  Fang, Yuhao Chen, Liying Chen
Pages: 1423-1425
Published online on: 17 June 2014

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Article

MicroRNA-26a inhibits cell proliferation and invasion of cervical cancer cells by targeting protein tyrosine phosphatase type IVA 1

Jing Dong, Long Sui, Qing Wang, Mingjun Chen, Hong Sun
Pages: 1426-1432
Published online on: 16 June 2014

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Article

Radioprotective effect of a pan-caspase inhibitor in a novel model of radiation injury to the nucleus of the abducens nerve

Jianguo Li, Li Lin, Liqing Du, Chang Xu, Yan Wang, Jia Cao, Qin Wang, Feiyue Fan, Xiaoping Wang, Yafei Wang, Qiang Liu
Pages: 1433-1437
Published online on: 16 June 2014

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Article

c-FLIPp43 induces activation of the nuclear factor‑κB signaling pathway in a dose-dependent manner in the A375 melanoma cell line

Yujue Wang, Yating Tu, Jiejie Lu, Juan Tao, Yan Li
Pages: 1438-1442
Published online on: 07 July 2014

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Article

Respiratory syncytial virus infection modulates interleukin‑8 production in respiratory epithelial cells through a transcription factor‑activator protein‑1 signaling pathway

Yao Zhou, Jin Yang, Huan Deng, Hong Xu, Jiamin Zhang, Weisong Jin, Haiyan Gao, Feng Liu, Deyu Zhao
Pages: 1443-1447
Published online on: 26 June 2014

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Article

Bone marrow mesenchymal stem cells improve myocardial function in a swine model of acute myocardial infarction

Jing-Jie Zhao, Xiao‑Cheng Liu, Feng Kong, Tong‑Gang  Qi, Guang‑Hui Cheng, Jue Wang, Chao Sun, Yun Luan
Pages: 1448-1454
Published online on: 14 July 2014

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Article

Amelioration of doxorubicin‑induced cardiotoxicity by resveratrol

Sameer E. Al‑Harthi, Ohoud M. Alarabi, Wafaa S. Ramadan, Mohamed N. Alaama, Huda M. Al‑Kreathy, Zoheir A. Damanhouri, Lateef M. Khan, Abdel‑Moneim M. Osman
Pages: 1455-1460
Published online on: 15 July 2014

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Article

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction

Bo Wang, Kai Chen, Wenming Xu, Di Chen, Wei Tang, Tian‑Song Xia
Pages: 1461-1468
Published online on: 17 June 2014

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Article

TLR9 and BAFF: Their expression in patients with IgA nephropathy

Weiwei Li, Xiaofei Peng, Yuyuan Liu, Hong Liu, Fuyou Liu, Liyu He, Yang Liu, Fan  Zhang, Chunyan Guo, Guochun Chen, Lei Zhang, Zheng Dong, Youming Peng
Pages: 1469-1474
Published online on: 01 July 2014

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Article

miR-137 regulates the migration of human umbilical vein endothelial cells by targeting ephrin-type A receptor 7

Yucheng Lu, Xueyuan Heng, Jixu Yu, Quanping Su, Xianghong  Guan, Cuiping You, Long Wang, Fengyuan Che
Pages: 1475-1480
Published online on: 13 June 2014

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Article

In vitro selection and identification of ssDNA aptamers recognizing the Ras protein

Zhi‑Wei Wang, Hong‑Bing Wu, Zhi‑Fu Mao, Xiao‑Ping Hu, Hao Zhang, Zhi‑Peng Hu, Zong‑Li Ren
Pages: 1481-1488
Published online on: 16 June 2014

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Article

Nucleolin identified by comparative mass‑spectra analysis is a potential marker for invasive progression of hepatocellular carcinoma

Bin Qian, Yusheng Yao, Yihong Liu, Maolin Yan, Ying Huang, Yanqing Chen
Pages: 1489-1494
Published online on: 13 June 2014

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Article

Inhibitory effects of Picrasma quassioides (D.Don) Benn. on airway inflammation in a murine model of allergic asthma

Na‑Rae Shin, In‑Sik Shin, Chan‑Mi Jeon, Ju‑Mi Hong, Sei‑Ryang Oh, Kyu‑Woung Hahn, Kyung‑Seop Ahn
Pages: 1495-1500
Published online on: 13 June 2014

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Article

Ulinastatin attenuates renal interstitial inflammation and inhibits fibrosis progression in rats under unilateral ureteral obstruction

Guo-Tao Jiang, Xiao Chen, Dong Li, Hui-Xia An, Jun-Dong Jiao
Pages: 1501-1508
Published online on: 13 June 2014

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Article

Estrogen protects cardiomyocytes against lipopolysaccharide by inhibiting autophagy

Fengmei  Wang, Jian Xiao, Yaofeng Shen, Feng Yao, Yu Chen
Pages: 1509-1512
Published online on: 07 July 2014

