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Article

Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats

  • Authors:
    • Yu‑Qing Chen
    • Ling Rong
    • Jian‑Ou Qiao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, P.R. China, Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China
  • Pages: 1400-1408
    |
    Published online on: June 16, 2014
       https://doi.org/10.3892/mmr.2014.2328
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Abstract

This study investigated the effect of Panax notoginseng saponins (PNS) on acute lung injury (ALI) induced by oleic acid (OA) and lipopolysaccharide (LPS). A total of 28 Wistar rats were divided into four groups: sham; sham + PNS; OA‑LPS‑induced ALI and ALI + PNS. Lung tissue histology, lung wet‑to‑dry (W/D) weight ratio, extravascular lung water (EVLW) and epithelial sodium channel α (αENaC) mRNA and protein expression were examined. In addition, levels of inflammatory cytokines, including tumor necrosis factor α (TNF‑α), interleukin (IL)‑6 and IL‑10, as well as total leukocyte and neutrophil counts, were analyzed in rat bronchoalveolar lavage fluid (BALF) and serum. ALI + PNS rats were observed to exhibit significantly lower pulmonary parenchymal damage and EVLW compared with ALI rats. Furthermore, total leukocyte and neutrophil counts, and levels of inflammatory cytokines were significantly decreased following PNS administration in ALI rats. In addition, the decrease in αENaC mRNA and protein expression observed in the lung tissue of ALI rats was partially restored following PNS treatment. PNS treatment was demonstrated to ameliorate OA‑LPS‑induced ALI, potentially through restoration of αENaC mRNA and protein expression and through PNS‑induced anti‑inflammatory effects.
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Copy and paste a formatted citation
Spandidos Publications style
Chen YQ, Rong L and Qiao JO: Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats. Mol Med Rep 10: 1400-1408, 2014.
APA
Chen, Y., Rong, L., & Qiao, J. (2014). Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats. Molecular Medicine Reports, 10, 1400-1408. https://doi.org/10.3892/mmr.2014.2328
MLA
Chen, Y., Rong, L., Qiao, J."Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats". Molecular Medicine Reports 10.3 (2014): 1400-1408.
Chicago
Chen, Y., Rong, L., Qiao, J."Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats". Molecular Medicine Reports 10, no. 3 (2014): 1400-1408. https://doi.org/10.3892/mmr.2014.2328
Copy and paste a formatted citation
x
Spandidos Publications style
Chen YQ, Rong L and Qiao JO: Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats. Mol Med Rep 10: 1400-1408, 2014.
APA
Chen, Y., Rong, L., & Qiao, J. (2014). Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats. Molecular Medicine Reports, 10, 1400-1408. https://doi.org/10.3892/mmr.2014.2328
MLA
Chen, Y., Rong, L., Qiao, J."Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats". Molecular Medicine Reports 10.3 (2014): 1400-1408.
Chicago
Chen, Y., Rong, L., Qiao, J."Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats". Molecular Medicine Reports 10, no. 3 (2014): 1400-1408. https://doi.org/10.3892/mmr.2014.2328
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