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Article

Podoplanin‑positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion

Jiang-Chao Li, Yan Li, Jiao-Yu Ai, Kai Chen, Ying‑Hui Zhu, Li Fu, Yan-Ru Qin, Li-Jing Wang, Xin-Yuan Guan
Pages: 1513-1518
Published online on: 17 June 2014

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Article

Arsenic trioxide and bortezomib interact synergistically to induce apoptosis in chronic myelogenous leukemia cells resistant to imatinib mesylate through Bcr/Abl‑dependent mechanisms

Wenbin Xu, Wei Wei, Qing Yu, Chao Wu, Chenjing Ye, Yingli Wu, Hua Yan
Pages: 1519-1524
Published online on: 16 June 2014

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Article

Perioperative changes in peripheral regulatory B cells of patients with esophageal cancer

Jiazhen Shi, Shibao Li, Yan Zhou, Lixin Wang, Jiangtao Wen, Yonghong Wang, Zhihua Kang
Pages: 1525-1530
Published online on: 19 June 2014

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Article

Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP‑2

Alex Chien Hwa Liao, Chia‑Cheng Kuo, Yei‑Chung Huang, Chi‑Wei Yeh, You‑Cheng Hseu, Jer‑Yuh Liu, Li‑Sung Hsu
Pages: 1531-1536
Published online on: 14 July 2014

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Article

microRNA‑802 promotes lung carcinoma proliferation by targeting the tumor suppressor menin

Lun‑Qing Wang, Gang Chen, Xiang‑Yan Liu, Fan‑Ying Liu, Shao‑Yan Jiang, Zhou Wang
Pages: 1537-1542
Published online on: 01 July 2014

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Article

Experimental chondrocyte hypertrophy is promoted by the activation of discoidin domain receptor 2

Sihan Zhang, Yu Zhong, Rongheng Li, Wei Wang, Li  Zeng, Zheming Wang, Ping Jia, Rui Wu
Pages: 1543-1548
Published online on: 17 June 2014

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Article

Transforming growth factor‑β1 induces epithelial‑mesenchymal transition and increased expression of matrix metalloproteinase‑16 via miR‑200b downregulation in bladder cancer cells

Min Feng Chen, Feng Zeng, Lin Qi, Xiong Bing Zu, Jun Wang, Long Fei Liu, Yuan Li
Pages: 1549-1554
Published online on: 07 July 2014

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Article

Inhibitory effects of hydroxysafflor yellow A on PDGF‑BB‑induced proliferation and migration of vascular smooth muscle cells via mediating Akt signaling

Yanmin Song, Lili Long, Ning Zhang, Yunhai Liu
Pages: 1555-1560
Published online on: 16 June 2014

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Article

Expression and effect of CXCL14 in colorectal carcinoma

Kezhi Lin, Ruanmin Zou, Feng Lin, Shuang Zheng, Xian Shen, Xiangyang Xue
Pages: 1561-1568
Published online on: 17 June 2014

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Article

Low‑dose radiation‑induced apoptosis in human leukemia K562 cells through mitochondrial pathways

Yong Xin, Hai-Bin Zhang, Tian-You Tang, Gui-Hong Liu, Jian‑She Wang, Guan Jiang, Long‑Zhen Zhang
Pages: 1569-1575
Published online on: 15 July 2014

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Article

Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes

Hui Chen, Yongjun Chen, Yanhong Tang, Jing Yang, Dandan Wang, Taihui Yu, Congxin Huang
Pages: 1576-1582
Published online on: 14 July 2014

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Expression and clinical significance of RCDG1 in renal cell carcinoma: A novel renal cancer‑associated gene

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Eupolyphaga sinensis Walker demonstrates angiogenic activity and inhibits A549 cell growth by targeting the KDR signaling pathway

Bingling Dai, Junpeng Qi, Rui Liu, Yanmin Zhang
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Haiyan Luan, Limin Yang, Lei Liu, Shuang Liu, Xiaolian Zhao, Hongyu Sui, Jingtao Wang, Shuqiu Wang
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Effect of Substance P on type II alveolar epithelial cells exposed to hyperoxia and its regulation of the Sonic hedgehog signaling pathway

Cong Liu, Lin Yang, Hongxing Dang, Fang Fang, Feng Xu
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High‑dose folic acid improves endothelial function by increasing tetrahydrobiopterin and decreasing homocysteine levels

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Congenital cataracts due to a novel 2‑bp deletion in CRYBA1/A3

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Recombinant Neisseria surface protein A is a potential vaccine candidate against Neisseria meningitides serogroup B

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Effects of polycystin‑1 N‑terminal fragment fusion protein on the proliferation and apoptosis of rat mesangial cells

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Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion

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The application of autologous platelet‑rich plasma gel in cartilage regeneration

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Human leptin protein activates the growth of HepG2 cells by inhibiting PERK‑mediated ER stress and apoptosis

Ying Xiong, Jie Zhang, Man Liu, Mingwei An, Ling Lei, Wuhua Guo
Pages: 1649-1655
Published online on: 14 July 2014

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Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
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Ayman A. Althubity
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Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
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Published online on: 03 November 2025

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Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
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Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
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Article Number: 21
Published online on: 29 October 2025

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Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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